Format

Send to:

Choose Destination

LAYN layilin [ Homo sapiens (human) ]

Gene ID: 143903, updated on 12-Sep-2021

Summary

Official Symbol
LAYNprovided by HGNC
Official Full Name
layilinprovided by HGNC
Primary source
HGNC:HGNC:29471
See related
Ensembl:ENSG00000204381 MIM:618843
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Expression
Broad expression in ovary (RPKM 7.0), thyroid (RPKM 6.2) and 20 other tissues See more
Orthologs
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

See LAYN in Genome Data Viewer
Location:
11q23.1
Exon count:
9
Annotation release Status Assembly Chr Location
109.20210514 current GRCh38.p13 (GCF_000001405.39) 11 NC_000011.10 (111540280..111561745)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (111411005..111432470)

Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene BTG anti-proliferation factor 4 Neighboring gene uncharacterized LOC728196 Neighboring gene microRNA 34c Neighboring gene HOATZ cilia and flagella associated protein Neighboring gene salt inducible kinase 2 Neighboring gene RN7SK pseudogene 273 Neighboring gene protein phosphatase 2 scaffold subunit Abeta

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

Associated conditions

Description Tests
Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population.
GeneReviews: Not available

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Homology

Clone Names

  • FLJ30977, FLJ31092

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables carbohydrate binding IEA
Inferred from Electronic Annotation
more info
 
enables hyaluronic acid binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables hyaluronic acid binding IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
located_in cell surface ISS
Inferred from Sequence or Structural Similarity
more info
 
located_in focal adhesion HDA PubMed 
NOT located_in focal adhesion ISS
Inferred from Sequence or Structural Similarity
more info
 
located_in integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
located_in ruffle ISS
Inferred from Sequence or Structural Similarity
more info
 

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001258390.2NP_001245319.1  layilin isoform 1 precursor

    See identical proteins and their annotated locations for NP_001245319.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
    Source sequence(s)
    AK055539, AK296231, AY358554, DA608521
    Consensus CDS
    CCDS58178.1
    UniProtKB/Swiss-Prot
    Q6UX15
    Related
    ENSP00000364765.3, ENST00000375615.7
    Conserved Domains (1) summary
    cd03595
    Location:38186
    CLECT_chondrolectin_like; C-type lectin-like domain (CTLD) of the type found in the human type-1A transmembrane proteins chondrolectin (CHODL) and layilin
  2. NM_001258391.2NP_001245320.1  layilin isoform 3

    See identical proteins and their annotated locations for NP_001245320.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) lacks two internal exons and initiates translation at an alternate start codon, compared to variant 1. The encoded isoform (3) is shorter and has a distinct N-terminus, compared to isoform 1.
    Source sequence(s)
    AK055539, AK296231, DA608521, DB006476
    Consensus CDS
    CCDS58179.1
    UniProtKB/Swiss-Prot
    Q6UX15
    Related
    ENSP00000392942.2, ENST00000436913.6
  3. NM_001318799.1NP_001305728.1  layilin isoform 4

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) differs in the 5' UTR and coding sequence compared to variant 1. The resulting isoform (4) is shorter at the N-terminus compared to isoform 1.
    Source sequence(s)
    AK055539, AP002008, DC398135
    UniProtKB/Swiss-Prot
    Q6UX15
    UniProtKB/TrEMBL
    B4DDS5
    Conserved Domains (1) summary
    cl02432
    Location:134
    CLECT; C-type lectin (CTL)/C-type lectin-like (CTLD) domain
  4. NM_178834.5NP_849156.1  layilin isoform 2 precursor

    See identical proteins and their annotated locations for NP_849156.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an exon in the 5' coding region, but maintains the reading frame, compared to variant 1. The encoded isoform (2) is shorter than isoform 1.
    Source sequence(s)
    AK055539, AK296231, DA608521
    Consensus CDS
    CCDS31676.1
    UniProtKB/Swiss-Prot
    Q6UX15
    Related
    ENSP00000364764.2, ENST00000375614.7
    Conserved Domains (1) summary
    cd03595
    Location:30178
    CLECT_chondrolectin_like; C-type lectin-like domain (CTLD) of the type found in the human type-1A transmembrane proteins chondrolectin (CHODL) and layilin

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000011.10 Reference GRCh38.p13 Primary Assembly

    Range
    111540280..111561745
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006718770.4XP_006718833.1  layilin isoform X2

    See identical proteins and their annotated locations for XP_006718833.1

    UniProtKB/Swiss-Prot
    Q6UX15
  2. XM_006718769.4XP_006718832.1  layilin isoform X1

    See identical proteins and their annotated locations for XP_006718832.1

    UniProtKB/TrEMBL
    B4DDS5
    Conserved Domains (1) summary
    cl02432
    Location:134
    CLECT; C-type lectin (CTL)/C-type lectin-like (CTLD) domain
Support Center