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Rbck1 RanBP-type and C3HC4-type zinc finger containing 1 [ Mus musculus (house mouse) ]

Gene ID: 24105, updated on 18-Apr-2024

Summary

Official Symbol
Rbck1provided by MGI
Official Full Name
RanBP-type and C3HC4-type zinc finger containing 1provided by MGI
Primary source
MGI:MGI:1344372
See related
Ensembl:ENSMUSG00000027466 AllianceGenome:MGI:1344372
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
UIP28; HOIL-1; HOIL-1L; Ubce7ip3
Summary
Predicted to enable several functions, including protein kinase C binding activity; protein sequestering activity; and ubiquitin binding activity. Involved in positive regulation of I-kappaB kinase/NF-kappaB signaling; positive regulation of NIK/NF-kappaB signaling; and positive regulation of apoptotic process. Acts upstream of or within negative regulation of necroptotic process and positive regulation of extrinsic apoptotic signaling pathway. Predicted to be part of LUBAC complex. Is expressed in central nervous system and retina. Human ortholog(s) of this gene implicated in glycogen storage disease. Orthologous to human RBCK1 (RANBP2-type and C3HC4-type zinc finger containing 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in adrenal adult (RPKM 103.1), thymus adult (RPKM 93.1) and 28 other tissues See more
Orthologs
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Genomic context

Location:
2 G3; 2 74.83 cM
Exon count:
15
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (152158254..152174592, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (152316334..152332663, complement)

Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E6001 Neighboring gene casein kinase 2, alpha 1 polypeptide Neighboring gene STARR-seq mESC enhancer starr_06051 Neighboring gene STARR-seq mESC enhancer starr_06052 Neighboring gene STARR-positive B cell enhancer ABC_E10153 Neighboring gene TBC1 domain family, member 20 Neighboring gene STARR-positive B cell enhancer ABC_E11172 Neighboring gene STARR-seq mESC enhancer starr_06055 Neighboring gene tribbles pseudokinase 3 Neighboring gene predicted gene 14164 Neighboring gene ribosomal protein, large, P0 pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables double-stranded DNA binding ISO
Inferred from Sequence Orthology
more info
 
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein kinase C binding ISO
Inferred from Sequence Orthology
more info
 
enables protein sequestering activity ISO
Inferred from Sequence Orthology
more info
 
enables transcription coactivator activity ISO
Inferred from Sequence Orthology
more info
 
enables transferase activity IEA
Inferred from Electronic Annotation
more info
 
enables ubiquitin binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables ubiquitin binding ISO
Inferred from Sequence Orthology
more info
 
enables ubiquitin ligase activator activity IDA
Inferred from Direct Assay
more info
PubMed 
enables ubiquitin-protein transferase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables ubiquitin-protein transferase activity ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
involved_in T cell receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in cytoplasmic sequestering of protein ISO
Inferred from Sequence Orthology
more info
 
involved_in defense response to bacterium ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of NF-kappaB transcription factor activity ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within negative regulation of necroptotic process IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in positive regulation of NF-kappaB transcription factor activity ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of apoptotic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of canonical NF-kappaB signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in positive regulation of canonical NF-kappaB signal transduction IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of canonical NF-kappaB signal transduction ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within positive regulation of extrinsic apoptotic signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of non-canonical NF-kappaB signal transduction IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
 
involved_in proteasome-mediated ubiquitin-dependent protein catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in proteasome-mediated ubiquitin-dependent protein catabolic process ISO
Inferred from Sequence Orthology
more info
 
involved_in protein linear polyubiquitination IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in protein linear polyubiquitination ISO
Inferred from Sequence Orthology
more info
 
involved_in protein polyubiquitination IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in protein polyubiquitination ISO
Inferred from Sequence Orthology
more info
 
involved_in tumor necrosis factor-mediated signaling pathway TAS
Traceable Author Statement
more info
PubMed 
Component Evidence Code Pubs
part_of LUBAC complex IBA
Inferred from Biological aspect of Ancestor
more info
 
part_of LUBAC complex IDA
Inferred from Direct Assay
more info
PubMed 
part_of LUBAC complex ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
ranBP-type and C3HC4-type zinc finger-containing protein 1
Names
RING-type E3 ubiquitin transferase HOIL-1
heme-oxidized IRP2 ubiquitin ligase 1 homolog
novel zinc finger, C3HC4 type (RING finger) protein
ubcM4-interacting protein 28
ubiquitin-conjugating enzyme 7-interacting protein 3
NP_001077390.1
NP_001408174.1
NP_001408175.1
NP_001408176.1
NP_001408177.1
NP_001408178.1
NP_001408179.1
NP_001408180.1
NP_001408181.1
NP_001408182.1
NP_001408183.1
NP_062679.2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001083921.2NP_001077390.1  ranBP-type and C3HC4-type zinc finger-containing protein 1 isoform a

