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Adamts12 ADAM metallopeptidase with thrombospondin type 1 motif 12 [ Mus musculus (house mouse) ]

Gene ID: 239337, updated on 8-Feb-2024

Summary

Official Symbol
Adamts12provided by MGI
Official Full Name
ADAM metallopeptidase with thrombospondin type 1 motif 12provided by MGI
Primary source
MGI:MGI:2146046
See related
Ensembl:ENSMUSG00000047497 AllianceGenome:MGI:2146046
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
ADAMTS-12
Summary
This gene encodes a member of "a disintegrin and metalloproteinase with thrombospondin motifs" (ADAMTS) family of multi-domain matrix-associated metalloendopeptidases that have diverse roles in tissue morphogenesis and pathophysiological remodeling, in inflammation and in vascular biology. The encoded preproprotein undergoes proteolytic processing to generate an active protease. Mice lacking the encoded protein exhibit increased angiogenic response and tumor invasion in different models of angiogenesis and, severe inflammation and delayed recovery when subjected to experimental conditions that induce colitis, endotoxic sepsis and pancreatitis. [provided by RefSeq, Jul 2016]
Expression
Biased expression in mammary gland adult (RPKM 5.1), subcutaneous fat pad adult (RPKM 4.1) and 12 other tissues See more
Orthologs
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Genomic context

See Adamts12 in Genome Data Viewer
Location:
15 A1; 15 5.43 cM
Exon count:
24
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 15 NC_000081.7 (11064781..11349321)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 15 NC_000081.6 (11064773..11349232)

Chromosome 15 - NC_000081.7Genomic Context describing neighboring genes Neighboring gene relaxin family peptide receptor 3 Neighboring gene predicted gene, 53884 Neighboring gene STARR-seq mESC enhancer starr_37989 Neighboring gene STARR-seq mESC enhancer starr_37990 Neighboring gene STARR-seq mESC enhancer starr_37991 Neighboring gene predicted gene, 34444 Neighboring gene predicted gene, 24844 Neighboring gene STARR-positive B cell enhancer ABC_E5468 Neighboring gene threonyl-tRNA synthetase 1

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables metalloendopeptidase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables metalloendopeptidase activity ISO
Inferred from Sequence Orthology
more info
 
enables metallopeptidase activity IEA
Inferred from Electronic Annotation
more info
 
enables peptidase activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in cell migration ISO
Inferred from Sequence Orthology
more info
 
involved_in cell-matrix adhesion ISO
Inferred from Sequence Orthology
more info
 
involved_in cellular response to BMP stimulus ISO
Inferred from Sequence Orthology
more info
 
involved_in cellular response to interleukin-1 ISO
Inferred from Sequence Orthology
more info
 
involved_in cellular response to tumor necrosis factor ISO
Inferred from Sequence Orthology
more info
 
involved_in chondrocyte differentiation IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in collagen fibril organization IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in extracellular matrix organization IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in extracellular matrix organization IEA
Inferred from Electronic Annotation
more info
 
involved_in negative regulation of cellular response to hepatocyte growth factor stimulus ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of cellular response to vascular endothelial growth factor stimulus ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of chondrocyte differentiation ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of hepatocyte growth factor receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in ossification IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in ossification involved in bone maturation IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in proteoglycan catabolic process ISO
Inferred from Sequence Orthology
more info
 
involved_in proteoglycan metabolic process IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in proteolysis IBA
Inferred from Biological aspect of Ancestor
more info
 
acts_upstream_of_or_within proteolysis IEA
Inferred from Electronic Annotation
more info
 
involved_in proteolysis IEA
Inferred from Electronic Annotation
more info
 
involved_in proteolysis involved in protein catabolic process ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of endothelial tube morphogenesis ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of inflammatory response ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
is_active_in extracellular matrix IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
A disintegrin and metalloproteinase with thrombospondin motifs 12
Names
a disintegrin-like and metallopeptidase (reprolysin type) with thrombospondin type 1 motif, 12
a disintegrin-like and metalloprotease (reprolysin type) with thrombospondin type 1 motif, 12

