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Plxnb2 plexin B2 [ Mus musculus (house mouse) ]

Gene ID: 140570, updated on 5-Jul-2025
Official Symbol
Plxnb2provided by MGI
Official Full Name
plexin B2provided by MGI
Primary source
MGI:MGI:2154239
See related
Ensembl:ENSMUSG00000036606 AllianceGenome:MGI:2154239
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Debt; plexin-B2
Summary
Enables semaphorin receptor activity. Involved in several processes, including nervous system development; regulation of neuron migration; and semaphorin-plexin signaling pathway. Acts upstream of or within positive regulation of axonogenesis. Located in plasma membrane. Is expressed in several structures, including alimentary system; brain; genitourinary system; respiratory system; and sensory organ. Orthologous to human PLXNB2 (plexin B2). [provided by Alliance of Genome Resources, Jul 2025]
Expression
Ubiquitous expression in colon adult (RPKM 85.9), ovary adult (RPKM 65.3) and 28 other tissues See more
Orthologs
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See Plxnb2 in Genome Data Viewer
Location:
15 E3; 15 44.68 cM
Exon count:
41
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 15 NC_000081.7 (89039752..89064960, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 15 NC_000081.6 (89155546..89182018, complement)

Chromosome 15 - NC_000081.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E8605 Neighboring gene mitogen-activated protein kinase 12 Neighboring gene mitogen-activated protein kinase 11 Neighboring gene microRNA 7118 Neighboring gene STARR-seq mESC enhancer starr_39459 Neighboring gene DENN domain containing 6B Neighboring gene microRNA 6958 Neighboring gene STARR-positive B cell enhancer ABC_E3151 Neighboring gene STARR-positive B cell enhancer ABC_E4146 Neighboring gene protein phosphatase 6, regulatory subunit 2 Neighboring gene SET binding factor 1

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Chemically induced (ENU) (1) 
  • Endonuclease-mediated (2)  1 citation
  • Gene trapped (1) 
  • Targeted (5)  1 citation
Products Interactant Other Gene Complex Source Pubs Description

Markers

Clone Names

  • mKIAA0315, 1110007H23Rik

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables semaphorin receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables semaphorin receptor activity IEA
Inferred from Electronic Annotation
more info
 
enables semaphorin receptor activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables signaling receptor activity IEA
Inferred from Electronic Annotation
more info
 
enables signaling receptor activity ISO
Inferred from Sequence Orthology
more info
 
enables transmembrane signaling receptor activity IDA
Inferred from Direct Assay
more info
PubMed 
enables transmembrane signaling receptor activity IEA
Inferred from Electronic Annotation
more info
 
enables transmembrane signaling receptor activity ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
involved_in brain development IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within cellular response to stress ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within cytoplasmic translation ISO
Inferred from Sequence Orthology
more info
 
involved_in excitatory synapse assembly IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in homophilic cell adhesion via plasma membrane adhesion molecules IEA
Inferred from Electronic Annotation
more info
 
involved_in homophilic cell adhesion via plasma membrane adhesion molecules ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of cell adhesion IBA
Inferred from Biological aspect of Ancestor
more info
 
acts_upstream_of_or_within negative regulation of translation in response to stress ISO
Inferred from Sequence Orthology
more info
 
involved_in neural tube closure IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in neuroblast proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of axonogenesis IBA
Inferred from Biological aspect of Ancestor
more info
 
acts_upstream_of_or_within positive regulation of axonogenesis IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in positive regulation of cell projection organization IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of neuron projection development IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of neuron projection development ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of translation IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of translation ISO
Inferred from Sequence Orthology
more info
 
involved_in receptor-mediated endocytosis IEA
Inferred from Electronic Annotation
more info
 
involved_in receptor-mediated endocytosis ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of GTPase activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of cell migration IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in regulation of cell shape IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in regulation of cell shape IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of neuron migration IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of neuron projection development IEA
Inferred from Electronic Annotation
more info
 
involved_in regulation of protein metabolic process IEA
Inferred from Electronic Annotation
more info
 
involved_in regulation of protein phosphorylation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in semaphorin-plexin signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in semaphorin-plexin signaling pathway IEA
Inferred from Electronic Annotation
more info
 
involved_in semaphorin-plexin signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in synapse assembly IBA
Inferred from Biological aspect of Ancestor
more info
 
acts_upstream_of_or_within tRNA stabilization ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
located_in extracellular matrix HDA PubMed 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in plasma membrane IEA
Inferred from Electronic Annotation
more info
 
