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PANX1 pannexin 1 [ Homo sapiens (human) ]

Gene ID: 24145, updated on 5-Dec-2021

Summary

Official Symbol
PANX1provided by HGNC
Official Full Name
pannexin 1provided by HGNC
Primary source
HGNC:HGNC:8599
See related
Ensembl:ENSG00000110218 MIM:608420
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
PX1; MRS1; OOMD7; UNQ2529
Summary
The protein encoded by this gene belongs to the innexin family. Innexin family members are the structural components of gap junctions. This protein and pannexin 2 are abundantly expressed in central nerve system (CNS) and are coexpressed in various neuronal populations. Studies in Xenopus oocytes suggest that this protein alone and in combination with pannexin 2 may form cell type-specific gap junctions with distinct properties. [provided by RefSeq, Jul 2008]
Expression
Ubiquitous expression in brain (RPKM 7.4), appendix (RPKM 5.7) and 25 other tissues See more
Orthologs
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Genomic context

See PANX1 in Genome Data Viewer
Location:
11q21
Exon count:
7
Annotation release Status Assembly Chr Location
109.20211119 current GRCh38.p13 (GCF_000001405.39) 11 NC_000011.10 (94128841..94185596)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (93862007..93915134)

Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene hypoxanthine phosphoribosyltransferase 1 pseudogene 3 Neighboring gene hephaestin like 1 Neighboring gene PHB1 pseudogene 16 Neighboring gene Sharpr-MPRA regulatory region 4215 Neighboring gene uncharacterized LOC105369435 Neighboring gene actin related protein 2/3 complex subunit 3 pseudogene 3

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Envelope surface glycoprotein gp120 env ATP is released from HIV-1 target cells through pannexin-1 channels upon interaction between the HIV-1 envelope protein and specific target cell receptors CD4 PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC21309

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables actin filament binding IEA
Inferred from Electronic Annotation
more info
 
enables calcium channel activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
NOT enables gap junction hemi-channel activity ISS
Inferred from Sequence or Structural Similarity
more info
 
enables leak channel activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables protease binding IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables scaffold protein binding IEA
Inferred from Electronic Annotation
more info
 
enables signaling receptor binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables structural molecule activity ISS
Inferred from Sequence or Structural Similarity
more info
 
enables transmembrane transporter binding IEA
Inferred from Electronic Annotation
more info
 
enables wide pore channel activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Process Evidence Code Pubs
involved_in calcium ion transmembrane transport IEA
Inferred from Electronic Annotation
more info
 
involved_in calcium ion transport IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in cation transport IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in cation transport IDA
Inferred from Direct Assay
more info
PubMed 
involved_in cell-cell signaling IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in oogenesis IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of interleukin-1 alpha production IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of interleukin-1 beta production IDA
Inferred from Direct Assay
more info
PubMed 
involved_in response to ATP IEA
Inferred from Electronic Annotation
more info
 
involved_in response to ischemia IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in bleb IDA
Inferred from Direct Assay
more info
PubMed 
located_in endoplasmic reticulum IDA
Inferred from Direct Assay
more info
PubMed 
located_in endoplasmic reticulum membrane IEA
Inferred from Electronic Annotation
more info
 
located_in gap junction IEA
Inferred from Electronic Annotation
more info
 
located_in integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
located_in membrane HDA PubMed 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in plasma membrane TAS
Traceable Author Statement
more info
 
part_of protein-containing complex IEA
Inferred from Electronic Annotation
more info
 

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_027936.1 RefSeqGene

    Range
    4914..58041
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_015368.4NP_056183.2  pannexin-1

    See identical proteins and their annotated locations for NP_056183.2

    Status: REVIEWED

    Source sequence(s)
    AF398509, AK074897, AP003966, AY359023, BC016931, CA418094
    Consensus CDS
    CCDS8296.1
    UniProtKB/Swiss-Prot
    Q96RD7
    UniProtKB/TrEMBL
    A0A024R397
    Related
    ENSP00000227638.3, ENST00000227638.8
    Conserved Domains (1) summary
    cl11443
    Location:233339
    Cas6; Class 1 CRISPR-associated endoribonuclease Cas6

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20211119

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000011.10 Reference GRCh38.p13 Primary Assembly

    Range
    94128841..94185596
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017017464.1XP_016872953.1  pannexin-1 isoform X1

    Conserved Domains (1) summary
    cl11443
    Location:91197
    Cas6-I-III; CRISPR/Cas system-associated RAMP superfamily protein Cas6
  2. XM_011542734.2XP_011541036.1  pannexin-1 isoform X1

    See identical proteins and their annotated locations for XP_011541036.1

    Conserved Domains (1) summary
    cl11443
    Location:91197
    Cas6-I-III; CRISPR/Cas system-associated RAMP superfamily protein Cas6
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