Format

Send to:

Choose Destination

ZMYND8 zinc finger MYND-type containing 8 [ Homo sapiens (human) ]

Gene ID: 23613, updated on 5-Jul-2020

Summary

Official Symbol
ZMYND8provided by HGNC
Official Full Name
zinc finger MYND-type containing 8provided by HGNC
Primary source
HGNC:HGNC:9397
See related
Ensembl:ENSG00000101040 MIM:615713
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
RACK7; PRKCBP1; PRO2893
Summary
The protein encoded by this gene is a receptor for activated C-kinase (RACK) protein. The encoded protein has been shown to bind in vitro to activated protein kinase C beta I. In addition, this protein is a cutaneous T-cell lymphoma-associated antigen. Finally, the protein contains a bromodomain and two zinc fingers, and is thought to be a transcriptional regulator. Multiple transcript variants encoding several different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Expression
Ubiquitous expression in adrenal (RPKM 6.9), testis (RPKM 4.9) and 25 other tissues See more
Orthologs

Genomic context

See ZMYND8 in Genome Data Viewer
Location:
20q13.12
Exon count:
29
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 20 NC_000020.11 (47209214..47356889, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 20 NC_000020.10 (45837994..45985485, complement)

Chromosome 20 - NC_000020.11Genomic Context describing neighboring genes Neighboring gene EYA transcriptional coactivator and phosphatase 2 Neighboring gene Sharpr-MPRA regulatory region 12423 Neighboring gene Sharpr-MPRA regulatory region 5760 Neighboring gene uncharacterized LOC100131496 Neighboring gene uncharacterized LOC101927377 Neighboring gene Sharpr-MPRA regulatory region 8686 Neighboring gene CRISPRi-validated cis-regulatory element chr20.2032 Neighboring gene CRISPRi-validated cis-regulatory element chr20.2033

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

NHGRI GWAS Catalog

Description
Genome-wide association study to characterize serum bilirubin elevations in patients with HCV treated with GS-9256, an HCV NS3 serine protease inhibitor.
NHGRI GWA Catalog

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Envelope surface glycoprotein gp120 env Genes, including GABRP, ADF, HINT, PRSS2, SDCBP, PTK9, PPP2R5B, ITGA3, PRKCBP1, HMOX2, HAT1, PPP1cB, and ICAM-1, are upregulated after treatment of human astrocytes with HIV-1 gp120 PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC31836

Gene Ontology Provided by GOA

Function Evidence Code Pubs
lysine-acetylated histone binding IDA
Inferred from Direct Assay
more info
PubMed 
methylated histone binding IDA
Inferred from Direct Assay
more info
PubMed 
protein N-terminus binding IEA
Inferred from Electronic Annotation
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein domain specific binding IDA
Inferred from Direct Assay
more info
PubMed 
repressing transcription factor binding ISS
Inferred from Sequence or Structural Similarity
more info
 
transcription corepressor activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
transcription corepressor activity ISS
Inferred from Sequence or Structural Similarity
more info
 
zinc ion binding IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
modulation of excitatory postsynaptic potential IEA
Inferred from Electronic Annotation
more info
 
negative regulation of cell migration IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of nucleic acid-templated transcription IEA
Inferred from Electronic Annotation
more info
 
positive regulation of dendritic spine development IEA
Inferred from Electronic Annotation
more info
 
positive regulation of dendritic spine maintenance IEA
Inferred from Electronic Annotation
more info
 
positive regulation of filopodium assembly IEA
Inferred from Electronic Annotation
more info
 
regulation of postsynaptic density protein 95 clustering IEA
Inferred from Electronic Annotation
more info
 
regulation of transcription, DNA-templated IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
Golgi apparatus IDA
Inferred from Direct Assay
more info
 
cytoplasm IMP
Inferred from Mutant Phenotype
more info
PubMed 
dendritic shaft IEA
Inferred from Electronic Annotation
more info
 
dendritic spine IEA
Inferred from Electronic Annotation
more info
 
nucleoplasm IDA
Inferred from Direct Assay
more info
 
nucleus IDA
Inferred from Direct Assay
more info
PubMed 
nucleus ISS
Inferred from Sequence or Structural Similarity
more info
 

