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Igf1 insulin-like growth factor 1 [ Rattus norvegicus (Norway rat) ]

Gene ID: 24482, updated on 26-Jul-2020

Summary

Official Symbol
Igf1provided by RGD
Official Full Name
insulin-like growth factor 1provided by RGD
Primary source
RGD:2868
See related
Ensembl:ENSRNOG00000004517
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
IGF
Summary
growth factor; plays a major role in mammalian growth [RGD, Feb 2006]
Expression
Biased expression in Liver (RPKM 1821.5), Uterus (RPKM 212.9) and 6 other tissues See more
Orthologs

Genomic context

See Igf1 in Genome Data Viewer
Location:
7q13
Exon count:
9
Annotation release Status Assembly Chr Location
106 current Rnor_6.0 (GCF_000001895.5) 7 NC_005106.4 (28412123..28491815)
106 current Rn_Celera (GCF_000002265.2) 7 AC_000075.1 (19453213..19527075)
104 previous assembly Rnor_5.0 (GCF_000001895.4) 7 NC_005106.3 (28528165..28607747)

Chromosome 7 - NC_005106.4Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC103692817 Neighboring gene uncharacterized LOC103692818 Neighboring gene hypothetical protein LOC679716 Neighboring gene PARP1 binding protein Neighboring gene pro-melanin-concentrating hormone

Genomic regions, transcripts, and products

Expression

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

General gene information

Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
growth factor activity IEA
Inferred from Electronic Annotation
more info
 
growth factor activity TAS
Traceable Author Statement
more info
PubMed 
hormone activity IDA
Inferred from Direct Assay
more info
PubMed 
hormone activity IEA
Inferred from Electronic Annotation
more info
 
hormone activity ISO
Inferred from Sequence Orthology
more info
 
insulin receptor binding IEA
Inferred from Electronic Annotation
more info
 
insulin receptor binding ISO
Inferred from Sequence Orthology
more info
 
insulin-like growth factor receptor binding IDA
Inferred from Direct Assay
more info
PubMed 
insulin-like growth factor receptor binding IEA
Inferred from Electronic Annotation
more info
 
insulin-like growth factor receptor binding ISO
Inferred from Sequence Orthology
more info
 
integrin binding IEA
Inferred from Electronic Annotation
more info
 
integrin binding ISO
Inferred from Sequence Orthology
more info
 
protein serine/threonine kinase activator activity IDA
Inferred from Direct Assay
more info
PubMed 
steroid binding IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
ERK1 and ERK2 cascade IEA
Inferred from Electronic Annotation
more info
 
ERK1 and ERK2 cascade ISO
Inferred from Sequence Orthology
more info
 
activation of MAPK activity IEA
Inferred from Electronic Annotation
more info
 
activation of MAPK activity ISO
Inferred from Sequence Orthology
more info
 
activation of protein kinase B activity IEA
Inferred from Electronic Annotation
more info
 
activation of protein kinase B activity ISO
Inferred from Sequence Orthology
more info
 
aging IEP
Inferred from Expression Pattern
more info
PubMed 
blood vessel remodeling ISO
Inferred from Sequence Orthology
more info
 
bone development IEP
Inferred from Expression Pattern
more info
PubMed 
bone mineralization involved in bone maturation IEA
Inferred from Electronic Annotation
more info
 
bone mineralization involved in bone maturation ISO
Inferred from Sequence Orthology
more info
 
branching morphogenesis of an epithelial tube ISO
Inferred from Sequence Orthology
more info
 
cardiac atrium development IEP
Inferred from Expression Pattern
more info
PubMed 
cell activation IEA
Inferred from Electronic Annotation
more info
 
cell activation ISO
Inferred from Sequence Orthology
more info
 
cell development ISO
Inferred from Sequence Orthology
more info
 
cell proliferation ISO
Inferred from Sequence Orthology
more info
 
cellular response to Thyroglobulin triiodothyronine IEP
Inferred from Expression Pattern
more info
PubMed 
cellular response to amyloid-beta IEA
Inferred from Electronic Annotation
more info
 
cellular response to amyloid-beta ISO
Inferred from Sequence Orthology
more info
 
cellular response to dexamethasone stimulus IEP
Inferred from Expression Pattern
more info
PubMed 
cellular response to electrical stimulus IEP
Inferred from Expression Pattern
more info
PubMed 
cellular response to estradiol stimulus IEP
Inferred from Expression Pattern
more info
PubMed 
cellular response to glucose stimulus ISO
Inferred from Sequence Orthology
more info
 
