U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Igf1 insulin-like growth factor 1 [ Rattus norvegicus (Norway rat) ]

Gene ID: 24482, updated on 19-May-2022

Summary

Official Symbol
Igf1provided by RGD
Official Full Name
insulin-like growth factor 1provided by RGD
Primary source
RGD:2868
See related
Ensembl:ENSRNOG00000004517 AllianceGenome:RGD:2868
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
IGF
Summary
Enables protein serine/threonine kinase activator activity; signaling receptor binding activity; and steroid binding activity. Involved in several processes, including cellular response to hormone stimulus; negative regulation of cell death; and positive regulation of cell differentiation. Located in several cellular components, including interstitial matrix; neuronal cell body; and platelet alpha granule. Used to study brain ischemia; diabetic neuropathy; and hypertension. Biomarker of several diseases, including alcoholic neuropathy; artery disease (multiple); congenital diaphragmatic hernia; folic acid deficiency anemia; and hypothyroidism (multiple). Human ortholog(s) of this gene implicated in several diseases, including acne; brain ischemia; diabetes mellitus (multiple); myopia; and neurodegenerative disease (multiple). Orthologous to human IGF1 (insulin like growth factor 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Liver (RPKM 1821.5), Uterus (RPKM 212.9) and 6 other tissues See more
Orthologs
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

See Igf1 in Genome Data Viewer
Location:
7q13
Exon count:
9
Annotation release Status Assembly Chr Location
108 current mRatBN7.2 (GCF_015227675.2) 7 NC_051342.1 (22282895..22361972)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 7 NC_005106.4 (28412123..28491815)

Chromosome 7 - NC_051342.1Genomic Context describing neighboring genes Neighboring gene mesoderm posterior 2 homolog Neighboring gene uncharacterized LOC120093845 Neighboring gene 14-3-3 protein gamma-like Neighboring gene PARP1 binding protein Neighboring gene pro-melanin-concentrating hormone

Genomic regions, transcripts, and products

Expression

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

General gene information

Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables growth factor activity IEA
Inferred from Electronic Annotation
more info
 
enables growth factor activity TAS
Traceable Author Statement
more info
PubMed 
enables hormone activity IDA
Inferred from Direct Assay
more info
PubMed 
enables hormone activity IEA
Inferred from Electronic Annotation
more info
 
enables hormone activity ISO
Inferred from Sequence Orthology
more info
 
enables insulin receptor binding IEA
Inferred from Electronic Annotation
more info
 
enables insulin receptor binding ISO
Inferred from Sequence Orthology
more info
 
enables insulin-like growth factor receptor binding IDA
Inferred from Direct Assay
more info
PubMed 
enables insulin-like growth factor receptor binding IEA
Inferred from Electronic Annotation
more info
 
enables insulin-like growth factor receptor binding ISO
Inferred from Sequence Orthology
more info
 
enables integrin binding IEA
Inferred from Electronic Annotation
more info
 
enables integrin binding ISO
Inferred from Sequence Orthology
more info
 
enables protein serine/threonine kinase activator activity IDA
Inferred from Direct Assay
more info
PubMed 
enables steroid binding IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
involved_in ERK1 and ERK2 cascade IEA
Inferred from Electronic Annotation
more info
 
involved_in ERK1 and ERK2 cascade ISO
Inferred from Sequence Orthology
more info
 
involved_in activation of protein kinase B activity IEA
Inferred from Electronic Annotation
more info
 
involved_in activation of protein kinase B activity ISO
Inferred from Sequence Orthology
more info
 
involved_in aging IEP
Inferred from Expression Pattern
more info
PubMed 
acts_upstream_of_or_within blood vessel remodeling ISO
Inferred from Sequence Orthology
more info
 
involved_in bone development IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in bone mineralization involved in bone maturation IEA
Inferred from Electronic Annotation
more info
 
involved_in bone mineralization involved in bone maturation ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within branching morphogenesis of an epithelial tube ISO
Inferred from Sequence Orthology
more info
 
involved_in cardiac atrium development IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in cell activation IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within cell activation ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within cell development ISO
Inferred from Sequence Orthology
more info
 
involved_in cell population proliferation ISO
Inferred from Sequence Orthology
more info
 
involved_in cellular response to Thyroglobulin triiodothyronine IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in cellular response to amyloid-beta IEA
Inferred from Electronic Annotation
more info
 
