Igf1 insulin-like growth factor 1 [ Rattus norvegicus (Norway rat) ]

Gene ID: 24482, updated on 2-Nov-2024

Summary

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Official Symbol: Igf1provided by RGD
Official Full Name: insulin-like growth factor 1provided by RGD
Primary source: RGD:2868
See related: EnsemblRapid:ENSRNOG00000004517 AllianceGenome:RGD:2868
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: IGF
Summary: Enables protein serine/threonine kinase activator activity; signaling receptor binding activity; and steroid binding activity. Involved in several processes, including cellular response to steroid hormone stimulus; negative regulation of apoptotic process; and positive regulation of cell differentiation. Located in several cellular components, including interstitial matrix; neuronal cell body; and platelet alpha granule. Used to study brain ischemia; diabetic neuropathy; and hypertension. Biomarker of several diseases, including alcoholic neuropathy; artery disease (multiple); borna disease; congenital diaphragmatic hernia; and hypothyroidism (multiple). Human ortholog(s) of this gene implicated in several diseases, including acne; brain ischemia; diabetes mellitus (multiple); myopia; and neurodegenerative disease (multiple). Orthologous to human IGF1 (insulin like growth factor 1). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in Liver (RPKM 1821.5), Uterus (RPKM 212.9) and 6 other tissues See more
Orthologs: human mouse all
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Genomic context

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See Igf1 in Genome Data Viewer

Location:: 7q13

Exon count:: 9

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	7	NC_086025.1 (24169608..24249446)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	7	NC_051342.1 (22282895..22361972)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	7	NC_005106.4 (28412123..28491815)

Chromosome 7 - NC_086025.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

GHRH-stimulated pituitary small extracellular vesicles inhibit hepatocyte proliferation and IGF-1 expression by its cargo miR-375-3p.
Title: GHRH-stimulated pituitary small extracellular vesicles inhibit hepatocyte proliferation and IGF-1 expression by its cargo miR-375-3p.
The Effect of Different Exercise Modalities on Sertoli-germ Cells Metabolic Interactions in High-fat Diet-induced Obesity Rat Models: Implication on Glucose and Lactate Transport, Igf1, and Igf1R-dependent Pathways.
Title: The Effect of Different Exercise Modalities on Sertoli-germ Cells Metabolic Interactions in High-fat Diet-induced Obesity Rat Models: Implication on Glucose and Lactate Transport, Igf1, and Igf1R-dependent Pathways.
The involvement of Akt, mTOR, and S6K in the in vivo effect of IGF-1 on the regulation of rat cardiac Na[+]/K[+]-ATPase.
Title: The involvement of Akt, mTOR, and S6K in the in vivo effect of IGF-1 on the regulation of rat cardiac Na(+)/K(+)-ATPase.
Rewiring of IGF1 secretion and enhanced IGF1R signaling induced by co-chaperone carboxyl-terminus of Hsp70 interacting protein in adipose-derived stem cells provide augmented cardioprotection in aging-hypertensive rats.
Title: Rewiring of IGF1 secretion and enhanced IGF1R signaling induced by co-chaperone carboxyl-terminus of Hsp70 interacting protein in adipose-derived stem cells provide augmented cardioprotection in aging-hypertensive rats.
Phosphorylation of AMPKalpha at Ser485/491 Is Dependent on Muscle Contraction and Not Muscle-Specific IGF-I Overexpression.
Title: Phosphorylation of AMPKα at Ser485/491 Is Dependent on Muscle Contraction and Not Muscle-Specific IGF-I Overexpression.
Asymmetric tri-layer sponge-nanofiber wound dressing containing insulin-like growth factor-1 and multi-walled carbon nanotubes for acceleration of full-thickness wound healing.
Title: Asymmetric tri-layer sponge-nanofiber wound dressing containing insulin-like growth factor-1 and multi-walled carbon nanotubes for acceleration of full-thickness wound healing.
Insulin-Like Growth Factor-1 Promotes Synaptogenesis Signaling, a Major Dysregulated Pathway in Malformation of Cortical Development, in a Rat Model.
Title: Insulin-Like Growth Factor-1 Promotes Synaptogenesis Signaling, a Major Dysregulated Pathway in Malformation of Cortical Development, in a Rat Model.
The impact of IGF-1 on alveolar bone remodeling and BMP-2 expression in orthodontic tooth movement in diabetic rats.
Title: The impact of IGF-1 on alveolar bone remodeling and BMP-2 expression in orthodontic tooth movement in diabetic rats.
Changes of the condylar cartilage and subchondral bone in the temporomandibular joints of rats under unilateral mastication and expression of Insulin-like Growth Factor-1.
Title: Changes of the condylar cartilage and subchondral bone in the temporomandibular joints of rats under unilateral mastication and expression of Insulin-like Growth Factor-1.
Increased testicular insulin-like growth factor 1 is associated with gonadal activation by recombinant growth hormone in immature rats.
Title: Increased testicular insulin-like growth factor 1 is associated with gonadal activation by recombinant growth hormone in immature rats.