cellular response to insulin stimulus IEP
Inferred from Expression Pattern
more info
PubMed 
cellular response to insulin-like growth factor stimulus ISO
Inferred from Sequence Orthology
more info
 
cellular response to nicotine IEP
Inferred from Expression Pattern
more info
PubMed 
cellular response to progesterone stimulus IEP
Inferred from Expression Pattern
more info
PubMed 
chondroitin sulfate proteoglycan biosynthetic process ISO
Inferred from Sequence Orthology
more info
 
circadian rhythm ISO
Inferred from Sequence Orthology
more info
 
cranial suture morphogenesis IEP
Inferred from Expression Pattern
more info
PubMed 
detection of mechanical stimulus involved in sensory perception IMP
Inferred from Mutant Phenotype
more info
PubMed 
exocrine pancreas development ISO
Inferred from Sequence Orthology
more info
 
extrinsic apoptotic signaling pathway in absence of ligand ISO
Inferred from Sequence Orthology
more info
 
female pregnancy IEP
Inferred from Expression Pattern
more info
PubMed 
glial cell differentiation ISO
Inferred from Sequence Orthology
more info
 
inner ear development ISO
Inferred from Sequence Orthology
more info
 
insulin-like growth factor receptor signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
insulin-like growth factor receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
 
insulin-like growth factor receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
 
lung alveolus development ISO
Inferred from Sequence Orthology
more info
 
lung development ISO
Inferred from Sequence Orthology
more info
 
lung lobe morphogenesis ISO
Inferred from Sequence Orthology
more info
 
lung vasculature development ISO
Inferred from Sequence Orthology
more info
 
mammary gland development ISO
Inferred from Sequence Orthology
more info
 
memory IMP
Inferred from Mutant Phenotype
more info
PubMed 
multicellular organism growth ISO
Inferred from Sequence Orthology
more info
 
muscle hypertrophy IEA
Inferred from Electronic Annotation
more info
 
muscle hypertrophy ISO
Inferred from Sequence Orthology
more info
 
myoblast differentiation IEA
Inferred from Electronic Annotation
more info
 
myoblast differentiation ISO
Inferred from Sequence Orthology
more info
 
myoblast proliferation IEA
Inferred from Electronic Annotation
more info
 
myoblast proliferation ISO
Inferred from Sequence Orthology
more info
 
myotube cell development IEA
Inferred from Electronic Annotation
more info
 
myotube cell development ISO
Inferred from Sequence Orthology
more info
 
negative regulation of ERK1 and ERK2 cascade ISO
Inferred from Sequence Orthology
more info
 
negative regulation of amyloid-beta formation IEA
Inferred from Electronic Annotation
more info
 
negative regulation of amyloid-beta formation ISO
Inferred from Sequence Orthology
more info
 
negative regulation of androgen receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
 
negative regulation of apoptotic process IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of apoptotic process ISO
Inferred from Sequence Orthology
more info
 
negative regulation of apoptotic process ISS
Inferred from Sequence or Structural Similarity
more info
 
negative regulation of cell proliferation ISO
Inferred from Sequence Orthology
more info
 
negative regulation of cholangiocyte apoptotic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of cysteine-type endopeptidase activity involved in apoptotic process IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of extrinsic apoptotic signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of extrinsic apoptotic signaling pathway IEA
Inferred from Electronic Annotation
more info
 
negative regulation of extrinsic apoptotic signaling pathway ISO
Inferred from Sequence Orthology
more info
 
negative regulation of gene expression ISO
Inferred from Sequence Orthology
more info
 
negative regulation of immune system process IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of interleukin-1 beta production IEA
Inferred from Electronic Annotation
more info
 
negative regulation of interleukin-1 beta production ISO
Inferred from Sequence Orthology
more info
 
negative regulation of muscle cell apoptotic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of neuroinflammatory response IEA
Inferred from Electronic Annotation
more info
 
negative regulation of neuroinflammatory response ISO
Inferred from Sequence Orthology
more info
 
negative regulation of neuron death IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of oligodendrocyte apoptotic process IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of oocyte development IEA
Inferred from Electronic Annotation
more info
 
negative regulation of oocyte development ISO
Inferred from Sequence Orthology
more info
 
negative regulation of peptidyl-tyrosine phosphorylation ISO
Inferred from Sequence Orthology
more info
 
negative regulation of release of cytochrome c from mitochondria ISO
Inferred from Sequence Orthology
more info
 
