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Eno1 enolase 1, alpha non-neuron [ Mus musculus (house mouse) ]

Gene ID: 13806, updated on 8-Jan-2023

Summary

Official Symbol
Eno1provided by MGI
Official Full Name
enolase 1, alpha non-neuronprovided by MGI
Primary source
MGI:MGI:95393
See related
Ensembl:ENSMUSG00000063524 AllianceGenome:MGI:95393
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
NNE; Eno-1; MBP-1
Summary
Enables RNA binding activity and phosphopyruvate hydratase activity. Acts upstream of or within cellular response to interleukin-7; in utero embryonic development; and positive regulation of binding activity. Is extrinsic component of plasma membrane. Is expressed in several structures, including alimentary system; genitourinary system; nervous system; respiratory system; and sensory organ. Human ortholog(s) of this gene implicated in Alzheimer's disease. Orthologous to human ENO1 (enolase 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in kidney adult (RPKM 310.6), subcutaneous fat pad adult (RPKM 285.5) and 28 other tissues See more
Orthologs
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Genomic context

See Eno1 in Genome Data Viewer
Location:
4 E2; 4 81.24 cM
Exon count:
14
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (150321165..150333336)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (150236708..150248879)

Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 52492 Neighboring gene solute carrier family 2 (facilitated glucose transporter), member 7 Neighboring gene carbonic anhydrase 6 Neighboring gene predicted gene, 33415 Neighboring gene arginine glutamic acid dipeptide (RE) repeats Neighboring gene small nuclear ribonucleoprotein F

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Gene trapped (2)  1 citation
  • Endonuclease-mediated (1) 

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC103111, MGC107267

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables DNA-binding transcription repressor activity, RNA polymerase II-specific ISO
Inferred from Sequence Orthology
more info
 
enables GTPase binding ISO
Inferred from Sequence Orthology
more info
 
enables RNA binding IDA
Inferred from Direct Assay
more info
PubMed 
enables RNA polymerase II transcription regulatory region sequence-specific DNA binding ISO
Inferred from Sequence Orthology
more info
 
enables enzyme binding ISO
Inferred from Sequence Orthology
more info
 
enables heat shock protein binding ISO
Inferred from Sequence Orthology
more info
 
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
 
enables phosphopyruvate hydratase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables phosphopyruvate hydratase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables phosphopyruvate hydratase activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables phosphopyruvate hydratase activity ISO
Inferred from Sequence Orthology
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein homodimerization activity ISO
Inferred from Sequence Orthology
more info
 
enables protein-containing complex binding ISO
Inferred from Sequence Orthology
more info
 
enables transcription corepressor activity ISO
Inferred from Sequence Orthology
more info
 
enables transcription corepressor binding ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
involved_in canonical glycolysis ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within cellular response to acid chemical IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within cellular response to interleukin-7 IDA
Inferred from Direct Assay
more info
PubMed 
involved_in gluconeogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in glycolytic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
acts_upstream_of_or_within in utero embryonic development IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of DNA-templated transcription ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of cell growth ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of hypoxia-induced intrinsic apoptotic signaling pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of ATP biosynthetic process ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within positive regulation of binding IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of muscle contraction ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of plasminogen activation ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
located_in cell cortex ISO
Inferred from Sequence Orthology
more info
 
located_in cell surface IDA
Inferred from Direct Assay
more info
PubMed 
located_in cell surface ISO
Inferred from Sequence Orthology
more info
 
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in cytosol ISO
Inferred from Sequence Orthology
more info
 
located_in growth cone ISO
Inferred from Sequence Orthology
more info
 
located_in membrane ISO
Inferred from Sequence Orthology
more info
 
located_in membrane raft ISO
Inferred from Sequence Orthology
more info
 
located_in myelin sheath HDA PubMed 
located_in neuron projection ISO
Inferred from Sequence Orthology
more info
 
located_in nuclear outer membrane ISO
Inferred from Sequence Orthology
more info
 
part_of phosphopyruvate hydratase complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
part_of phosphopyruvate hydratase complex ISO
Inferred from Sequence Orthology
more info
 
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
 
located_in synaptic membrane ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
alpha-enolase
Names
2-phospho-D-glycerate hydro-lyase
2-phospho-D-glycerate hydrolase
c-Myc promoter binding protein
non-neural enolase
NP_001366056.1
NP_001366057.1
NP_075608.2
XP_036019540.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001379127.1NP_001366056.1  alpha-enolase isoform 1

    Status: VALIDATED

    Source sequence(s)
    AL606903
    Conserved Domains (1) summary
    PLN00191
    Location:2432
    PLN00191; enolase
  2. NM_001379128.1NP_001366057.1  alpha-enolase isoform 2

    Status: VALIDATED

    Source sequence(s)
    AL606903
    UniProtKB/Swiss-Prot
    Q9DCY7
    UniProtKB/TrEMBL
    A0A8C6I1E7, Q5XKE1
    Conserved Domains (1) summary
    PLN00191
    Location:2432
    PLN00191; enolase
  3. NM_023119.2NP_075608.2  alpha-enolase isoform 2

    See identical proteins and their annotated locations for NP_075608.2

    Status: VALIDATED

    Source sequence(s)
    BC083334, BU526382
    Consensus CDS
    CCDS18971.1
    UniProtKB/Swiss-Prot
    P17182, Q9DCY7
    UniProtKB/TrEMBL
    A0A8C6I1E7, Q5FW97, Q5XKE1
    Related
    ENSMUSP00000079727.7, ENSMUST00000080926.13
    Conserved Domains (1) summary
    PLN00191
    Location:2432
    PLN00191; enolase

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000070.7 Reference GRCm39 C57BL/6J

    Range
    150321165..150333336
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036163647.1XP_036019540.1  alpha-enolase isoform X1

    Conserved Domains (1) summary
    PLN00191
    Location:2432
    PLN00191; enolase