General protein information

Preferred Names
protein kinase C-binding protein 1
Names
CTCL tumor antigen se14-3
cutaneous T-cell lymphoma-associated antigen se14-3
predicted protein of HQ2893
zinc finger MYND domain-containing protein 8

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001281769.1NP_001268698.1  protein kinase C-binding protein 1 isoform d

    See identical proteins and their annotated locations for NP_001268698.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) lacks several exons and its 3'-terminal exon extends past a splice site that is used in variant 1. The encoded isoform (d) has a shorter and distinct C-terminus, compared to isoform a.
    Source sequence(s)
    BC092432, BX095755, DC362133
    UniProtKB/TrEMBL
    Q569J9
    Conserved Domains (1) summary
    cd15538
    Location:110150
    PHD_PRKCBP1; PHD finger found in protein kinase C-binding protein 1 (PRKCBP1)
  2. NM_001281771.3NP_001268700.1  protein kinase C-binding protein 1 isoform e

    See identical proteins and their annotated locations for NP_001268700.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (5) has multiple differences in the coding region but maintains the reading frame, compared to variant 1. The encoded isoform (e) is shorter, compared to isoform a.
    Source sequence(s)
    AI275390, AL022342, BC136608, BC146802, DQ368671, DR422399
    Consensus CDS
    CCDS63304.1
    UniProtKB/Swiss-Prot
    Q9ULU4
    UniProtKB/TrEMBL
    A6H8Y8
    Related
    ENSP00000392964.2, ENST00000458360.6
    Conserved Domains (7) summary
    cd05841
    Location:264344
    BS69_related; The PWWP domain is part of BS69 protein, a nuclear protein that specifically binds adenoviral E1A and Epstein-Barr viral EBNA2 proteins, suppressing their transactivation functions. BS69 is a multi-domain protein, containing bromo, PHD, PWWP, and MYND ...
    cd05508
    Location:146244
    Bromo_RACK7; Bromodomain, RACK7_like subfamily. RACK7 (also called human protein kinase C-binding protein) was identified as a potential tumor suppressor genes, it shares domain architecture with BS69/ZMYND11; both have been implicated in the regulation of cellular ...
    cd15538
    Location:85125
    PHD_PRKCBP1; PHD finger found in protein kinase C-binding protein 1 (PRKCBP1)
    pfam01753
    Location:896930
    zf-MYND; MYND finger
    pfam07798
    Location:801892
    DUF1640; Protein of unknown function (DUF1640)
    pfam10243
    Location:599892
    MIP-T3; Microtubule-binding protein MIP-T3
    pfam12064
    Location:421615
    DUF3544; Domain of unknown function (DUF3544)
  3. NM_001281772.2NP_001268701.1  protein kinase C-binding protein 1 isoform f