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
 
is_active_in plasma membrane ISO
Inferred from Sequence Orthology
more info
 
part_of semaphorin receptor complex IBA
Inferred from Biological aspect of Ancestor
more info
 
Preferred Names
plexin-B2
Names
differentially expressed in brain tumors

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001159521.3NP_001152993.1  plexin-B2 isoform 1 precursor

    See identical proteins and their annotated locations for NP_001152993.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript. Variants 1-3 encode the same protein.
    Source sequence(s)
    AC113069, AC160538
    Consensus CDS
    CCDS49698.1
    UniProtKB/Swiss-Prot
    B2RXS4, Q3UH76
    Conserved Domains (7) summary
    cd01179
    Location:898984
    IPT_plexin_repeat2; Second repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT domain present ...
    cd01180
    Location:806897
    IPT_plexin_repeat1; First repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT domain present ...
    pfam01437
    Location:471519
    PSI; Plexin repeat
    pfam08337
    Location:12751809
    Plexin_cytopl; Plexin cytoplasmic RasGAP domain
    pfam17960
    Location:528615
    TIG_plexin; TIG domain
    cl15674
    Location:9861069
    IPT; Immunoglobulin-like fold, Plexins, Transcription factors (IPT). IPTs are also known as Transcription factor ImmunoGlobin (TIG) domains. They are present in intracellular transcription factors, cell surface receptors (such as plexins and scatter factor ...
    cl15693
    Location:27469
    Sema; The Sema domain, a protein interacting module, of semaphorins and plexins
  2. NM_001284506.2NP_001271435.1  plexin-B2 isoform 1 precursor

    See identical proteins and their annotated locations for NP_001271435.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR, compared to variant 1. Variants 1-3 encode the same protein.
    Source sequence(s)
    AC113069, AC160538
    Consensus CDS
    CCDS49698.1
    UniProtKB/Swiss-Prot
    B2RXS4, Q3UH76
    Related
    ENSMUSP00000051731.10, ENSMUST00000060808.10
    Conserved Domains (7) summary
    cd01179
    Location:898984
    IPT_plexin_repeat2; Second repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT domain present ...
    cd01180
    Location:806897
    IPT_plexin_repeat1; First repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT domain present ...
    pfam01437
    Location:471519
    PSI; Plexin repeat
    pfam08337
    Location:12751809
    Plexin_cytopl; Plexin cytoplasmic RasGAP domain
    pfam17960
    Location:528615
    TIG_plexin; TIG domain
    cl15674
    Location:9861069
    IPT; Immunoglobulin-like fold, Plexins, Transcription factors (IPT). IPTs are also known as Transcription factor ImmunoGlobin (TIG) domains. They are present in intracellular transcription factors, cell surface receptors (such as plexins and scatter factor ...
    cl15693
    Location:27469
    Sema; The Sema domain, a protein interacting module, of semaphorins and plexins
  3. NM_001416425.1NP_001403354.1  plexin-B2 isoform 1 precursor

    Status: VALIDATED

    Source sequence(s)
    AC113069, AC160538
    UniProtKB/Swiss-Prot
    B2RXS4, Q3UH76
  4. NM_001416426.1NP_001403355.1  plexin-B2 isoform 1 precursor

    Status: VALIDATED

    Source sequence(s)
    AC113069, AC160538
    UniProtKB/Swiss-Prot
    B2RXS4, Q3UH76
  5. NM_001416427.1NP_001403356.1  plexin-B2 isoform 1 precursor

    Status: VALIDATED

    Source sequence(s)
    AC113069, AC160538
    UniProtKB/Swiss-Prot
    B2RXS4, Q3UH76
  6. NM_001416428.1NP_001403357.1  plexin-B2 isoform 1 precursor

    Status: VALIDATED

    Source sequence(s)
    AC113069, AC160538
    UniProtKB/Swiss-Prot
    B2RXS4, Q3UH76
  7. NM_001416429.1NP_001403358.1  plexin-B2 isoform 1 precursor

