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Rbck1 RanBP-type and C3HC4-type zinc finger containing 1 [ Mus musculus (house mouse) ]

Gene ID: 24105, updated on 8-Dec-2022

Summary

Official Symbol
Rbck1provided by MGI
Official Full Name
RanBP-type and C3HC4-type zinc finger containing 1provided by MGI
Primary source
MGI:MGI:1344372
See related
Ensembl:ENSMUSG00000027466 AllianceGenome:MGI:1344372
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
UIP28; HOIL-1; HOIL-1L; Ubce7ip3
Summary
Predicted to enable several functions, including protein kinase C binding activity; protein sequestering activity; and ubiquitin binding activity. Involved in positive regulation of I-kappaB kinase/NF-kappaB signaling; positive regulation of NIK/NF-kappaB signaling; and positive regulation of apoptotic process. Acts upstream of or within negative regulation of necroptotic process and positive regulation of extrinsic apoptotic signaling pathway. Predicted to be part of LUBAC complex. Is expressed in central nervous system and retina. Human ortholog(s) of this gene implicated in glycogen storage disease. Orthologous to human RBCK1 (RANBP2-type and C3HC4-type zinc finger containing 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in adrenal adult (RPKM 103.1), thymus adult (RPKM 93.1) and 28 other tissues See more
Orthologs
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Genomic context

See Rbck1 in Genome Data Viewer
Location:
2; 2 G3
Exon count:
14
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (152158254..152174583, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (152316334..152332663, complement)

Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene casein kinase 2, alpha 1 polypeptide Neighboring gene TBC1 domain family, member 20 Neighboring gene tribbles pseudokinase 3 Neighboring gene predicted gene 14164 Neighboring gene ribosomal protein, large, P0 pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables double-stranded DNA binding ISO
Inferred from Sequence Orthology
more info
 
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein kinase C binding ISO
Inferred from Sequence Orthology
more info
 
enables protein sequestering activity ISO
Inferred from Sequence Orthology
more info
 
enables transcription coactivator activity ISO
Inferred from Sequence Orthology
more info
 
enables transferase activity IEA
Inferred from Electronic Annotation
more info
 
enables ubiquitin binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables ubiquitin binding ISO
Inferred from Sequence Orthology
more info
 
enables ubiquitin-protein transferase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables ubiquitin-protein transferase activity ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
involved_in T cell receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in cytoplasmic sequestering of protein ISO
Inferred from Sequence Orthology
more info
 
involved_in defense response to bacterium ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of NF-kappaB transcription factor activity ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within negative regulation of necroptotic process IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in positive regulation of I-kappaB kinase/NF-kappaB signaling IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in positive regulation of I-kappaB kinase/NF-kappaB signaling IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of I-kappaB kinase/NF-kappaB signaling ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of NF-kappaB transcription factor activity ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of NIK/NF-kappaB signaling IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of apoptotic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within positive regulation of extrinsic apoptotic signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
 
involved_in proteasome-mediated ubiquitin-dependent protein catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in proteasome-mediated ubiquitin-dependent protein catabolic process ISO
Inferred from Sequence Orthology
more info
 
involved_in protein linear polyubiquitination IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in protein linear polyubiquitination ISO
Inferred from Sequence Orthology
more info
 
involved_in protein polyubiquitination ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
part_of LUBAC complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
part_of LUBAC complex ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
ranBP-type and C3HC4-type zinc finger-containing protein 1
Names
RING-type E3 ubiquitin transferase HOIL-1
heme-oxidized IRP2 ubiquitin ligase 1 homolog
novel zinc finger, C3HC4 type (RING finger) protein
ubcM4-interacting protein 28
ubiquitin-conjugating enzyme 7-interacting protein 3
NP_001077390.1
NP_001342211.1
NP_062679.2
XP_006499508.1
XP_006499509.1
XP_006499510.1
XP_030106804.1
XP_030106805.1
XP_030106806.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001083921.1NP_001077390.1  ranBP-type and C3HC4-type zinc finger-containing protein 1 isoform a

    See identical proteins and their annotated locations for NP_001077390.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longer isoform (a). Variants 1 and 2 both encode the same isoform (a).
    Source sequence(s)
    AI853834, AK085559, AK166075, CX238505
    Consensus CDS
    CCDS38273.1
    UniProtKB/Swiss-Prot
    Q8C2I0, Q9WUB0
    Related
    ENSMUSP00000105473.3, ENSMUST00000109847.9
    Conserved Domains (4) summary
    cd01799
    Location:57131
    Hoil1_N; Ubiquitin-like domain of HOIL1
    smart00547
    Location:195215
    ZnF_RBZ; Zinc finger domain
    sd00029
    Location:195214
    zf-RanBP2; RanBP2-type Zn finger [structural motif]
    pfam13445
    Location:280322
    zf-RING_UBOX; RING-type zinc-finger
  2. NM_001355282.1NP_001342211.1  ranBP-type and C3HC4-type zinc finger-containing protein 1 isoform b

