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Rabgap1 RAB GTPase activating protein 1 [ Mus musculus (house mouse) ]

Gene ID: 227800, updated on 7-May-2024

Summary

Official Symbol
Rabgap1provided by MGI
Official Full Name
RAB GTPase activating protein 1provided by MGI
Primary source
MGI:MGI:2385139
See related
Ensembl:ENSMUSG00000035437 AllianceGenome:MGI:2385139
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Gapcena; mKIAA4104
Summary
Predicted to enable GTPase activator activity and small GTPase binding activity. Predicted to be involved in activation of GTPase activity and intracellular protein transport. Predicted to be located in cytosol. Orthologous to human RABGAP1 (RAB GTPase activating protein 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in CNS E14 (RPKM 5.5), CNS E18 (RPKM 5.5) and 26 other tissues See more
Orthologs
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Genomic context

See Rabgap1 in Genome Data Viewer
Location:
2 B; 2 24.19 cM
Exon count:
28
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (37333274..37463653)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (37443263..37573420)

Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E4442 Neighboring gene STARR-positive B cell enhancer ABC_E1004 Neighboring gene zinc finger and BTB domain containing 6 Neighboring gene zinc finger and BTB domain containing 26 Neighboring gene nucleoporin 37 pseudogene Neighboring gene G protein-coupled receptor 21 Neighboring gene spermatid perinuclear RNA binding protein Neighboring gene zinc finger protein 609 pseudogene Neighboring gene microRNA 5128

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 
  • Targeted (2) 

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Clone Names

  • KIAA4104, MGC30493

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables GTPase activator activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables GTPase activator activity ISO
Inferred from Sequence Orthology
more info
 
enables small GTPase binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables small GTPase binding ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
acts_upstream_of_or_within cell cycle IEA
Inferred from Electronic Annotation
more info
 
involved_in regulation of GTPase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in regulation of GTPase activity ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 
located_in cytoskeleton IEA
Inferred from Electronic Annotation
more info
 
located_in cytosol ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
rab GTPase-activating protein 1
Names
GAP and centrosome-associated protein
rab6 GTPase activating protein (GAP and centrosome-associated)
rab6 GTPase-activating protein GAPCenA

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001033960.1NP_001029132.1  rab GTPase-activating protein 1 isoform b

    See identical proteins and their annotated locations for NP_001029132.1

    Status: VALIDATED

    Source sequence(s)
    AK044346
    Consensus CDS
    CCDS16003.1
    UniProtKB/Swiss-Prot
    A2AWA9
    Related
    ENSMUSP00000068835.4, ENSMUST00000066055.10
    Conserved Domains (3) summary
    smart00164
    Location:558767
    TBC; Domain in Tre-2, BUB2p, and Cdc16p. Probable Rab-GAPs
    cd01211
    Location:140268
    PTB_Rab6GAP; GTPase activating protein for Rab 6 Phosphotyrosine-binding (PTB) domain
    pfam12473
    Location:302432
    DUF3694; Kinesin protein
  2. NM_001362956.1NP_001349885.1  rab GTPase-activating protein 1 isoform a

    Status: VALIDATED

    Source sequence(s)
    AL953890
    Consensus CDS
    CCDS16002.1
    UniProtKB/Swiss-Prot
    A2AWA9, Q5DTN1, Q8BQ32, Q8C8W3, Q8CD74, Q8R312
    UniProtKB/TrEMBL
    B2RRC5
    Related
    ENSMUSP00000108542.2, ENSMUST00000112920.2
    Conserved Domains (4) summary
    smart00164
    Location:558767
    TBC; Domain in Tre-2, BUB2p, and Cdc16p. Probable Rab-GAPs
    cd01211
    Location:140268
    PTB_Rab6GAP; GTPase activating protein for Rab 6 Phosphotyrosine-binding (PTB) domain
    pfam12473
    Location:302432
    DUF3694; Kinesin protein
    cl25742
    Location:7891013
    ERM; Ezrin/radixin/moesin family
  3. NM_001362957.1NP_001349886.1  rab GTPase-activating protein 1 isoform b

