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Tbpl1 TATA box binding protein-like 1 [ Mus musculus (house mouse) ]

Gene ID: 237336, updated on 18-Apr-2024

Summary

Official Symbol
Tbpl1provided by MGI
Official Full Name
TATA box binding protein-like 1provided by MGI
Primary source
MGI:MGI:1339946
See related
Ensembl:ENSMUSG00000071359 AllianceGenome:MGI:1339946
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
STD; TLF; TRP; Tlp; TRF2; 4732475G08
Summary
Predicted to enable RNA polymerase II core promoter sequence-specific DNA binding activity and RNA polymerase II general transcription initiation factor activity. Acts upstream of or within acrosome assembly; dTTP biosynthetic process; and spermatid nucleus differentiation. Located in cytoplasm and nucleus. Part of transcription factor TFIIA complex. Is expressed in several structures, including central nervous system; early conceptus; ganglia; gonad; and sensory organ. Orthologous to human TBPL1 (TATA-box binding protein like 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in testis adult (RPKM 19.3), CNS E14 (RPKM 9.1) and 25 other tissues See more
Orthologs
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Genomic context

Location:
10 A3; 10 10.25 cM
Exon count:
9
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 10 NC_000076.7 (22579776..22607882, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 10 NC_000076.6 (22703877..22732666, complement)

Chromosome 10 - NC_000076.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_26019 Neighboring gene STARR-seq mESC enhancer starr_26020 Neighboring gene STARR-seq mESC enhancer starr_26021 Neighboring gene predicted gene, 40610 Neighboring gene STARR-seq mESC enhancer starr_26022 Neighboring gene STARR-seq mESC enhancer starr_26023 Neighboring gene STARR-seq mESC enhancer starr_26024 Neighboring gene STARR-seq mESC enhancer starr_26025 Neighboring gene predicted gene, 40612 Neighboring gene STARR-seq mESC enhancer starr_26026 Neighboring gene predicted gene, 46216 Neighboring gene STARR-seq mESC enhancer starr_26029 Neighboring gene solute carrier family 2 (facilitated glucose transporter), member 12 Neighboring gene STARR-seq mESC enhancer starr_26030 Neighboring gene microRNA 7663 Neighboring gene STARR-seq mESC enhancer starr_26034 Neighboring gene STARR-seq mESC enhancer starr_26035 Neighboring gene glyceraldehyde-3-phosphate dehydrogenase pseudogene Neighboring gene predicted gene 10824 Neighboring gene transcription factor 21

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables DNA binding IEA
Inferred from Electronic Annotation
more info
 
enables RNA polymerase II core promoter sequence-specific DNA binding ISO
Inferred from Sequence Orthology
more info
 
enables RNA polymerase II general transcription initiation factor activity ISO
Inferred from Sequence Orthology
more info
 
enables general transcription initiation factor activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Component Evidence Code Pubs
located_in cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
located_in male germ cell nucleus IDA
Inferred from Direct Assay
more info
PubMed 
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 
part_of transcription factor TFIIA complex IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
TATA box-binding protein-like 1
Names
21 kDa TBP-like protein
TATA box binding protein-like protein
TATA box-binding protein-like protein 1
TATA box-binding protein-related factor 2
TBP-like 1
TBP-like factor
TBP-like protein 1
TBP-related factor 2
TBP-related protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001421603.1NP_001408532.1  TATA box-binding protein-like 1 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC166256
  2. NM_001421604.1NP_001408533.1  TATA box-binding protein-like 1 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC166256
    UniProtKB/Swiss-Prot
    P62340
  3. NM_001421605.1NP_001408534.1  TATA box-binding protein-like 1 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC166256
    UniProtKB/Swiss-Prot
    P62340
  4. NM_001421606.1NP_001408535.1  TATA box-binding protein-like 1 isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC166256
  5. NM_001421607.1NP_001408536.1  TATA box-binding protein-like 1 isoform 4

    Status: VALIDATED

    Source sequence(s)
    AC166256
  6. NM_001421608.1NP_001408537.1  TATA box-binding protein-like 1 isoform 5

    Status: VALIDATED

    Source sequence(s)
    AC166256
  7. NM_011603.6NP_035733.1  TATA box-binding protein-like 1 isoform 1

    See identical proteins and their annotated locations for NP_035733.1

    Status: VALIDATED

    Source sequence(s)
    AC166256
    Consensus CDS
    CCDS23730.1
    UniProtKB/Swiss-Prot
    P62340
    UniProtKB/TrEMBL
    Q8K073
    Related
    ENSMUSP00000114223.2, ENSMUST00000127698.8
    Conserved Domains (1) summary
    cd04517
    Location:9180
    TLF; TBP-like factors (TLF; also called TLP, TRF, TRP), which are found in most metazoans. TLFs and TBPs have well-conserved core domains; however, they only share about 60% similarity. TLFs, like TBPs, interact with TFIIA and TFIIB, which are part of the ...

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000076.7 Reference GRCm39 C57BL/6J

    Range
    22579776..22607882 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)