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Gpr158 G protein-coupled receptor 158 [ Mus musculus (house mouse) ]

Gene ID: 241263, updated on 4-May-2024

Summary

Official Symbol
Gpr158provided by MGI
Official Full Name
G protein-coupled receptor 158provided by MGI
Primary source
MGI:MGI:2441697
See related
Ensembl:ENSMUSG00000045967 AllianceGenome:MGI:2441697
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
mGlyR; mKIAA1136; 5330427M13Rik
Summary
Predicted to enable G protein-coupled receptor activity. Acts upstream of or within G protein-coupled receptor signaling pathway and protein localization to plasma membrane. Located in membrane. Is expressed in eye; male reproductive gland or organ; nervous system; and small intestine. Orthologous to human GPR158 (G protein-coupled receptor 158). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in cerebellum adult (RPKM 13.3), cortex adult (RPKM 13.2) and 4 other tissues See more
Orthologs
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Genomic context

See Gpr158 in Genome Data Viewer
Location:
2 A3; 2 14.92 cM
Exon count:
11
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (21372378..21835355)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (21367567..21830544)

Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene PHD finger protein 3 pseudogene Neighboring gene predicted gene, 54105 Neighboring gene STARR-seq mESC enhancer starr_03893 Neighboring gene STARR-seq mESC enhancer starr_03894 Neighboring gene STARR-seq mESC enhancer starr_03895 Neighboring gene STARR-seq mESC enhancer starr_03896 Neighboring gene high mobility group box 1 pseudogene Neighboring gene STARR-seq mESC enhancer starr_03897 Neighboring gene STARR-seq mESC enhancer starr_03898 Neighboring gene STARR-seq mESC enhancer starr_03899 Neighboring gene predicted gene, 52587 Neighboring gene STARR-seq mESC enhancer starr_03901 Neighboring gene STARR-seq mESC enhancer starr_03902 Neighboring gene predicted gene, 24886 Neighboring gene predicted gene, 39766 Neighboring gene STARR-seq mESC enhancer starr_03903 Neighboring gene predicted gene, 39767 Neighboring gene STARR-seq mESC enhancer starr_03905 Neighboring gene STARR-seq mESC enhancer starr_03907 Neighboring gene 3-phosphoglycerate dehydrogenase pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (3) 
  • Targeted (3)  1 citation

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Clone Names

  • KIAA1136

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables G protein-coupled glycine receptor activity ISO
Inferred from Sequence Orthology
more info
 
enables G protein-coupled receptor activity IEA
Inferred from Electronic Annotation
more info
 
enables enzyme activator activity IDA
Inferred from Direct Assay
more info
PubMed 
enables enzyme activator activity ISO
Inferred from Sequence Orthology
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables transmembrane signaling receptor activity IDA
Inferred from Direct Assay
more info
PubMed 
enables transmembrane signaling receptor activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
located_in cell projection IEA
Inferred from Electronic Annotation
more info
 
located_in membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
 
is_active_in plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in plasma membrane ISO
Inferred from Sequence Orthology
more info
 
is_active_in postsynaptic density membrane IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in postsynaptic density membrane IEP
Inferred from Expression Pattern
more info
PubMed 
is_active_in postsynaptic density membrane IMP
Inferred from Mutant Phenotype
more info
PubMed 
is_active_in postsynaptic membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in synapse IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
metabotropic glycine receptor
Names
probable G-protein coupled receptor 158

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001004761.1NP_001004761.1  metabotropic glycine receptor precursor

    See identical proteins and their annotated locations for NP_001004761.1

    Status: VALIDATED

    Source sequence(s)
    AB093287, AK083234
    Consensus CDS
    CCDS15722.1
    UniProtKB/Swiss-Prot
    B1AWY4, Q8C419, Q8CHB0
    Related
    ENSMUSP00000049708.8, ENSMUST00000055946.8
    Conserved Domains (1) summary
    pfam00003
    Location:428667
    7tm_3; 7 transmembrane sweet-taste receptor of 3 GCPR

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000068.8 Reference GRCm39 C57BL/6J

    Range
    21372378..21835355
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_175706.3: Suppressed sequence

    Description
    NM_175706.3: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript and the protein.