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PLXNB2 plexin B2 [ Homo sapiens (human) ]

Gene ID: 23654, updated on 17-Jun-2019

Summary

Official Symbol
PLXNB2provided by HGNC
Official Full Name
plexin B2provided by HGNC
Primary source
HGNC:HGNC:9104
See related
Ensembl:ENSG00000196576 MIM:604293
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
MM1; PLEXB2; Nbla00445; dJ402G11.3
Summary
Members of the B class of plexins, such as PLXNB2 are transmembrane receptors that participate in axon guidance and cell migration in response to semaphorins (Perrot et al. (2002) [PubMed 12183458]).[supplied by OMIM, Mar 2008]
Expression
Ubiquitous expression in kidney (RPKM 34.6), spleen (RPKM 29.9) and 25 other tissues See more
Orthologs

Genomic context

See PLXNB2 in Genome Data Viewer
Location:
22q13.33
Exon count:
40
Annotation release Status Assembly Chr Location
109.20190607 current GRCh38.p13 (GCF_000001405.39) 22 NC_000022.11 (50274979..50307646, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 22 NC_000022.10 (50713408..50746062, complement)

Chromosome 22 - NC_000022.11Genomic Context describing neighboring genes Neighboring gene mitogen-activated protein kinase 12 Neighboring gene mitogen-activated protein kinase 11 Neighboring gene uncharacterized LOC105373096 Neighboring gene DENN domain containing 6B Neighboring gene protein phosphatase 6 regulatory subunit 2 Neighboring gene RNA, 7SL, cytoplasmic 500, pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Phenotypes

NHGRI GWAS Catalog

Description
Genome-wide association study identifies three novel susceptibility loci for severe Acne vulgaris.
NHGRI GWA Catalog

Pathways from BioSystems

  • Axon guidance, organism-specific biosystem (from KEGG)
    Axon guidance, organism-specific biosystemAxon guidance represents a key stage in the formation of neuronal network. Axons are guided by a variety of guidance factors, such as netrins, ephrins, Slits, and semaphorins. These guidance cues are...
  • Axon guidance, conserved biosystem (from KEGG)
    Axon guidance, conserved biosystemAxon guidance represents a key stage in the formation of neuronal network. Axons are guided by a variety of guidance factors, such as netrins, ephrins, Slits, and semaphorins. These guidance cues are...

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • KIAA0315

Gene Ontology Provided by GOA

Function Evidence Code Pubs
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
semaphorin receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
semaphorin receptor activity ISS
Inferred from Sequence or Structural Similarity
more info
 
Process Evidence Code Pubs
brain development ISS
Inferred from Sequence or Structural Similarity
more info
 
excitatory synapse assembly ISS
Inferred from Sequence or Structural Similarity
more info
 
homophilic cell adhesion via plasma membrane adhesion molecules IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of cell adhesion IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
neural tube closure ISS
Inferred from Sequence or Structural Similarity
more info
 
neuroblast proliferation ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of axonogenesis IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
positive regulation of neuron projection development IDA
Inferred from Direct Assay
more info
PubMed 
regulation of GTPase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
regulation of GTPase activity ISS
Inferred from Sequence or Structural Similarity
more info
 
regulation of cell migration IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
regulation of cell shape IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
regulation of cell shape ISS
Inferred from Sequence or Structural Similarity
more info
 
regulation of neuron migration ISS
Inferred from Sequence or Structural Similarity
more info
 
regulation of protein phosphorylation ISS
Inferred from Sequence or Structural Similarity
more info
 
semaphorin-plexin signaling pathway ISS
Inferred from Sequence or Structural Similarity
more info
 
semaphorin-plexin signaling pathway involved in axon guidance IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
cell surface HDA PubMed 
extracellular exosome HDA PubMed 
integral component of plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
integral component of plasma membrane ISS
Inferred from Sequence or Structural Similarity
more info
 
semaphorin receptor complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_012401.4NP_036533.2  plexin-B2 precursor

    See identical proteins and their annotated locations for NP_036533.2

    Status: VALIDATED

    Source sequence(s)
    AB002313, AL022328, BC000221, BX649592, CT010163
    Consensus CDS
    CCDS43035.1
    UniProtKB/Swiss-Prot
    O15031
    Related
    ENSP00000352288.4, ENST00000359337.9
    Conserved Domains (6) summary
    cd11276
    Location:27467
    Sema_plexin_B2; The Sema domain, a protein interacting module, of Plexin B2
    cd01179
    Location:895981
    IPT_plexin_repeat2; Second repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT domain present ...
    cd01180
    Location:803894
    IPT_plexin_repeat1; First repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT domain present ...
    pfam01437
    Location:469517
    PSI; Plexin repeat
    pfam01833
    Location:9831091
    TIG; IPT/TIG domain
    pfam08337
    Location:12711805
    Plexin_cytopl; Plexin cytoplasmic RasGAP domain

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000022.11 Reference GRCh38.p13 Primary Assembly

    Range
    50274979..50307646 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006724413.2XP_006724476.1  plexin-B2 isoform X2

