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Dmtf1 cyclin D binding myb like transcription factor 1 [ Mus musculus (house mouse) ]

Gene ID: 23857, updated on 21-May-2024

Summary

Official Symbol
Dmtf1provided by MGI
Official Full Name
cyclin D binding myb like transcription factor 1provided by MGI
Primary source
MGI:MGI:1344415
See related
Ensembl:ENSMUSG00000042508 AllianceGenome:MGI:1344415
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Dimp; Dmp1
Summary
Enables DNA-binding transcription activator activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in positive regulation of transcription by RNA polymerase II. Predicted to be located in cytosol and nucleoplasm. Predicted to be active in nucleus. Is expressed in several structures, including central nervous system; early conceptus; genitourinary system; limb; and retina. Orthologous to human DMTF1 (cyclin D binding myb like transcription factor 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in CNS E14 (RPKM 13.2), CNS E18 (RPKM 12.2) and 24 other tissues See more
Orthologs
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Genomic context

See Dmtf1 in Genome Data Viewer
Location:
5 A1; 5 3.69 cM
Exon count:
19
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (9168868..9211782, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (9118868..9161806, complement)

Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_12400 Neighboring gene coiled-coil domain-containing protein 72 pseudogene Neighboring gene STARR-positive B cell enhancer mm9_chr5:8997064-8997365 Neighboring gene carnitine O-octanoyltransferase Neighboring gene STARR-seq mESC enhancer starr_12401 Neighboring gene STARR-seq mESC enhancer starr_12402 Neighboring gene STARR-seq mESC enhancer starr_12403 Neighboring gene predicted gene, 40264 Neighboring gene STARR-seq mESC enhancer starr_12404 Neighboring gene STARR-seq mESC enhancer starr_12405 Neighboring gene STARR-seq mESC enhancer starr_12406 Neighboring gene transmembrane protein 243, mitochondrial Neighboring gene STARR-positive B cell enhancer ABC_E10301 Neighboring gene predicted gene, 46901 Neighboring gene predicted gene, 24666 Neighboring gene protein phosphatase 1, regulatory (inhibitor) subunit 14B pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 
  • Targeted (1)  1 citation

General protein information

Preferred Names
cyclin-D-binding Myb-like transcription factor 1
Names
D-interacting myb-like protein
cyclin D binding myb-like transcription factor 1D-interacting myb-like protein
cyclin-D-interacting Myb-like protein 1
mDmp1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001110327.2NP_001103797.1  cyclin-D-binding Myb-like transcription factor 1 isoform 2

    See identical proteins and their annotated locations for NP_001103797.1

    Status: VALIDATED

    Source sequence(s)
    AC107763, AC158121
    Consensus CDS
    CCDS51412.1
    UniProtKB/TrEMBL
    V9GXX1
    Related
    ENSMUSP00000092627.5, ENSMUST00000095017.11
    Conserved Domains (4) summary
    smart00717
    Location:274330
    SANT; SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains
    cd00167
    Location:338388
    SANT; 'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric DNA tandem repeatsas part of the capping complex. Binding is sequence dependent for repeats which contain the G/C rich motif [C2-3 A (CA)1-6]. The domain is ...
    pfam00249
    Location:274329
    Myb_DNA-binding; Myb-like DNA-binding domain
    pfam13921
    Location:228284
    Myb_DNA-bind_6; Myb-like DNA-binding domain
  2. NM_001425525.1NP_001412454.1  cyclin-D-binding Myb-like transcription factor 1 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC107763, AC158121
  3. NM_001425526.1NP_001412455.1  cyclin-D-binding Myb-like transcription factor 1 isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC107763, AC158121
  4. NM_001425527.1NP_001412456.1  cyclin-D-binding Myb-like transcription factor 1 isoform 4

    Status: VALIDATED

    Source sequence(s)
    AC107763, AC158121
    Related
    ENSMUSP00000139361.2, ENSMUST00000183973.8
  5. NM_001425528.1NP_001412457.1  cyclin-D-binding Myb-like transcription factor 1 isoform 5

    Status: VALIDATED

    Source sequence(s)
    AC107763, AC158121
  6. NM_011806.4NP_035936.3  cyclin-D-binding Myb-like transcription factor 1 isoform 1

