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TMEM8B transmembrane protein 8B [ Homo sapiens (human) ]

Gene ID: 51754, updated on 23-Nov-2021

Summary

Official Symbol
TMEM8Bprovided by HGNC
Official Full Name
transmembrane protein 8Bprovided by HGNC
Primary source
HGNC:HGNC:21427
See related
Ensembl:ENSG00000137103 MIM:616888
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
NAG5; NGX6; FP588; NAG-5; NGX6a; C9orf127; LINC00950
Expression
Ubiquitous expression in brain (RPKM 4.5), ovary (RPKM 3.3) and 23 other tissues See more
Orthologs
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Genomic context

See TMEM8B in Genome Data Viewer
Location:
9p13.3
Exon count:
19
Annotation release Status Assembly Chr Location
109.20211119 current GRCh38.p13 (GCF_000001405.39) 9 NC_000009.12 (35825817..35865515)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 9 NC_000009.11 (35829225..35865512)

Chromosome 9 - NC_000009.12Genomic Context describing neighboring genes Neighboring gene natriuretic peptide receptor 2 Neighboring gene sperm associated antigen 8 Neighboring gene histidine triad nucleotide binding protein 2 Neighboring gene family with sequence similarity 221 member B Neighboring gene olfactory receptor family 13 subfamily E member 1 pseudogene Neighboring gene olfactory receptor family 13 subfamily J member 1 Neighboring gene NADH:ubiquinone oxidoreductase subunit A5 pseudogene 4

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ30363, FLJ30741, MGC120460, DKFZp547N0218

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
involved_in cell-matrix adhesion IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of growth IEA
Inferred from Electronic Annotation
more info
 
involved_in regulation of mitotic cell cycle TAS
Traceable Author Statement
more info
PubMed 
Component Evidence Code Pubs
located_in cell surface IDA
Inferred from Direct Assay
more info
PubMed 
located_in endoplasmic reticulum IEA
Inferred from Electronic Annotation
more info
 
located_in integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
located_in mitochondrion IEA
Inferred from Electronic Annotation
more info
 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
transmembrane protein 8B
Names
nasopharyngeal carcinoma expressed 6
nasopharyngeal carcinoma related protein
nasopharyngeal carcinoma-associated gene 6 protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001042589.3NP_001036054.1  transmembrane protein 8B isoform a

    See identical proteins and their annotated locations for NP_001036054.1

    Status: VALIDATED

    Source sequence(s)
    AL133410, BC043384
    Consensus CDS
    CCDS43800.1
    UniProtKB/Swiss-Prot
    A6NDV4
    Related
    ENSP00000367230.4, ENST00000377991.9
    Conserved Domains (1) summary
    pfam12036
    Location:245415
    DUF3522; Protein of unknown function (DUF3522)
  2. NM_001042590.4NP_001036055.2  transmembrane protein 8B isoform c

    Status: VALIDATED

    Source sequence(s)
    AL133410
    Related
    ENSP00000493496.1, ENST00000643932.2
    Conserved Domains (2) summary
    pfam12036
    Location:697867
    DUF3522; Protein of unknown function (DUF3522)
    cl26464
    Location:34144
    Atrophin-1; Atrophin-1 family
  3. NM_001363620.1NP_001350549.1  transmembrane protein 8B isoform d

    Status: VALIDATED

    Source sequence(s)
    AL133410
    Conserved Domains (2) summary
    pfam12036
    Location:697751
    DUF3522; Protein of unknown function (DUF3522)
    cl26464
    Location:34144
    Atrophin-1; Atrophin-1 family
  4. NM_001363621.1NP_001350550.1  transmembrane protein 8B isoform b

    Status: VALIDATED

    Source sequence(s)
    AL133410
    Related
    ENSP00000367235.1, ENST00000377996.5
    Conserved Domains (1) summary
    pfam12036
    Location:245299
    DUF3522; Protein of unknown function (DUF3522)
  5. NM_001363622.1NP_001350551.1  transmembrane protein 8B isoform e

    Status: VALIDATED

    Source sequence(s)
    AL133410
    Conserved Domains (1) summary
    pfam12036
    Location:245361
    DUF3522; Protein of unknown function (DUF3522)
  6. NM_001363625.1NP_001350554.1  transmembrane protein 8B isoform f

    Status: VALIDATED

    Source sequence(s)
    AL133410, BC064951
    Conserved Domains (1) summary
    cl26464
    Location:34144
    Atrophin-1; Atrophin-1 family
  7. NM_016446.4NP_057530.2  transmembrane protein 8B isoform b

    See identical proteins and their annotated locations for NP_057530.2

    Status: VALIDATED

    Source sequence(s)
    AF188239, AL133410
    Consensus CDS
    CCDS6595.1
    UniProtKB/Swiss-Prot
    A6NDV4
    Related
    ENSP00000395810.2, ENST00000439587.6
    Conserved Domains (1) summary
    pfam12036
    Location:245299
    DUF3522; Protein of unknown function (DUF3522)

