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RABGAP1 RAB GTPase activating protein 1 [ Homo sapiens (human) ]

Gene ID: 23637, updated on 4-Jul-2021

Summary

Official Symbol
RABGAP1provided by HGNC
Official Full Name
RAB GTPase activating protein 1provided by HGNC
Primary source
HGNC:HGNC:17155
See related
Ensembl:ENSG00000011454 MIM:615882
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
GAPCENA; TBC1D11
Expression
Ubiquitous expression in thyroid (RPKM 21.8), brain (RPKM 18.2) and 25 other tissues See more
Orthologs
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Genomic context

See RABGAP1 in Genome Data Viewer
Location:
9q33.2-q33.3
Exon count:
32
Annotation release Status Assembly Chr Location
109.20210514 current GRCh38.p13 (GCF_000001405.39) 9 NC_000009.12 (122931640..123104869)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 9 NC_000009.11 (125703299..125867145)

Chromosome 9 - NC_000009.12Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105379839 Neighboring gene zinc finger and BTB domain containing 6 Neighboring gene zinc finger and BTB domain containing 26 Neighboring gene RNY1 pseudogene 15 Neighboring gene ribosomal protein S25 pseudogene 8 Neighboring gene COP9 signalosome subunit 2 pseudogene Neighboring gene G protein-coupled receptor 21 Neighboring gene MIR600 host gene Neighboring gene microRNA 600 Neighboring gene spermatid perinuclear RNA binding protein Neighboring gene uncharacterized LOC105376265

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • DKFZp586D2123

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables GTPase activator activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables GTPase activator activity IDA
Inferred from Direct Assay
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables small GTPase binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables tubulin binding TAS
Traceable Author Statement
more info
PubMed 
Process Evidence Code Pubs
involved_in activation of GTPase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in cell cycle IEA
Inferred from Electronic Annotation
more info
 
involved_in intracellular protein transport IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in regulation of GTPase activity IDA
Inferred from Direct Assay
more info
PubMed 
NOT involved_in regulation of cilium assembly IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
located_in centrosome TAS
Traceable Author Statement
more info
PubMed 
located_in cytosol IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytosol TAS
Traceable Author Statement
more info
 
part_of microtubule associated complex TAS
Traceable Author Statement
more info
PubMed 

General protein information

Preferred Names
rab GTPase-activating protein 1
Names
GAP and centrosome-associated protein
Rab6 GTPase activating protein, GAPCenA
TBC1 domain family, member 11
rab6 GTPase activating protein (GAP and centrosome-associated)
rab6 GTPase-activating protein GAPCenA

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_012197.4NP_036329.3  rab GTPase-activating protein 1

    See identical proteins and their annotated locations for NP_036329.3

    Status: VALIDATED

    Source sequence(s)
    AA948302, AL365338, BC054492, BG622097
    Consensus CDS
    CCDS6848.2
    UniProtKB/Swiss-Prot
    Q9Y3P9
    Related
    ENSP00000362751.4, ENST00000373647.9
    Conserved Domains (4) summary
    smart00164
    Location:563772
    TBC; Domain in Tre-2, BUB2p, and Cdc16p. Probable Rab-GAPs
    COG1196
    Location:8231047
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    cd01211
    Location:145273
    PTB_Rab6GAP; GTPase activating protein for Rab 6 Phosphotyrosine-binding (PTB) domain
    pfam12473
    Location:307437
    DUF3694; Kinesin protein

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000009.12 Reference GRCh38.p13 Primary Assembly

    Range
    122931640..123104869
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017014567.2XP_016870056.1  rab GTPase-activating protein 1 isoform X1

    UniProtKB/Swiss-Prot
    Q9Y3P9
    Conserved Domains (4) summary
    smart00164
    Location:563772
    TBC; Domain in Tre-2, BUB2p, and Cdc16p. Probable Rab-GAPs
    COG1196
    Location:8231047
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    cd01211
    Location:145273
    PTB_Rab6GAP; GTPase activating protein for Rab 6 Phosphotyrosine-binding (PTB) domain
    pfam12473
    Location:307437
    DUF3694; Kinesin protein
  2. XM_017014569.1XP_016870058.1  rab GTPase-activating protein 1 isoform X1

    UniProtKB/Swiss-Prot
    Q9Y3P9
    Conserved Domains (4) summary
    smart00164
    Location:563772
    TBC; Domain in Tre-2, BUB2p, and Cdc16p. Probable Rab-GAPs
    COG1196
    Location:8231047
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    cd01211
    Location:145273
    PTB_Rab6GAP; GTPase activating protein for Rab 6 Phosphotyrosine-binding (PTB) domain
    pfam12473
    Location:307437
    DUF3694; Kinesin protein
  3. XM_011518442.3XP_011516744.1  rab GTPase-activating protein 1 isoform X3

