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HCAR1 hydroxycarboxylic acid receptor 1 [ Homo sapiens (human) ]

Gene ID: 27198, updated on 3-Dec-2022

Summary

Official Symbol
HCAR1provided by HGNC
Official Full Name
hydroxycarboxylic acid receptor 1provided by HGNC
Primary source
HGNC:HGNC:4532
See related
Ensembl:ENSG00000196917 MIM:606923; AllianceGenome:HGNC:4532
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
HCA1; GPR81; LACR1; FKSG80; GPR104; TAGPCR; TA-GPCR
Summary
G protein-coupled receptors (GPCRs, or GPRs), such as GPR81, contain 7 transmembrane domains and transduce extracellular signals through heterotrimeric G proteins.[supplied by OMIM, Feb 2005]
Orthologs
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Genomic context

See HCAR1 in Genome Data Viewer
Location:
12q24.31
Exon count:
1
Annotation release Status Assembly Chr Location
110 current GRCh38.p14 (GCF_000001405.40) 12 NC_000012.12 (122726076..122730844, complement)
110 current T2T-CHM13v2.0 (GCF_009914755.1) 12 NC_060936.1 (122721458..122726228, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 12 NC_000012.11 (123210623..123215391, complement)

Chromosome 12 - NC_000012.12Genomic Context describing neighboring genes Neighboring gene microRNA 9902-2 Neighboring gene hydroxycarboxylic acid receptor 3 Neighboring gene Sharpr-MPRA regulatory region 1215 Neighboring gene density regulated re-initiation and release factor

Genomic regions, transcripts, and products

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables G protein-coupled receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Process Evidence Code Pubs
involved_in G protein-coupled receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in negative regulation of lipid catabolic process IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in plasma membrane TAS
Traceable Author Statement
more info
 

General protein information

Preferred Names
hydroxycarboxylic acid receptor 1
Names
G protein-coupled receptor 104
G-protein coupled receptor 81
T-cell activation G protein-coupled receptor
hydroxy-carboxylic acid receptor 1
lactate receptor 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_032554.4NP_115943.1  hydroxycarboxylic acid receptor 1

    See identical proteins and their annotated locations for NP_115943.1

    Status: VALIDATED

    Source sequence(s)
    AC026333, AF345568
    Consensus CDS
    CCDS9236.1
    UniProtKB/Swiss-Prot
    Q6NXU5, Q9BXC0
    UniProtKB/TrEMBL
    A0A4Y1JWP1
    Related
    ENSP00000389255.1, ENST00000432564.3
    Conserved Domains (1) summary
    cd15201
    Location:16289
    7tmA_HCAR1-3; hydroxycarboxylic acid receptors, member of the class A family of seven-transmembrane G protein-coupled receptors

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 110 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000012.12 Reference GRCh38.p14 Primary Assembly

    Range
    122726076..122730844 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060936.1 Alternate T2T-CHM13v2.0

    Range
    122721458..122726228 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)