Plxnb2 plexin B2 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Plxnb2provided by MGI
Official Full Name: plexin B2provided by MGI
Primary source: MGI:MGI:2154239
See related: Ensembl:ENSMUSG00000036606 AllianceGenome:MGI:2154239
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Debt; plexin-B2
Summary: Enables semaphorin receptor activity. Involved in several processes, including nervous system development; regulation of neuron migration; and semaphorin-plexin signaling pathway. Acts upstream of or within positive regulation of axonogenesis. Located in plasma membrane. Is expressed in several structures, including alimentary system; brain; genitourinary system; respiratory system; and sensory organ. Orthologous to human PLXNB2 (plexin B2). [provided by Alliance of Genome Resources, Jul 2025]
Expression: Ubiquitous expression in colon adult (RPKM 85.9), ovary adult (RPKM 65.3) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 15 E3; 15 44.68 cM

Exon count:: 41

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	15	NC_000081.7 (89039752..89064960, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	15	NC_000081.6 (89155546..89182018, complement)

Chromosome 15 - NC_000081.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

In vivo interaction screening reveals liver-derived constraints to metastasis.
Title: In vivo interaction screening reveals liver-derived constraints to metastasis.
Astrocyte-to-microglia communication via Sema4B-Plexin-B2 modulates injury-induced reactivity of microglia.
Title: Astrocyte-to-microglia communication via Sema4B-Plexin-B2 modulates injury-induced reactivity of microglia.
Mutated axon guidance gene PLXNB2 sustains growth and invasiveness of stem cells isolated from cancers of unknown primary.
Title: Mutated axon guidance gene PLXNB2 sustains growth and invasiveness of stem cells isolated from cancers of unknown primary.
Glial receptor PLXNB2 regulates schizophrenia-related stress perception via the amygdala.
Title: Glial receptor PLXNB2 regulates schizophrenia-related stress perception via the amygdala.
Plexin-B2 controls the timing of differentiation and the motility of cerebellar granule neurons.
Title: Plexin-B2 controls the timing of differentiation and the motility of cerebellar granule neurons.
The impact of Semaphorin 4C/Plexin-B2 signaling on fear memory via remodeling of neuronal and synaptic morphology.
Title: The impact of Semaphorin 4C/Plexin-B2 signaling on fear memory via remodeling of neuronal and synaptic morphology.
Osteoclasts protect bone blood vessels against senescence through the angiogenin/plexin-B2 axis.
Title: Osteoclasts protect bone blood vessels against senescence through the angiogenin/plexin-B2 axis.
Myeloid cells protect intestinal epithelial barrier integrity through the angiogenin/plexin-B2 axis.
Title: Myeloid cells protect intestinal epithelial barrier integrity through the angiogenin/plexin-B2 axis.
Plexin B2 Is a Regulator of Monocyte Apoptotic Cell Disassembly.
Title: Plexin B2 Is a Regulator of Monocyte Apoptotic Cell Disassembly.
Plexin-B2 as an important link that integrates biochemical cues and physical interactions of injury-activated microglia and with the injury microenvironment during wound healing
Title: Microglia and macrophages promote corralling, wound compaction and recovery after spinal cord injury via Plexin-B2.

Submit: New GeneRIF Correction See all GeneRIFs (26)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Chemically induced (ENU) (1)
Endonuclease-mediated (2) 1 citation
Gene trapped (1)
Targeted (5) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Plxnb2 (e-PCR), detects polymorphism
- UniSTS:525265