    See identical proteins and their annotated locations for XP_011516744.1

    Conserved Domains (4) summary
    smart00164
    Location:394603
    TBC; Domain in Tre-2, BUB2p, and Cdc16p. Probable Rab-GAPs
    COG1196
    Location:654878
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    cd01211
    Location:1104
    PTB_Rab6GAP; GTPase activating protein for Rab 6 Phosphotyrosine-binding (PTB) domain
    pfam12473
    Location:138268
    DUF3694; Kinesin protein
  4. XM_024447475.1XP_024303243.1  rab GTPase-activating protein 1 isoform X4

    Conserved Domains (3) summary
    smart00164
    Location:563772
    TBC; Domain in Tre-2, BUB2p, and Cdc16p. Probable Rab-GAPs
    cd01211
    Location:145273
    PTB_Rab6GAP; GTPase activating protein for Rab 6 Phosphotyrosine-binding (PTB) domain
    pfam12473
    Location:307437
    DUF3694; Kinesin protein
  5. XM_011518444.2XP_011516746.1  rab GTPase-activating protein 1 isoform X5

    Conserved Domains (3) summary
    smart00164
    Location:563663
    TBC; Domain in Tre-2, BUB2p, and Cdc16p. Probable Rab-GAPs
    cd01211
    Location:145273
    PTB_Rab6GAP; GTPase activating protein for Rab 6 Phosphotyrosine-binding (PTB) domain
    pfam12473
    Location:356437
    DUF3694; Kinesin protein
  6. XM_024447476.1XP_024303244.1  rab GTPase-activating protein 1 isoform X6

    Conserved Domains (3) summary
    cd01211
    Location:145273
    PTB_Rab6GAP; GTPase activating protein for Rab 6 Phosphotyrosine-binding (PTB) domain
    pfam12473
    Location:307437
    DUF3694; Kinesin protein
    cl02495
    Location:563597
    RabGAP-TBC; Rab-GTPase-TBC domain
  7. XM_011518441.2XP_011516743.1  rab GTPase-activating protein 1 isoform X1

    See identical proteins and their annotated locations for XP_011516743.1

    UniProtKB/Swiss-Prot
    Q9Y3P9
    Conserved Domains (4) summary
    smart00164
    Location:563772
    TBC; Domain in Tre-2, BUB2p, and Cdc16p. Probable Rab-GAPs
    COG1196
    Location:8231047
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    cd01211
    Location:145273
    PTB_Rab6GAP; GTPase activating protein for Rab 6 Phosphotyrosine-binding (PTB) domain
    pfam12473
    Location:307437
    DUF3694; Kinesin protein
  8. XM_011518440.3XP_011516742.1  rab GTPase-activating protein 1 isoform X1

    See identical proteins and their annotated locations for XP_011516742.1

    UniProtKB/Swiss-Prot
    Q9Y3P9
    Conserved Domains (4) summary
    smart00164
    Location:563772
    TBC; Domain in Tre-2, BUB2p, and Cdc16p. Probable Rab-GAPs
    COG1196
    Location:8231047
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    cd01211
    Location:145273
    PTB_Rab6GAP; GTPase activating protein for Rab 6 Phosphotyrosine-binding (PTB) domain
    pfam12473
    Location:307437
    DUF3694; Kinesin protein
  9. XM_017014570.1XP_016870059.1  rab GTPase-activating protein 1 isoform X3

    Conserved Domains (4) summary
    smart00164
    Location:394603
    TBC; Domain in Tre-2, BUB2p, and Cdc16p. Probable Rab-GAPs
    COG1196
    Location:654878
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    cd01211
    Location:1104
    PTB_Rab6GAP; GTPase activating protein for Rab 6 Phosphotyrosine-binding (PTB) domain
    pfam12473
    Location:138268
    DUF3694; Kinesin protein
  10. XM_017014568.1XP_016870057.1  rab GTPase-activating protein 1 isoform X1

    UniProtKB/Swiss-Prot
    Q9Y3P9
    Conserved Domains (4) summary
    smart00164
    Location:563772
    TBC; Domain in Tre-2, BUB2p, and Cdc16p. Probable Rab-GAPs
    COG1196
    Location:8231047
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    cd01211
    Location:145273
    PTB_Rab6GAP; GTPase activating protein for Rab 6 Phosphotyrosine-binding (PTB) domain
    pfam12473
    Location:307437
    DUF3694; Kinesin protein
  11. XM_024447474.1XP_024303242.1  rab GTPase-activating protein 1 isoform X2

    Conserved Domains (4) summary
    smart00164
    Location:495704
    TBC; Domain in Tre-2, BUB2p, and Cdc16p. Probable Rab-GAPs
    COG1196
    Location:755979
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    cd01211
    Location:77205
    PTB_Rab6GAP; GTPase activating protein for Rab 6 Phosphotyrosine-binding (PTB) domain
    pfam12473
    Location:239369
    DUF3694; Kinesin protein
  12. XM_024447477.1XP_024303245.1  rab GTPase-activating protein 1 isoform X7

    Conserved Domains (2) summary
    pfam00566
    Location:1111
    RabGAP-TBC; Rab-GTPase-TBC domain
    NF033930
    Location:203386
    pneumo_PspA; pneumococcal surface protein A
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