involved_in cellular response to amyloid-beta ISO
Inferred from Sequence Orthology
more info
 
involved_in cellular response to dexamethasone stimulus IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in cellular response to electrical stimulus IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in cellular response to estradiol stimulus IEP
Inferred from Expression Pattern
more info
PubMed 
acts_upstream_of_or_within cellular response to glucose stimulus ISO
Inferred from Sequence Orthology
more info
 
involved_in cellular response to insulin stimulus IEP
Inferred from Expression Pattern
more info
PubMed 
acts_upstream_of_or_within cellular response to insulin-like growth factor stimulus ISO
Inferred from Sequence Orthology
more info
 
involved_in cellular response to nicotine IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in cellular response to progesterone stimulus IEP
Inferred from Expression Pattern
more info
PubMed 
acts_upstream_of_or_within chondroitin sulfate proteoglycan biosynthetic process ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within circadian rhythm ISO
Inferred from Sequence Orthology
more info
 
involved_in cranial suture morphogenesis IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in detection of mechanical stimulus involved in sensory perception IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within exocrine pancreas development ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within extrinsic apoptotic signaling pathway in absence of ligand ISO
Inferred from Sequence Orthology
more info
 
involved_in female pregnancy IEP
Inferred from Expression Pattern
more info
PubMed 
acts_upstream_of_or_within glial cell differentiation ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within inner ear development ISO
Inferred from Sequence Orthology
more info
 
involved_in insulin-like growth factor receptor signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
involved_in insulin-like growth factor receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within insulin-like growth factor receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in insulin-like growth factor receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within lung alveolus development ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within lung development ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within lung lobe morphogenesis ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within lung vasculature development ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within mammary gland development ISO
Inferred from Sequence Orthology
more info
 
involved_in memory IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within multicellular organism growth ISO
Inferred from Sequence Orthology
more info
 
involved_in muscle hypertrophy IEA
Inferred from Electronic Annotation
more info
 
involved_in muscle hypertrophy ISO
Inferred from Sequence Orthology
more info
 
involved_in myoblast differentiation IEA
Inferred from Electronic Annotation
more info
 
involved_in myoblast differentiation ISO
Inferred from Sequence Orthology
more info
 
involved_in myoblast proliferation IEA
Inferred from Electronic Annotation
more info
 
involved_in myoblast proliferation ISO
Inferred from Sequence Orthology
more info
 
involved_in myotube cell development IEA
Inferred from Electronic Annotation
more info
 
involved_in myotube cell development ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within negative regulation of ERK1 and ERK2 cascade ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of amyloid-beta formation IEA
Inferred from Electronic Annotation
more info
 
involved_in negative regulation of amyloid-beta formation ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within negative regulation of androgen receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of apoptotic process IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within negative regulation of apoptotic process ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of apoptotic process ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of apoptotic process ISS
Inferred from Sequence or Structural Similarity
more info
 
acts_upstream_of_or_within negative regulation of cell population proliferation ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of cholangiocyte apoptotic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of cysteine-type endopeptidase activity involved in apoptotic process IDA
Inferred from Direct Assay
more info
PubMed 
involved_in negative regulation of extrinsic apoptotic signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
involved_in negative regulation of extrinsic apoptotic signaling pathway IEA
Inferred from Electronic Annotation
more info
 
involved_in negative regulation of extrinsic apoptotic signaling pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of gene expression ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of immune system process IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of interleukin-1 beta production IEA
Inferred from Electronic Annotation
more info
 
involved_in negative regulation of interleukin-1 beta production ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of muscle cell apoptotic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of neuroinflammatory response IEA
Inferred from Electronic Annotation
more info
 
involved_in negative regulation of neuroinflammatory response ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of neuron death IDA
Inferred from Direct Assay
more info
PubMed 
involved_in negative regulation of oligodendrocyte apoptotic process IDA
Inferred from Direct Assay
more info
PubMed 
involved_in negative regulation of oocyte development IEA
Inferred from Electronic Annotation
more info
 
involved_in negative regulation of oocyte development ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within negative regulation of peptidyl-tyrosine phosphorylation ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of release of cytochrome c from mitochondria ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of release of cytochrome c from mitochondria ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in negative regulation of smooth muscle cell apoptotic process ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of tumor necrosis factor production IEA
Inferred from Electronic Annotation
more info
 