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) contains an alternate internal exon compared to variant 1. The resulting isoform (b) is shorter at the N-terminus compared to isoform a.
    Source sequence(s)
    AL831735, AL928568
    Conserved Domains (3) summary
    smart00547
    Location:4565
    ZnF_RBZ; Zinc finger domain
    sd00029
    Location:4564
    zf-RanBP2; RanBP2-type Zn finger [structural motif]
    cd16633
    Location:126180
    mRING-HC-C3HC3D_RBR_HOIL1; Modified RING finger, HC subclass (C3HC3D-type), found in heme-oxidized IRP2 ubiquitin ligase 1 (HOIL-1) and similar proteins
  3. NM_019705.3NP_062679.2  ranBP-type and C3HC4-type zinc finger-containing protein 1 isoform a

    See identical proteins and their annotated locations for NP_062679.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1 and 2 both encode the same isoform (a).
    Source sequence(s)
    AI853834, AK085559, AK166075, BY084037, BY267597
    Consensus CDS
    CCDS38273.1
    UniProtKB/Swiss-Prot
    Q8C2I0, Q9WUB0
    Related
    ENSMUSP00000028964.8, ENSMUST00000028964.14
    Conserved Domains (4) summary
    cd01799
    Location:57131
    Hoil1_N; Ubiquitin-like domain of HOIL1
    smart00547
    Location:195215
    ZnF_RBZ; Zinc finger domain
    sd00029
    Location:195214
    zf-RanBP2; RanBP2-type Zn finger [structural motif]
    pfam13445
    Location:280322
    zf-RING_UBOX; RING-type zinc-finger

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000068.8 Reference GRCm39 C57BL/6J

    Range
    152158254..152174583 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_030250945.1XP_030106805.1  ranBP-type and C3HC4-type zinc finger-containing protein 1 isoform X4

    Conserved Domains (1) summary
    cl17238
    Location:159185
    RING_Ubox; The superfamily of RING finger (Really Interesting New Gene) domain and U-box domain
  2. XM_006499446.2XP_006499509.1  ranBP-type and C3HC4-type zinc finger-containing protein 1 isoform X1

    See identical proteins and their annotated locations for XP_006499509.1

    Conserved Domains (4) summary
    smart00547
    Location:194214
    ZnF_RBZ; Zinc finger domain
    sd00029
    Location:194213
    zf-RanBP2; RanBP2-type Zn finger [structural motif]
    cd16633
    Location:275329
    mRING-HC-C3HC3D_RBR_HOIL1; Modified RING finger, HC subclass (C3HC3D-type), found in heme-oxidized IRP2 ubiquitin ligase 1 (HOIL-1) and similar proteins
    cd01799
    Location:52132
    Ubl_HOIL1; ubiquitin-like (Ubl) domain found in heme-oxidized IRP2 ubiquitin ligase 1 (HOIL-1) and similar proteins
  3. XM_006499447.5XP_006499510.1  ranBP-type and C3HC4-type zinc finger-containing protein 1 isoform X2

    Conserved Domains (4) summary
    smart00547
    Location:195215
    ZnF_RBZ; Zinc finger domain
    sd00029
    Location:195214
    zf-RanBP2; RanBP2-type Zn finger [structural motif]
    cd01799
    Location:53133
    Ubl_HOIL1; ubiquitin-like (Ubl) domain found in heme-oxidized IRP2 ubiquitin ligase 1 (HOIL-1) and similar proteins
    pfam01485
    Location:355381
    IBR; IBR domain, a half RING-finger domain
  4. XM_030250944.2XP_030106804.1  ranBP-type and C3HC4-type zinc finger-containing protein 1 isoform X3

    Conserved Domains (4) summary
    smart00547
    Location:194214
    ZnF_RBZ; Zinc finger domain
    sd00029
    Location:194213
    zf-RanBP2; RanBP2-type Zn finger [structural motif]
    cd01799
    Location:52132
    Ubl_HOIL1; ubiquitin-like (Ubl) domain found in heme-oxidized IRP2 ubiquitin ligase 1 (HOIL-1) and similar proteins
    pfam01485
    Location:354380
    IBR; IBR domain, a half RING-finger domain
  5. XM_030250946.1XP_030106806.1  ranBP-type and C3HC4-type zinc finger-containing protein 1 isoform X4

    Conserved Domains (1) summary
    cl17238
    Location:159185
    RING_Ubox; The superfamily of RING finger (Really Interesting New Gene) domain and U-box domain
  6. XM_006499445.4XP_006499508.1  ranBP-type and C3HC4-type zinc finger-containing protein 1 isoform X1

    See identical proteins and their annotated locations for XP_006499508.1

    Conserved Domains (4) summary
    smart00547
    Location:194214
    ZnF_RBZ; Zinc finger domain
    sd00029
    Location:194213
    zf-RanBP2; RanBP2-type Zn finger [structural motif]
    cd16633
    Location:275329
    mRING-HC-C3HC3D_RBR_HOIL1; Modified RING finger, HC subclass (C3HC3D-type), found in heme-oxidized IRP2 ubiquitin ligase 1 (HOIL-1) and similar proteins
    cd01799
    Location:52132
    Ubl_HOIL1; ubiquitin-like (Ubl) domain found in heme-oxidized IRP2 ubiquitin ligase 1 (HOIL-1) and similar proteins