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Sarm1 sterile alpha and HEAT/Armadillo motif containing 1 [ Mus musculus (house mouse) ]

Gene ID: 237868, updated on 1-Jul-2024

Summary

Official Symbol
Sarm1provided by MGI
Official Full Name
sterile alpha and HEAT/Armadillo motif containing 1provided by MGI
Primary source
MGI:MGI:2136419
See related
Ensembl:ENSMUSG00000050132 AllianceGenome:MGI:2136419
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Sarm; MyD885; A830091I15Rik
Summary
Enables NAD+ nucleosidase activity. Involved in NAD catabolic process; positive regulation of neuron death; and regulation of dendrite morphogenesis. Acts upstream of or within regulation of apoptotic process and response to glucose. Located in several cellular components, including dendrite; microtubule; and mitochondrion. Is extrinsic component of mitochondrial outer membrane. Is expressed in immune system; nervous system; neural retina; and tongue. Orthologous to human SARM1 (sterile alpha and TIR motif containing 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in whole brain E14.5 (RPKM 11.0), CNS E18 (RPKM 9.7) and 9 other tissues See more
Orthologs
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Genomic context

See Sarm1 in Genome Data Viewer
Location:
11 B5; 11 46.74 cM
Exon count:
9
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (78361099..78388642, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (78470273..78497816, complement)

Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 30367 Neighboring gene forkhead box N1 Neighboring gene solute carrier family 13 (sodium-dependent dicarboxylate transporter), member 2, opposite strand Neighboring gene solute carrier family 13 (sodium-dependent dicarboxylate transporter), member 2 Neighboring gene solute carrier family 46, member 1 Neighboring gene STARR-positive B cell enhancer ABC_E10695 Neighboring gene SEBOX homeobox Neighboring gene vitronectin

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables NAD+ nucleosidase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables NAD+ nucleosidase activity ISO
Inferred from Sequence Orthology
more info
 
enables NAD+ nucleotidase, cyclic ADP-ribose generating ISO
Inferred from Sequence Orthology
more info
 
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
 
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables signaling adaptor activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in NAD catabolic process IDA
Inferred from Direct Assay
more info
PubMed 
involved_in NAD catabolic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in NAD catabolic process ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within cell differentiation IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within immune system process IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within innate immune response IEA
Inferred from Electronic Annotation
more info
 
involved_in negative regulation of MyD88-independent toll-like receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within nervous system development IEA
Inferred from Electronic Annotation
more info
 
involved_in nervous system process IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in protein localization to mitochondrion IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of dendrite morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within regulation of neuron apoptotic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of synapse pruning IDA
Inferred from Direct Assay
more info
PubMed 
involved_in regulation of synapse pruning IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in response to axon injury ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within response to glucose IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in signal transduction IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in cell projection IEA
Inferred from Electronic Annotation
more info
 
is_active_in cell surface IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in dendrite IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in dendrite IMP
Inferred from Mutant Phenotype
more info
PubMed 
located_in microtubule IDA
Inferred from Direct Assay
more info
PubMed 
located_in microtubule cytoskeleton IDA
Inferred from Direct Assay
more info
PubMed 
located_in mitochondrial outer membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in mitochondrion IDA
Inferred from Direct Assay
more info
PubMed 
located_in mitochondrion ISO
Inferred from Sequence Orthology
more info
 
is_active_in neuromuscular junction IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in neuromuscular junction IMP
Inferred from Mutant Phenotype
more info
PubMed 
part_of protein-containing complex IDA
Inferred from Direct Assay
more info
PubMed 
located_in synapse IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
NAD(+) hydrolase SARM1
Names
NADP(+) hydrolase SARM1
NADase SARM1
Tir-1 homolog
sterile alpha and TIR motif containing 1
sterile alpha and TIR motif-containing protein 1
NP_001161993.1
NP_766383.2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001168521.1NP_001161993.1  NAD(+) hydrolase SARM1 isoform 1

    See identical proteins and their annotated locations for NP_001161993.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AL591177, BC080850, BU704378
    Consensus CDS
    CCDS48857.1
    UniProtKB/TrEMBL
    A0PJL3
    Related
    ENSMUSP00000103922.4, ENSMUST00000108287.10
    Conserved Domains (4) summary
    cd09501
    Location:409477
    SAM_SARM1-like_repeat1; SAM domain ot SARM1-like proteins, repeat 1
    cd09502
    Location:479544
    SAM_SARM1-like_repeat2; SAM domain of SARM1-like, repeat 2
    smart00454
    Location:409476
    SAM; Sterile alpha motif
    smart00255
    Location:601742
    TIR; Toll - interleukin 1 - resistance
  2. NM_172795.3NP_766383.2  NAD(+) hydrolase SARM1 isoform 2

    See identical proteins and their annotated locations for NP_766383.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an alternate in-frame splice site in the coding region, compared to variant 1. This results in a shorter protein (isoform 2), compared to isoform 1.
    Source sequence(s)
    AL591177, BC080850
    Consensus CDS
    CCDS25105.1
    UniProtKB/Swiss-Prot
    Q5SYG5, Q5SYG6, Q6A054, Q6PDS3, Q6SZW0, Q8BRI9
    UniProtKB/TrEMBL
    A0PJL3
    Related
    ENSMUSP00000051059.7, ENSMUST00000061174.7
    Conserved Domains (4) summary
    cd09501
    Location:409477
    SAM_SARM1-like_repeat1; SAM domain ot SARM1-like proteins, repeat 1
    cd09502
    Location:479547
    SAM_SARM1-like_repeat2; SAM domain of SARM1-like, repeat 2
    smart00454
    Location:409476
    SAM; Sterile alpha motif
    smart00255
    Location:561702
    TIR; Toll - interleukin 1 - resistance

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000077.7 Reference GRCm39 C57BL/6J

    Range
    78361099..78388642 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

RNA

  1. XR_001780001.2 RNA Sequence