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Farsb phenylalanyl-tRNA synthetase, beta subunit [ Mus musculus (house mouse) ]

Gene ID: 23874, updated on 8-Dec-2022

Summary

Official Symbol
Farsbprovided by MGI
Official Full Name
phenylalanyl-tRNA synthetase, beta subunitprovided by MGI
Primary source
MGI:MGI:1346035
See related
Ensembl:ENSMUSG00000026245 AllianceGenome:MGI:1346035
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Frsb; Farsa; Farsl; Farslb
Summary
Predicted to enable phenylalanine-tRNA ligase activity. Predicted to be involved in phenylalanyl-tRNA aminoacylation and protein heterotetramerization. Predicted to act upstream of or within translation. Predicted to be located in cytoplasm. Predicted to be part of phenylalanine-tRNA ligase complex. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; respiratory system; and sensory organ. Orthologous to human FARSB (phenylalanyl-tRNA synthetase subunit beta). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in placenta adult (RPKM 23.6), liver E14 (RPKM 19.9) and 27 other tissues See more
Orthologs
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Genomic context

See Farsb in Genome Data Viewer
Location:
1; 1 C4
Exon count:
20
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (78394595..78465534, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (78417958..78488897, complement)

Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene sphingosine-1-phosphate phosphatase 2 Neighboring gene predicted gene, 51634 Neighboring gene proteasome (prosome, macropain) subunit, alpha type 2 pseudogene Neighboring gene monoacylglycerol O-acyltransferase 1 Neighboring gene predicted gene, 39665 Neighboring gene RIKEN cDNA 5730419F03 gene Neighboring gene U6 spliceosomal RNA

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 
enables RNA binding IEA
Inferred from Electronic Annotation
more info
 
enables aminoacyl-tRNA ligase activity IEA
Inferred from Electronic Annotation
more info
 
enables ligase activity IEA
Inferred from Electronic Annotation
more info
 
enables magnesium ion binding IEA
Inferred from Electronic Annotation
more info
 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
 
contributes_to phenylalanine-tRNA ligase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables phenylalanine-tRNA ligase activity ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
involved_in phenylalanyl-tRNA aminoacylation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in phenylalanyl-tRNA aminoacylation ISO
Inferred from Sequence Orthology
more info
 
involved_in protein heterotetramerization ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within translation IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 
part_of phenylalanine-tRNA ligase complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
part_of phenylalanine-tRNA ligase complex ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
phenylalanine--tRNA ligase beta subunit
Names
PheRS alpha
phenylalanine tRNA synthetase alpha
phenylalanine--tRNA ligase beta chain
phenylalanine-tRNA synthetase-like, beta subunit
phenylalanyl-tRNA synthetase beta chain
NP_001265004.1
NP_035941.2
XP_036020538.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001278075.1NP_001265004.1  phenylalanine--tRNA ligase beta subunit

    See identical proteins and their annotated locations for NP_001265004.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 3' UTR, compared to variant 1. Variants 1 and 2 encode the same protein.
    Source sequence(s)
    AC158559, AK012154, AK045432
    Consensus CDS
    CCDS15084.1
    UniProtKB/Swiss-Prot
    Q9CWZ8, Q9WUA2
    UniProtKB/TrEMBL
    Q9CZU5
    Related
    ENSMUSP00000129828.2, ENSMUST00000170217.8
    Conserved Domains (4) summary
    smart00873
    Location:118279
    B3_4; B3/4 domain
    PLN02265
    Location:1589
    PLN02265; probable phenylalanyl-tRNA synthetase beta chain
    cd00769
    Location:392588
    PheRS_beta_core; Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA, PheRS is an ...
    pfam03484
    Location:310374
    B5; tRNA synthetase B5 domain
  2. NM_011811.4NP_035941.2  phenylalanine--tRNA ligase beta subunit

    See identical proteins and their annotated locations for NP_035941.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest variant. Variants 1 and 2 encode the same protein.
    Source sequence(s)
    AC158559, AK010271, BM212593
    Consensus CDS
    CCDS15084.1
    UniProtKB/Swiss-Prot
    Q9CWZ8, Q9WUA2
    Related
    ENSMUSP00000069508.8, ENSMUST00000068333.14
    Conserved Domains (4) summary
    smart00873
    Location:118279
    B3_4; B3/4 domain
    PLN02265
    Location:1589
    PLN02265; probable phenylalanyl-tRNA synthetase beta chain
    cd00769
    Location:392588
    PheRS_beta_core; Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA, PheRS is an ...
    pfam03484
    Location:310374
    B5; tRNA synthetase B5 domain

RNA

  1. NR_102757.1 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) uses an alternate 5' splice site, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AC158559, AK012154, AK045432, BM212593, CN693684
    Related
    ENSMUST00000189529.7
  2. NR_102758.1 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) lacks an alternate 5' exon, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AC158559, AK010271, AK134799, BM212593

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000067.7 Reference GRCm39 C57BL/6J

    Range
    78394595..78465534 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036164645.1XP_036020538.1  phenylalanine--tRNA ligase beta subunit isoform X1

    Conserved Domains (1) summary
    PLN02265
    Location:27595
    PLN02265; probable phenylalanyl-tRNA synthetase beta chain

RNA

  1. XR_865550.2 RNA Sequence

  2. XR_004942238.1 RNA Sequence