    See identical proteins and their annotated locations for NP_035936.3

    Status: VALIDATED

    Source sequence(s)
    AC107763, AC158121
    Consensus CDS
    CCDS19088.1
    UniProtKB/Swiss-Prot
    P70413, Q3TUR9, Q80VR8, Q8BQX6, Q8CA56, Q8CCZ0, Q8CE22
    UniProtKB/TrEMBL
    V9GXX1
    Related
    ENSMUSP00000071815.6, ENSMUST00000071921.13
    Conserved Domains (3) summary
    COG5147
    Location:122378
    REB1; Myb superfamily proteins, including transcription factors and mRNA splicing factors [Transcription / RNA processing and modification / Cell division and chromosome partitioning]
    pfam00249
    Location:274329
    Myb_DNA-binding; Myb-like DNA-binding domain
    pfam13921
    Location:228284
    Myb_DNA-bind_6; Myb-like DNA-binding domain

RNA

  1. NR_152858.2 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC107763, AC158121
  2. NR_152859.2 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC107763, AC158121
    Related
    ENSMUST00000184159.8
  3. NR_152860.2 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC107763, AC158121
  4. NR_152861.2 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC107763, AC158121
    Related
    ENSMUST00000183448.8
  5. NR_189314.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC107763, AC158121
  6. NR_189315.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC107763, AC158121
    Related
    ENSMUST00000184888.8
  7. NR_189316.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC107763, AC158121
  8. NR_189317.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC107763, AC158121
  9. NR_189318.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC107763, AC158121
  10. NR_189319.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC107763, AC158121

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000071.7 Reference GRCm39 C57BL/6J

    Range
    9168868..9211782 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036165110.1XP_036021003.1  cyclin-D-binding Myb-like transcription factor 1 isoform X7

    Conserved Domains (2) summary
    smart00717
    Location:70123
    SANT; SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains
    pfam00249
    Location:863
    Myb_DNA-binding; Myb-like DNA-binding domain
  2. XM_036165108.1XP_036021001.1  cyclin-D-binding Myb-like transcription factor 1 isoform X6

    Conserved Domains (3) summary
    COG5147
    Location:81337
    REB1; Myb superfamily proteins, including transcription factors and mRNA splicing factors [Transcription / RNA processing and modification / Cell division and chromosome partitioning]
    pfam13921
    Location:187243
    Myb_DNA-bind_6; Myb-like DNA-binding domain
    pfam00249
    Location:233288
    Myb_DNA-binding; Myb-like DNA-binding domain
  3. XM_036165109.1XP_036021002.1  cyclin-D-binding Myb-like transcription factor 1 isoform X7

    Conserved Domains (2) summary
    smart00717
    Location:70123
    SANT; SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains
    pfam00249
    Location:863
    Myb_DNA-binding; Myb-like DNA-binding domain
  4. XM_011240669.2XP_011238971.1  cyclin-D-binding Myb-like transcription factor 1 isoform X3

    UniProtKB/TrEMBL
    V9GXX1
    Conserved Domains (3) summary
    COG5147
    Location:122378
    REB1; Myb superfamily proteins, including transcription factors and mRNA splicing factors [Transcription / RNA processing and modification / Cell division and chromosome partitioning]
    pfam00249
    Location:274329
    Myb_DNA-binding; Myb-like DNA-binding domain
    pfam13921
    Location:228284
    Myb_DNA-bind_6; Myb-like DNA-binding domain
  5. XM_036165107.1XP_036021000.1  cyclin-D-binding Myb-like transcription factor 1 isoform X2

    UniProtKB/TrEMBL
    V9GXX1
    Conserved Domains (3) summary
    COG5147
    Location:81337
    REB1; Myb superfamily proteins, including transcription factors and mRNA splicing factors [Transcription / RNA processing and modification / Cell division and chromosome partitioning]
    pfam13921
    Location:187243
    Myb_DNA-bind_6; Myb-like DNA-binding domain
    pfam00249
    Location:233288
    Myb_DNA-binding; Myb-like DNA-binding domain
  6. XM_011240668.3XP_011238970.1  cyclin-D-binding Myb-like transcription factor 1 isoform X1

    See identical proteins and their annotated locations for XP_011238970.1

    UniProtKB/Swiss-Prot
    P70413, Q3TUR9, Q80VR8, Q8BQX6, Q8CA56, Q8CCZ0, Q8CE22
    UniProtKB/TrEMBL
    V9GXX1
    Conserved Domains (3) summary
    COG5147
    Location:122378
    REB1; Myb superfamily proteins, including transcription factors and mRNA splicing factors [Transcription / RNA processing and modification / Cell division and chromosome partitioning]
    pfam00249
    Location:274329
    Myb_DNA-binding; Myb-like DNA-binding domain
    pfam13921
    Location:228284
    Myb_DNA-bind_6; Myb-like DNA-binding domain

RNA

  1. XR_004942513.1 RNA Sequence