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Eno1 enolase 1 [ Rattus norvegicus (Norway rat) ]

Gene ID: 24333, updated on 4-Nov-2022

Summary

Official Symbol
Eno1provided by RGD
Official Full Name
enolase 1provided by RGD
Primary source
RGD:2553
See related
Ensembl:ENSRNOG00000017895 AllianceGenome:RGD:2553
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Nne
Summary
Enables several functions, including heat shock protein binding activity; phosphopyruvate hydratase activity; and protein homodimerization activity. Involved in ERK1 and ERK2 cascade; canonical glycolysis; and cellular response to hypoxia. Located in several cellular components, including growth cone; membrane raft; and synaptic membrane. Part of phosphopyruvate hydratase complex. Biomarker of hypertension. Human ortholog(s) of this gene implicated in Alzheimer's disease. Orthologous to human ENO1 (enolase 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Kidney (RPKM 3105.7), Thymus (RPKM 1709.3) and 9 other tissues See more
Orthologs
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Genomic context

See Eno1 in Genome Data Viewer
Location:
5q36
Exon count:
15
Annotation release Status Assembly Chr Location
108 current mRatBN7.2 (GCF_015227675.2) 5 NC_051340.1 (160719951..160731337)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 5 NC_005104.4 (167288223..167299610)

Chromosome 5 - NC_051340.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC120103042 Neighboring gene carbonic anhydrase 6 Neighboring gene uncharacterized LOC120103043 Neighboring gene small nuclear ribonucleoprotein G pseudogene Neighboring gene arginine-glutamic acid dipeptide repeats

Genomic regions, transcripts, and products

Expression

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables DNA-binding transcription repressor activity, RNA polymerase II-specific ISO
Inferred from Sequence Orthology
more info
 
enables GTPase binding ISO
Inferred from Sequence Orthology
more info
 
enables RNA binding ISO
Inferred from Sequence Orthology
more info
 
enables RNA polymerase II transcription regulatory region sequence-specific DNA binding ISO
Inferred from Sequence Orthology
more info
 
enables enzyme binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables heat shock protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables identical protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables magnesium ion binding IEA
Inferred from Electronic Annotation
more info
 
enables phosphopyruvate hydratase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables phosphopyruvate hydratase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables phosphopyruvate hydratase activity IEA
Inferred from Electronic Annotation
more info
 
enables phosphopyruvate hydratase activity ISO
Inferred from Sequence Orthology
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein homodimerization activity IDA
Inferred from Direct Assay
more info
PubMed 
enables protein homodimerization activity ISO
Inferred from Sequence Orthology
more info
 
enables protein-containing complex binding IDA
Inferred from Direct Assay
more info
PubMed 
enables transcription corepressor activity ISO
Inferred from Sequence Orthology
more info
 
enables transcription corepressor binding ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
involved_in ERK1 and ERK2 cascade IDA
Inferred from Direct Assay
more info
PubMed 
involved_in canonical glycolysis IDA
Inferred from Direct Assay
more info
PubMed 
involved_in canonical glycolysis ISO
Inferred from Sequence Orthology
more info
 
involved_in cellular response to hypoxia IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within cellular response to interleukin-7 ISO
Inferred from Sequence Orthology
more info
 
involved_in gluconeogenesis ISO
Inferred from Sequence Orthology
more info
 
involved_in glycolytic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in glycolytic process IDA
Inferred from Direct Assay
more info
PubMed 
involved_in glycolytic process IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within in utero embryonic development ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of DNA-templated transcription ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of cell growth ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of hypoxia-induced intrinsic apoptotic signaling pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of ATP biosynthetic process ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within positive regulation of binding ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of muscle contraction ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of plasminogen activation ISO
Inferred from Sequence Orthology
more info
 
involved_in response to virus ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
located_in cell cortex IDA
Inferred from Direct Assay
more info
PubMed 
located_in cell cortex ISO
Inferred from Sequence Orthology
more info
 