negative regulation of release of cytochrome c from mitochondria ISS
Inferred from Sequence or Structural Similarity
more info
 
negative regulation of smooth muscle cell apoptotic process ISO
Inferred from Sequence Orthology
more info
 
negative regulation of tumor necrosis factor production IEA
Inferred from Electronic Annotation
more info
 
negative regulation of tumor necrosis factor production ISO
Inferred from Sequence Orthology
more info
 
negative regulation of vascular associated smooth muscle cell apoptotic process IEA
Inferred from Electronic Annotation
more info
 
negative regulation of vascular associated smooth muscle cell apoptotic process ISO
Inferred from Sequence Orthology
more info
 
nervous system development ISO
Inferred from Sequence Orthology
more info
 
osteoblast differentiation ISO
Inferred from Sequence Orthology
more info
 
phosphatidylinositol 3-kinase signaling IEA
Inferred from Electronic Annotation
more info
 
phosphatidylinositol 3-kinase signaling ISO
Inferred from Sequence Orthology
more info
 
phosphatidylinositol-mediated signaling ISO
Inferred from Sequence Orthology
more info
 
positive regulation of DNA binding ISO
Inferred from Sequence Orthology
more info
 
positive regulation of MAPK cascade ISO
Inferred from Sequence Orthology
more info
 
positive regulation of Ras protein signal transduction IEA
Inferred from Electronic Annotation
more info
 
positive regulation of Ras protein signal transduction ISO
Inferred from Sequence Orthology
more info
 
positive regulation of activated T cell proliferation IEA
Inferred from Electronic Annotation
more info
 
positive regulation of activated T cell proliferation ISO
Inferred from Sequence Orthology
more info
 
positive regulation of blood vessel endothelial cell migration IGI
Inferred from Genetic Interaction
more info
PubMed 
positive regulation of calcineurin-NFAT signaling cascade IEA
Inferred from Electronic Annotation
more info
 
positive regulation of calcineurin-NFAT signaling cascade ISO
Inferred from Sequence Orthology
more info
 
positive regulation of cardiac muscle hypertrophy ISO
Inferred from Sequence Orthology
more info
 
positive regulation of cell growth IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of cell growth IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of cell growth involved in cardiac muscle cell development IEA
Inferred from Electronic Annotation
more info
 
positive regulation of cell growth involved in cardiac muscle cell development ISO
Inferred from Sequence Orthology
more info
 
positive regulation of cell migration ISO
Inferred from Sequence Orthology
more info
 
positive regulation of cell proliferation ISO
Inferred from Sequence Orthology
more info
 
positive regulation of cell proliferation ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of cerebellar granule cell precursor proliferation ISO
Inferred from Sequence Orthology
more info
 
positive regulation of epithelial cell proliferation IEA
Inferred from Electronic Annotation
more info
 
positive regulation of epithelial cell proliferation ISO
Inferred from Sequence Orthology
more info
 
positive regulation of fat cell differentiation IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of fibroblast proliferation IEA
Inferred from Electronic Annotation
more info
 
positive regulation of fibroblast proliferation ISO
Inferred from Sequence Orthology
more info
 
positive regulation of gene expression ISO
Inferred from Sequence Orthology
more info
 
positive regulation of glial cell proliferation IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of glucose import IEA
Inferred from Electronic Annotation
more info
 
positive regulation of glucose import ISO
Inferred from Sequence Orthology
more info
 
positive regulation of glucose import ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of glycogen biosynthetic process IEA
Inferred from Electronic Annotation
more info
 
positive regulation of glycogen biosynthetic process ISO
Inferred from Sequence Orthology
more info
 
positive regulation of glycogen biosynthetic process ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of glycolytic process IEA
Inferred from Electronic Annotation
more info
 
positive regulation of glycolytic process ISO
Inferred from Sequence Orthology
more info
 
positive regulation of glycoprotein biosynthetic process IEA
Inferred from Electronic Annotation
more info
 
positive regulation of glycoprotein biosynthetic process ISO
Inferred from Sequence Orthology
more info
 
positive regulation of insulin-like growth factor receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
 
positive regulation of insulin-like growth factor receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
 
positive regulation of mitotic nuclear division IEA
Inferred from Electronic Annotation
more info
 
positive regulation of mitotic nuclear division ISO
Inferred from Sequence Orthology
more info
 
positive regulation of myelination ISO
Inferred from Sequence Orthology
more info
 
positive regulation of myoblast proliferation ISO
Inferred from Sequence Orthology
more info
 
