Format

Send to:

Choose Destination

Capn10 calpain 10 [ Mus musculus (house mouse) ]

Gene ID: 23830, updated on 31-Jan-2019

Summary

Official Symbol
Capn10provided by MGI
Official Full Name
calpain 10provided by MGI
Primary source
MGI:MGI:1344392
See related
Ensembl:ENSMUSG00000026270
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Capn8; AW049679; mKIAA1845
Expression
Ubiquitous expression in genital fat pad adult (RPKM 19.1), ovary adult (RPKM 16.4) and 28 other tissues See more
Orthologs

Genomic context

See Capn10 in Genome Data Viewer
Location:
1; 1 D
Exon count:
12
Annotation release Status Assembly Chr Location
106 current GRCm38.p4 (GCF_000001635.24) 1 NC_000067.6 (92934408..92947948)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 1 NC_000067.5 (94830985..94844525)

Chromosome 1 - NC_000067.6Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA 5033417F24 gene Neighboring gene dual specificity phosphatase 28 Neighboring gene arginyl aminopeptidase (aminopeptidase B)-like 1 Neighboring gene RIKEN cDNA 9430060I03 gene Neighboring gene G protein-coupled receptor 35 Neighboring gene predicted gene, 36424

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from BioSystems

  • Integrin-mediated Cell Adhesion, organism-specific biosystem (from WikiPathways)
    Integrin-mediated Cell Adhesion, organism-specific biosystemIntegrins are receptors that mediate attachment between a cell and the tissues surrounding it, which may be other cells or the extracellular matrix (ECM). They also play a role in cell signaling and ...

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
SNARE binding ISO
Inferred from Sequence Orthology
more info
 
calcium-dependent cysteine-type endopeptidase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
calcium-dependent cysteine-type endopeptidase activity ISO
Inferred from Sequence Orthology
more info
 
cysteine-type peptidase activity IEA
Inferred from Electronic Annotation
more info
 
cytoskeletal protein binding ISO
Inferred from Sequence Orthology
more info
 
hydrolase activity IEA
Inferred from Electronic Annotation
more info
 
peptidase activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
actin cytoskeleton reorganization IMP
Inferred from Mutant Phenotype
more info
PubMed 
actin cytoskeleton reorganization ISO
Inferred from Sequence Orthology
more info
 
aging ISO
Inferred from Sequence Orthology
more info
 
autophagy of mitochondrion ISO
Inferred from Sequence Orthology
more info
 
cellular response to insulin stimulus IMP
Inferred from Mutant Phenotype
more info
PubMed 
cellular response to insulin stimulus ISO
Inferred from Sequence Orthology
more info
 
mitochondrion organization ISO
Inferred from Sequence Orthology
more info
 
positive regulation of apoptotic process ISO
Inferred from Sequence Orthology
more info
 
positive regulation of glucose import IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of glucose import ISO
Inferred from Sequence Orthology
more info
 
positive regulation of insulin secretion ISO
Inferred from Sequence Orthology
more info
 
positive regulation of intracellular transport IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of type B pancreatic cell apoptotic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
proteolysis IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
proteolysis ISO
Inferred from Sequence Orthology
more info
 
response to nutrient levels ISO
Inferred from Sequence Orthology
more info
 
type B pancreatic cell apoptotic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
type B pancreatic cell apoptotic process ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
cell cortex ISO
Inferred from Sequence Orthology
more info
 
cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cytoplasm ISO
Inferred from Sequence Orthology
more info
 
cytoskeleton ISO
Inferred from Sequence Orthology
more info
 
cytosol ISO
Inferred from Sequence Orthology
more info
 
intracellular membrane-bounded organelle ISO
Inferred from Sequence Orthology
more info
 
mitochondrial inner membrane ISO
Inferred from Sequence Orthology
more info
 
mitochondrial intermembrane space ISO
Inferred from Sequence Orthology
more info
 
mitochondrial matrix ISO
Inferred from Sequence Orthology
more info
 
mitochondrial outer membrane ISO
Inferred from Sequence Orthology
more info
 
mitochondrion ISO
Inferred from Sequence Orthology
more info
 
nucleus ISO
Inferred from Sequence Orthology
more info
 
plasma membrane ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
calpain-10
Names
CANP 10
calcium-activated neutral proteinase 10
calpain 8
NP_035926.2

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_011796.2NP_035926.2  calpain-10

    See identical proteins and their annotated locations for NP_035926.2

    Status: VALIDATED

    Source sequence(s)
    BB747799, BC010969, BI986964
    Consensus CDS
    CCDS15181.1
    UniProtKB/Swiss-Prot
    Q9ESK3
    Related
    ENSMUSP00000027488.4, ENSMUST00000027488.10
    Conserved Domains (3) summary
    smart00720
    Location:338488
    calpain_III; calpain_III domain
    cd00044
    Location:8319
    CysPc; Calpains, domains IIa, IIb; calcium-dependent cytoplasmic cysteine proteinases, papain-like. Functions in cytoskeletal remodeling processes, cell differentiation, apoptosis and signal transduction.
    cd00214
    Location:506647
    Calpain_III; Calpain, subdomain III. Calpains are calcium-activated cytoplasmic cysteine proteinases, participate in cytoskeletal remodeling processes, cell differentiation, apoptosis and signal transduction. Catalytic domain and the two calmodulin-like domains are ...

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38.p4 C57BL/6J

Genomic

  1. NC_000067.6 Reference GRCm38.p4 C57BL/6J

    Range
    92934408..92947948
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Support Center