Submit: New GeneRIF Correction See all GeneRIFs (366)

General gene information

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Markers

Igf1 (e-PCR), detects polymorphism
- UniSTS:526082

D7Rat226 (e-PCR), detects polymorphism
- UniSTS:228174

RH143798 (e-PCR)
- UniSTS:233044

Igf1 (e-PCR), detects polymorphism
- UniSTS:516198

Igf1 (e-PCR), detects polymorphism
- UniSTS:143466

Igf1 (e-PCR), detects polymorphism
- UniSTS:143467

Igf1 (e-PCR), detects polymorphism
- UniSTS:143469

RH94417 (e-PCR)
- UniSTS:119665

Igf1 (e-PCR), detects polymorphism
- UniSTS:506995

RH142569 (e-PCR)
- UniSTS:231816

GDB:384821 (e-PCR)
- UniSTS:157100

RH142608 (e-PCR)
- UniSTS:231855

Igf1 (e-PCR), detects polymorphism
- UniSTS:516546

RH94801 (e-PCR)
- UniSTS:120047

Igf1 (e-PCR), detects polymorphism
- UniSTS:465393

MARC_16386-16387:1017081416:1 (e-PCR)
- UniSTS:268018

D7Mit23 (e-PCR), detects polymorphism
- UniSTS:118003

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables growth factor activity	IEA Inferred from Electronic Annotation more info
enables growth factor activity	ISO Inferred from Sequence Orthology more info
enables growth factor activity	TAS Traceable Author Statement more info	PubMed
enables hormone activity	IBA Inferred from Biological aspect of Ancestor more info
enables hormone activity	IDA Inferred from Direct Assay more info	PubMed
enables hormone activity	IEA Inferred from Electronic Annotation more info
enables hormone activity	ISO Inferred from Sequence Orthology more info
enables insulin receptor binding	IEA Inferred from Electronic Annotation more info
enables insulin receptor binding	ISO Inferred from Sequence Orthology more info
enables insulin-like growth factor receptor binding	IBA Inferred from Biological aspect of Ancestor more info
enables insulin-like growth factor receptor binding	IDA Inferred from Direct Assay more info	PubMed
enables insulin-like growth factor receptor binding	IEA Inferred from Electronic Annotation more info
enables insulin-like growth factor receptor binding	ISO Inferred from Sequence Orthology more info
enables integrin binding	IEA Inferred from Electronic Annotation more info
enables integrin binding	ISO Inferred from Sequence Orthology more info
enables protein serine/threonine kinase activator activity	IDA Inferred from Direct Assay more info	PubMed
enables receptor ligand activity	ISO Inferred from Sequence Orthology more info
enables steroid binding	IDA Inferred from Direct Assay more info	PubMed
enables transmembrane receptor protein tyrosine kinase activator activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in activation of protein kinase B activity	IEA Inferred from Electronic Annotation more info
involved_in activation of protein kinase B activity	ISO Inferred from Sequence Orthology more info
acts_upstream_of androgen receptor signaling pathway	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within blood vessel remodeling	ISO Inferred from Sequence Orthology more info
involved_in bone development	IEP Inferred from Expression Pattern more info	PubMed
involved_in bone mineralization involved in bone maturation	IEA Inferred from Electronic Annotation more info
involved_in bone mineralization involved in bone maturation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within branching morphogenesis of an epithelial tube	ISO Inferred from Sequence Orthology more info
involved_in cardiac atrium development	IEP Inferred from Expression Pattern more info	PubMed
involved_in cell activation	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within cell activation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within cell development	ISO Inferred from Sequence Orthology more info
involved_in cell population proliferation	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of cell population proliferation	ISO Inferred from Sequence Orthology more info
involved_in cell population proliferation	ISO Inferred from Sequence Orthology more info
involved_in cell surface receptor signaling pathway via STAT	IEA Inferred from Electronic Annotation more info
involved_in cell surface receptor signaling pathway via STAT	ISO Inferred from Sequence Orthology more info
involved_in cellular response to Thyroglobulin triiodothyronine	IEP Inferred from Expression Pattern more info	PubMed
involved_in cellular response to amyloid-beta	IEA Inferred from Electronic Annotation more info
involved_in cellular response to amyloid-beta	ISO Inferred from Sequence Orthology more info
involved_in cellular response to dexamethasone stimulus	IEP Inferred from Expression Pattern more info	PubMed
involved_in cellular response to electrical stimulus	IEP Inferred from Expression Pattern more info	PubMed
involved_in cellular response to estradiol stimulus	IEP Inferred from Expression Pattern more info	PubMed
acts_upstream_of_or_within cellular response to glucose stimulus	ISO Inferred from Sequence Orthology more info
involved_in cellular response to insulin stimulus	IEP Inferred from Expression Pattern more info	PubMed
acts_upstream_of_or_within cellular response to insulin-like growth factor stimulus	ISO Inferred from Sequence Orthology more info
involved_in cellular response to nicotine	IEP Inferred from Expression Pattern more info	PubMed
involved_in cellular response to progesterone stimulus	IEP Inferred from Expression Pattern more info	PubMed
involved_in cellular response to zinc ion starvation	IEP Inferred from Expression Pattern more info	PubMed