positive regulation of osteoblast differentiation IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of osteoblast differentiation IEA
Inferred from Electronic Annotation
more info
 
positive regulation of osteoblast differentiation ISO
Inferred from Sequence Orthology
more info
 
positive regulation of peptidyl-tyrosine phosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of peptidyl-tyrosine phosphorylation ISO
Inferred from Sequence Orthology
more info
 
positive regulation of phosphatidylinositol 3-kinase signaling IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of phosphatidylinositol 3-kinase signaling IEA
Inferred from Electronic Annotation
more info
 
positive regulation of phosphatidylinositol 3-kinase signaling ISO
Inferred from Sequence Orthology
more info
 
positive regulation of protein kinase B signaling ISO
Inferred from Sequence Orthology
more info
 
positive regulation of protein secretion IEA
Inferred from Electronic Annotation
more info
 
positive regulation of protein secretion ISO
Inferred from Sequence Orthology
more info
 
positive regulation of protein serine/threonine kinase activity IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of smooth muscle cell migration IEA
Inferred from Electronic Annotation
more info
 
positive regulation of smooth muscle cell migration ISO
Inferred from Sequence Orthology
more info
 
positive regulation of smooth muscle cell proliferation ISO
Inferred from Sequence Orthology
more info
 
positive regulation of steroid hormone biosynthetic process IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of transcription by RNA polymerase II IEA
Inferred from Electronic Annotation
more info
 
positive regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
 
positive regulation of transcription regulatory region DNA binding IEA
Inferred from Electronic Annotation
more info
 
positive regulation of transcription regulatory region DNA binding ISO
Inferred from Sequence Orthology
more info
 
positive regulation of transcription, DNA-templated ISO
Inferred from Sequence Orthology
more info
 
positive regulation of trophectodermal cell proliferation IEA
Inferred from Electronic Annotation
more info
 
positive regulation of trophectodermal cell proliferation ISO
Inferred from Sequence Orthology
more info
 
positive regulation of tyrosine phosphorylation of STAT protein IEA
Inferred from Electronic Annotation
more info
 
positive regulation of tyrosine phosphorylation of STAT protein ISO
Inferred from Sequence Orthology
more info
 
positive regulation of vascular endothelial cell proliferation IGI
Inferred from Genetic Interaction
more info
PubMed 
positive regulation of vascular smooth muscle cell proliferation IEA
Inferred from Electronic Annotation
more info
 
positive regulation of vascular smooth muscle cell proliferation ISO
Inferred from Sequence Orthology
more info
 
prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis ISO
Inferred from Sequence Orthology
more info
 
prostate gland epithelium morphogenesis ISO
Inferred from Sequence Orthology
more info
 
prostate gland growth ISO
Inferred from Sequence Orthology
more info
 
prostate gland stromal morphogenesis ISO
Inferred from Sequence Orthology
more info
 
protein kinase B signaling IEA
Inferred from Electronic Annotation
more info
 
protein kinase B signaling ISO
Inferred from Sequence Orthology
more info
 
protein stabilization IEA
Inferred from Electronic Annotation
more info
 
protein stabilization ISO
Inferred from Sequence Orthology
more info
 
proteoglycan biosynthetic process IEA
Inferred from Electronic Annotation
more info
 
proteoglycan biosynthetic process ISO
Inferred from Sequence Orthology
more info
 
regulation of calcium ion transport IDA
Inferred from Direct Assay
more info
PubMed 
regulation of cell proliferation IDA
Inferred from Direct Assay
more info
PubMed 
regulation of establishment or maintenance of cell polarity ISO
Inferred from Sequence Orthology
more info
 
regulation of gene expression ISO
Inferred from Sequence Orthology
more info
 
regulation of multicellular organism growth IEA
Inferred from Electronic Annotation
more info
 
regulation of multicellular organism growth ISO
Inferred from Sequence Orthology
more info
 
regulation of nitric oxide biosynthetic process ISO
Inferred from Sequence Orthology
more info
 
regulation of protein metabolic process ISO
Inferred from Sequence Orthology
more info
 
regulation of protein phosphorylation ISO
Inferred from Sequence Orthology
more info
 
