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ZNF318 zinc finger protein 318 [ Homo sapiens (human) ]

Gene ID: 24149, updated on 17-Sep-2024

Summary

Official Symbol
ZNF318provided by HGNC
Official Full Name
zinc finger protein 318provided by HGNC
Primary source
HGNC:HGNC:13578
See related
Ensembl:ENSG00000171467 MIM:617512; AllianceGenome:HGNC:13578
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
TZF; ZFP318; HRIHFB2436
Summary
Predicted to enable protein heterodimerization activity and protein homodimerization activity. Predicted to be involved in negative regulation of transcription, DNA-templated and positive regulation of transcription, DNA-templated. Located in cytosol and nucleoplasm. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in testis (RPKM 18.5), lymph node (RPKM 10.0) and 24 other tissues See more
Orthologs
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Genomic context

See ZNF318 in Genome Data Viewer
Location:
6p21.1
Exon count:
10
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 6 NC_000006.12 (43336070..43369647, complement)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 6 NC_060930.1 (43164983..43198559, complement)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 6 NC_000006.11 (43303808..43337385, complement)

Chromosome 6 - NC_000006.12Genomic Context describing neighboring genes Neighboring gene ribosomal protein L12 pseudogene 47 Neighboring gene Sharpr-MPRA regulatory region 12728 Neighboring gene ribosomal protein L34 pseudogene 14 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 24597 Neighboring gene MPRA-validated peak5813 silencer Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 17225 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 17226 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 17227 Neighboring gene atherin-like Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 17228 Neighboring gene ribosomal protein S2 pseudogene 28 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 24598 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 24599 Neighboring gene uncharacterized LOC105375065 Neighboring gene Sharpr-MPRA regulatory region 12040 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr6:43380603-43381102 Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr6:43393233-43393754 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 24600 Neighboring gene ATP binding cassette subfamily C member 10 Neighboring gene microRNA 6780b

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Potential readthrough

Included gene: CRIP3

Clone Names

  • FLJ21852

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables nucleic acid binding IEA
Inferred from Electronic Annotation
more info
 
enables protein homodimerization activity ISS
Inferred from Sequence or Structural Similarity
more info
 
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in meiotic cell cycle IEA
Inferred from Electronic Annotation
more info
 
involved_in negative regulation of DNA-templated transcription IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in negative regulation of DNA-templated transcription ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in positive regulation of DNA-templated transcription IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in positive regulation of DNA-templated transcription ISS
Inferred from Sequence or Structural Similarity
more info
 
Component Evidence Code Pubs
located_in cytosol IDA
Inferred from Direct Assay
more info
 
is_active_in nucleoplasm IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in nucleoplasm IDA
Inferred from Direct Assay
more info
 

General protein information

Preferred Names
zinc finger protein 318
Names
endocrine regulator
endocrine regulatory protein
testicular zinc finger

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_014345.3NP_055160.2  zinc finger protein 318

    See identical proteins and their annotated locations for NP_055160.2

    Status: VALIDATED

    Source sequence(s)
    AK027061, AL583834, AL590383, BC098434
    Consensus CDS
    CCDS4895.2
    UniProtKB/Swiss-Prot
    O94796, Q4G0E4, Q5VUA4, Q8NEM6, Q9UNU8, Q9Y2W9
    Related
    ENSP00000354964.2, ENST00000361428.3
    Conserved Domains (2) summary
    smart00451
    Location:11331167
    ZnF_U1; U1-like zinc finger
    cl19107
    Location:8671012
    SPFH_like; core domain of the SPFH (stomatin, prohibitin, flotillin, and HflK/C) superfamily

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000006.12 Reference GRCh38.p14 Primary Assembly

    Range
    43336070..43369647 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060930.1 Alternate T2T-CHM13v2.0

    Range
    43164983..43198559 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)