BB195788 (e-PCR)
- UniSTS:209128

Debt (e-PCR), detects polymorphism
- UniSTS:142842

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables semaphorin receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables semaphorin receptor activity	IEA Inferred from Electronic Annotation more info
enables semaphorin receptor activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables signaling receptor activity	IEA Inferred from Electronic Annotation more info
enables signaling receptor activity	ISO Inferred from Sequence Orthology more info
enables transmembrane signaling receptor activity	IDA Inferred from Direct Assay more info	PubMed
enables transmembrane signaling receptor activity	IEA Inferred from Electronic Annotation more info
enables transmembrane signaling receptor activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in brain development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within cellular response to stress	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within cytoplasmic translation	ISO Inferred from Sequence Orthology more info
involved_in excitatory synapse assembly	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in homophilic cell adhesion via plasma membrane adhesion molecules	IEA Inferred from Electronic Annotation more info
involved_in homophilic cell adhesion via plasma membrane adhesion molecules	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of cell adhesion	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within negative regulation of translation in response to stress	ISO Inferred from Sequence Orthology more info
involved_in neural tube closure	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in neuroblast proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of axonogenesis	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within positive regulation of axonogenesis	IGI Inferred from Genetic Interaction more info	PubMed
involved_in positive regulation of cell projection organization	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of neuron projection development	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of neuron projection development	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of translation	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of translation	ISO Inferred from Sequence Orthology more info
involved_in receptor-mediated endocytosis	IEA Inferred from Electronic Annotation more info
involved_in receptor-mediated endocytosis	ISO Inferred from Sequence Orthology more info
involved_in regulation of GTPase activity	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of cell migration	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of cell shape	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of cell shape	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of neuron migration	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of neuron projection development	IEA Inferred from Electronic Annotation more info
involved_in regulation of protein metabolic process	IEA Inferred from Electronic Annotation more info
involved_in regulation of protein phosphorylation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in semaphorin-plexin signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in semaphorin-plexin signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in semaphorin-plexin signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in synapse assembly	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within tRNA stabilization	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in extracellular matrix	HDA more info	PubMed
located_in membrane	IEA Inferred from Electronic Annotation more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed
is_active_in plasma membrane	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info
is_active_in plasma membrane	ISO Inferred from Sequence Orthology more info
part_of semaphorin receptor complex	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: plexin-B2

Names: differentially expressed in brain tumors

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001159521.3 → NP_001152993.1 plexin-B2 isoform 1 precursor

See identical proteins and their annotated locations for NP_001152993.1

Status: VALIDATED

Description

Transcript Variant: This variant (1) represents the longest transcript. Variants 1-3 encode the same protein.

Source sequence(s)

AC113069, AC160538

Consensus CDS

CCDS49698.1

UniProtKB/Swiss-Prot

B2RXS4, Q3UH76

Conserved Domains (7) summary

cd01179
Location:898 → 984

IPT_plexin_repeat2; Second repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT domain present ...

cd01180
Location:806 → 897

IPT_plexin_repeat1; First repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT domain present ...

pfam01437
Location:471 → 519

PSI; Plexin repeat

pfam08337
Location:1275 → 1809

Plexin_cytopl; Plexin cytoplasmic RasGAP domain

pfam17960
Location:528 → 615

TIG_plexin; TIG domain

cl15674
Location:986 → 1069

IPT; Immunoglobulin-like fold, Plexins, Transcription factors (IPT). IPTs are also known as Transcription factor ImmunoGlobin (TIG) domains. They are present in intracellular transcription factors, cell surface receptors (such as plexins and scatter factor ...

cl15693
Location:27 → 469

Sema; The Sema domain, a protein interacting module, of semaphorins and plexins
NM_001284506.2 → NP_001271435.1 plexin-B2 isoform 1 precursor

See identical proteins and their annotated locations for NP_001271435.1

Status: VALIDATED

Description

Transcript Variant: This variant (3) differs in the 5' UTR, compared to variant 1. Variants 1-3 encode the same protein.

Source sequence(s)

AC113069, AC160538

Consensus CDS

CCDS49698.1

UniProtKB/Swiss-Prot

B2RXS4, Q3UH76

Related

ENSMUSP00000051731.10, ENSMUST00000060808.10

Conserved Domains (7) summary

cd01179
Location:898 → 984

IPT_plexin_repeat2; Second repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT domain present ...

cd01180
Location:806 → 897

IPT_plexin_repeat1; First repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT domain present ...

pfam01437
Location:471 → 519

PSI; Plexin repeat

pfam08337
Location:1275 → 1809

Plexin_cytopl; Plexin cytoplasmic RasGAP domain

pfam17960
Location:528 → 615

TIG_plexin; TIG domain

cl15674
Location:986 → 1069

IPT; Immunoglobulin-like fold, Plexins, Transcription factors (IPT). IPTs are also known as Transcription factor ImmunoGlobin (TIG) domains. They are present in intracellular transcription factors, cell surface receptors (such as plexins and scatter factor ...

cl15693
Location:27 → 469

Sema; The Sema domain, a protein interacting module, of semaphorins and plexins
NM_001416425.1 → NP_001403354.1 plexin-B2 isoform 1 precursor

Status: VALIDATED

Source sequence(s)

AC113069, AC160538

UniProtKB/Swiss-Prot

B2RXS4, Q3UH76
NM_001416426.1 → NP_001403355.1 plexin-B2 isoform 1 precursor

Status: VALIDATED

Source sequence(s)

AC113069, AC160538

UniProtKB/Swiss-Prot

B2RXS4, Q3UH76
NM_001416427.1 → NP_001403356.1 plexin-B2 isoform 1 precursor

Status: VALIDATED

Source sequence(s)