involved_in negative regulation of tumor necrosis factor production ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of vascular associated smooth muscle cell apoptotic process IEA
Inferred from Electronic Annotation
more info
 
involved_in negative regulation of vascular associated smooth muscle cell apoptotic process ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within nervous system development ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within osteoblast differentiation ISO
Inferred from Sequence Orthology
more info
 
involved_in phosphatidylinositol 3-kinase signaling IEA
Inferred from Electronic Annotation
more info
 
involved_in phosphatidylinositol 3-kinase signaling ISO
Inferred from Sequence Orthology
more info
 
involved_in phosphatidylinositol-mediated signaling ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of DNA binding ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of ERK1 and ERK2 cascade IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of ERK1 and ERK2 cascade ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of MAPK cascade ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of Ras protein signal transduction IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of Ras protein signal transduction ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of activated T cell proliferation IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of activated T cell proliferation ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of blood vessel endothelial cell migration IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in positive regulation of calcineurin-NFAT signaling cascade IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of calcineurin-NFAT signaling cascade ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of cardiac muscle hypertrophy ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of cell growth IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of cell growth IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of cell growth involved in cardiac muscle cell development IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of cell growth involved in cardiac muscle cell development ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of cell migration ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within positive regulation of cell population proliferation ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of cell population proliferation ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of cell population proliferation ISS
Inferred from Sequence or Structural Similarity
more info
 
acts_upstream_of_or_within positive regulation of cerebellar granule cell precursor proliferation ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of epithelial cell proliferation IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of epithelial cell proliferation ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of fat cell differentiation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of fibroblast proliferation IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of fibroblast proliferation ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of gene expression IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of gene expression ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of glial cell proliferation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of glucose import IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of glucose import ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of glucose import ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in positive regulation of glycogen biosynthetic process IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of glycogen biosynthetic process ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of glycogen biosynthetic process ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in positive regulation of glycolytic process IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of glycolytic process ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of glycoprotein biosynthetic process IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of glycoprotein biosynthetic process ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of insulin-like growth factor receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of insulin-like growth factor receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of mitotic nuclear division IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of mitotic nuclear division ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of myelination ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within positive regulation of myoblast proliferation ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of osteoblast differentiation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of osteoblast differentiation IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of osteoblast differentiation ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of peptidyl-tyrosine phosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of peptidyl-tyrosine phosphorylation ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of phosphatidylinositol 3-kinase signaling IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of phosphatidylinositol 3-kinase signaling IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within positive regulation of phosphatidylinositol 3-kinase signaling ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of phosphatidylinositol 3-kinase signaling ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within positive regulation of protein kinase B signaling ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of protein secretion IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of protein secretion ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of protein serine/threonine kinase activity IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of smooth muscle cell migration IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of smooth muscle cell migration ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of smooth muscle cell proliferation ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of steroid hormone biosynthetic process IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of transcription by RNA polymerase II IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of transcription regulatory region DNA binding IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of transcription regulatory region DNA binding ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of transcription, DNA-templated ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of trophectodermal cell proliferation IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of trophectodermal cell proliferation ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of tyrosine phosphorylation of STAT protein IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of tyrosine phosphorylation of STAT protein ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of vascular associated smooth muscle cell proliferation IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of vascular associated smooth muscle cell proliferation ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of vascular endothelial cell proliferation IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within prostate gland epithelium morphogenesis ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within prostate gland growth ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within prostate gland stromal morphogenesis ISO
Inferred from Sequence Orthology
more info
 
involved_in protein kinase B signaling IEA
Inferred from Electronic Annotation
more info
 
involved_in protein kinase B signaling ISO
Inferred from Sequence Orthology
more info
 
involved_in protein stabilization IEA
Inferred from Electronic Annotation
more info
 
involved_in protein stabilization ISO
Inferred from Sequence Orthology
more info
 
involved_in proteoglycan biosynthetic process IEA
Inferred from Electronic Annotation
more info
 
involved_in proteoglycan biosynthetic process ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of calcium ion transport IDA
Inferred from Direct Assay
more info
PubMed 
involved_in regulation of cell population proliferation IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within regulation of establishment or maintenance of cell polarity ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of gene expression ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of multicellular organism growth IEA
Inferred from Electronic Annotation
more info
 
