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Hcar1 hydrocarboxylic acid receptor 1 [ Mus musculus (house mouse) ]

Gene ID: 243270, updated on 2-Nov-2024

Summary

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Official Symbol
Hcar1provided by MGI
Official Full Name
hydrocarboxylic acid receptor 1provided by MGI
Primary source
MGI:MGI:2441671
See related
Ensembl:ENSMUSG00000049241 AllianceGenome:MGI:2441671
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Gpr81
Summary
Enables G protein-coupled receptor activity. Involved in G protein-coupled receptor signaling pathway and negative regulation of lipid catabolic process. Is active in membrane. Is expressed in retina ganglion cell layer and retina layer. Orthologous to human HCAR1 (hydroxycarboxylic acid receptor 1). [provided by Alliance of Genome Resources, Nov 2024]
Orthologs
human all
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Genomic context

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See Hcar1 in Genome Data Viewer
Location:
5 F; 5 63.24 cM
Exon count:
1
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (124014802..124018066, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (123876739..123880003, complement)

Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene kinetochore associated 1 Neighboring gene hydroxycarboxylic acid receptor 2 Neighboring gene STARR-seq mESC enhancer starr_14329 Neighboring gene STARR-positive B cell enhancer ABC_E4789 Neighboring gene STARR-positive B cell enhancer ABC_E6379 Neighboring gene density-regulated protein Neighboring gene STARR-seq mESC enhancer starr_14330 Neighboring gene STARR-positive B cell enhancer mm9_chr5:124397405-124397706 Neighboring gene coiled-coil domain containing 62

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Deletion of GPR81 activates CREB/Smad7 pathway and alleviates liver fibrosis in mice. Zhi Y, et al. Mol Med, 2024 Jul 9. PMID 38982366, Free PMC Article
  2. Elucidation of signaling and functional activities of an orphan GPCR, GPR81. Ge H, et al. J Lipid Res, 2008 Apr. PMID 18174606
  3. An autocrine lactate loop mediates insulin-dependent inhibition of lipolysis through GPR81. Ahmed K, et al. Cell Metab, 2010 Apr 7. PMID 20374963
  4. Inflammation inhibits GPR81 expression in adipose tissue. Feingold KR, et al. Inflamm Res, 2011 Oct. PMID 21751047
  5. Lactate produced during labor modulates uterine inflammation via GPR81 (HCA(1)). Madaan A, et al. Am J Obstet Gynecol, 2017 Jan. PMID 27615440

See all (47) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Deletion of GPR81 activates CREB/Smad7 pathway and alleviates liver fibrosis in mice.
    Title: Deletion of GPR81 activates CREB/Smad7 pathway and alleviates liver fibrosis in mice.
  2. Lactate secreted via MCT4 from bonecolonizing breast cancer excites sensory neurons via GPR81.
    Title: Lactate secreted via MCT4 from bone‑colonizing breast cancer excites sensory neurons via GPR81.
  3. Activation of brain lactate receptor GPR81 aggravates exercise-induced central fatigue.
    Title: Activation of brain lactate receptor GPR81 aggravates exercise-induced central fatigue.
  4. Activation of GPR81 Aggravates Remote Organ Injury During Hepatic Ischemia-Reperfusion Injury.
    Title: Activation of GPR81 Aggravates Remote Organ Injury During Hepatic Ischemia-Reperfusion Injury.
  5. Overexpressing the hydroxycarboxylic acid receptor 1 in mouse brown adipose tissue restores glucose tolerance and insulin sensitivity in diet-induced obese mice.
    Title: Overexpressing the hydroxycarboxylic acid receptor 1 in mouse brown adipose tissue restores glucose tolerance and insulin sensitivity in diet-induced obese mice.
  6. Activation of lactate receptor HCAR1 down-modulates neuronal activity in rodent and human brain tissue.
    Title: Activation of lactate receptor HCAR1 down-modulates neuronal activity in rodent and human brain tissue.
  7. Lactate receptor HCAR1 regulates neurogenesis and microglia activation after neonatal hypoxia-ischemia.
    Title: Lactate receptor HCAR1 regulates neurogenesis and microglia activation after neonatal hypoxia-ischemia.
  8. Neuronal GPR81 regulates developmental brain angiogenesis and promotes brain recovery after a hypoxic ischemic insult.
    Title: Neuronal GPR81 regulates developmental brain angiogenesis and promotes brain recovery after a hypoxic ischemic insult.
  9. Lactate activates hypothalamic POMC neurons by intercellular signaling.
    Title: Lactate activates hypothalamic POMC neurons by intercellular signaling.
  10. Participation of L-Lactate and Its Receptor HCAR1/GPR81 in Neurovisual Development.
    Title: Participation of L-Lactate and Its Receptor HCAR1/GPR81 in Neurovisual Development.
Submit: New GeneRIF Correction See all GeneRIFs (28)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (3) 
  • Targeted (2)  1 citation

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables G protein-coupled receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables G protein-coupled receptor activity IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in G protein-coupled receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in G protein-coupled receptor signaling pathway IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in negative regulation of lipid catabolic process IDA
Inferred from Direct Assay
more info
 PubMed 
Component Evidence Code Pubs
located_in intracellular organelle ISO
Inferred from Sequence Orthology
more info
 PubMed 
is_active_in membrane IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
 PubMed 

General protein information

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Preferred Names
hydroxycarboxylic acid receptor 1
Names
G-protein coupled receptor 81

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_175520.5 → NP_780729.3  hydroxycarboxylic acid receptor 1

    Status: VALIDATED

    Source sequence(s)
    AC122753, AC129582
    Consensus CDS
    CCDS19669.2
    UniProtKB/Swiss-Prot
    B9EJ36, Q8C131
    UniProtKB/TrEMBL
    A0A4Y1JWM1, E9PZR8
    Related
    ENSMUSP00000129280.3, ENSMUST00000164267.3
    Conserved Domains (1) summary
    cd15201
    Location:16 → 289
    7tmA_HCAR1-3; hydroxycarboxylic acid receptors, member of the class A family of seven-transmembrane G protein-coupled receptors

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000071.7 Reference GRCm39 C57BL/6J

    Range
    124014802..124018066 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8C131.1 GenPept UniProtKB/Swiss-Prot:Q8C131

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
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