acts_upstream_of cerebellar granule cell precursor proliferation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within chondroitin sulfate proteoglycan biosynthetic process	ISO Inferred from Sequence Orthology more info
involved_in circadian rhythm	ISO Inferred from Sequence Orthology more info
involved_in cranial suture morphogenesis	IEP Inferred from Expression Pattern more info	PubMed
involved_in detection of mechanical stimulus involved in sensory perception	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within exocrine pancreas development	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within extrinsic apoptotic signaling pathway in absence of ligand	ISO Inferred from Sequence Orthology more info
involved_in female pregnancy	IEP Inferred from Expression Pattern more info	PubMed
acts_upstream_of_or_within glial cell differentiation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within inner ear development	ISO Inferred from Sequence Orthology more info
involved_in insulin-like growth factor receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in insulin-like growth factor receptor signaling pathway	IDA Inferred from Direct Assay more info	PubMed
involved_in insulin-like growth factor receptor signaling pathway	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within insulin-like growth factor receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in insulin-like growth factor receptor signaling pathway	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within lung alveolus development	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within lung development	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within lung lobe morphogenesis	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within lung vasculature development	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within mammary gland development	ISO Inferred from Sequence Orthology more info
involved_in memory	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within multicellular organism growth	ISO Inferred from Sequence Orthology more info
involved_in muscle hypertrophy	IEA Inferred from Electronic Annotation more info
involved_in muscle hypertrophy	ISO Inferred from Sequence Orthology more info
involved_in myoblast differentiation	IEA Inferred from Electronic Annotation more info
involved_in myoblast differentiation	ISO Inferred from Sequence Orthology more info
involved_in myoblast proliferation	IEA Inferred from Electronic Annotation more info
involved_in myoblast proliferation	ISO Inferred from Sequence Orthology more info
involved_in myotube cell development	IEA Inferred from Electronic Annotation more info
involved_in myotube cell development	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within myotube differentiation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within negative regulation of ERK1 and ERK2 cascade	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of amyloid-beta formation	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of amyloid-beta formation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within negative regulation of androgen receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of apoptotic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of apoptotic process	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within negative regulation of apoptotic process	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of apoptotic process	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of apoptotic process	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within negative regulation of cell population proliferation	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of cholangiocyte apoptotic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of extrinsic apoptotic signaling pathway	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of extrinsic apoptotic signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of extrinsic apoptotic signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of gene expression	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of immune system process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of interleukin-1 beta production	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of interleukin-1 beta production	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of muscle cell apoptotic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of neuroinflammatory response	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of neuroinflammatory response	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of oligodendrocyte apoptotic process	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of oocyte development	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of oocyte development	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within negative regulation of peptidyl-tyrosine phosphorylation	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of release of cytochrome c from mitochondria	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of release of cytochrome c from mitochondria	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of smooth muscle cell apoptotic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of smooth muscle cell apoptotic process	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of tumor necrosis factor production	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of tumor necrosis factor production	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of vascular associated smooth muscle cell apoptotic process	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of vascular associated smooth muscle cell apoptotic process	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within nervous system development	ISO Inferred from Sequence Orthology more info
