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Gmcl1 germ cell-less, spermatogenesis associated 1 [ Mus musculus (house mouse) ]

Gene ID: 23885, updated on 2-Nov-2024

Summary

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Official Symbol
Gmcl1provided by MGI
Official Full Name
germ cell-less, spermatogenesis associated 1provided by MGI
Primary source
MGI:MGI:1345156
See related
Ensembl:ENSMUSG00000001157 AllianceGenome:MGI:1345156
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
DIP; Gcl; Gcl-1; glc-1; Btbd13; mglc-1; 2810049L19Rik
Summary
Predicted to enable cullin family protein binding activity and identical protein binding activity. Acts upstream of or within regulation of DNA-templated transcription. Located in nuclear envelope and nuclear matrix. Is expressed in several structures, including cerebral cortex; genitourinary system; hemolymphoid system gland; liver; and lung. Orthologous to several human genes including GMCL1 (germ cell-less 1, spermatogenesis associated). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Ubiquitous expression in testis adult (RPKM 18.2), CNS E14 (RPKM 8.7) and 27 other tissues See more
Orthologs
human all
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Genomic context

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See Gmcl1 in Genome Data Viewer
Location:
6 D1; 6 37.75 cM
Exon count:
14
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 6 NC_000072.7 (86668750..86710377, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 6 NC_000072.6 (86691768..86733395, complement)

Chromosome 6 - NC_000072.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E860 Neighboring gene CapStarr-seq enhancer MGSCv37_chr6:86634487-86634670 Neighboring gene MAX dimerization protein 1 Neighboring gene small nuclear ribonucleoprotein 27 (U4/U6.U5) Neighboring gene STARR-positive B cell enhancer ABC_E3661 Neighboring gene annexin A4 Neighboring gene STARR-seq mESC enhancer starr_16540 Neighboring gene CapStarr-seq enhancer MGSCv37_chr6:86774247-86774356 Neighboring gene RIKEN cDNA 2610306M01 gene Neighboring gene STARR-positive B cell enhancer ABC_E6451 Neighboring gene AP2 associated kinase 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Molecular cloning and genomic organization of mouse homologue of Drosophila germ cell-less and its expression in germ lineage cells. Kimura T, et al. Biochem Biophys Res Commun, 1999 Aug 19. PMID 10448096
  2. Stage-specific expression of mouse germ cell-less-1 (mGCL-1), and multiple deformations during mgcl-1 deficient spermatogenesis leading to reduced fertility. Maekawa M, et al. Arch Histol Cytol, 2004 Nov. PMID 15700541
  3. Mouse germ cell-less as an essential component for nuclear integrity. Kimura T, et al. Mol Cell Biol, 2003 Feb. PMID 12556490, Free PMC Article
  4. Integration of a growth-suppressing BTB/POZ domain protein with the DP component of the E2F transcription factor. de la Luna S, et al. EMBO J, 1999 Jan 4. PMID 9878064, Free PMC Article
  5. Enhanced degradation of MDM2 by a nuclear envelope component, mouse germ cell-less. Masuhara M, et al. Biochem Biophys Res Commun, 2003 Sep 5. PMID 12927808

See all (23) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Gmcl1 interacts with the DP component of the E2F transcription factor.
    Title: Integration of a growth-suppressing BTB/POZ domain protein with the DP component of the E2F transcription factor.
  2. the mgcl-1 gene product appears to be essential for appropriate nuclear-lamina organization, which in turn is essential for normal sperm morphogenesis and chromatin remodeling.
    Title: Mouse germ cell-less as an essential component for nuclear integrity.
  3. mGCL-1 is a factor modulating MDM2-p53 axis by enhanced degradation of MDM2
    Title: Enhanced degradation of MDM2 by a nuclear envelope component, mouse germ cell-less.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables cullin family protein binding ISO
Inferred from Sequence Orthology
more info
  
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in germ cell development IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within regulation of DNA-templated transcription IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within spermatogenesis TAS
Traceable Author Statement
more info
 PubMed 
Component Evidence Code Pubs
located_in nuclear envelope IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nuclear matrix IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
germ cell-less protein-like 1
Names
DP-interacting protein
germ cell-less homolog 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_011818.3 → NP_035948.3  germ cell-less protein-like 1

    See identical proteins and their annotated locations for NP_035948.3

    Status: VALIDATED

    Source sequence(s)
    AF163665, AK004716, CJ122611, CX567687
    Consensus CDS
    CCDS20316.1
    UniProtKB/Swiss-Prot
    Q920G9, Q9DBW5, Q9QUP6
    UniProtKB/TrEMBL
    Q3UID6
    Related
    ENSMUSP00000001185.8, ENSMUST00000001185.14
    Conserved Domains (3) summary
    smart00225
    Location:107 → 206
    BTB; Broad-Complex, Tramtrack and Bric a brac
    smart00875
    Location:211 → 281
    BACK; BTB And C-terminal Kelch
    pfam00651
    Location:96 → 203
    BTB; BTB/POZ domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000072.7 Reference GRCm39 C57BL/6J

    Range
    86668750..86710377 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006506056.4 → XP_006506119.1  germ cell-less protein-like 1 isoform X1

    Conserved Domains (1) summary
    cl28903
    Location:1 → 45
    BACK; BACK (BTB and C-terminal Kelch) domain

RNA

  1. XR_377446.4 RNA Sequence

  2. XR_003956194.1 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q920G9.2 GenPept UniProtKB/Swiss-Prot:Q920G9

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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