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GABARAPL1 GABA type A receptor associated protein like 1 [ Homo sapiens (human) ]

Gene ID: 23710, updated on 8-Jul-2021

Summary

Official Symbol
GABARAPL1provided by HGNC
Official Full Name
GABA type A receptor associated protein like 1provided by HGNC
Primary source
HGNC:HGNC:4068
See related
Ensembl:ENSG00000139112 MIM:607420
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
ATG8; GEC1; APG8L; ATG8B; ATG8L; APG8-LIKE
Expression
Broad expression in brain (RPKM 136.2), kidney (RPKM 101.2) and 23 other tissues See more
Orthologs
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Genomic context

See GABARAPL1 in Genome Data Viewer
Location:
12p13.2
Exon count:
4
Annotation release Status Assembly Chr Location
109.20210514 current GRCh38.p13 (GCF_000001405.39) 12 NC_000012.12 (10212877..10223128)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 12 NC_000012.11 (10365476..10375727)

Chromosome 12 - NC_000012.12Genomic Context describing neighboring genes Neighboring gene oxidized low density lipoprotein receptor 1 Neighboring gene transmembrane protein 52B Neighboring gene uncharacterized LOC107984509 Neighboring gene GABARAPL1 antisense RNA 1 Neighboring gene killer cell lectin like receptor D1 Neighboring gene uncharacterized LOC105369656 Neighboring gene long intergenic non-protein coding RNA 2617

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables GABA receptor binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables GABA receptor binding ISS
Inferred from Sequence or Structural Similarity
more info
 
enables Tat protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables beta-tubulin binding ISS
Inferred from Sequence or Structural Similarity
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables ubiquitin protein ligase binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables ubiquitin protein ligase binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
involved_in autophagosome assembly IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in autophagy of mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in cellular response to nitrogen starvation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in macroautophagy IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
located_in Golgi apparatus IEA
Inferred from Electronic Annotation
more info
 
is_active_in autophagosome IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in autophagosome IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in autophagosome membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in autophagosome membrane TAS
Traceable Author Statement
more info
 
located_in cell body IEA
Inferred from Electronic Annotation
more info
 
located_in cytoplasmic vesicle membrane IEA
Inferred from Electronic Annotation
more info
 
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in cytosol TAS
Traceable Author Statement
more info
 
located_in dendrite cytoplasm IEA
Inferred from Electronic Annotation
more info
 
located_in dendrite membrane IEA
Inferred from Electronic Annotation
more info
 
located_in endoplasmic reticulum IEA
Inferred from Electronic Annotation
more info
 
located_in microtubule IEA
Inferred from Electronic Annotation
more info
 
colocalizes_with mitochondrion IGI
Inferred from Genetic Interaction
more info
PubMed 

General protein information

Preferred Names
gamma-aminobutyric acid receptor-associated protein-like 1
Names
GABA(A) receptor-associated protein-like 1
early estrogen-regulated protein
glandular epithelial cell protein 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001363598.2NP_001350527.1  gamma-aminobutyric acid receptor-associated protein-like 1 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC115676, DC365706
    Consensus CDS
    CCDS86280.1
    Related
    ENSP00000411256.2, ENST00000421801.6
    Conserved Domains (1) summary
    cl28922
    Location:596
    Ubiquitin_like_fold; Beta-grasp ubiquitin-like fold
  2. NM_031412.4NP_113600.1  gamma-aminobutyric acid receptor-associated protein-like 1 isoform 2

    See identical proteins and their annotated locations for NP_113600.1

    Status: VALIDATED

    Source sequence(s)
    AC115676, BC028315
    Consensus CDS
    CCDS8620.1
    UniProtKB/Swiss-Prot
    Q9H0R8
    UniProtKB/TrEMBL
    A0A024RAP5
    Related
    ENSP00000266458.5, ENST00000266458.10
    Conserved Domains (1) summary
    cd16127
    Location:5111
    Ubl_ATG8_GABARAP_like; ubiquitin-like (Ubl) domain found in gamma-aminobutyric acid receptor-associated protein (GABARAP) and similar proteins; sub-family of the autophagy-related 8 (ATG8) protein family

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000012.12 Reference GRCh38.p13 Primary Assembly

    Range
    10212877..10223128
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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