involved_in osteoblast differentiation	ISO Inferred from Sequence Orthology more info
acts_upstream_of phosphatidylinositol 3-kinase/protein kinase B signal transduction	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of D-glucose import	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of D-glucose import	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of D-glucose import	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of DNA-templated transcription	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of ERK1 and ERK2 cascade	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of ERK1 and ERK2 cascade	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of MAPK cascade	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of MAPK cascade	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of Ras protein signal transduction	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of Ras protein signal transduction	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of activated T cell proliferation	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of activated T cell proliferation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of blood vessel endothelial cell migration	IGI Inferred from Genetic Interaction more info	PubMed
involved_in positive regulation of calcineurin-NFAT signaling cascade	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of calcineurin-NFAT signaling cascade	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cardiac muscle hypertrophy	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cell growth	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of cell growth	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of cell growth involved in cardiac muscle cell development	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of cell growth involved in cardiac muscle cell development	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cell migration	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cell population proliferation	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of cell population proliferation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cell population proliferation	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within positive regulation of cerebellar granule cell precursor proliferation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of epithelial cell proliferation	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of epithelial cell proliferation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of fat cell differentiation	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of fibroblast proliferation	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of fibroblast proliferation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of gene expression	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of gene expression	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of glial cell proliferation	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of glycogen biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of glycogen biosynthetic process	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of glycogen biosynthetic process	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of glycolytic process	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of glycolytic process	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of glycoprotein biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of glycoprotein biosynthetic process	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of insulin-like growth factor receptor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of insulin-like growth factor receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of mitotic nuclear division	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of mitotic nuclear division	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of myelination	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of myoblast proliferation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of osteoblast differentiation	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of osteoblast differentiation	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of osteoblast differentiation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of peptidyl-tyrosine phosphorylation	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of peptidyl-tyrosine phosphorylation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of protein secretion	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of protein secretion	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of smooth muscle cell migration	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of smooth muscle cell migration	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of smooth muscle cell proliferation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of steroid hormone biosynthetic process	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of transcription by RNA polymerase II	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of trophectodermal cell proliferation	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of trophectodermal cell proliferation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of type B pancreatic cell proliferation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of vascular associated smooth muscle cell proliferation	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of vascular associated smooth muscle cell proliferation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of vascular endothelial cell proliferation	IGI Inferred from Genetic Interaction more info	PubMed
