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SARM1 sterile alpha and TIR motif containing 1 [ Homo sapiens (human) ]

Gene ID: 23098, updated on 22-Sep-2022

Summary

Official Symbol
SARM1provided by HGNC
Official Full Name
sterile alpha and TIR motif containing 1provided by HGNC
Primary source
HGNC:HGNC:17074
See related
Ensembl:ENSG00000004139 MIM:607732; AllianceGenome:HGNC:17074
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
SARM; HsTIR; SAMD2; hSARM1; MyD88-5
Summary
Enables NAD+ nucleotidase, cyclic ADP-ribose generating and identical protein binding activity. Involved in NAD catabolic process; positive regulation of neuron death; and response to axon injury. Located in mitochondrion. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in duodenum (RPKM 30.5), small intestine (RPKM 14.6) and 23 other tissues See more
Orthologs
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Genomic context

See SARM1 in Genome Data Viewer
Location:
17q11.2
Exon count:
9
Annotation release Status Assembly Chr Location
110 current GRCh38.p14 (GCF_000001405.40) 17 NC_000017.11 (28371694..28404049)
110 current T2T-CHM13v2.0 (GCF_009914755.1) 17 NC_060941.1 (29313546..29345902)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (26698715..26731067)

Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene transmembrane protein 199 Neighboring gene SEBOX homeobox Neighboring gene vitronectin Neighboring gene solute carrier family 46 member 1 Neighboring gene uncharacterized LOC124903964 Neighboring gene H3 histone pseudogene 41

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

EBI GWAS Catalog

Description
Meta-analysis of genome-wide association studies identifies two loci associated with circulating osteoprotegerin levels.
EBI GWAS Catalog

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ36296, FLJ57960, KIAA0524

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables NAD(P)+ nucleosidase activity IEA
Inferred from Electronic Annotation
more info
 
enables NAD+ nucleosidase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables NAD+ nucleotidase, cyclic ADP-ribose generating IDA
Inferred from Direct Assay
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables signaling adaptor activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in NAD catabolic process IDA
Inferred from Direct Assay
more info
PubMed 
involved_in cell differentiation IEA
Inferred from Electronic Annotation
more info
 
involved_in innate immune response IEA
Inferred from Electronic Annotation
more info
 
involved_in negative regulation of MyD88-independent toll-like receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
 
involved_in nervous system development IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of neuron death IDA
Inferred from Direct Assay
more info
PubMed 
involved_in regulation of dendrite morphogenesis ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in regulation of neuron apoptotic process IEA
Inferred from Electronic Annotation
more info
 
involved_in regulation of neuron death IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in regulation of neuron death ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in response to axon injury IDA
Inferred from Direct Assay
more info
PubMed 
involved_in response to glucose IEA
Inferred from Electronic Annotation
more info
 
involved_in signal transduction IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in axon IEA
Inferred from Electronic Annotation
more info
 
located_in cytoplasm ISS
Inferred from Sequence or Structural Similarity
more info
 
located_in cytosol TAS
Traceable Author Statement
more info
 
is_active_in dendrite IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in dendrite ISS
Inferred from Sequence or Structural Similarity
more info
 
located_in extrinsic component of mitochondrial outer membrane IEA
Inferred from Electronic Annotation
more info
 
located_in microtubule ISS
Inferred from Sequence or Structural Similarity
more info
 
located_in mitochondrion IDA
Inferred from Direct Assay
more info
PubMed 
located_in synapse ISS
Inferred from Sequence or Structural Similarity
more info
 

General protein information

Preferred Names
NAD(+) hydrolase SARM1
Names
NADP(+) hydrolase SARM1
NADase SARM1
SAM domain-containing protein 2
sterile alpha and Armadillo repeat protein
sterile alpha and HEAT/Armadillo motif protein, ortholog of Drosophila
sterile alpha and TIR motif-containing protein 1
sterile alpha motif domain-containing protein 2
tir-1 homolog
NP_055892.2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_015077.4NP_055892.2  NAD(+) hydrolase SARM1 precursor

    See identical proteins and their annotated locations for NP_055892.2

    Status: VALIDATED

    Source sequence(s)
    AB011096, AC015917, AK314609, BC040429, BC122860, BG820141
    Consensus CDS
    CCDS11230.2
    UniProtKB/Swiss-Prot
    Q6SZW1, Q9NXY5
    UniProtKB/TrEMBL
    Q05B42, Q0D2N8
    Related
    ENSP00000468032.2, ENST00000585482.6
    Conserved Domains (3) summary
    cd09501
    Location:409477
    SAM_SARM1-like_repeat1; SAM domain ot SARM1-like proteins, repeat 1
    cd09502
    Location:478547
    SAM_SARM1-like_repeat2; SAM domain of SARM1-like, repeat 2
    smart00255
    Location:561702
    TIR; Toll - interleukin 1 - resistance

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 110 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000017.11 Reference GRCh38.p14 Primary Assembly

    Range
    28371694..28404049
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060941.1 Alternate T2T-CHM13v2.0

    Range
    29313546..29345902
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)