    Status: REVIEWED

    Description
    Transcript Variant: This variant (6) differs in the 5' UTR, has multiple coding region differences, and initiates translation from an alternate start codon, compared to variant 1. The encoded isoform (f) is shorter and has a distinct N-terminus, compared to isoform a.
    Source sequence(s)
    AB032951, AI275390, AK294511, AL022342, BC146802, DC362133, DQ368674, DR422399
    Consensus CDS
    CCDS74738.1
    UniProtKB/Swiss-Prot
    Q9ULU4
    UniProtKB/TrEMBL
    A6H8Y8
    Related
    ENSP00000379577.4, ENST00000396281.8
    Conserved Domains (6) summary
    cd05841
    Location:269349
    BS69_related; The PWWP domain is part of BS69 protein, a nuclear protein that specifically binds adenoviral E1A and Epstein-Barr viral EBNA2 proteins, suppressing their transactivation functions. BS69 is a multi-domain protein, containing bromo, PHD, PWWP, and MYND ...
    cd05508
    Location:151249
    Bromo_RACK7; Bromodomain, RACK7_like subfamily. RACK7 (also called human protein kinase C-binding protein) was identified as a potential tumor suppressor genes, it shares domain architecture with BS69/ZMYND11; both have been implicated in the regulation of cellular ...
    cd15538
    Location:90130
    PHD_PRKCBP1; PHD finger found in protein kinase C-binding protein 1 (PRKCBP1)
    pfam01753
    Location:10281062
    zf-MYND; MYND finger
    pfam07798
    Location:9331024
    DUF1640; Protein of unknown function (DUF1640)
    pfam12064
    Location:426620
    DUF3544; Domain of unknown function (DUF3544)
  4. NM_001281773.2NP_001268702.1  protein kinase C-binding protein 1 isoform g

    See identical proteins and their annotated locations for NP_001268702.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (7) differs in its 5' UTR, uses an alternate in-frame splice site in the central coding region, and initiates translation from a downstream start codon, compared to variant 1. The encoded isoform (g) is longer, compared to isoform a.
    Source sequence(s)
    AI275390, AK299899, AL022342, BC146802, DC362133, DR422399
    Consensus CDS
    CCDS63300.1
    UniProtKB/Swiss-Prot
    Q9ULU4
    UniProtKB/TrEMBL
    A6H8Y8
    Related
    ENSP00000348246.4, ENST00000355972.8
    Conserved Domains (6) summary
    cd05841
    Location:269349
    BS69_related; The PWWP domain is part of BS69 protein, a nuclear protein that specifically binds adenoviral E1A and Epstein-Barr viral EBNA2 proteins, suppressing their transactivation functions. BS69 is a multi-domain protein, containing bromo, PHD, PWWP, and MYND ...
    cd05508
    Location:151249
    Bromo_RACK7; Bromodomain, RACK7_like subfamily. RACK7 (also called human protein kinase C-binding protein) was identified as a potential tumor suppressor genes, it shares domain architecture with BS69/ZMYND11; both have been implicated in the regulation of cellular ...
    cd15538
    Location:90130
    PHD_PRKCBP1; PHD finger found in protein kinase C-binding protein 1 (PRKCBP1)
    pfam01753
    Location:10281062
    zf-MYND; MYND finger
    pfam07798
    Location:9331024
    DUF1640; Protein of unknown function (DUF1640)
    pfam12064
    Location:426620
    DUF3544; Domain of unknown function (DUF3544)
  5. NM_001281774.3NP_001268703.1  protein kinase C-binding protein 1 isoform h

    See identical proteins and their annotated locations for NP_001268703.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (8) differs in its 5' UTR, and initiates translation from a downstream start codon, compared to variant 1. The encoded isoform (h) has a shorter N-terminus, compared to isoform a.
    Source sequence(s)
    AI275390, AL022342, BC146802, BX641005, DQ368669, DR422399
    Consensus CDS
    CCDS63301.1
    UniProtKB/Swiss-Prot
    Q9ULU4
    UniProtKB/TrEMBL
    A6H8Y8
    Related
    ENSP00000262975.4, ENST00000262975.8
    Conserved Domains (6) summary
    cd05841
    Location:269349
    BS69_related; The PWWP domain is part of BS69 protein, a nuclear protein that specifically binds adenoviral E1A and Epstein-Barr viral EBNA2 proteins, suppressing their transactivation functions. BS69 is a multi-domain protein, containing bromo, PHD, PWWP, and MYND ...
    cd05508
    Location:151249
    Bromo_RACK7; Bromodomain, RACK7_like subfamily. RACK7 (also called human protein kinase C-binding protein) was identified as a potential tumor suppressor genes, it shares domain architecture with BS69/ZMYND11; both have been implicated in the regulation of cellular ...
    cd15538
    Location:90130
    PHD_PRKCBP1; PHD finger found in protein kinase C-binding protein 1 (PRKCBP1)
    pfam01753
    Location:9821016
    zf-MYND; MYND finger
    pfam07798
    Location:887978
    DUF1640; Protein of unknown function (DUF1640)
    pfam12064
    Location:426620
    DUF3544; Domain of unknown function (DUF3544)
  6. NM_001281775.3NP_001268704.1  protein kinase C-binding protein 1 isoform i