    Status: VALIDATED

    Source sequence(s)
    AL953890
    Consensus CDS
    CCDS16003.1
    Conserved Domains (3) summary
    smart00164
    Location:558767
    TBC; Domain in Tre-2, BUB2p, and Cdc16p. Probable Rab-GAPs
    cd01211
    Location:140268
    PTB_Rab6GAP; GTPase activating protein for Rab 6 Phosphotyrosine-binding (PTB) domain
    pfam12473
    Location:302432
    DUF3694; Kinesin protein
  4. NM_001362958.1NP_001349887.1  rab GTPase-activating protein 1 isoform c

    Status: VALIDATED

    Source sequence(s)
    AL953890
    Conserved Domains (4) summary
    smart00164
    Location:490699
    TBC; Domain in Tre-2, BUB2p, and Cdc16p. Probable Rab-GAPs
    cd01211
    Location:72200
    PTB_Rab6GAP; GTPase activating protein for Rab 6 Phosphotyrosine-binding (PTB) domain
    pfam12473
    Location:234364
    DUF3694; Kinesin protein
    cl25742
    Location:721945
    ERM; Ezrin/radixin/moesin family
  5. NM_146121.2NP_666233.2  rab GTPase-activating protein 1 isoform a

    See identical proteins and their annotated locations for NP_666233.2

    Status: VALIDATED

    Source sequence(s)
    AK220489, BY021872
    Consensus CDS
    CCDS16002.1
    UniProtKB/Swiss-Prot
    A2AWA9, Q5DTN1, Q8BQ32, Q8C8W3, Q8CD74, Q8R312
    UniProtKB/TrEMBL
    B2RRC5
    Related
    ENSMUSP00000061624.6, ENSMUST00000061179.12
    Conserved Domains (4) summary
    smart00164
    Location:558767
    TBC; Domain in Tre-2, BUB2p, and Cdc16p. Probable Rab-GAPs
    cd01211
    Location:140268
    PTB_Rab6GAP; GTPase activating protein for Rab 6 Phosphotyrosine-binding (PTB) domain
    pfam12473
    Location:302432
    DUF3694; Kinesin protein
    cl25742
    Location:7891013
    ERM; Ezrin/radixin/moesin family

RNA

  1. NR_156419.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AL953890

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000068.8 Reference GRCm39 C57BL/6J

    Range
    37333274..37463653
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006497997.5XP_006498060.1  rab GTPase-activating protein 1 isoform X2

    Conserved Domains (3) summary
    smart00164
    Location:558767
    TBC; Domain in Tre-2, BUB2p, and Cdc16p. Probable Rab-GAPs
    cd01211
    Location:140268
    PTB_Rab6GAP; GTPase activating protein for Rab 6 Phosphotyrosine-binding (PTB) domain
    pfam12473
    Location:302432
    DUF3694; Kinesin protein
  2. XM_006497995.5XP_006498058.1  rab GTPase-activating protein 1 isoform X1

    Conserved Domains (4) summary
    smart00164
    Location:540749
    TBC; Domain in Tre-2, BUB2p, and Cdc16p. Probable Rab-GAPs
    cd01211
    Location:122250
    PTB_Rab6GAP; GTPase activating protein for Rab 6 Phosphotyrosine-binding (PTB) domain
    pfam00769
    Location:771997
    ERM; Ezrin/radixin/moesin family
    pfam12473
    Location:284414
    DUF3694; Kinesin protein
  3. XM_030250053.1XP_030105913.1  rab GTPase-activating protein 1 isoform X2

    Conserved Domains (3) summary
    smart00164
    Location:558767
    TBC; Domain in Tre-2, BUB2p, and Cdc16p. Probable Rab-GAPs
    cd01211
    Location:140268
    PTB_Rab6GAP; GTPase activating protein for Rab 6 Phosphotyrosine-binding (PTB) domain
    pfam12473
    Location:302432
    DUF3694; Kinesin protein