Format

Send to

Choose Destination
See comment in PubMed Commons below
Mediators Inflamm. 2014;2014:649718. doi: 10.1155/2014/649718. Epub 2014 Apr 28.

ADAMTS-12: a multifaced metalloproteinase in arthritis and inflammation.

Author information

1
Department of Orthopaedic Surgery, New York University Medical Center, New York, NY 10003, USA ; Department of Orthopaedic Surgery, Shandong University, Jinan, Shandong 250012, China.
2
Department of Orthopaedic Surgery, New York University Medical Center, New York, NY 10003, USA.
3
Department of Orthopaedic Surgery, Shandong University, Jinan, Shandong 250012, China.
4
Department of Orthopaedic Surgery, New York University Medical Center, New York, NY 10003, USA ; Department of Cell Biology, New York University School of Medicine, New York, NY 10016, USA.

Abstract

ADAMTS-12 is a member of a disintegrin and metalloproteinase with thrombospondin motifs (ADAMTS) family of proteases, which were known to play important roles in various biological and pathological processes, such as development, angiogenesis, inflammation, cancer, arthritis, and atherosclerosis. In this review, we briefly summarize the structural organization of ADAMTS-12; concentrate on the emerging role of ADAMTS-12 in several pathophysiological conditions, including intervertebral disc degeneration, tumorigenesis and angioinhibitory effects, pediatric stroke, gonad differentiation, trophoblast invasion, and genetic linkage to schizophrenia and asthma, with special focus on its role in arthritis and inflammation; and end with the perspective research of ADAMTS-12 and its potential as a promising diagnostic and therapeutic target in various kinds of diseases and conditions.

PMID:
24876675
PMCID:
PMC4020202
DOI:
10.1155/2014/649718
[Indexed for MEDLINE]
Free PMC Article
PubMed Commons home

PubMed Commons

0 comments

    Supplemental Content

    Full text links

    Icon for Hindawi Publishing Corporation Icon for PubMed Central
    Loading ...
    Support Center