    See identical proteins and their annotated locations for NP_001268704.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (9) uses an alternate in-frame splice site in the central coding region, compared to variant 1. The encoded isoform (i) is longer, compared to isoform a.
    Source sequence(s)
    AI275390, AL022342, BC146802, DC362133, DQ368673, DR422399
    Consensus CDS
    CCDS63306.1
    UniProtKB/Swiss-Prot
    Q9ULU4
    UniProtKB/TrEMBL
    A6H8Y8
    Related
    ENSP00000420095.2, ENST00000471951.6
    Conserved Domains (6) summary
    cd05841
    Location:289369
    BS69_related; The PWWP domain is part of BS69 protein, a nuclear protein that specifically binds adenoviral E1A and Epstein-Barr viral EBNA2 proteins, suppressing their transactivation functions. BS69 is a multi-domain protein, containing bromo, PHD, PWWP, and MYND ...
    cd05508
    Location:171269
    Bromo_RACK7; Bromodomain, RACK7_like subfamily. RACK7 (also called human protein kinase C-binding protein) was identified as a potential tumor suppressor genes, it shares domain architecture with BS69/ZMYND11; both have been implicated in the regulation of cellular ...
    cd15538
    Location:110150
    PHD_PRKCBP1; PHD finger found in protein kinase C-binding protein 1 (PRKCBP1)
    pfam01753
    Location:10481082
    zf-MYND; MYND finger
    pfam07798
    Location:9531044
    DUF1640; Protein of unknown function (DUF1640)
    pfam12064
    Location:446640
    DUF3544; Domain of unknown function (DUF3544)
  7. NM_001281776.3NP_001268705.1  protein kinase C-binding protein 1 isoform j

    See identical proteins and their annotated locations for NP_001268705.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (10) lacks an in-frame exon in the central coding region, compared to variant 1. The encoded isoform (j) is shorter, compared to isoform a.
    Source sequence(s)
    AI275390, AK299899, AL022342, BC146802, DC362133, DQ082999, DR422399
    UniProtKB/Swiss-Prot
    Q9ULU4
    UniProtKB/TrEMBL
    A6H8Y8
    Related
    ENSP00000482048.1, ENST00000611941.4
    Conserved Domains (7) summary
    cd05841
    Location:289369
    BS69_related; The PWWP domain is part of BS69 protein, a nuclear protein that specifically binds adenoviral E1A and Epstein-Barr viral EBNA2 proteins, suppressing their transactivation functions. BS69 is a multi-domain protein, containing bromo, PHD, PWWP, and MYND ...
    cd05508
    Location:171269
    Bromo_RACK7; Bromodomain, RACK7_like subfamily. RACK7 (also called human protein kinase C-binding protein) was identified as a potential tumor suppressor genes, it shares domain architecture with BS69/ZMYND11; both have been implicated in the regulation of cellular ...
    cd15538
    Location:110150
    PHD_PRKCBP1; PHD finger found in protein kinase C-binding protein 1 (PRKCBP1)
    pfam01753
    Location:921955
    zf-MYND; MYND finger
    pfam07798
    Location:826917
    DUF1640; Protein of unknown function (DUF1640)
    pfam10243
    Location:624917
    MIP-T3; Microtubule-binding protein MIP-T3
    pfam12064
    Location:446640
    DUF3544; Domain of unknown function (DUF3544)
  8. NM_001281777.3NP_001268706.1  protein kinase C-binding protein 1 isoform k

