Format

Send to:

Choose Destination

STX12 syntaxin 12 [ Homo sapiens (human) ]

Gene ID: 23673, updated on 15-Apr-2019

Summary

Official Symbol
STX12provided by HGNC
Official Full Name
syntaxin 12provided by HGNC
Primary source
HGNC:HGNC:11430
See related
Ensembl:ENSG00000117758 MIM:606892
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
STX13; STX14
Expression
Ubiquitous expression in thyroid (RPKM 63.8), fat (RPKM 35.7) and 25 other tissues See more
Orthologs

Genomic context

See STX12 in Genome Data Viewer
Location:
1p35.3
Exon count:
9
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 1 NC_000001.11 (27773183..27824452)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (28099694..28150963)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene RNA, U6 small nuclear 424, pseudogene Neighboring gene family with sequence similarity 76 member A Neighboring gene ribulose-5-phosphate-3-epimerase pseudogene 3 Neighboring gene RNA, U6 small nuclear 1245, pseudogene Neighboring gene protein phosphatase 1 regulatory subunit 8 Neighboring gene small Cajal body-specific RNA 1

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Pathways from BioSystems

  • Phagosome, organism-specific biosystem (from KEGG)
    Phagosome, organism-specific biosystemPhagocytosis is the process of taking in relatively large particles by a cell, and is a central mechanism in the tissue remodeling, inflammation, and defense against infectious agents. A phagosome is...
  • Phagosome, conserved biosystem (from KEGG)
    Phagosome, conserved biosystemPhagocytosis is the process of taking in relatively large particles by a cell, and is a central mechanism in the tissue remodeling, inflammation, and defense against infectious agents. A phagosome is...

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC51957

Gene Ontology Provided by GOA

Function Evidence Code Pubs
SNAP receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
SNARE binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
autophagosome assembly IMP
Inferred from Mutant Phenotype
more info
PubMed 
cholesterol efflux IDA
Inferred from Direct Assay
more info
PubMed 
intracellular protein transport IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein stabilization IDA
Inferred from Direct Assay
more info
PubMed 
vesicle docking IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
vesicle fusion IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
colocalizes_with BLOC-1 complex IDA
Inferred from Direct Assay
more info
PubMed 
Golgi membrane IEA
Inferred from Electronic Annotation
more info
 
SNARE complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
SNARE complex IDA
Inferred from Direct Assay
more info
PubMed 
early endosome membrane IEA
Inferred from Electronic Annotation
more info
 
endomembrane system IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
integral component of membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
integral component of synaptic vesicle membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
membrane raft IDA
Inferred from Direct Assay
more info
PubMed 
phagocytic vesicle IDA
Inferred from Direct Assay
more info
PubMed 
phagophore assembly site IMP
Inferred from Mutant Phenotype
more info
PubMed 
postsynaptic recycling endosome IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
recycling endosome membrane IEA
Inferred from Electronic Annotation
more info
 
synaptic vesicle IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
vesicle IMP
Inferred from Mutant Phenotype
more info
PubMed 

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_177424.3NP_803173.1  syntaxin-12

    See identical proteins and their annotated locations for NP_803173.1

    Status: VALIDATED

    Source sequence(s)
    AF070635, AL035306, BM148993
    Consensus CDS
    CCDS310.1
    UniProtKB/Swiss-Prot
    Q86Y82
    Related
    ENSP00000363054.4, ENST00000373943.9
    Conserved Domains (2) summary
    cd15876
    Location:181247
    SNARE_syntaxin12; SNARE motif of syntaxin 12
    pfam14523
    Location:30132
    Syntaxin_2; Syntaxin-like protein

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p12 Primary Assembly

    Range
    27773183..27824452
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Support Center