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Nsrp1 nuclear speckle regulatory protein 1 [ Mus musculus (house mouse) ]

Gene ID: 237859, updated on 12-May-2024

Summary

Official Symbol
Nsrp1provided by MGI
Official Full Name
nuclear speckle regulatory protein 1provided by MGI
Primary source
MGI:MGI:2144305
See related
Ensembl:ENSMUSG00000037958 AllianceGenome:MGI:2144305
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Ccdc55; NSpr70; NSrp70; 8030451K07
Summary
Predicted to enable mRNA binding activity. Acts upstream of or within in utero embryonic development. Predicted to be located in nuclear speck. Predicted to be part of ribonucleoprotein complex. Orthologous to human NSRP1 (nuclear speckle splicing regulatory protein 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in CNS E11.5 (RPKM 7.3), placenta adult (RPKM 3.5) and 19 other tissues See more
Orthologs
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Genomic context

See Nsrp1 in Genome Data Viewer
Location:
11 B5; 11 46.21 cM
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (76935118..76969263, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (77044292..77078437, complement)

Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer mm9_chr11:76759053-76759354 Neighboring gene STARR-seq mESC enhancer starr_30047 Neighboring gene bleomycin hydrolase Neighboring gene solute carrier family 6 member 4 gene promoter Neighboring gene solute carrier family 6 (neurotransmitter transporter, serotonin), member 4 Neighboring gene predicted gene 12343 Neighboring gene STARR-seq mESC enhancer starr_30048 Neighboring gene STARR-seq mESC enhancer starr_30049 Neighboring gene predicted gene, 22772 Neighboring gene STARR-seq mESC enhancer starr_30050 Neighboring gene STARR-positive B cell enhancer ABC_E592 Neighboring gene microRNA 423 Neighboring gene EF-hand calcium binding domain 5 Neighboring gene ATPase, H+ transporting, lysosomal V1 subunit G1 pseudogene Neighboring gene upstream transcription factor 1 pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (2) 
  • Gene trapped (1) 
  • Targeted (2)  1 citation

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Clone Names

  • MGC107323

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables RNA binding IEA
Inferred from Electronic Annotation
more info
 
enables mRNA binding ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
acts_upstream_of_or_within RNA splicing IEA
Inferred from Electronic Annotation
more info
 
involved_in developmental process ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within in utero embryonic development IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within mRNA processing IEA
Inferred from Electronic Annotation
more info
 
involved_in regulation of alternative mRNA splicing, via spliceosome ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
located_in nuclear speck ISO
Inferred from Sequence Orthology
more info
 
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
 
part_of ribonucleoprotein complex ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
nuclear speckle splicing regulatory protein 1
Names
coiled-coil domain containing 55
coiled-coil domain-containing protein 55
nuclear speckle-related protein 70

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001012309.2NP_001012309.1  nuclear speckle splicing regulatory protein 1

    See identical proteins and their annotated locations for NP_001012309.1

    Status: VALIDATED

    Source sequence(s)
    AK078762, AK161058, AL603842, BF462050
    Consensus CDS
    CCDS25075.1
    UniProtKB/Swiss-Prot
    Q5NCR9
    Related
    ENSMUSP00000099552.2, ENSMUST00000102494.8
    Conserved Domains (1) summary
    pfam09745
    Location:57176
    DUF2040; Coiled-coil domain-containing protein 55 (DUF2040)

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000077.7 Reference GRCm39 C57BL/6J

    Range
    76935118..76969263 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)