located_in cell surface IDA
Inferred from Direct Assay
more info
PubMed 
located_in cell surface ISO
Inferred from Sequence Orthology
more info
 
located_in cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in cytosol IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytosol ISO
Inferred from Sequence Orthology
more info
 
located_in extrinsic component of plasma membrane ISO
Inferred from Sequence Orthology
more info
 
located_in growth cone IDA
Inferred from Direct Assay
more info
PubMed 
located_in membrane ISO
Inferred from Sequence Orthology
more info
 
located_in membrane raft IDA
Inferred from Direct Assay
more info
PubMed 
located_in neuron projection IDA
Inferred from Direct Assay
more info
PubMed 
located_in nuclear outer membrane ISO
Inferred from Sequence Orthology
more info
 
part_of phosphopyruvate hydratase complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
part_of phosphopyruvate hydratase complex IC
Inferred by Curator
more info
PubMed 
part_of phosphopyruvate hydratase complex IDA
Inferred from Direct Assay
more info
PubMed 
part_of phosphopyruvate hydratase complex IEA
Inferred from Electronic Annotation
more info
 
part_of phosphopyruvate hydratase complex ISO
Inferred from Sequence Orthology
more info
 
located_in plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
 
located_in synaptic membrane IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
alpha-enolase
Names
2-phospho-D-glycerate hydro-lyase
enolase 1, (alpha)
enolase 1, alpha non-neuron
non-neural enolase
NP_001103378.1
NP_036686.2
XP_006239506.1
XP_038965185.1
XP_038965186.1

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001109908.1NP_001103378.1  alpha-enolase

    See identical proteins and their annotated locations for NP_001103378.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1 and 2 encode the same protein.
    Source sequence(s)
    BC078896
    UniProtKB/Swiss-Prot
    P04764, Q6P504
    UniProtKB/TrEMBL
    Q4QR91, Q5BJ93
    Related
    ENSRNOP00000073191.1, ENSRNOT00000081579.2
    Conserved Domains (1) summary
    PLN00191
    Location:2432
    PLN00191; enolase
  2. NM_012554.3NP_036686.2  alpha-enolase

    See identical proteins and their annotated locations for NP_036686.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the shorter transcript. Variants 1 and 2 encode the same protein.
    Source sequence(s)
    BC091572, CB809779
    UniProtKB/Swiss-Prot
    P04764, Q6P504
    UniProtKB/TrEMBL
    Q4QR91, Q5BJ93
    Related
    ENSRNOP00000024106.6, ENSRNOT00000024106.8
    Conserved Domains (1) summary
    PLN00191
    Location:2432
    PLN00191; enolase

RefSeqs of Annotated Genomes: Rattus norvegicus Annotation Release 108 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference mRatBN7.2 Primary Assembly

Genomic

  1. NC_051340.1 Reference mRatBN7.2 Primary Assembly

    Range
    160719951..160731337
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039109257.1XP_038965185.1  alpha-enolase isoform X1

    UniProtKB/Swiss-Prot
    Q6P504
    UniProtKB/TrEMBL
    Q4QR91
    Conserved Domains (1) summary
    PLN00191
    Location:2432
    PLN00191; enolase
  2. XM_006239444.3XP_006239506.1  alpha-enolase isoform X2

    UniProtKB/TrEMBL
    A0A8I6ART9
    Related
    ENSRNOP00000096876.1, ENSRNOT00000119075.1
    Conserved Domains (2) summary
    PLN00191
    Location:2432
    PLN00191; enolase
    cd03313
    Location:5416
    enolase; Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions.
  3. XM_039109258.1XP_038965186.1  alpha-enolase isoform X1

    UniProtKB/Swiss-Prot
    Q6P504
    UniProtKB/TrEMBL
    Q4QR91
    Conserved Domains (1) summary
    PLN00191
    Location:2432
    PLN00191; enolase