AC113069, AC160538

UniProtKB/Swiss-Prot

B2RXS4, Q3UH76
NM_001416428.1 → NP_001403357.1 plexin-B2 isoform 1 precursor

Status: VALIDATED

Source sequence(s)

AC113069, AC160538

UniProtKB/Swiss-Prot

B2RXS4, Q3UH76
NM_001416429.1 → NP_001403358.1 plexin-B2 isoform 1 precursor

Status: VALIDATED

Source sequence(s)

AC113069, AC160538

UniProtKB/Swiss-Prot

B2RXS4, Q3UH76
NM_001416430.1 → NP_001403359.1 plexin-B2 isoform 1 precursor

Status: VALIDATED

Source sequence(s)

AC113069, AC160538

UniProtKB/Swiss-Prot

B2RXS4, Q3UH76
NM_001416431.1 → NP_001403360.1 plexin-B2 isoform 1 precursor

Status: VALIDATED

Source sequence(s)

AC113069, AC160538

UniProtKB/Swiss-Prot

B2RXS4, Q3UH76
NM_001416432.1 → NP_001403361.1 plexin-B2 isoform 1 precursor

Status: VALIDATED

Source sequence(s)

AC113069

UniProtKB/Swiss-Prot

B2RXS4, Q3UH76
NM_001416433.1 → NP_001403362.1 plexin-B2 isoform 1 precursor

Status: VALIDATED

Source sequence(s)

AC113069

UniProtKB/Swiss-Prot

B2RXS4, Q3UH76
NM_001416434.1 → NP_001403363.1 plexin-B2 isoform 1 precursor

Status: VALIDATED

Source sequence(s)

AC113069

UniProtKB/Swiss-Prot

B2RXS4, Q3UH76
NM_001416435.1 → NP_001403364.1 plexin-B2 isoform 2 precursor

Status: VALIDATED

Source sequence(s)

AC113069, AC160538
NM_001416436.1 → NP_001403365.1 plexin-B2 isoform 3 precursor

Status: VALIDATED

Source sequence(s)

AC113069, AC160538
NM_001416437.1 → NP_001403366.1 plexin-B2 isoform 4 precursor

Status: VALIDATED

Source sequence(s)

AC113069, AC160538
NM_138749.4 → NP_620088.2 plexin-B2 isoform 1 precursor

See identical proteins and their annotated locations for NP_620088.2

Status: VALIDATED

Description

Transcript Variant: This variant (2) differs in the 5' UTR, compared to variant 1. Variants 1-3 encode the same protein.

Source sequence(s)

AC113069, AC160538

Consensus CDS

CCDS49698.1

UniProtKB/Swiss-Prot

B2RXS4, Q3UH76

Related

ENSMUSP00000104955.2, ENSMUST00000109331.9

Conserved Domains (7) summary

cd01179
Location:898 → 984

IPT_plexin_repeat2; Second repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT domain present ...

cd01180
Location:806 → 897

IPT_plexin_repeat1; First repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT domain present ...

pfam01437
Location:471 → 519

PSI; Plexin repeat

pfam08337
Location:1275 → 1809

Plexin_cytopl; Plexin cytoplasmic RasGAP domain

pfam17960
Location:528 → 615

TIG_plexin; TIG domain

cl15674
Location:986 → 1069

IPT; Immunoglobulin-like fold, Plexins, Transcription factors (IPT). IPTs are also known as Transcription factor ImmunoGlobin (TIG) domains. They are present in intracellular transcription factors, cell surface receptors (such as plexins and scatter factor ...

cl15693
Location:27 → 469

Sema; The Sema domain, a protein interacting module, of semaphorins and plexins

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000081.7 Reference GRCm39 C57BL/6J

Range

89039752..89064960 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_030248318.2 → XP_030104178.1 plexin-B2 isoform X1

UniProtKB/Swiss-Prot

B2RXS4, Q3UH76

Conserved Domains (7) summary

cd01179
Location:898 → 984

IPT_plexin_repeat2; Second repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT domain present ...

cd01180
Location:806 → 897

IPT_plexin_repeat1; First repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT domain present ...

pfam01437
Location:471 → 519

PSI; Plexin repeat

pfam08337
Location:1275 → 1809

Plexin_cytopl; Plexin cytoplasmic RasGAP domain

pfam17960
Location:528 → 615

TIG_plexin; TIG domain

cl15674
Location:986 → 1069

IPT; Immunoglobulin-like fold, Plexins, Transcription factors (IPT). IPTs are also known as Transcription factor ImmunoGlobin (TIG) domains. They are present in intracellular transcription factors, cell surface receptors (such as plexins and scatter factor ...

cl15693
Location:27 → 469

Sema; The Sema domain, a protein interacting module, of semaphorins and plexins