involved_in postsynaptic modulation of chemical synaptic transmission	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within prostate gland epithelium morphogenesis	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within prostate gland growth	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within prostate gland stromal morphogenesis	ISO Inferred from Sequence Orthology more info
involved_in protein stabilization	IEA Inferred from Electronic Annotation more info
involved_in protein stabilization	ISO Inferred from Sequence Orthology more info
involved_in proteoglycan biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in proteoglycan biosynthetic process	ISO Inferred from Sequence Orthology more info
involved_in regulation of calcium ion transport	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of cell population proliferation	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within regulation of establishment or maintenance of cell polarity	ISO Inferred from Sequence Orthology more info
involved_in regulation of gene expression	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within regulation of nitric oxide biosynthetic process	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within regulation of protein metabolic process	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within regulation of protein phosphorylation	ISO Inferred from Sequence Orthology more info
involved_in regulation of translation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in response to activity	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to caffeine	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to epidermal growth factor	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to estradiol	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to ethanol	IDA Inferred from Direct Assay more info	PubMed
involved_in response to ethanol	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to glucocorticoid	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to growth hormone	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to heat	IEA Inferred from Electronic Annotation more info
involved_in response to heat	ISO Inferred from Sequence Orthology more info
involved_in response to hypoxia	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to lipopolysaccharide	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to mechanical stimulus	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to nicotine	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to nutrient	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to nutrient levels	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to organic cyclic compound	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to starvation	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to steroid hormone	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to thyroid hormone	IEP Inferred from Expression Pattern more info	PubMed
involved_in retinal cell apoptotic process	IDA Inferred from Direct Assay more info	PubMed
involved_in signal transduction	IEA Inferred from Electronic Annotation more info
involved_in skeletal muscle satellite cell maintenance involved in skeletal muscle regeneration	IEA Inferred from Electronic Annotation more info
involved_in skeletal muscle satellite cell maintenance involved in skeletal muscle regeneration	ISO Inferred from Sequence Orthology more info
acts_upstream_of type B pancreatic cell proliferation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within type I pneumocyte differentiation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within type II pneumocyte differentiation	ISO Inferred from Sequence Orthology more info
involved_in wound healing	IEA Inferred from Electronic Annotation more info
involved_in wound healing	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
part_of alphav-beta3 integrin-IGF-1-IGF1R complex	IEA Inferred from Electronic Annotation more info
part_of alphav-beta3 integrin-IGF-1-IGF1R complex	ISO Inferred from Sequence Orthology more info
part_of alphav-beta3 integrin-IGF-1-IGF1R complex	ISS Inferred from Sequence or Structural Similarity more info
located_in exocytic vesicle	ISO Inferred from Sequence Orthology more info
located_in exocytic vesicle	ISS Inferred from Sequence or Structural Similarity more info
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info
located_in extracellular space	IDA Inferred from Direct Assay more info	PubMed
located_in extracellular space	IEA Inferred from Electronic Annotation more info
located_in extracellular space	ISO Inferred from Sequence Orthology more info
is_active_in glutamatergic synapse	ISO Inferred from Sequence Orthology more info
part_of insulin-like growth factor ternary complex	IEA Inferred from Electronic Annotation more info
part_of insulin-like growth factor ternary complex	ISO Inferred from Sequence Orthology more info
located_in interstitial matrix	IDA Inferred from Direct Assay more info	PubMed
located_in neuronal cell body	IDA Inferred from Direct Assay more info	PubMed
is_active_in neuronal dense core vesicle lumen	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
located_in platelet alpha granule	IDA Inferred from Direct Assay more info	PubMed
located_in postsynapse	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: insulin-like growth factor I