    Status: VALIDATED

    Source sequence(s)
    AC113069, AC160538
    UniProtKB/Swiss-Prot
    B2RXS4, Q3UH76
  8. NM_001416430.1NP_001403359.1  plexin-B2 isoform 1 precursor

    Status: VALIDATED

    Source sequence(s)
    AC113069, AC160538
    UniProtKB/Swiss-Prot
    B2RXS4, Q3UH76
  9. NM_001416431.1NP_001403360.1  plexin-B2 isoform 1 precursor

    Status: VALIDATED

    Source sequence(s)
    AC113069, AC160538
    UniProtKB/Swiss-Prot
    B2RXS4, Q3UH76
  10. NM_001416432.1NP_001403361.1  plexin-B2 isoform 1 precursor

    Status: VALIDATED

    Source sequence(s)
    AC113069
    UniProtKB/Swiss-Prot
    B2RXS4, Q3UH76
  11. NM_001416433.1NP_001403362.1  plexin-B2 isoform 1 precursor

    Status: VALIDATED

    Source sequence(s)
    AC113069
    UniProtKB/Swiss-Prot
    B2RXS4, Q3UH76
  12. NM_001416434.1NP_001403363.1  plexin-B2 isoform 1 precursor

    Status: VALIDATED

    Source sequence(s)
    AC113069
    UniProtKB/Swiss-Prot
    B2RXS4, Q3UH76
  13. NM_001416435.1NP_001403364.1  plexin-B2 isoform 2 precursor

    Status: VALIDATED

    Source sequence(s)
    AC113069, AC160538
  14. NM_001416436.1NP_001403365.1  plexin-B2 isoform 3 precursor

    Status: VALIDATED

    Source sequence(s)
    AC113069, AC160538
  15. NM_001416437.1NP_001403366.1  plexin-B2 isoform 4 precursor

    Status: VALIDATED

    Source sequence(s)
    AC113069, AC160538
  16. NM_138749.4NP_620088.2  plexin-B2 isoform 1 precursor

    See identical proteins and their annotated locations for NP_620088.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR, compared to variant 1. Variants 1-3 encode the same protein.
    Source sequence(s)
    AC113069, AC160538
    Consensus CDS
    CCDS49698.1
    UniProtKB/Swiss-Prot
    B2RXS4, Q3UH76
    Related
    ENSMUSP00000104955.2, ENSMUST00000109331.9
    Conserved Domains (7) summary
    cd01179
    Location:898984
    IPT_plexin_repeat2; Second repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT domain present ...
    cd01180
    Location:806897
    IPT_plexin_repeat1; First repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT domain present ...
    pfam01437
    Location:471519
    PSI; Plexin repeat
    pfam08337
    Location:12751809
    Plexin_cytopl; Plexin cytoplasmic RasGAP domain
    pfam17960
    Location:528615
    TIG_plexin; TIG domain
    cl15674
    Location:9861069
    IPT; Immunoglobulin-like fold, Plexins, Transcription factors (IPT). IPTs are also known as Transcription factor ImmunoGlobin (TIG) domains. They are present in intracellular transcription factors, cell surface receptors (such as plexins and scatter factor ...
    cl15693
    Location:27469
    Sema; The Sema domain, a protein interacting module, of semaphorins and plexins

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000081.7 Reference GRCm39 C57BL/6J

    Range
    89039752..89064960 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_030248318.2XP_030104178.1  plexin-B2 isoform X1

    UniProtKB/Swiss-Prot
    B2RXS4, Q3UH76
    Conserved Domains (7) summary
    cd01179
    Location:898984
    IPT_plexin_repeat2; Second repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT domain present ...
    cd01180
    Location:806897
    IPT_plexin_repeat1; First repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT domain present ...
    pfam01437
    Location:471519
    PSI; Plexin repeat
    pfam08337
    Location:12751809
    Plexin_cytopl; Plexin cytoplasmic RasGAP domain
    pfam17960
    Location:528615
    TIG_plexin; TIG domain
    cl15674
    Location:9861069
    IPT; Immunoglobulin-like fold, Plexins, Transcription factors (IPT). IPTs are also known as Transcription factor ImmunoGlobin (TIG) domains. They are present in intracellular transcription factors, cell surface receptors (such as plexins and scatter factor ...
    cl15693
    Location:27469
    Sema; The Sema domain, a protein interacting module, of semaphorins and plexins