involved_in regulation of multicellular organism growth ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within regulation of nitric oxide biosynthetic process ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within regulation of protein metabolic process ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within regulation of protein phosphorylation ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of translation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in response to activity IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in response to caffeine IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in response to epidermal growth factor IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in response to estradiol IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in response to ethanol IDA
Inferred from Direct Assay
more info
PubMed 
involved_in response to ethanol IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in response to glucocorticoid IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in response to growth hormone IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in response to heat IEA
Inferred from Electronic Annotation
more info
 
involved_in response to heat ISO
Inferred from Sequence Orthology
more info
 
involved_in response to hypoxia IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in response to lipopolysaccharide IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in response to mechanical stimulus IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in response to nicotine IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in response to nutrient IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in response to nutrient levels IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in response to organic cyclic compound IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in response to organic substance IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in response to starvation IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in response to steroid hormone IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in response to thyroid hormone IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in signal transduction IEA
Inferred from Electronic Annotation
more info
 
involved_in skeletal muscle satellite cell maintenance involved in skeletal muscle regeneration IEA
Inferred from Electronic Annotation
more info
 
involved_in skeletal muscle satellite cell maintenance involved in skeletal muscle regeneration ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within type I pneumocyte differentiation ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within type II pneumocyte differentiation ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within water homeostasis ISO
Inferred from Sequence Orthology
more info
 
involved_in wound healing IEA
Inferred from Electronic Annotation
more info
 
involved_in wound healing ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
part_of alphav-beta3 integrin-IGF-1-IGF1R complex IEA
Inferred from Electronic Annotation
more info
 
part_of alphav-beta3 integrin-IGF-1-IGF1R complex ISO
Inferred from Sequence Orthology
more info
 
part_of alphav-beta3 integrin-IGF-1-IGF1R complex ISS
Inferred from Sequence or Structural Similarity
more info
 
located_in cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
located_in exocytic vesicle ISO
Inferred from Sequence Orthology
more info
 
located_in exocytic vesicle ISS
Inferred from Sequence or Structural Similarity
more info
 
located_in extracellular space IDA
Inferred from Direct Assay
more info
PubMed 
located_in extracellular space IEA
Inferred from Electronic Annotation
more info
 
located_in extracellular space ISO
Inferred from Sequence Orthology
more info
 
part_of insulin-like growth factor ternary complex IEA
Inferred from Electronic Annotation
more info
 
part_of insulin-like growth factor ternary complex ISO
Inferred from Sequence Orthology
more info
 
located_in interstitial matrix IDA
Inferred from Direct Assay
more info
PubMed 
located_in neuronal cell body IDA
Inferred from Direct Assay
more info
PubMed 
located_in plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
 
located_in platelet alpha granule IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
insulin-like growth factor I
Names
IGF-I
somatomedin

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001082477.2NP_001075946.2  insulin-like growth factor I isoform a preproprotein

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) differs in the 5' UTR and 5' coding region, compared to variant 3. These differences cause translation initiation from a distinct start codon and result in an isoform (a) with a novel C-terminus, compared to isoform c. This isoform is also known as IIC.
    Source sequence(s)
    BC086374, CB761687, M15480, M17593
    UniProtKB/Swiss-Prot
    P08025
    UniProtKB/TrEMBL
    A0A0G2JX40, Q5RK13, Q63261
    Related
    ENSRNOP00000070124.1, ENSRNOT00000085680.2
    Conserved Domains (1) summary
    cd04368
    Location:33100
    IlGF; IlGF, insulin_like growth factors; specific to vertebrates. Members include a number of peptides including insulin-like growth factors I and II, which play a variety of roles in controlling processes such as growth, differentiation, and reproduction. On ...
  2. NM_001082478.1NP_001075947.1  insulin-like growth factor I isoform c preproprotein

    See identical proteins and their annotated locations for NP_001075947.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) represents the longest variant and encodes isoform c. This isoform is also known as IB.
    Source sequence(s)
    BC086374, CB751206, CB761687, M15480
    UniProtKB/Swiss-Prot
    P08025
    UniProtKB/TrEMBL
    F8WFZ5, Q5RK13
    Conserved Domains (1) summary
    cd04368
    Location:49116
    IlGF; IlGF, insulin_like growth factors; specific to vertebrates. Members include a number of peptides including insulin-like growth factors I and II, which play a variety of roles in controlling processes such as growth, differentiation, and reproduction. On ...
  3. NM_001082479.1NP_001075948.1  insulin-like growth factor I isoform d preproprotein