regulation of translation IMP
Inferred from Mutant Phenotype
more info
PubMed 
response to activity IEP
Inferred from Expression Pattern
more info
PubMed 
response to caffeine IEP
Inferred from Expression Pattern
more info
PubMed 
response to epidermal growth factor IEP
Inferred from Expression Pattern
more info
PubMed 
response to estradiol IEP
Inferred from Expression Pattern
more info
PubMed 
response to ethanol IDA
Inferred from Direct Assay
more info
PubMed 
response to ethanol IEP
Inferred from Expression Pattern
more info
PubMed 
response to glucocorticoid IEP
Inferred from Expression Pattern
more info
PubMed 
response to growth hormone IEP
Inferred from Expression Pattern
more info
PubMed 
response to heat IEA
Inferred from Electronic Annotation
more info
 
response to heat ISO
Inferred from Sequence Orthology
more info
 
response to hypoxia IEP
Inferred from Expression Pattern
more info
PubMed 
response to lipopolysaccharide IEP
Inferred from Expression Pattern
more info
PubMed 
response to mechanical stimulus IEP
Inferred from Expression Pattern
more info
PubMed 
response to nicotine IEP
Inferred from Expression Pattern
more info
PubMed 
response to nutrient IEP
Inferred from Expression Pattern
more info
PubMed 
response to nutrient levels IEP
Inferred from Expression Pattern
more info
PubMed 
response to organic cyclic compound IEP
Inferred from Expression Pattern
more info
PubMed 
response to organic substance IEP
Inferred from Expression Pattern
more info
PubMed 
response to starvation IEP
Inferred from Expression Pattern
more info
PubMed 
response to steroid hormone IEP
Inferred from Expression Pattern
more info
PubMed 
response to thyroid hormone IEP
Inferred from Expression Pattern
more info
PubMed 
signal transduction IEA
Inferred from Electronic Annotation
more info
 
skeletal muscle satellite cell maintenance involved in skeletal muscle regeneration IEA
Inferred from Electronic Annotation
more info
 
skeletal muscle satellite cell maintenance involved in skeletal muscle regeneration ISO
Inferred from Sequence Orthology
more info
 
type I pneumocyte differentiation ISO
Inferred from Sequence Orthology
more info
 
type II pneumocyte differentiation ISO
Inferred from Sequence Orthology
more info
 
water homeostasis ISO
Inferred from Sequence Orthology
more info
 
wound healing ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
alphav-beta3 integrin-IGF-1-IGF1R complex IEA
Inferred from Electronic Annotation
more info
 
alphav-beta3 integrin-IGF-1-IGF1R complex ISO
Inferred from Sequence Orthology
more info
 
alphav-beta3 integrin-IGF-1-IGF1R complex ISS
Inferred from Sequence or Structural Similarity
more info
 
cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
exocytic vesicle ISO
Inferred from Sequence Orthology
more info
 
exocytic vesicle ISS
Inferred from Sequence or Structural Similarity
more info
 
extracellular space IDA
Inferred from Direct Assay
more info
PubMed 
extracellular space IEA
Inferred from Electronic Annotation
more info
 
extracellular space ISO
Inferred from Sequence Orthology
more info
 
insulin-like growth factor ternary complex IEA
Inferred from Electronic Annotation
more info
 
insulin-like growth factor ternary complex ISO
Inferred from Sequence Orthology
more info
 
interstitial matrix IDA
Inferred from Direct Assay
more info
PubMed 
neuronal cell body IDA
Inferred from Direct Assay
more info
PubMed 
plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
platelet alpha granule IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
insulin-like growth factor I
Names
IGF-I
somatomedin

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001082477.2NP_001075946.2  insulin-like growth factor I isoform a preproprotein

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) differs in the 5' UTR and 5' coding region, compared to variant 3. These differences cause translation initiation from a distinct start codon and result in an isoform (a) with a novel C-terminus, compared to isoform c. This isoform is also known as IIC.
    Source sequence(s)
    BC086374, CB761687, M15480, M17593
    UniProtKB/Swiss-Prot
    P08025
    UniProtKB/TrEMBL
    A0A0G2JX40, Q5RK13, Q63261
    Related
    ENSRNOP00000070124.1, ENSRNOT00000085680.1
    Conserved Domains (1) summary
    cd04368
    Location:33100
    IlGF; IlGF, insulin_like growth factors; specific to vertebrates. Members include a number of peptides including insulin-like growth factors I and II, which play a variety of roles in controlling processes such as growth, differentiation, and reproduction. On ...
  2. NM_001082478.1NP_001075947.1  insulin-like growth factor I isoform c preproprotein