Names: IGF-I; somatomedin

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001082477.2 → NP_001075946.2 insulin-like growth factor I isoform a preproprotein

Status: VALIDATED

Description

Transcript Variant: This variant (1) differs in the 5' UTR and 5' coding region, compared to variant 3. These differences cause translation initiation from a distinct start codon and result in an isoform (a) with a novel C-terminus, compared to isoform c. This isoform is also known as IIC.

Source sequence(s)

BC086374, CB761687, M15480, M17593

UniProtKB/TrEMBL

A0A0G2JX40

Conserved Domains (1) summary

cd04368
Location:33 → 100

IlGF; IlGF, insulin_like growth factors; specific to vertebrates. Members include a number of peptides including insulin-like growth factors I and II, which play a variety of roles in controlling processes such as growth, differentiation, and reproduction. On ...
NM_001082478.1 → NP_001075947.1 insulin-like growth factor I isoform c preproprotein

See identical proteins and their annotated locations for NP_001075947.1

Status: VALIDATED

Description

Transcript Variant: This variant (3) represents the longest variant and encodes isoform c. This isoform is also known as IB.

Source sequence(s)

BC086374, CB751206, CB761687, M15480

UniProtKB/TrEMBL

A6IFM0, A6IFM1, F8WFZ5

Related

ENSRNOP00000005995.5, ENSRNOT00000005995.7

Conserved Domains (1) summary

cd04368
Location:49 → 116

IlGF; IlGF, insulin_like growth factors; specific to vertebrates. Members include a number of peptides including insulin-like growth factors I and II, which play a variety of roles in controlling processes such as growth, differentiation, and reproduction. On ...
NM_001082479.1 → NP_001075948.1 insulin-like growth factor I isoform d preproprotein

See identical proteins and their annotated locations for NP_001075948.1

Status: VALIDATED

Description

Transcript Variant: This variant (4) lacks an alternate frame-shifting exon in the 3' coding region, compared to variant 3, resulting in a protein (isoform d) with a novel C-terminus, compared to isoform c. This isoform is also known as IA.

Source sequence(s)

BC086374, CB751206, CB761687

UniProtKB/Swiss-Prot

P08024, P08025

UniProtKB/TrEMBL

A6IFL5, Q5RK13

Related

ENSRNOP00000035899.6, ENSRNOT00000038780.8

Conserved Domains (1) summary

cd04368
Location:49 → 116

IlGF; insulin_like growth factors; specific to vertebrates. Members include a number of peptides including insulin-like growth factors I and II, which play a variety of roles in controlling processes such as growth, differentiation, and reproduction. On a ...
NM_178866.4 → NP_849197.3 insulin-like growth factor I isoform b preproprotein

Status: VALIDATED

Description

Transcript Variant: This variant (2) differs in the 5' UTR and has multiple coding region differences which include the absence of an alternate frame-shifting exon, compared to variant 3. These differences cause translation initiation from a distinct start codon and result in an isoform (b) with novel N- and C-termini, compared to isoform c. This isoform is also known as IIA.

Source sequence(s)

BC086374, CB761687

UniProtKB/TrEMBL

Q5RK13

Related

ENSRNOP00000110287.1, ENSRNOT00000130023.1

Conserved Domains (1) summary

cd04368
Location:33 → 100

IlGF; IlGF, insulin_like growth factors; specific to vertebrates. Members include a number of peptides including insulin-like growth factors I and II, which play a variety of roles in controlling processes such as growth, differentiation, and reproduction. On ...

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086025.1 Reference GRCr8

Range

24169608..24249446

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_063262981.1 → XP_063119051.1 insulin-like growth factor I isoform X1

UniProtKB/TrEMBL

A6IFM0, F8WFZ5
XM_063262982.1 → XP_063119052.1 insulin-like growth factor I isoform X2

UniProtKB/Swiss-Prot

P08024, P08025

UniProtKB/TrEMBL

A6IFL5
XM_006241193.5 → XP_006241255.1 insulin-like growth factor I isoform X2

See identical proteins and their annotated locations for XP_006241255.1

UniProtKB/Swiss-Prot

P08024, P08025

UniProtKB/TrEMBL

A6IFL5, Q5RK13

Related

ENSRNOP00000097781.2, ENSRNOT00000118307.2

Conserved Domains (1) summary

cd04368
Location:49 → 116

IlGF; insulin_like growth factors; specific to vertebrates. Members include a number of peptides including insulin-like growth factors I and II, which play a variety of roles in controlling processes such as growth, differentiation, and reproduction. On a ...
XM_006241191.4 → XP_006241253.1 insulin-like growth factor I isoform X1

See identical proteins and their annotated locations for XP_006241253.1

UniProtKB/TrEMBL

A6IFM0, A6IFM1, F8WFZ5

Conserved Domains (1) summary

cd04368
Location:49 → 116

IlGF; IlGF, insulin_like growth factors; specific to vertebrates. Members include a number of peptides including insulin-like growth factors I and II, which play a variety of roles in controlling processes such as growth, differentiation, and reproduction. On ...
XM_006241194.5 → XP_006241256.1 insulin-like growth factor I isoform X3

UniProtKB/TrEMBL

Q5RK13

Related

ENSRNOP00000100217.1, ENSRNOT00000139084.1

Conserved Domains (1) summary

cd04368
Location:23 → 90

IlGF; insulin_like growth factors; specific to vertebrates. Members include a number of peptides including insulin-like growth factors I and II, which play a variety of roles in controlling processes such as growth, differentiation, and reproduction. On a ...