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20211119

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000009.12 Reference GRCh38.p13 Primary Assembly

    Range
    35825817..35865515
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017014806.1XP_016870295.1  transmembrane protein 8B isoform X3

    Conserved Domains (1) summary
    pfam12036
    Location:245357
    DUF3522; Protein of unknown function (DUF3522)
  2. XM_011517911.2XP_011516213.1  transmembrane protein 8B isoform X1

    See identical proteins and their annotated locations for XP_011516213.1

    Conserved Domains (1) summary
    pfam12036
    Location:271383
    DUF3522; Protein of unknown function (DUF3522)
  3. XM_024447571.1XP_024303339.1  transmembrane protein 8B isoform X3

    Conserved Domains (1) summary
    pfam12036
    Location:245357
    DUF3522; Protein of unknown function (DUF3522)
  4. XM_011517910.3XP_011516212.1  transmembrane protein 8B isoform X1

    See identical proteins and their annotated locations for XP_011516212.1

    Conserved Domains (1) summary
    pfam12036
    Location:271383
    DUF3522; Protein of unknown function (DUF3522)
  5. XM_011517902.2XP_011516204.1  transmembrane protein 8B isoform X2

    Conserved Domains (1) summary
    pfam12036
    Location:271441
    DUF3522; Protein of unknown function (DUF3522)
  6. XM_011517901.2XP_011516203.1  transmembrane protein 8B isoform X1

    See identical proteins and their annotated locations for XP_011516203.1

    Conserved Domains (1) summary
    pfam12036
    Location:271383
    DUF3522; Protein of unknown function (DUF3522)
  7. XM_011517903.2XP_011516205.1  transmembrane protein 8B isoform X4

    Conserved Domains (1) summary
    pfam12036
    Location:271387
    DUF3522; Protein of unknown function (DUF3522)
  8. XM_005251483.4XP_005251540.3  transmembrane protein 8B isoform X3

    See identical proteins and their annotated locations for XP_005251540.3

    Conserved Domains (1) summary
    pfam12036
    Location:245357
    DUF3522; Protein of unknown function (DUF3522)
  9. XM_024447570.1XP_024303338.1  transmembrane protein 8B isoform X5

    Conserved Domains (1) summary
    pfam12036
    Location:245361
    DUF3522; Protein of unknown function (DUF3522)
  10. XM_011517905.1XP_011516207.1  transmembrane protein 8B isoform X7

  11. XM_011517915.2XP_011516217.1  transmembrane protein 8B isoform X3

    See identical proteins and their annotated locations for XP_011516217.1

    Conserved Domains (1) summary
    pfam12036
    Location:245357
    DUF3522; Protein of unknown function (DUF3522)
  12. XM_011517912.2XP_011516214.1  transmembrane protein 8B isoform X1

    See identical proteins and their annotated locations for XP_011516214.1

    Conserved Domains (1) summary
    pfam12036
    Location:271383
    DUF3522; Protein of unknown function (DUF3522)
  13. XM_011517908.2XP_011516210.1  transmembrane protein 8B isoform X1

    See identical proteins and their annotated locations for XP_011516210.1

    Conserved Domains (1) summary
    pfam12036
    Location:271383
    DUF3522; Protein of unknown function (DUF3522)
  14. XM_011517913.2XP_011516215.1  transmembrane protein 8B isoform X1

    See identical proteins and their annotated locations for XP_011516215.1

    Conserved Domains (1) summary
    pfam12036
    Location:271383
    DUF3522; Protein of unknown function (DUF3522)
  15. XM_011517914.2XP_011516216.1  transmembrane protein 8B isoform X1

    See identical proteins and their annotated locations for XP_011516216.1

    Conserved Domains (1) summary
    pfam12036
    Location:271383
    DUF3522; Protein of unknown function (DUF3522)
  16. XM_017014805.1XP_016870294.1  transmembrane protein 8B isoform X8

    Conserved Domains (1) summary
    pfam12036
    Location:438550
    DUF3522; Protein of unknown function (DUF3522)
  17. XM_017014807.1XP_016870296.1  transmembrane protein 8B isoform X10

  18. XM_011517916.2XP_011516218.1  transmembrane protein 8B isoform X9

    Conserved Domains (1) summary
    pfam12036
    Location:213325
    DUF3522; Protein of unknown function (DUF3522)
  19. XM_011517918.3XP_011516220.1  transmembrane protein 8B isoform X11

    Conserved Domains (1) summary
    pfam12036
    Location:161273
    DUF3522; Protein of unknown function (DUF3522)

RNA

  1. XR_001746322.1 RNA Sequence

  2. XR_002956793.1 RNA Sequence

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NR_024006.1: Suppressed sequence

    Description
    NR_024006.1: This RefSeq was removed because the gene was discontinued.
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