    See identical proteins and their annotated locations for NP_001268706.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (11) uses an alternate in-frame splice site in the central coding region, compared to variant 1. The encoded isoform (k) is shorter, compared to isoform a.
    Source sequence(s)
    AI275390, AL022342, BC146802, DC362133, DQ368672, DR422399
    UniProtKB/Swiss-Prot
    Q9ULU4
    UniProtKB/TrEMBL
    A6H8Y8
    Related
    ENSP00000361093.5, ENST00000372023.7
    Conserved Domains (6) summary
    cd05841
    Location:264344
    BS69_related; The PWWP domain is part of BS69 protein, a nuclear protein that specifically binds adenoviral E1A and Epstein-Barr viral EBNA2 proteins, suppressing their transactivation functions. BS69 is a multi-domain protein, containing bromo, PHD, PWWP, and MYND ...
    cd05508
    Location:146244
    Bromo_RACK7; Bromodomain, RACK7_like subfamily. RACK7 (also called human protein kinase C-binding protein) was identified as a potential tumor suppressor genes, it shares domain architecture with BS69/ZMYND11; both have been implicated in the regulation of cellular ...
    cd15538
    Location:85125
    PHD_PRKCBP1; PHD finger found in protein kinase C-binding protein 1 (PRKCBP1)
    pfam01753
    Location:9771011
    zf-MYND; MYND finger
    pfam07798
    Location:882973
    DUF1640; Protein of unknown function (DUF1640)
    pfam12064
    Location:421615
    DUF3544; Domain of unknown function (DUF3544)
  9. NM_001281778.3NP_001268707.1  protein kinase C-binding protein 1 isoform l

    See identical proteins and their annotated locations for NP_001268707.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (12) has multiple differences in the coding region but maintains the reading frame, compared to variant 1. The encoded isoform (l) is shorter, compared to isoform a.
    Source sequence(s)
    AI275390, AL022342, BC146802, DC362133, DQ368674, DR422399
    UniProtKB/Swiss-Prot
    Q9ULU4
    UniProtKB/TrEMBL
    A6H8Y8
    Conserved Domains (6) summary
    cd05841
    Location:264344
    BS69_related; The PWWP domain is part of BS69 protein, a nuclear protein that specifically binds adenoviral E1A and Epstein-Barr viral EBNA2 proteins, suppressing their transactivation functions. BS69 is a multi-domain protein, containing bromo, PHD, PWWP, and MYND ...
    cd05508
    Location:146244
    Bromo_RACK7; Bromodomain, RACK7_like subfamily. RACK7 (also called human protein kinase C-binding protein) was identified as a potential tumor suppressor genes, it shares domain architecture with BS69/ZMYND11; both have been implicated in the regulation of cellular ...
    cd15538
    Location:85125
    PHD_PRKCBP1; PHD finger found in protein kinase C-binding protein 1 (PRKCBP1)
    pfam01753
    Location:10231057
    zf-MYND; MYND finger
    pfam07798
    Location:9281019
    DUF1640; Protein of unknown function (DUF1640)
    pfam12064
    Location:421615
    DUF3544; Domain of unknown function (DUF3544)
  10. NM_001281779.3NP_001268708.1  protein kinase C-binding protein 1 isoform m

