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NSRP1 nuclear speckle splicing regulatory protein 1 [ Homo sapiens (human) ]

Gene ID: 84081, updated on 12-Oct-2019

Summary

Official Symbol
NSRP1provided by HGNC
Official Full Name
nuclear speckle splicing regulatory protein 1provided by HGNC
Primary source
HGNC:HGNC:25305
See related
Ensembl:ENSG00000126653 MIM:616173
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
CCDC55; NSrp70; HSPC095
Expression
Ubiquitous expression in testis (RPKM 8.3), thyroid (RPKM 8.1) and 25 other tissues See more
Orthologs

Genomic context

See NSRP1 in Genome Data Viewer
Location:
17q11.2
Exon count:
8
Annotation release Status Assembly Chr Location
109.20190905 current GRCh38.p13 (GCF_000001405.39) 17 NC_000017.11 (30116807..30186475)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (28443821..28513493)

Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene EF-hand calcium binding domain 5 Neighboring gene RNY4 pseudogene 13 Neighboring gene syntaxin 18 pseudogene 1 Neighboring gene microRNA 3184 Neighboring gene microRNA 423 Neighboring gene uncharacterized LOC107984991 Neighboring gene solute carrier family 6 member 4 Neighboring gene serotonin transporter intronic VNTR enhancer

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ37233, DKFZp434K1421

Gene Ontology Provided by GOA

Function Evidence Code Pubs
RNA binding HDA PubMed 
mRNA binding IDA
Inferred from Direct Assay
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
RNA splicing IEA
Inferred from Electronic Annotation
more info
 
developmental process IMP
Inferred from Mutant Phenotype
more info
PubMed 
mRNA processing IEA
Inferred from Electronic Annotation
more info
 
regulation of alternative mRNA splicing, via spliceosome IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
nuclear speck IDA
Inferred from Direct Assay
more info
PubMed 
nucleoplasm IDA
Inferred from Direct Assay
more info
 
nucleus IDA
Inferred from Direct Assay
more info
PubMed 
ribonucleoprotein complex IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
nuclear speckle splicing regulatory protein 1
Names
coiled-coil domain containing 55
coiled-coil domain-containing protein 55
nuclear speckle-related protein 70

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001261467.1NP_001248396.1  nuclear speckle splicing regulatory protein 1 isoform 2

    See identical proteins and their annotated locations for NP_001248396.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an exon in the 5' coding region, compared to variant 1, which results in a protein (isoform 2) with a shorter N-terminus, compared to isoform (1).
    Source sequence(s)
    AA811439, AL136806, BC143539, DC327004
    Consensus CDS
    CCDS74025.1
    UniProtKB/Swiss-Prot
    Q9H0G5
    UniProtKB/TrEMBL
    A0A024QZ33, B7ZL27
    Related
    ENSP00000477862.1, ENST00000612959.4
    Conserved Domains (1) summary
    pfam09745
    Location:4123
    DUF2040; Coiled-coil domain-containing protein 55 (DUF2040)
  2. NM_032141.4NP_115517.1  nuclear speckle splicing regulatory protein 1 isoform 1

    See identical proteins and their annotated locations for NP_115517.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AA811439, AL136806, BC105044, DC327004
    Consensus CDS
    CCDS11255.1
    UniProtKB/Swiss-Prot
    Q9H0G5
    Related
    ENSP00000247026.5, ENST00000247026.10
    Conserved Domains (1) summary
    pfam09745
    Location:58177
    DUF2040; Coiled-coil domain-containing protein 55 (DUF2040)

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109.20190905

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000017.11 Reference GRCh38.p13 Primary Assembly

    Range
    30116807..30186475
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011525345.2XP_011523647.1  nuclear speckle splicing regulatory protein 1 isoform X1

    Conserved Domains (1) summary
    pfam09745
    Location:37156
    DUF2040; Coiled-coil domain-containing protein 55 (DUF2040)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_001033563.1: Suppressed sequence

    Description
    NM_001033563.1: This RefSeq was permanently suppressed because it is a nonsense-mediated mRNA decay (NMD) candidate.
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