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TBPL1 TATA-box binding protein like 1 [ Homo sapiens (human) ]

Gene ID: 9519, updated on 5-Apr-2020

Summary

Official Symbol
TBPL1provided by HGNC
Official Full Name
TATA-box binding protein like 1provided by HGNC
Primary source
HGNC:HGNC:11589
See related
Ensembl:ENSG00000028839 MIM:605521
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
TLF; TLP; STUD; TRF2; MGC:8389; MGC:9620
Summary
This gene encodes a member of the TATA box-binding protein family. TATA box-binding proteins play a critical role in transcription by RNA polymerase II as components of the transcription factor IID (TFIID) complex. The encoded protein does not bind to the TATA box and initiates transcription from TATA-less promoters. This gene plays a critical role in spermatogenesis, and single nucleotide polymorphisms in this gene may be associated with male infertility. Alternatively spliced transcript variants have been observed for this gene, and a pseudogene of this gene is located on the long arm of chromosome 3. [provided by RefSeq, Nov 2011]
Expression
Broad expression in testis (RPKM 58.3), bone marrow (RPKM 8.1) and 20 other tissues See more
Orthologs

Genomic context

See TBPL1 in Genome Data Viewer
Location:
6q23.2
Exon count:
9
Annotation release Status Assembly Chr Location
109.20200228 current GRCh38.p13 (GCF_000001405.39) 6 NC_000006.12 (133952170..133990432)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 6 NC_000006.11 (134273308..134308638)

Chromosome 6 - NC_000006.12Genomic Context describing neighboring genes Neighboring gene TCF21 antisense RNA inducing promoter demethylation Neighboring gene long intergenic non-protein coding RNA 1312 Neighboring gene transcription factor 21 Neighboring gene epithelial splicing regulatory protein 1 pseudogene Neighboring gene solute carrier family 2 member 12 Neighboring gene high mobility group AT-hook 1 pseudogene 7

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Process Evidence Code Pubs
DNA-templated transcription, initiation IEA
Inferred from Electronic Annotation
more info
 
acrosome assembly IEA
Inferred from Electronic Annotation
more info
 
dTTP biosynthetic process IEA
Inferred from Electronic Annotation
more info
 
positive regulation of transcription by RNA polymerase II IDA
Inferred from Direct Assay
more info
PubMed 
spermatid nucleus differentiation IEA
Inferred from Electronic Annotation
more info
 
transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
transcription by RNA polymerase II TAS
Traceable Author Statement
more info
PubMed 
Component Evidence Code Pubs
cytoplasm IEA
Inferred from Electronic Annotation
more info
 
transcription factor TFIIA complex IEA
Inferred from Electronic Annotation
more info
 
transcription factor complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
TATA box-binding protein-like protein 1
Names
21-kDA TBP-like protein
TATA box-binding protein-related factor 2
TBP-like 1
TBP-related factor 2
TBP-related protein
second TBP of unique DNA protein

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_031808.2 RefSeqGene

    Range
    5001..40331
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001253676.1NP_001240605.1  TATA box-binding protein-like protein 1

    See identical proteins and their annotated locations for NP_001240605.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longer transcript. Variants 1 and 2 encode the same protein.
    Source sequence(s)
    AI187713, AK292320, BI828497, R42082
    Consensus CDS
    CCDS5168.1
    UniProtKB/Swiss-Prot
    P62380
    Related
    ENSP00000478795.1, ENST00000613034.4
    Conserved Domains (1) summary
    cd04517
    Location:9180
    TLF; TBP-like factors (TLF; also called TLP, TRF, TRP), which are found in most metazoans. TLFs and TBPs have well-conserved core domains; however, they only share about 60% similarity. TLFs, like TBPs, interact with TFIIA and TFIIB, which are part of the ...
  2. NM_004865.4NP_004856.1  TATA box-binding protein-like protein 1

    See identical proteins and their annotated locations for NP_004856.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1 and 2 encode the same protein.
    Source sequence(s)
    AL035699, BC017559, BI560657, R42082
    Consensus CDS
    CCDS5168.1
    UniProtKB/Swiss-Prot
    P62380
    Related
    ENSP00000237264.3, ENST00000237264.9
    Conserved Domains (1) summary
    cd04517
    Location:9180
    TLF; TBP-like factors (TLF; also called TLP, TRF, TRP), which are found in most metazoans. TLFs and TBPs have well-conserved core domains; however, they only share about 60% similarity. TLFs, like TBPs, interact with TFIIA and TFIIB, which are part of the ...

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000006.12 Reference GRCh38.p13 Primary Assembly

    Range
    133952170..133990432
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017011513.1XP_016867002.1  TATA box-binding protein-like protein 1 isoform X1

    UniProtKB/Swiss-Prot
    P62380
    Conserved Domains (1) summary
    cd04517
    Location:9180
    TLF; TBP-like factors (TLF; also called TLP, TRF, TRP), which are found in most metazoans. TLFs and TBPs have well-conserved core domains; however, they only share about 60% similarity. TLFs, like TBPs, interact with TFIIA and TFIIB, which are part of the ...
  2. XM_024446592.1XP_024302360.1  TATA box-binding protein-like protein 1 isoform X1

    Related
    ENSP00000356845.1, ENST00000367871.5
    Conserved Domains (1) summary
    cd04517
    Location:9180
    TLF; TBP-like factors (TLF; also called TLP, TRF, TRP), which are found in most metazoans. TLFs and TBPs have well-conserved core domains; however, they only share about 60% similarity. TLFs, like TBPs, interact with TFIIA and TFIIB, which are part of the ...
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