    Status: REVIEWED

    Description
    Transcript Variant: This variant (13) differs in its 5' UTR and initiates translation at a downstream start codon, compared to variant 1. The encoded isoform (m) has a shorter N-terminus, compared to isoform a.
    Source sequence(s)
    AI275390, AL022342, BC146802, DC362133, DQ368675, DR422399
    UniProtKB/TrEMBL
    A6H8Y8, Q2HXV5
    Conserved Domains (4) summary
    cd05841
    Location:21101
    BS69_related; The PWWP domain is part of BS69 protein, a nuclear protein that specifically binds adenoviral E1A and Epstein-Barr viral EBNA2 proteins, suppressing their transactivation functions. BS69 is a multi-domain protein, containing bromo, PHD, PWWP, and MYND ...
    pfam01753
    Location:734768
    zf-MYND; MYND finger
    pfam07798
    Location:639730
    DUF1640; Protein of unknown function (DUF1640)
    pfam12064
    Location:178372
    DUF3544; Domain of unknown function (DUF3544)
  11. NM_001281780.3NP_001268709.1  protein kinase C-binding protein 1 isoform n

    Status: REVIEWED

    Description
    Transcript Variant: This variant (14) differs in its 5' UTR, lacks an in-frame exon in the 3' coding region, and initiates translation at a downstream start codon, compared to variant 1. The encoded isoform (n) is shorter, compared to isoform a.
    Source sequence(s)
    AI275390, AL022342, BC146802, DC362133, DQ368676, DR422399
    UniProtKB/TrEMBL
    A6H8Y8, Q2HXV5
    Conserved Domains (4) summary
    cd05841
    Location:21101
    BS69_related; The PWWP domain is part of BS69 protein, a nuclear protein that specifically binds adenoviral E1A and Epstein-Barr viral EBNA2 proteins, suppressing their transactivation functions. BS69 is a multi-domain protein, containing bromo, PHD, PWWP, and MYND ...
    pfam01753
    Location:734768
    zf-MYND; MYND finger
    pfam07798
    Location:639730
    DUF1640; Protein of unknown function (DUF1640)
    pfam12064
    Location:178372
    DUF3544; Domain of unknown function (DUF3544)
  12. NM_001281781.3NP_001268710.1  protein kinase C-binding protein 1 isoform o

    See identical proteins and their annotated locations for NP_001268710.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (15) has multiple differences in the coding region but maintains the reading frame, compared to variant 1. The encoded isoform (o) is shorter, compared to isoform a.
    Source sequence(s)
    AI275390, AL022342, BC146802, DC362133, DQ368677, DR422399
    UniProtKB/Swiss-Prot
    Q9ULU4
    UniProtKB/TrEMBL
    A6H8Y8
    Conserved Domains (6) summary
    cd05841
    Location:264344
    BS69_related; The PWWP domain is part of BS69 protein, a nuclear protein that specifically binds adenoviral E1A and Epstein-Barr viral EBNA2 proteins, suppressing their transactivation functions. BS69 is a multi-domain protein, containing bromo, PHD, PWWP, and MYND ...
    cd05508
    Location:146244
    Bromo_RACK7; Bromodomain, RACK7_like subfamily. RACK7 (also called human protein kinase C-binding protein) was identified as a potential tumor suppressor genes, it shares domain architecture with BS69/ZMYND11; both have been implicated in the regulation of cellular ...
    cd15538
    Location:85125
    PHD_PRKCBP1; PHD finger found in protein kinase C-binding protein 1 (PRKCBP1)
    pfam01753
    Location:930964
    zf-MYND; MYND finger
    pfam07798
    Location:835926
    DUF1640; Protein of unknown function (DUF1640)
    pfam12064
    Location:421568
    DUF3544; Domain of unknown function (DUF3544)
  13. NM_001281782.3NP_001268711.1  protein kinase C-binding protein 1 isoform p