    See identical proteins and their annotated locations for NP_001077390.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes isoform (a). Variants 1 and 2 both encode the same isoform (a).
    Source sequence(s)
    AL831735, AL928568
    Consensus CDS
    CCDS38273.1
    UniProtKB/Swiss-Prot
    A2ANR4, Q3TM86, Q8C2I0, Q9WUB0
    Related
    ENSMUSP00000105473.3, ENSMUST00000109847.9
    Conserved Domains (4) summary
    cd01799
    Location:57131
    Hoil1_N; Ubiquitin-like domain of HOIL1
    smart00547
    Location:195215
    ZnF_RBZ; Zinc finger domain
    sd00029
    Location:195214
    zf-RanBP2; RanBP2-type Zn finger [structural motif]
    pfam13445
    Location:280322
    zf-RING_UBOX; RING-type zinc-finger
  2. NM_001421245.1NP_001408174.1  ranBP-type and C3HC4-type zinc finger-containing protein 1 isoform c

    Status: VALIDATED

    Source sequence(s)
    AL831735, AL928568
  3. NM_001421246.1NP_001408175.1  ranBP-type and C3HC4-type zinc finger-containing protein 1 isoform c

    Status: VALIDATED

    Source sequence(s)
    AL831735, AL928568
  4. NM_001421247.1NP_001408176.1  ranBP-type and C3HC4-type zinc finger-containing protein 1 isoform d

    Status: VALIDATED

    Source sequence(s)
    AL831735, AL928568
  5. NM_001421248.1NP_001408177.1  ranBP-type and C3HC4-type zinc finger-containing protein 1 isoform d

    Status: VALIDATED

    Source sequence(s)
    AL831735, AL928568
  6. NM_001421249.1NP_001408178.1  ranBP-type and C3HC4-type zinc finger-containing protein 1 isoform e

    Status: VALIDATED

    Source sequence(s)
    AL831735, AL928568
  7. NM_001421250.1NP_001408179.1  ranBP-type and C3HC4-type zinc finger-containing protein 1 isoform f

    Status: VALIDATED

    Source sequence(s)
    AL831735, AL928568
  8. NM_001421251.1NP_001408180.1  ranBP-type and C3HC4-type zinc finger-containing protein 1 isoform g

    Status: VALIDATED

    Source sequence(s)
    AL831735, AL928568
  9. NM_001421252.1NP_001408181.1  ranBP-type and C3HC4-type zinc finger-containing protein 1 isoform h

    Status: VALIDATED

    Source sequence(s)
    AL831735, AL928568
  10. NM_001421253.1NP_001408182.1  ranBP-type and C3HC4-type zinc finger-containing protein 1 isoform i

    Status: VALIDATED

    Source sequence(s)
    AL831735, AL928568
  11. NM_001421254.1NP_001408183.1  ranBP-type and C3HC4-type zinc finger-containing protein 1 isoform j

    Status: VALIDATED

    Source sequence(s)
    AL831735, AL928568
  12. NM_019705.4NP_062679.2  ranBP-type and C3HC4-type zinc finger-containing protein 1 isoform a

    See identical proteins and their annotated locations for NP_062679.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1 and 2 both encode the same isoform (a).
    Source sequence(s)
    AL831735, AL928568
    Consensus CDS
    CCDS38273.1
    UniProtKB/Swiss-Prot
    A2ANR4, Q3TM86, Q8C2I0, Q9WUB0
    Related
    ENSMUSP00000028964.8, ENSMUST00000028964.14
    Conserved Domains (4) summary
    cd01799
    Location:57131
    Hoil1_N; Ubiquitin-like domain of HOIL1
    smart00547
    Location:195215
    ZnF_RBZ; Zinc finger domain
    sd00029
    Location:195214
    zf-RanBP2; RanBP2-type Zn finger [structural motif]
    pfam13445
    Location:280322
    zf-RING_UBOX; RING-type zinc-finger

RNA

  1. NR_185278.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AL831735, AL928568
  2. NR_185279.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AL831735, AL928568
  3. NR_185280.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AL831735, AL928568
  4. NR_185281.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AL831735, AL928568
  5. NR_185282.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AL831735, AL928568
  6. NR_185283.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AL831735, AL928568
  7. NR_185284.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AL831735, AL928568

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000068.8 Reference GRCm39 C57BL/6J

    Range
    152158254..152174592 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)