    See identical proteins and their annotated locations for NP_001075947.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) represents the longest variant and encodes isoform c. This isoform is also known as IB.
    Source sequence(s)
    BC086374, CB751206, CB761687, M15480
    UniProtKB/Swiss-Prot
    P08025
    UniProtKB/TrEMBL
    F8WFZ5, Q5RK13
    Related
    ENSRNOP00000073824.1, ENSRNOT00000081822.1
    Conserved Domains (1) summary
    cd04368
    Location:49116
    IlGF; IlGF, insulin_like growth factors; specific to vertebrates. Members include a number of peptides including insulin-like growth factors I and II, which play a variety of roles in controlling processes such as growth, differentiation, and reproduction. On ...
  3. NM_001082479.1NP_001075948.1  insulin-like growth factor I isoform d preproprotein

    See identical proteins and their annotated locations for NP_001075948.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) lacks an alternate frame-shifting exon in the 3' coding region, compared to variant 3, resulting in a protein (isoform d) with a novel C-terminus, compared to isoform c. This isoform is also known as IA.
    Source sequence(s)
    BC086374, CB751206, CB761687
    UniProtKB/Swiss-Prot
    P08025
    UniProtKB/TrEMBL
    Q5RK13
    Related
    ENSRNOP00000035899.4, ENSRNOT00000038780.6
    Conserved Domains (1) summary
    cd04368
    Location:49116
    IlGF; IlGF, insulin_like growth factors; specific to vertebrates. Members include a number of peptides including insulin-like growth factors I and II, which play a variety of roles in controlling processes such as growth, differentiation, and reproduction. On ...
  4. NM_178866.4NP_849197.3  insulin-like growth factor I isoform b preproprotein

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR and has multiple coding region differences which include the absence of an alternate frame-shifting exon, compared to variant 3. These differences cause translation initiation from a distinct start codon and result in an isoform (b) with novel N- and C-termini, compared to isoform c. This isoform is also known as IIA.
    Source sequence(s)
    BC086374, CB761687
    UniProtKB/TrEMBL
    Q5RK13
    Conserved Domains (1) summary
    cd04368
    Location:33100
    IlGF; IlGF, insulin_like growth factors; specific to vertebrates. Members include a number of peptides including insulin-like growth factors I and II, which play a variety of roles in controlling processes such as growth, differentiation, and reproduction. On ...

RefSeqs of Annotated Genomes: Rattus norvegicus Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Rnor_6.0 Primary Assembly

Genomic

  1. NC_005106.4 Reference Rnor_6.0 Primary Assembly

    Range
    28412123..28491815
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006241192.1XP_006241254.1  insulin-like growth factor I isoform X1

    See identical proteins and their annotated locations for XP_006241254.1

    UniProtKB/Swiss-Prot
    P08025
    UniProtKB/TrEMBL
    F8WFZ5
    Conserved Domains (1) summary
    cd04368
    Location:49116
    IlGF; IlGF, insulin_like growth factors; specific to vertebrates. Members include a number of peptides including insulin-like growth factors I and II, which play a variety of roles in controlling processes such as growth, differentiation, and reproduction. On ...
  2. XM_006241191.2XP_006241253.1  insulin-like growth factor I isoform X1

    See identical proteins and their annotated locations for XP_006241253.1

    UniProtKB/Swiss-Prot
    P08025
    UniProtKB/TrEMBL
    F8WFZ5
    Related
    ENSRNOP00000005995.5, ENSRNOT00000005995.5
    Conserved Domains (1) summary
    cd04368
    Location:49116
    IlGF; IlGF, insulin_like growth factors; specific to vertebrates. Members include a number of peptides including insulin-like growth factors I and II, which play a variety of roles in controlling processes such as growth, differentiation, and reproduction. On ...
  3. XM_006241193.3XP_006241255.1  insulin-like growth factor I isoform X2

    See identical proteins and their annotated locations for XP_006241255.1

    UniProtKB/Swiss-Prot
    P08025
    Conserved Domains (1) summary
    cd04368
    Location:49116
    IlGF; IlGF, insulin_like growth factors; specific to vertebrates. Members include a number of peptides including insulin-like growth factors I and II, which play a variety of roles in controlling processes such as growth, differentiation, and reproduction. On ...
  4. XM_006241194.3XP_006241256.1  insulin-like growth factor I isoform X3

    Conserved Domains (1) summary
    cd04368
    Location:2390
    IlGF; IlGF, insulin_like growth factors; specific to vertebrates. Members include a number of peptides including insulin-like growth factors I and II, which play a variety of roles in controlling processes such as growth, differentiation, and reproduction. On ...

Alternate Rn_Celera

Genomic

  1. AC_000075.1 Alternate Rn_Celera

    Range
    19453213..19527075
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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