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SARM1 sterile alpha and TIR motif containing 1 [ Homo sapiens (human) ]

Gene ID: 23098, updated on 2-Mar-2021

Summary

Official Symbol
SARM1provided by HGNC
Official Full Name
sterile alpha and TIR motif containing 1provided by HGNC
Primary source
HGNC:HGNC:17074
See related
Ensembl:ENSG00000004139 MIM:607732
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
SARM; HsTIR; SAMD2; hSARM1; MyD88-5
Expression
Ubiquitous expression in duodenum (RPKM 30.5), small intestine (RPKM 14.6) and 23 other tissues See more
Orthologs
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Genomic context

See SARM1 in Genome Data Viewer
Location:
17q11.2
Exon count:
9
Annotation release Status Assembly Chr Location
109.20210226 current GRCh38.p13 (GCF_000001405.39) 17 NC_000017.11 (28371694..28404049)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (26698715..26731067)

Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene SEBOX homeobox Neighboring gene vitronectin Neighboring gene solute carrier family 46 member 1 Neighboring gene H3 histone pseudogene 41 Neighboring gene RAP1A, member of RAS oncogene family pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

Associated conditions

Description Tests
Meta-analysis of genome-wide association studies identifies two loci associated with circulating osteoprotegerin levels.
GeneReviews: Not available

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ36296, FLJ57960, KIAA0524

Gene Ontology Provided by GOA

Function Evidence Code Pubs
NAD(P)+ nucleosidase activity IEA
Inferred from Electronic Annotation
more info
 
NAD+ nucleosidase activity IDA
Inferred from Direct Assay
more info
PubMed 
NAD+ nucleotidase, cyclic ADP-ribose generating IDA
Inferred from Direct Assay
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
signaling adaptor activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
NAD catabolic process IDA
Inferred from Direct Assay
more info
PubMed 
cell differentiation IEA
Inferred from Electronic Annotation
more info
 
innate immune response IEA
Inferred from Electronic Annotation
more info
 
negative regulation of MyD88-independent toll-like receptor signaling pathway TAS
Traceable Author Statement
more info
 
nervous system development IEA
Inferred from Electronic Annotation
more info
 
positive regulation of neuron death IDA
Inferred from Direct Assay
more info
PubMed 
regulation of apoptotic process IEA
Inferred from Electronic Annotation
more info
 
regulation of dendrite morphogenesis ISS
Inferred from Sequence or Structural Similarity
more info
 
regulation of neuron death IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
regulation of neuron death ISS
Inferred from Sequence or Structural Similarity
more info
 
response to axon injury IDA
Inferred from Direct Assay
more info
PubMed 
response to glucose IEA
Inferred from Electronic Annotation
more info
 
signal transduction IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
axon IEA
Inferred from Electronic Annotation
more info
 
cytoplasm ISS
Inferred from Sequence or Structural Similarity
more info
 
cytosol TAS
Traceable Author Statement
more info
 
dendrite IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
dendrite ISS
Inferred from Sequence or Structural Similarity
more info
 
extrinsic component of mitochondrial outer membrane IEA
Inferred from Electronic Annotation
more info
 
microtubule ISS
Inferred from Sequence or Structural Similarity
more info
 
mitochondrion IDA
Inferred from Direct Assay
more info
PubMed 
synapse ISS
Inferred from Sequence or Structural Similarity
more info
 

General protein information

Preferred Names
NAD(+) hydrolase SARM1
Names
NADP(+) hydrolase SARM1
NADase SARM1
SAM domain-containing protein 2
sterile alpha and Armadillo repeat protein
sterile alpha and HEAT/Armadillo motif protein, ortholog of Drosophila
sterile alpha and TIR motif-containing protein 1
sterile alpha motif domain-containing protein 2
tir-1 homolog
NP_055892.2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_015077.4NP_055892.2  NAD(+) hydrolase SARM1 precursor

    See identical proteins and their annotated locations for NP_055892.2

    Status: VALIDATED

    Source sequence(s)
    AB011096, AC015917, AK314609, BC040429, BC122860, BG820141
    Consensus CDS
    CCDS11230.2
    UniProtKB/Swiss-Prot
    Q6SZW1
    UniProtKB/TrEMBL
    Q05B42, Q0D2N8
    Related
    ENSP00000468032.2, ENST00000585482.6
    Conserved Domains (3) summary
    cd09501
    Location:409477
    SAM_SARM1-like_repeat1; SAM domain ot SARM1-like proteins, repeat 1
    cd09502
    Location:478547
    SAM_SARM1-like_repeat2; SAM domain of SARM1-like, repeat 2
    smart00255
    Location:561702
    TIR; Toll - interleukin 1 - resistance

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210226

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000017.11 Reference GRCh38.p13 Primary Assembly

    Range
    28371694..28404049
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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