    See identical proteins and their annotated locations for XP_006724476.1

    UniProtKB/Swiss-Prot
    O15031
    Conserved Domains (6) summary
    cd11276
    Location:27467
    Sema_plexin_B2; The Sema domain, a protein interacting module, of Plexin B2
    cd01179
    Location:895981
    IPT_plexin_repeat2; Second repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT domain present ...
    cd01180
    Location:803894
    IPT_plexin_repeat1; First repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT domain present ...
    pfam01437
    Location:469517
    PSI; Plexin repeat
    pfam01833
    Location:9831091
    TIG; IPT/TIG domain
    pfam08337
    Location:12711805
    Plexin_cytopl; Plexin cytoplasmic RasGAP domain
  2. XM_005261911.4XP_005261968.1  plexin-B2 isoform X2

    See identical proteins and their annotated locations for XP_005261968.1

    UniProtKB/Swiss-Prot
    O15031
    Conserved Domains (6) summary
    cd11276
    Location:27467
    Sema_plexin_B2; The Sema domain, a protein interacting module, of Plexin B2
    cd01179
    Location:895981
    IPT_plexin_repeat2; Second repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT domain present ...
    cd01180
    Location:803894
    IPT_plexin_repeat1; First repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT domain present ...
    pfam01437
    Location:469517
    PSI; Plexin repeat
    pfam01833
    Location:9831091
    TIG; IPT/TIG domain
    pfam08337
    Location:12711805
    Plexin_cytopl; Plexin cytoplasmic RasGAP domain
  3. XM_005261909.1XP_005261966.1  plexin-B2 isoform X2

    See identical proteins and their annotated locations for XP_005261966.1

    UniProtKB/Swiss-Prot
    O15031
    Related
    ENSP00000409171.1, ENST00000449103.5
    Conserved Domains (6) summary
    cd11276
    Location:27467
    Sema_plexin_B2; The Sema domain, a protein interacting module, of Plexin B2
    cd01179
    Location:895981
    IPT_plexin_repeat2; Second repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT domain present ...
    cd01180
    Location:803894
    IPT_plexin_repeat1; First repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT domain present ...
    pfam01437
    Location:469517
    PSI; Plexin repeat
    pfam01833
    Location:9831091
    TIG; IPT/TIG domain
    pfam08337
    Location:12711805
    Plexin_cytopl; Plexin cytoplasmic RasGAP domain
  4. XM_017028703.1XP_016884192.1  plexin-B2 isoform X2

    UniProtKB/Swiss-Prot
    O15031
    Conserved Domains (6) summary
    cd11276
    Location:27467
    Sema_plexin_B2; The Sema domain, a protein interacting module, of Plexin B2
    cd01179
    Location:895981
    IPT_plexin_repeat2; Second repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT domain present ...
    cd01180
    Location:803894
    IPT_plexin_repeat1; First repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT domain present ...
    pfam01437
    Location:469517
    PSI; Plexin repeat
    pfam01833
    Location:9831091
    TIG; IPT/TIG domain
    pfam08337
    Location:12711805
    Plexin_cytopl; Plexin cytoplasmic RasGAP domain
  5. XM_011530682.2XP_011528984.1  plexin-B2 isoform X1

    Conserved Domains (6) summary
    cd11276
    Location:90530
    Sema_plexin_B2; The Sema domain, a protein interacting module, of Plexin B2
    cd01179
    Location:9581044
    IPT_plexin_repeat2; Second repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT domain present ...
    cd01180
    Location:866957
    IPT_plexin_repeat1; First repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT domain present ...
    pfam01437
    Location:532580
    PSI; Plexin repeat
    pfam01833
    Location:10461154
    TIG; IPT/TIG domain
    pfam08337
    Location:13341868
    Plexin_cytopl; Plexin cytoplasmic RasGAP domain
  6. XM_017028704.2XP_016884193.1  plexin-B2 isoform X2

    UniProtKB/Swiss-Prot
    O15031
    Conserved Domains (6) summary
    cd11276
    Location:27467
    Sema_plexin_B2; The Sema domain, a protein interacting module, of Plexin B2
    cd01179
    Location:895981
    IPT_plexin_repeat2; Second repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT domain present ...
    cd01180
    Location:803894
    IPT_plexin_repeat1; First repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT domain present ...
    pfam01437
    Location:469517
    PSI; Plexin repeat
    pfam01833
    Location:9831091
    TIG; IPT/TIG domain
    pfam08337
    Location:12711805
    Plexin_cytopl; Plexin cytoplasmic RasGAP domain
  7. XM_005261910.3XP_005261967.1  plexin-B2 isoform X2

    See identical proteins and their annotated locations for XP_005261967.1

    UniProtKB/Swiss-Prot
    O15031
    Conserved Domains (6) summary
    cd11276
    Location:27467
    Sema_plexin_B2; The Sema domain, a protein interacting module, of Plexin B2
    cd01179
    Location:895981
    IPT_plexin_repeat2; Second repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT domain present ...
    cd01180
    Location:803894
    IPT_plexin_repeat1; First repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT domain present ...
    pfam01437
    Location:469517
    PSI; Plexin repeat
    pfam01833
    Location:9831091
    TIG; IPT/TIG domain
    pfam08337
    Location:12711805
    Plexin_cytopl; Plexin cytoplasmic RasGAP domain

RNA

  1. XR_002958678.1 RNA Sequence

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