Gabarapl1 gamma-aminobutyric acid (GABA) A receptor-associated protein-like 1 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Gabarapl1provided by MGI
Official Full Name: gamma-aminobutyric acid (GABA) A receptor-associated protein-like 1provided by MGI
Primary source: MGI:MGI:1914980
See related: Ensembl:ENSMUSG00000030161 AllianceGenome:MGI:1914980
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: GECI; Apg8l; Atg8l; MNCb-0091; 3110025G09Rik; 9130422N19Rik
Summary: Predicted to enable several functions, including GABA receptor binding activity; Tat protein binding activity; and ubiquitin protein ligase binding activity. Predicted to be involved in autophagosome assembly; autophagy of mitochondrion; and cellular response to nitrogen starvation. Predicted to act upstream of or within autophagy. Predicted to be located in several cellular components, including Golgi apparatus; cell body; and dendrite. Predicted to be active in autophagosome membrane and cytosol. Predicted to colocalize with mitochondrion. Is expressed in axial skeleton; ganglia; sensory organ; trigeminal nerve; and urinary system. Orthologous to human GABARAPL1 (GABA type A receptor associated protein like 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Broad expression in kidney adult (RPKM 281.6), cortex adult (RPKM 138.5) and 21 other tissues See more
Orthologs: human all
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Genomic context

Location:: 6; 6 F3

Exon count:: 4

Annotation release	Status	Assembly	Chr	Location
109	current	GRCm39 (GCF_000001635.27)	6	NC_000072.7 (129510155..129519294)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	6	NC_000072.6 (129533192..129542331)

Chromosome 6 - NC_000072.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Knockdown of p62 or GABARAPL1 reduced cell survival upon proteasome inhibition.
Title: Rapid induction of p62 and GABARAPL1 upon proteasome inhibition promotes survival before autophagy activation.
Cells that lacked GABARAPs and mice that lacked Gate-16 alone were defective in the IFN-gamma-induced clearance of vacuolar pathogens such as Toxoplasma. GABARAPs are uniquely required for antimicrobial host defense through cytosolic distribution of interferon-inducible GTPases.
Title: Essential role for GABARAP autophagy proteins in interferon-inducible GTPase-mediated host defense.
study of cerebral GABARAPL1 protein expression provides insight into its role in the development and homeostasis of the mouse brain
Title: Specific distribution of the autophagic protein GABARAPL1/GEC1 in the developing and adult mouse brain and identification of neuronal populations expressing GABARAPL1/GEC1.
analysis of specific functions of GABARAPL1 [review]
Title: GABARAPL1 (GEC1): original or copycat?
GABARAPL1 negatively regulates Wnt/beta-catenin signaling by mediating Dvl2 degradation through the autophagy pathway.
Title: GABARAPL1 negatively regulates Wnt/β-catenin signaling by mediating Dvl2 degradation through the autophagy pathway.
because of its stronger binding for hKOPR, GEC1 is able to be recruited by hKOPR sufficiently without membrane association via its C-terminal modification; however, du GABARAP appears to require C-terminal modifications to enhance KOPR expression.
Title: Effects of C-terminal modifications of GEC1 protein and gamma-aminobutyric acid type A (GABA(A)) receptor-associated protein (GABARAP), two microtubule-associated proteins, on kappa opioid receptor expression.
Expression of mouse Atg8L in HEK293 cells led to cleavage of its C-terminus. (Atg8L/Apg8l)and is the fourth modifier of mammalian Atg8 conjugation. (ATG8L/Apg8L)
Title: Atg8L/Apg8L is the fourth mammalian modifier of mammalian Atg8 conjugation mediated by human Atg4B, Atg7 and Atg3.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (3) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Homologs of the Gabarapl1 gene: The Gabarapl1 gene is conserved in human, chimpanzee, Rhesus monkey, dog, cow, rat, chicken, zebrafish, fruit fly, mosquito, C.elegans, S.cerevisiae, K.lactis, E.gossypii, S.pombe, M.oryzae, N.crassa, A.thaliana, and frog.
Orthologs from Annotation Pipeline: 287 organisms have orthologs with human gene Gabarapl1
Orthologs

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables GABA receptor binding	IBA Inferred from Biological aspect of Ancestor more info	PubMed
enables Tat protein binding	ISO Inferred from Sequence Orthology more info
enables cytoskeletal protein binding	ISA Inferred from Sequence Alignment more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein-membrane adaptor activity	ISO Inferred from Sequence Orthology more info	PubMed
enables ubiquitin protein ligase binding	IBA Inferred from Biological aspect of Ancestor more info	PubMed
enables ubiquitin protein ligase binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in autophagosome assembly	IBA Inferred from Biological aspect of Ancestor more info	PubMed
acts_upstream_of_or_within autophagy	IEA Inferred from Electronic Annotation more info
involved_in autophagy of mitochondrion	IBA Inferred from Biological aspect of Ancestor more info	PubMed
involved_in cellular response to nitrogen starvation	IBA Inferred from Biological aspect of Ancestor more info	PubMed
involved_in glycophagy	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in macroautophagy	IBA Inferred from Biological aspect of Ancestor more info	PubMed
involved_in substrate localization to autophagosome	ISO Inferred from Sequence Orthology more info	PubMed

Component	Evidence Code	Pubs
located_in Golgi apparatus	ISO Inferred from Sequence Orthology more info
is_active_in autophagosome	IBA Inferred from Biological aspect of Ancestor more info	PubMed
located_in autophagosome	ISO Inferred from Sequence Orthology more info	PubMed
is_active_in autophagosome membrane	IBA Inferred from Biological aspect of Ancestor more info	PubMed
located_in cell body	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in cytoplasmic vesicle	IEA Inferred from Electronic Annotation more info
located_in cytoskeleton	IEA Inferred from Electronic Annotation more info
is_active_in cytosol	IBA Inferred from Biological aspect of Ancestor more info	PubMed
located_in dendrite cytoplasm	ISO Inferred from Sequence Orthology more info
located_in dendrite membrane	ISO Inferred from Sequence Orthology more info
located_in endoplasmic reticulum	ISO Inferred from Sequence Orthology more info
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in microtubule	IEA Inferred from Electronic Annotation more info
colocalizes_with mitochondrion	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: gamma-aminobutyric acid receptor-associated protein-like 1

Names: GABA(A) receptor-associated protein like 1; GEC-1; glandular epithelial cell protein 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_020590.4 → NP_065615.1 gamma-aminobutyric acid receptor-associated protein-like 1

See identical proteins and their annotated locations for NP_065615.1

Status: PROVISIONAL

Source sequence(s)

AK018687

Consensus CDS

CCDS51923.1

UniProtKB/Swiss-Prot

Q8R3R8

UniProtKB/TrEMBL

A0A6P5PVK8, A0A8C6N4U1

Related

ENSMUSP00000032264.7, ENSMUST00000032264.9

Conserved Domains (1) summary

cd16127
Location:5 → 111

Ubl_ATG8_GABARAP_like; ubiquitin-like (Ubl) domain found in gamma-aminobutyric acid receptor-associated protein (GABARAP) and similar proteins; sub-family of the autophagy-related 8 (ATG8) protein family