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Lgi4 leucine-rich repeat LGI family, member 4 [ Mus musculus (house mouse) ]

Gene ID: 243914, updated on 8-Feb-2024

Summary

Official Symbol
Lgi4provided by MGI
Official Full Name
leucine-rich repeat LGI family, member 4provided by MGI
Primary source
MGI:MGI:2180197
See related
Ensembl:ENSMUSG00000036560 AllianceGenome:MGI:2180197
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
clp; Lgil3
Summary
Involved in regulation of myelination. Acts upstream of or within adult locomotory behavior and neurogenesis. Located in extracellular space. Is expressed in several structures, including adipose tissue; alimentary system; nervous system; reproductive system; and sensory organ. Human ortholog(s) of this gene implicated in arthrogryposis multiplex congenita-1 and childhood absence epilepsy. Orthologous to human LGI4 (leucine rich repeat LGI family member 4). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in stomach adult (RPKM 10.9), bladder adult (RPKM 9.6) and 18 other tissues See more
Orthologs
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Genomic context

See Lgi4 in Genome Data Viewer
Location:
7 B1; 7 19.29 cM
Exon count:
12
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (30758360..30770347)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (31058909..31070935)

Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 38984 Neighboring gene FXYD domain-containing ion transport regulator 7 Neighboring gene FXYD domain-containing ion transport regulator 1 Neighboring gene FXYD domain-containing ion transport regulator 3 Neighboring gene predicted gene, 53358 Neighboring gene hepsin Neighboring gene STARR-positive B cell enhancer mm9_chr7:31896031-31896332

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

Phenotypes

Associated conditions

Description Tests
claw paw
GeneReviews: Not available

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Spontaneous (1) 
  • Targeted (5)  1 citation
  • Endonuclease-mediated (2) 

Pathways from PubChem

General gene information

Markers

Clone Names

  • MGC107385

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Component Evidence Code Pubs
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
 
is_active_in extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in extracellular space IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
leucine-rich repeat LGI family member 4
Names
LGI1-like protein 3
leucine-rich glioma inactivated protein 4

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001419302.1NP_001406231.1  leucine-rich repeat LGI family member 4 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC149055, AC158993
    UniProtKB/TrEMBL
    Q3UYI9
  2. NM_144556.3NP_653139.2  leucine-rich repeat LGI family member 4 isoform 1 precursor

    See identical proteins and their annotated locations for NP_653139.2

    Status: VALIDATED

    Source sequence(s)
    AC149055, AC158993
    Consensus CDS
    CCDS21124.1
    UniProtKB/Swiss-Prot
    Q8K1S1, Q8K4Y8
    UniProtKB/TrEMBL
    Q3UYI9
    Related
    ENSMUSP00000041579.8, ENSMUST00000039775.9
    Conserved Domains (5) summary
    smart00082
    Location:158206
    LRRCT; Leucine rich repeat C-terminal domain
    sd00031
    Location:5477
    LRR_1; leucine-rich repeat [structural motif]
    pfam03736
    Location:396438
    EPTP; EPTP domain
    pfam12799
    Location:102140
    LRR_4; Leucine Rich repeats (2 copies)
    pfam13855
    Location:76136
    LRR_8; Leucine rich repeat

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000073.7 Reference GRCm39 C57BL/6J

    Range
    30758360..30770347
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036153096.1XP_036008989.1  leucine-rich repeat LGI family member 4 isoform X1

    UniProtKB/TrEMBL
    Q3UYI9
    Conserved Domains (4) summary
    TIGR00864
    Location:131192
    PCC; polycystin cation channel protein
    sd00031
    Location:5477
    LRR_1; leucine-rich repeat [structural motif]
    pfam03736
    Location:394434
    EPTP; EPTP domain
    pfam13855
    Location:76136
    LRR_8; Leucine rich repeat
  2. XM_011250576.4XP_011248878.1  leucine-rich repeat LGI family member 4 isoform X4

    Conserved Domains (3) summary
    TIGR00864
    Location:131192
    PCC; polycystin cation channel protein
    sd00031
    Location:5477
    LRR_1; leucine-rich repeat [structural motif]
    pfam13855
    Location:77136
    LRR_8; Leucine rich repeat
  3. XM_006539958.5XP_006540021.2  leucine-rich repeat LGI family member 4 isoform X2

    See identical proteins and their annotated locations for XP_006540021.2

    UniProtKB/TrEMBL
    Q3UYI9
    Conserved Domains (4) summary
    TIGR00864
    Location:70131
    PCC; polycystin cation channel protein
    sd00031
    Location:1740
    LRR_1; leucine-rich repeat [structural motif]
    pfam13855
    Location:1675
    LRR_8; Leucine rich repeat
    pfam03736
    Location:336376
    EPTP; EPTP domain
  4. XM_036153097.1XP_036008990.1  leucine-rich repeat LGI family member 4 isoform X3

    Conserved Domains (1) summary
    pfam03736
    Location:162202
    EPTP; EPTP domain