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GPR158 G protein-coupled receptor 158 [ Homo sapiens (human) ]

Gene ID: 57512, updated on 22-Sep-2022

Summary

Official Symbol
GPR158provided by HGNC
Official Full Name
G protein-coupled receptor 158provided by HGNC
Primary source
HGNC:HGNC:23689
See related
Ensembl:ENSG00000151025 MIM:614573; AllianceGenome:HGNC:23689
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
Predicted to enable G protein-coupled receptor activity. Predicted to act upstream of or within G protein-coupled receptor signaling pathway and protein localization to plasma membrane. Predicted to be located in membrane. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in brain (RPKM 11.3), adrenal (RPKM 0.9) and 1 other tissue See more
Orthologs
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Genomic context

See GPR158 in Genome Data Viewer
Location:
10p12.1
Exon count:
13
Annotation release Status Assembly Chr Location
110 current GRCh38.p14 (GCF_000001405.40) 10 NC_000010.11 (25175001..25602229)
110 current T2T-CHM13v2.0 (GCF_009914755.1) 10 NC_060934.1 (25193234..25626794)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 10 NC_000010.10 (25463930..25891158)

Chromosome 10 - NC_000010.11Genomic Context describing neighboring genes Neighboring gene Sharpr-MPRA regulatory region 97 Neighboring gene threonine synthase like 1 Neighboring gene enkurin, TRPC channel interacting protein Neighboring gene long intergenic non-protein coding RNA 1516 Neighboring gene GPR158 antisense RNA 1 Neighboring gene RN7SK pseudogene 220 Neighboring gene Sharpr-MPRA regulatory region 12818 Neighboring gene long intergenic non-protein coding RNA 836 Neighboring gene GPN-loop GTPase 3 pseudogene 1 Neighboring gene histone cell cycle regulator pseudogene 1

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

EBI GWAS Catalog

Description
Genome wide association study (GWAS) of Chagas cardiomyopathy in Trypanosoma cruzi seropositive subjects.
EBI GWAS Catalog
Genome-wide association study of antibody response to smallpox vaccine.
EBI GWAS Catalog
Loci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancers.
EBI GWAS Catalog

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ37801, KIAA1136

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables G protein-coupled receptor activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in G protein-coupled receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
 
involved_in protein localization to plasma membrane IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
probable G-protein coupled receptor 158

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_020752.3NP_065803.2  probable G-protein coupled receptor 158 precursor

    See identical proteins and their annotated locations for NP_065803.2

    Status: VALIDATED

    Source sequence(s)
    AL139821, AL161654, AL355587, AY528411
    Consensus CDS
    CCDS31166.1
    UniProtKB/Swiss-Prot
    Q5T848, Q9ULT3
    Related
    ENSP00000365529.3, ENST00000376351.4
    Conserved Domains (1) summary
    pfam00003
    Location:428667
    7tm_3; 7 transmembrane sweet-taste receptor of 3 GCPR

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 110 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000010.11 Reference GRCh38.p14 Primary Assembly

    Range
    25175001..25602229
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017016452.3XP_016871941.1  probable G-protein coupled receptor 158 isoform X1

RNA

  1. XR_930512.4 RNA Sequence

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060934.1 Alternate T2T-CHM13v2.0

    Range
    25193234..25626794
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)