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FARSB phenylalanyl-tRNA synthetase subunit beta [ Homo sapiens (human) ]

Gene ID: 10056, updated on 5-Jul-2020

Summary

Official Symbol
FARSBprovided by HGNC
Official Full Name
phenylalanyl-tRNA synthetase subunit betaprovided by HGNC
Primary source
HGNC:HGNC:17800
See related
Ensembl:ENSG00000116120 MIM:609690
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
FRSB; PheHB; PheRS; FARSLB; RILDBC; HSPC173; NEDBLLA
Summary
This gene encodes a highly conserved enzyme that belongs to the aminoacyl-tRNA synthetase class IIc subfamily. This enzyme comprises the regulatory beta subunits that form a tetramer with two catalytic alpha subunits. In the presence of ATP, this tetramer is responsible for attaching L-phenylalanine to the terminal adenosine of the appropriate tRNA. A pseudogene located on chromosome 10 has been identified. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2015]
Expression
Ubiquitous expression in brain (RPKM 8.3), testis (RPKM 8.2) and 25 other tissues See more
Orthologs

Genomic context

See FARSB in Genome Data Viewer
Location:
2q36.1
Exon count:
19
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 2 NC_000002.12 (222566899..222656092, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (223436162..223520827, complement)

Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene sphingosine-1-phosphate phosphatase 2 Neighboring gene RNA, U6 small nuclear 619, pseudogene Neighboring gene glyceraldehyde 3 phosphate dehydrogenase pseudogene 49 Neighboring gene tripartite motif containing 60 pseudogene Neighboring gene uncharacterized LOC105373902 Neighboring gene monoacylglycerol O-acyltransferase 1 Neighboring gene RRAS2 pseudogene 2 Neighboring gene Sharpr-MPRA regulatory region 6546

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
ATP binding IEA
Inferred from Electronic Annotation
more info
 
RNA binding IEA
Inferred from Electronic Annotation
more info
 
magnesium ion binding IEA
Inferred from Electronic Annotation
more info
 
phenylalanine-tRNA ligase activity IDA
Inferred from Direct Assay
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
phenylalanyl-tRNA aminoacylation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
phenylalanyl-tRNA aminoacylation IDA
Inferred from Direct Assay
more info
PubMed 
protein heterotetramerization IDA
Inferred from Direct Assay
more info
PubMed 
tRNA aminoacylation for protein translation TAS
Traceable Author Statement
more info
 
translation TAS
Traceable Author Statement
more info
PubMed 
Component Evidence Code Pubs
cytoplasm TAS
Traceable Author Statement
more info
PubMed 
cytosol TAS
Traceable Author Statement
more info
 
membrane HDA PubMed 
phenylalanine-tRNA ligase complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
phenylalanine-tRNA ligase complex IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
phenylalanine--tRNA ligase beta subunit
Names
phenylalanine tRNA ligase 1, beta, cytoplasmic
phenylalanine-tRNA ligase beta chain
phenylalanine-tRNA synthetase-like, beta subunit
phenylalanyl-tRNA synthetase beta chain
phenylalanyl-tRNA synthetase beta subunit
phenylalanyl-tRNA synthetase-like, beta subunit
NP_005678.3
XP_006712232.1
XP_011508768.1
XP_016858599.1
XP_024308260.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_005687.5NP_005678.3  phenylalanine--tRNA ligase beta subunit

    See identical proteins and their annotated locations for NP_005678.3

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the shorter transcript and encodes the functional protein.
    Source sequence(s)
    AC097461, AF042346, BG721840
    Consensus CDS
    CCDS2454.1
    UniProtKB/Swiss-Prot
    Q9NSD9
    Related
    ENSP00000281828.6, ENST00000281828.8
    Conserved Domains (4) summary
    smart00873
    Location:118279
    B3_4; B3/4 domain
    PLN02265
    Location:1589
    PLN02265; probable phenylalanyl-tRNA synthetase beta chain
    cd00769
    Location:392588
    PheRS_beta_core; Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA, PheRS is an ...
    pfam03484
    Location:310374
    B5; tRNA synthetase B5 domain

RNA

  1. NR_130154.2 RNA Sequence

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) contains an alternate internal exon compared to variant 1. This variant is represented as non-coding because the use of the 5'-most supported translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AC097461, BC022273

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000002.12 Reference GRCh38.p13 Primary Assembly

    Range
    222566899..222656092 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011510466.2XP_011508768.1  phenylalanine--tRNA ligase beta subunit isoform X1

    See identical proteins and their annotated locations for XP_011508768.1

    UniProtKB/Swiss-Prot
    Q9NSD9
    Conserved Domains (1) summary
    cl27259
    Location:1490
    B5; tRNA synthetase B5 domain
  2. XM_006712169.2XP_006712232.1  phenylalanine--tRNA ligase beta subunit isoform X1

    See identical proteins and their annotated locations for XP_006712232.1

    UniProtKB/Swiss-Prot
    Q9NSD9
    Conserved Domains (1) summary
    cl27259
    Location:1490
    B5; tRNA synthetase B5 domain
  3. XM_024452492.1XP_024308260.1  phenylalanine--tRNA ligase beta subunit isoform X1

    Conserved Domains (1) summary
    cl27259
    Location:1490
    B5; tRNA synthetase B5 domain
  4. XM_017003110.2XP_016858599.1  phenylalanine--tRNA ligase beta subunit isoform X1

    UniProtKB/Swiss-Prot
    Q9NSD9
    Conserved Domains (1) summary
    cl27259
    Location:1490
    B5; tRNA synthetase B5 domain
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