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Tmem8b transmembrane protein 8B [ Mus musculus (house mouse) ]

Gene ID: 242409, updated on 8-Feb-2024

Summary

Official Symbol
Tmem8bprovided by MGI
Official Full Name
transmembrane protein 8Bprovided by MGI
Primary source
MGI:MGI:2441680
See related
Ensembl:ENSMUSG00000078716 AllianceGenome:MGI:2441680
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
4930500O05Rik
Summary
Predicted to be involved in cell-matrix adhesion. Predicted to act upstream of or within cell adhesion and regulation of growth. Predicted to be located in cell surface. Predicted to be active in plasma membrane. Orthologous to human TMEM8B (transmembrane protein 8B). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in testis adult (RPKM 21.3), whole brain E14.5 (RPKM 8.4) and 22 other tissues See more
Orthologs
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Genomic context

See Tmem8b in Genome Data Viewer
Location:
4 A5; 4 23.05 cM
Exon count:
16
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (43668971..43692668)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (43668971..43692668)

Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene histidine triad nucleotide binding protein 2 Neighboring gene small EDRK-rich factor 2 pseudogene Neighboring gene family with sequence similarity 221, member B Neighboring gene small EDRK-rich factor 2 pseudogene Neighboring gene olfactory receptor family 13 subfamily E member 8 Neighboring gene olfactory receptor family 13 subfamily J member 1

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (2) 

General gene information

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
 
Process Evidence Code Pubs
acts_upstream_of_or_within cell adhesion IEA
Inferred from Electronic Annotation
more info
 
involved_in cell-matrix adhesion ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
located_in cell surface ISO
Inferred from Sequence Orthology
more info
 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 
located_in endoplasmic reticulum IEA
Inferred from Electronic Annotation
more info
 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
located_in mitochondrion IEA
Inferred from Electronic Annotation
more info
 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
 
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
 

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001085508.2NP_001078977.1  transmembrane protein 8B isoform 1

    See identical proteins and their annotated locations for NP_001078977.1

    Status: VALIDATED

    Source sequence(s)
    AK029713, AK148848, CB248373, CO042254
    Consensus CDS
    CCDS51168.1
    UniProtKB/Swiss-Prot
    B1AWJ5, B9EJV2
    Related
    ENSMUSP00000103497.3, ENSMUST00000107865.9
    Conserved Domains (1) summary
    pfam12036
    Location:245415
    DUF3522; Protein of unknown function (DUF3522)
  2. NM_001355718.1NP_001342647.1  transmembrane protein 8B isoform 2

    Status: VALIDATED

    Source sequence(s)
    AK029713, AK148848, CB248373, CO042254
    Conserved Domains (1) summary
    pfam12036
    Location:285455
    DUF3522; Protein of unknown function (DUF3522)
  3. NM_001368840.1NP_001355769.1  transmembrane protein 8B isoform 3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) represents the longest transcript and encodes the longest isoform (3).
    Source sequence(s)
    AL732626
    Consensus CDS
    CCDS89738.1
    UniProtKB/TrEMBL
    B1AWJ4
    Related
    ENSMUSP00000103498.3, ENSMUST00000107866.9
    Conserved Domains (2) summary
    pfam09770
    Location:195
    PAT1; Topoisomerase II-associated protein PAT1
    pfam12036
    Location:704874
    DUF3522; Protein of unknown function (DUF3522)
  4. NM_001368841.1NP_001355770.1  transmembrane protein 8B isoform 4

    Status: VALIDATED

    Source sequence(s)
    AL732626
    Conserved Domains (1) summary
    pfam12036
    Location:285401
    DUF3522; Protein of unknown function (DUF3522)
  5. NM_001368842.1NP_001355771.1  transmembrane protein 8B isoform 5

    Status: VALIDATED

    Source sequence(s)
    AL732626
    Conserved Domains (1) summary
    pfam12036
    Location:245361
    DUF3522; Protein of unknown function (DUF3522)

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000070.7 Reference GRCm39 C57BL/6J

    Range
    43668971..43692668
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011250030.4XP_011248332.1  transmembrane protein 8B isoform X3

    See identical proteins and their annotated locations for XP_011248332.1

    UniProtKB/Swiss-Prot
    B1AWJ5, B9EJV2
    Related
    ENSMUSP00000103496.2, ENSMUST00000107864.8
    Conserved Domains (1) summary
    pfam12036
    Location:245415
    DUF3522; Protein of unknown function (DUF3522)
  2. XM_030253531.2XP_030109391.1  transmembrane protein 8B isoform X2

    Conserved Domains (1) summary
    pfam12036
    Location:285455
    DUF3522; Protein of unknown function (DUF3522)
  3. XM_011250028.4XP_011248330.1  transmembrane protein 8B isoform X1

    Conserved Domains (2) summary
    pfam09770
    Location:195
    PAT1; Topoisomerase II-associated protein PAT1
    pfam12036
    Location:704820
    DUF3522; Protein of unknown function (DUF3522)
  4. XM_036164110.1XP_036020003.1  transmembrane protein 8B isoform X3

    UniProtKB/Swiss-Prot
    B1AWJ5, B9EJV2
    Conserved Domains (1) summary
    pfam12036
    Location:245415
    DUF3522; Protein of unknown function (DUF3522)
  5. XM_030253530.2XP_030109390.1  transmembrane protein 8B isoform X2

    Conserved Domains (1) summary
    pfam12036
    Location:285455
    DUF3522; Protein of unknown function (DUF3522)
  6. XM_030253533.2XP_030109393.1  transmembrane protein 8B isoform X4

    Conserved Domains (1) summary
    pfam12036
    Location:285401
    DUF3522; Protein of unknown function (DUF3522)
  7. XM_036164109.1XP_036020002.1  transmembrane protein 8B isoform X2

    Conserved Domains (1) summary
    pfam12036
    Location:285455
    DUF3522; Protein of unknown function (DUF3522)
  8. XM_030253532.1XP_030109392.1  transmembrane protein 8B isoform X2

    Conserved Domains (1) summary
    pfam12036
    Location:285455
    DUF3522; Protein of unknown function (DUF3522)

RNA

  1. XR_001784142.3 RNA Sequence