    See identical proteins and their annotated locations for NP_001075948.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) lacks an alternate frame-shifting exon in the 3' coding region, compared to variant 3, resulting in a protein (isoform d) with a novel C-terminus, compared to isoform c. This isoform is also known as IA.
    Source sequence(s)
    BC086374, CB751206, CB761687
    UniProtKB/Swiss-Prot
    P08025
    UniProtKB/TrEMBL
    Q5RK13
    Conserved Domains (1) summary
    cd04368
    Location:49116
    IlGF; insulin_like growth factors; specific to vertebrates. Members include a number of peptides including insulin-like growth factors I and II, which play a variety of roles in controlling processes such as growth, differentiation, and reproduction. On a ...
  4. NM_178866.4NP_849197.3  insulin-like growth factor I isoform b preproprotein

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR and has multiple coding region differences which include the absence of an alternate frame-shifting exon, compared to variant 3. These differences cause translation initiation from a distinct start codon and result in an isoform (b) with novel N- and C-termini, compared to isoform c. This isoform is also known as IIA.
    Source sequence(s)
    BC086374, CB761687
    UniProtKB/TrEMBL
    Q5RK13
    Conserved Domains (1) summary
    cd04368
    Location:33100
    IlGF; IlGF, insulin_like growth factors; specific to vertebrates. Members include a number of peptides including insulin-like growth factors I and II, which play a variety of roles in controlling processes such as growth, differentiation, and reproduction. On ...

RefSeqs of Annotated Genomes: Rattus norvegicus Annotation Release 108 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference mRatBN7.2 Primary Assembly

Genomic

  1. NC_051342.1 Reference mRatBN7.2 Primary Assembly

    Range
    22282895..22361972
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006241193.4XP_006241255.1  insulin-like growth factor I isoform X2

    See identical proteins and their annotated locations for XP_006241255.1

    UniProtKB/Swiss-Prot
    P08025
    Related
    ENSRNOP00000097781.1, ENSRNOT00000118307.1
    Conserved Domains (1) summary
    cd04368
    Location:49116
    IlGF; insulin_like growth factors; specific to vertebrates. Members include a number of peptides including insulin-like growth factors I and II, which play a variety of roles in controlling processes such as growth, differentiation, and reproduction. On a ...
  2. XM_006241191.3XP_006241253.1  insulin-like growth factor I isoform X1

    See identical proteins and their annotated locations for XP_006241253.1

    UniProtKB/Swiss-Prot
    P08025
    UniProtKB/TrEMBL
    F8WFZ5
    Related
    ENSRNOP00000005995.5, ENSRNOT00000005995.6
    Conserved Domains (1) summary
    cd04368
    Location:49116
    IlGF; IlGF, insulin_like growth factors; specific to vertebrates. Members include a number of peptides including insulin-like growth factors I and II, which play a variety of roles in controlling processes such as growth, differentiation, and reproduction. On ...
  3. XM_006241194.4XP_006241256.1  insulin-like growth factor I isoform X3

    Conserved Domains (1) summary
    cd04368
    Location:2390
    IlGF; insulin_like growth factors; specific to vertebrates. Members include a number of peptides including insulin-like growth factors I and II, which play a variety of roles in controlling processes such as growth, differentiation, and reproduction. On a ...
  4. XM_039078402.1XP_038934330.1  insulin-like growth factor I isoform X3

    Conserved Domains (1) summary
    cd04368
    Location:2390
    IlGF; insulin_like growth factors; specific to vertebrates. Members include a number of peptides including insulin-like growth factors I and II, which play a variety of roles in controlling processes such as growth, differentiation, and reproduction. On a ...
  5. XM_039078401.1XP_038934329.1  insulin-like growth factor I isoform X3

    Conserved Domains (1) summary
    cd04368
    Location:2390
    IlGF; insulin_like growth factors; specific to vertebrates. Members include a number of peptides including insulin-like growth factors I and II, which play a variety of roles in controlling processes such as growth, differentiation, and reproduction. On a ...