    See identical proteins and their annotated locations for NP_001268711.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (16) uses an alternate in-frame splice site and lacks an in-frame exon in the central coding region, compared to variant 1. The encoded isoform (p) is shorter, compared to isoform a.
    Source sequence(s)
    AI275390, AL022342, BC146802, DC362133, DQ368678, DR422399
    Consensus CDS
    CCDS63305.1
    UniProtKB/Swiss-Prot
    Q9ULU4
    UniProtKB/TrEMBL
    A0A087WVZ6, A6H8Y8
    Related
    ENSP00000479806.2, ENST00000617418.4
    Conserved Domains (6) summary
    cd05841
    Location:264344
    BS69_related; The PWWP domain is part of BS69 protein, a nuclear protein that specifically binds adenoviral E1A and Epstein-Barr viral EBNA2 proteins, suppressing their transactivation functions. BS69 is a multi-domain protein, containing bromo, PHD, PWWP, and MYND ...
    cd05508
    Location:146244
    Bromo_RACK7; Bromodomain, RACK7_like subfamily. RACK7 (also called human protein kinase C-binding protein) was identified as a potential tumor suppressor genes, it shares domain architecture with BS69/ZMYND11; both have been implicated in the regulation of cellular ...
    cd15538
    Location:85125
    PHD_PRKCBP1; PHD finger found in protein kinase C-binding protein 1 (PRKCBP1)
    pfam01753
    Location:950984
    zf-MYND; MYND finger
    pfam11068
    Location:875939
    YlqD; YlqD protein
    pfam12064
    Location:421615
    DUF3544; Domain of unknown function (DUF3544)
  14. NM_001281783.3NP_001268712.1  protein kinase C-binding protein 1 isoform q

    See identical proteins and their annotated locations for NP_001268712.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (17) uses an alternate in-frame splice site in the central coding region and lacks an in-frame exon in the 3' coding region, compared to variant 1. The encoded isoform (q) is longer, compared to isoform a.
    Source sequence(s)
    AI275390, AL022342, BC146802, DC362133, DQ368679, DR422399
    UniProtKB/Swiss-Prot
    Q9ULU4
    UniProtKB/TrEMBL
    A6H8Y8
    Conserved Domains (6) summary
    cd05841
    Location:289369
    BS69_related; The PWWP domain is part of BS69 protein, a nuclear protein that specifically binds adenoviral E1A and Epstein-Barr viral EBNA2 proteins, suppressing their transactivation functions. BS69 is a multi-domain protein, containing bromo, PHD, PWWP, and MYND ...
    cd05508
    Location:171269
    Bromo_RACK7; Bromodomain, RACK7_like subfamily. RACK7 (also called human protein kinase C-binding protein) was identified as a potential tumor suppressor genes, it shares domain architecture with BS69/ZMYND11; both have been implicated in the regulation of cellular ...
    cd15538
    Location:110150
    PHD_PRKCBP1; PHD finger found in protein kinase C-binding protein 1 (PRKCBP1)
    pfam01753
    Location:10481082
    zf-MYND; MYND finger
    pfam07798
    Location:9531044
    DUF1640; Protein of unknown function (DUF1640)
    pfam12064
    Location:446640
    DUF3544; Domain of unknown function (DUF3544)
  15. NM_001281784.3NP_001268713.1  protein kinase C-binding protein 1 isoform r

    See identical proteins and their annotated locations for NP_001268713.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (18) has multiple differences in the coding region but maintains the reading frame, compared to variant 1. The encoded isoform (r) is shorter, compared to isoform a.
    Source sequence(s)
    AI275390, AL022342, BC146802, DC362133, DQ368680, DR422399
    Consensus CDS
    CCDS63303.1
    UniProtKB/Swiss-Prot
    Q9ULU4
    UniProtKB/TrEMBL
    A6H8Y8
    Related
    ENSP00000443086.3, ENST00000540497.5
    Conserved Domains (6) summary
    cd05841
    Location:264344
    BS69_related; The PWWP domain is part of BS69 protein, a nuclear protein that specifically binds adenoviral E1A and Epstein-Barr viral EBNA2 proteins, suppressing their transactivation functions. BS69 is a multi-domain protein, containing bromo, PHD, PWWP, and MYND ...
    cd05508
    Location:146244
    Bromo_RACK7; Bromodomain, RACK7_like subfamily. RACK7 (also called human protein kinase C-binding protein) was identified as a potential tumor suppressor genes, it shares domain architecture with BS69/ZMYND11; both have been implicated in the regulation of cellular ...
    cd15538
    Location:85125
    PHD_PRKCBP1; PHD finger found in protein kinase C-binding protein 1 (PRKCBP1)
    pfam01753
    Location:9761010
    zf-MYND; MYND finger
    pfam07798
    Location:881972
    DUF1640; Protein of unknown function (DUF1640)
    pfam12064
    Location:421568
    DUF3544; Domain of unknown function (DUF3544)
  16. NM_001363714.1NP_001350643.1  protein kinase C-binding protein 1 isoform s

