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Hcar1 hydrocarboxylic acid receptor 1 [ Mus musculus (house mouse) ]

Gene ID: 243270, updated on 8-Feb-2024

Summary

Official Symbol
Hcar1provided by MGI
Official Full Name
hydrocarboxylic acid receptor 1provided by MGI
Primary source
MGI:MGI:2441671
See related
Ensembl:ENSMUSG00000049241 AllianceGenome:MGI:2441671
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Gpr81
Summary
Enables G protein-coupled receptor activity. Involved in G protein-coupled receptor signaling pathway and negative regulation of lipid catabolic process. Is active in membrane. Orthologous to human HCAR1 (hydroxycarboxylic acid receptor 1). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
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Genomic context

See Hcar1 in Genome Data Viewer
Location:
5 F; 5 63.24 cM
Exon count:
1
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (124014802..124018066, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (123876739..123880003, complement)

Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene kinetochore associated 1 Neighboring gene hydroxycarboxylic acid receptor 2 Neighboring gene STARR-seq mESC enhancer starr_14329 Neighboring gene STARR-positive B cell enhancer ABC_E4789 Neighboring gene STARR-positive B cell enhancer ABC_E6379 Neighboring gene density-regulated protein Neighboring gene STARR-seq mESC enhancer starr_14330 Neighboring gene STARR-positive B cell enhancer mm9_chr5:124397405-124397706 Neighboring gene coiled-coil domain containing 62

Genomic regions, transcripts, and products

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (1)  1 citation
  • Endonuclease-mediated (3) 

Pathways from PubChem

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables G protein-coupled receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables G protein-coupled receptor activity IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
located_in intracellular organelle ISO
Inferred from Sequence Orthology
more info
PubMed 
is_active_in membrane IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
PubMed 

General protein information

Preferred Names
hydroxycarboxylic acid receptor 1
Names
G-protein coupled receptor 81

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_175520.5NP_780729.3  hydroxycarboxylic acid receptor 1

    Status: VALIDATED

    Source sequence(s)
    AC122753, AC129582
    Consensus CDS
    CCDS19669.2
    UniProtKB/Swiss-Prot
    B9EJ36, Q8C131
    UniProtKB/TrEMBL
    A0A4Y1JWM1, E9PZR8
    Related
    ENSMUSP00000129280.3, ENSMUST00000164267.3
    Conserved Domains (1) summary
    cd15201
    Location:16289
    7tmA_HCAR1-3; hydroxycarboxylic acid receptors, member of the class A family of seven-transmembrane G protein-coupled receptors

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000071.7 Reference GRCm39 C57BL/6J

    Range
    124014802..124018066 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)