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Gabarapl1 GABA type A receptor associated protein like 1 [ Mus musculus (house mouse) ]

Gene ID: 57436, updated on 1-Mar-2024

Summary

Official Symbol
Gabarapl1provided by MGI
Official Full Name
GABA type A receptor associated protein like 1provided by MGI
Primary source
MGI:MGI:1914980
See related
Ensembl:ENSMUSG00000030161 AllianceGenome:MGI:1914980
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
GECI; Apg8l; Atg8l; MNCb-0091; 3110025G09Rik; 9130422N19Rik
Summary
Predicted to enable several functions, including GABA receptor binding activity; Tat protein binding activity; and ubiquitin protein ligase binding activity. Predicted to be involved in autophagosome assembly; autophagy of mitochondrion; and cellular response to nitrogen starvation. Predicted to act upstream of or within autophagy. Predicted to be located in several cellular components, including Golgi apparatus; cell body; and dendrite. Predicted to be active in autophagosome membrane and cytosol. Predicted to colocalize with mitochondrion. Is expressed in axial skeleton; ganglia; sensory organ; trigeminal nerve; and urinary system. Orthologous to human GABARAPL1 (GABA type A receptor associated protein like 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in kidney adult (RPKM 281.6), cortex adult (RPKM 138.5) and 21 other tissues See more
Orthologs
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Genomic context

See Gabarapl1 in Genome Data Viewer
Location:
6 F3; 6 63.39 cM
Exon count:
4
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 6 NC_000072.7 (129510155..129519294)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 6 NC_000072.6 (129533192..129542331)

Chromosome 6 - NC_000072.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 45969 Neighboring gene oxidized low density lipoprotein (lectin-like) receptor 1 Neighboring gene transmembrane protein 52B Neighboring gene RIKEN cDNA 1700101I11 gene Neighboring gene STARR-positive B cell enhancer mm9_chr6:129481855-129482155 Neighboring gene STARR-positive B cell enhancer ABC_E10411 Neighboring gene killer cell lectin-like receptor family E member 1 Neighboring gene STARR-positive B cell enhancer mm9_chr6:129531448-129531748 Neighboring gene killer cell lectin-like receptor, subfamily D, member 1

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables GABA receptor binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables Tat protein binding ISO
Inferred from Sequence Orthology
more info
 
enables cytoskeletal protein binding ISA
Inferred from Sequence Alignment
more info
PubMed 
enables phosphatidylethanolamine binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables phospholipid binding ISO
Inferred from Sequence Orthology
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein-membrane adaptor activity ISO
Inferred from Sequence Orthology
more info
PubMed 
enables ubiquitin protein ligase binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables ubiquitin protein ligase binding ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
involved_in autophagosome assembly IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in autophagosome maturation IBA
Inferred from Biological aspect of Ancestor
more info
 
acts_upstream_of_or_within autophagy IEA
Inferred from Electronic Annotation
more info
 
involved_in autophagy of mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in cellular response to nitrogen starvation IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in glycophagy IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in substrate localization to autophagosome ISO
Inferred from Sequence Orthology
more info
PubMed 
Component Evidence Code Pubs
located_in Golgi apparatus IEA
Inferred from Electronic Annotation
more info
 
located_in autophagosome ISO
Inferred from Sequence Orthology
more info
PubMed 
is_active_in autophagosome membrane IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in cell body ISO
Inferred from Sequence Orthology
more info
 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 
located_in cytoplasmic vesicle IEA
Inferred from Electronic Annotation
more info
 
located_in cytoskeleton IEA
Inferred from Electronic Annotation
more info
 
located_in dendrite cytoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in dendrite membrane ISO
Inferred from Sequence Orthology
more info
 
located_in endoplasmic reticulum IEA
Inferred from Electronic Annotation
more info
 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
located_in microtubule IEA
Inferred from Electronic Annotation
more info
 
colocalizes_with mitochondrion ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
gamma-aminobutyric acid receptor-associated protein-like 1
Names
GABA(A) receptor-associated protein like 1
GEC-1
gamma-aminobutyric acid (GABA) A receptor-associated protein-like 1
glandular epithelial cell protein 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_020590.4NP_065615.1  gamma-aminobutyric acid receptor-associated protein-like 1

    See identical proteins and their annotated locations for NP_065615.1

    Status: PROVISIONAL

    Source sequence(s)
    AK018687
    Consensus CDS
    CCDS51923.1
    UniProtKB/Swiss-Prot
    Q3TG14, Q3TJB9, Q3TXZ5, Q8R3R8
    Related
    ENSMUSP00000032264.7, ENSMUST00000032264.9
    Conserved Domains (1) summary
    cd16127
    Location:5111
    Ubl_ATG8_GABARAP_like; ubiquitin-like (Ubl) domain found in gamma-aminobutyric acid receptor-associated protein (GABARAP) and similar proteins; sub-family of the autophagy-related 8 (ATG8) protein family

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000072.7 Reference GRCm39 C57BL/6J

    Range
    129510155..129519294
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)