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_175501.3NP_780710.2  A disintegrin and metalloproteinase with thrombospondin motifs 12 preproprotein

    See identical proteins and their annotated locations for NP_780710.2

    Status: REVIEWED

    Source sequence(s)
    AC159963, AI605170, AJ537452, AK028459, AK028812, AK135354, BB839765
    Consensus CDS
    CCDS27384.1
    UniProtKB/Swiss-Prot
    E9QKD6, Q811B3, Q8BK92, Q8BKY1
    Related
    ENSMUSP00000057796.8, ENSMUST00000061318.9
    Conserved Domains (6) summary
    smart00209
    Location:549600
    TSP1; Thrombospondin type 1 repeats
    cd04273
    Location:250457
    ZnMc_ADAMTS_like; Zinc-dependent metalloprotease, ADAMTS_like subgroup. ADAMs (A Disintegrin And Metalloprotease) are glycoproteins, which play roles in cell signaling, cell fusion, and cell-cell interactions. This particular subfamily represents domain architectures that ...
    pfam01421
    Location:250460
    Reprolysin; Reprolysin (M12B) family zinc metalloprotease
    pfam01562
    Location:80196
    Pep_M12B_propep; Reprolysin family propeptide
    pfam05986
    Location:706816
    ADAM_spacer1; ADAM-TS Spacer 1
    cl15456
    Location:519680
    ADAM_CR; ADAM cysteine-rich

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000081.7 Reference GRCm39 C57BL/6J

    Range
    11064781..11349321
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036159390.1XP_036015283.1  A disintegrin and metalloproteinase with thrombospondin motifs 12 isoform X1

    Conserved Domains (7) summary
    smart00209
    Location:549600
    TSP1; Thrombospondin type 1 repeats
    cd04273
    Location:250457
    ZnMc_ADAMTS_like; Zinc-dependent metalloprotease, ADAMTS_like subgroup. ADAMs (A Disintegrin And Metalloprotease) are glycoproteins, which play roles in cell signaling, cell fusion, and cell-cell interactions. This particular subfamily represents domain architectures that ...
    pfam05986
    Location:706816
    ADAM_spacer1; ADAM-TS Spacer 1
    pfam01562
    Location:53197
    Pep_M12B_propep; Reprolysin family propeptide
    pfam17771
    Location:472536
    ADAM_CR_2; ADAM cysteine-rich domain
    pfam19030
    Location:14331489
    TSP1_ADAMTS; Thrombospondin type 1 domain
    cl15456
    Location:519680
    ADAM_CR; ADAM cysteine-rich
  2. XM_036159391.1XP_036015284.1  A disintegrin and metalloproteinase with thrombospondin motifs 12 isoform X2

    Conserved Domains (7) summary
    smart00209
    Location:549600
    TSP1; Thrombospondin type 1 repeats
    cd04273
    Location:250457
    ZnMc_ADAMTS_like; Zinc-dependent metalloprotease, ADAMTS_like subgroup. ADAMs (A Disintegrin And Metalloprotease) are glycoproteins, which play roles in cell signaling, cell fusion, and cell-cell interactions. This particular subfamily represents domain architectures that ...
    pfam05986
    Location:706816
    ADAM_spacer1; ADAM-TS Spacer 1
    pfam01562
    Location:53197
    Pep_M12B_propep; Reprolysin family propeptide
    pfam17771
    Location:472536
    ADAM_CR_2; ADAM cysteine-rich domain
    pfam19030
    Location:14211477
    TSP1_ADAMTS; Thrombospondin type 1 domain
    cl15456
    Location:519680
    ADAM_CR; ADAM cysteine-rich
  3. XM_036159392.1XP_036015285.1  A disintegrin and metalloproteinase with thrombospondin motifs 12 isoform X3

    Conserved Domains (2) summary
    pfam05986
    Location:150260
    ADAM_spacer1; ADAM-TS Spacer 1
    pfam19030
    Location:925981
    TSP1_ADAMTS; Thrombospondin type 1 domain