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Stx12 syntaxin 12 [ Mus musculus (house mouse) ]

Gene ID: 100226, updated on 6-May-2024

Summary

Official Symbol
Stx12provided by MGI
Official Full Name
syntaxin 12provided by MGI
Primary source
MGI:MGI:1931027
See related
Ensembl:ENSMUSG00000028879 AllianceGenome:MGI:1931027
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Stx13
Summary
Predicted to enable SNAP receptor activity and SNARE binding activity. Predicted to be involved in several processes, including cholesterol efflux; organelle fusion; and protein stabilization. Predicted to act upstream of or within protein transport. Predicted to be located in several cellular components, including membrane raft; phagocytic vesicle; and phagophore assembly site. Predicted to be part of BLOC-1 complex and SNARE complex. Predicted to be active in postsynaptic recycling endosome and synaptic vesicle. Predicted to be integral component of synaptic vesicle membrane. Is expressed in cranial ganglion; dorsal root ganglion; hindbrain; and sensory organ. Orthologous to human STX12 (syntaxin 12). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in CNS E18 (RPKM 53.2), whole brain E14.5 (RPKM 41.6) and 28 other tissues See more
Orthologs
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Genomic context

See Stx12 in Genome Data Viewer
Location:
4 D2.3; 4 66.01 cM
Exon count:
9
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (132581375..132611769, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (132854064..132884458, complement)

Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene thymocyte selection associated family member 2 Neighboring gene STARR-positive B cell enhancer ABC_E2125 Neighboring gene STARR-positive B cell enhancer ABC_E4675 Neighboring gene STARR-positive B cell enhancer ABC_E3521 Neighboring gene protein phosphatase 1, regulatory subunit 8 Neighboring gene CapStarr-seq enhancer MGSCv37_chr4:132399078-132399187 Neighboring gene CapStarr-seq enhancer MGSCv37_chr4:132399191-132399374 Neighboring gene predicted gene, 22767 Neighboring gene prostaglandin-endoperoxide synthase 2 pseudogene Neighboring gene family with sequence similarity 76, member A

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables SNAP receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables SNARE binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
involved_in autophagosome assembly IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in autophagosome assembly ISO
Inferred from Sequence Orthology
more info
 
involved_in cholesterol efflux ISO
Inferred from Sequence Orthology
more info
 
involved_in endocytic recycling ISO
Inferred from Sequence Orthology
more info
 
involved_in intracellular protein transport IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in protein stabilization ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within protein transport IEA
Inferred from Electronic Annotation
more info
 
involved_in regulation of postsynaptic membrane neurotransmitter receptor levels ISO
Inferred from Sequence Orthology
more info
 
involved_in synaptic vesicle to endosome fusion ISO
Inferred from Sequence Orthology
more info
 
involved_in vesicle docking IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in vesicle fusion IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in vesicle-mediated transport IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
part_of BLOC-1 complex ISO
Inferred from Sequence Orthology
more info
 
located_in Golgi apparatus ISO
Inferred from Sequence Orthology
more info
 
part_of SNARE complex IBA
Inferred from Biological aspect of Ancestor
more info
 
part_of SNARE complex ISO
Inferred from Sequence Orthology
more info
 
is_active_in endomembrane system IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in endosome IEA
Inferred from Electronic Annotation
more info
 
located_in intracellular membrane-bounded organelle ISO
Inferred from Sequence Orthology
more info
 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
located_in membrane raft ISO
Inferred from Sequence Orthology
more info
 
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in phagocytic vesicle ISO
Inferred from Sequence Orthology
more info
 
located_in phagophore assembly site ISO
Inferred from Sequence Orthology
more info
 
is_active_in postsynaptic endosome membrane ISO
Inferred from Sequence Orthology
more info
 
is_active_in postsynaptic recycling endosome IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in postsynaptic recycling endosome ISO
Inferred from Sequence Orthology
more info
 
located_in recycling endosome ISO
Inferred from Sequence Orthology
more info
 
is_active_in synaptic vesicle IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in synaptic vesicle ISO
Inferred from Sequence Orthology
more info
 
is_active_in synaptic vesicle membrane IBA
Inferred from Biological aspect of Ancestor
more info
 
is_active_in synaptic vesicle membrane ISO
Inferred from Sequence Orthology
more info
 
located_in synaptic vesicle membrane ISO
Inferred from Sequence Orthology
more info
 
located_in vesicle ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
syntaxin-12
Names
syntaxin 13

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_133887.5NP_598648.1  syntaxin-12

    See identical proteins and their annotated locations for NP_598648.1

    Status: VALIDATED

    Source sequence(s)
    AL671190
    Consensus CDS
    CCDS18737.1
    UniProtKB/Swiss-Prot
    Q3UIV9, Q921T9, Q9ER00
    UniProtKB/TrEMBL
    Q3TIL5
    Related
    ENSMUSP00000030698.5, ENSMUST00000030698.5
    Conserved Domains (3) summary
    cd00179
    Location:21164
    SynN; Syntaxin N-terminus domain; syntaxins are nervous system-specific proteins implicated in the docking of synaptic vesicles with the presynaptic plasma membrane; they are a family of receptors for intracellular transport vesicles; each target membrane may ...
    cd15876
    Location:181247
    SNARE_syntaxin12; SNARE motif of syntaxin 12
    pfam00804
    Location:26213
    Syntaxin; Syntaxin

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000070.7 Reference GRCm39 C57BL/6J

    Range
    132581375..132611769 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)