    Status: REVIEWED

    Source sequence(s)
    AK295747, AL022342, AL031666
    Consensus CDS
    CCDS86962.1
    Related
    ENSP00000439800.1, ENST00000536340.5
    Conserved Domains (8) summary
    cd05841
    Location:296376
    BS69_related; The PWWP domain is part of BS69 protein, a nuclear protein that specifically binds adenoviral E1A and Epstein-Barr viral EBNA2 proteins, suppressing their transactivation functions. BS69 is a multi-domain protein, containing bromo, PHD, PWWP, and MYND ...
    cd05508
    Location:178276
    Bromo_RACK7; Bromodomain, RACK7_like subfamily. RACK7 (also called human protein kinase C-binding protein) was identified as a potential tumor suppressor genes, it shares domain architecture with BS69/ZMYND11; both have been implicated in the regulation of cellular ...
    cd15538
    Location:117157
    PHD_PRKCBP1; PHD finger found in protein kinase C-binding protein 1 (PRKCBP1)
    pfam01753
    Location:10551089
    zf-MYND; MYND finger
    pfam07798
    Location:9601051
    DUF1640; Protein of unknown function (DUF1640)
    pfam10243
    Location:634795
    MIP-T3; Microtubule-binding protein MIP-T3
    pfam12064
    Location:445647
    DUF3544; Domain of unknown function (DUF3544)
    cl26267
    Location:31160
    ING; Inhibitor of growth proteins N-terminal histone-binding
  17. NM_001363741.2NP_001350670.1  protein kinase C-binding protein 1 isoform t

    Status: REVIEWED

    Source sequence(s)
    AL022342, AL031666
    Consensus CDS
    CCDS86961.1
    Related
    ENSP00000312237.7, ENST00000311275.11
    Conserved Domains (8) summary
    cd05841
    Location:269349
    BS69_related; The PWWP domain is part of BS69 protein, a nuclear protein that specifically binds adenoviral E1A and Epstein-Barr viral EBNA2 proteins, suppressing their transactivation functions. BS69 is a multi-domain protein, containing bromo, PHD, PWWP, and MYND ...
    cd05508
    Location:151249
    Bromo_RACK7; Bromodomain, RACK7_like subfamily. RACK7 (also called human protein kinase C-binding protein) was identified as a potential tumor suppressor genes, it shares domain architecture with BS69/ZMYND11; both have been implicated in the regulation of cellular ...
    cd15538
    Location:90130
    PHD_PRKCBP1; PHD finger found in protein kinase C-binding protein 1 (PRKCBP1)
    pfam01753
    Location:10281062
    zf-MYND; MYND finger
    pfam07798
    Location:9331024
    DUF1640; Protein of unknown function (DUF1640)
    pfam10243
    Location:607768
    MIP-T3; Microtubule-binding protein MIP-T3
    pfam12064
    Location:418620
    DUF3544; Domain of unknown function (DUF3544)
    cl26267
    Location:4133
    ING; Inhibitor of growth proteins N-terminal histone-binding
  18. NM_012408.6NP_036540.3  protein kinase C-binding protein 1 isoform b

    See identical proteins and their annotated locations for NP_036540.3

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) lacks an in-frame exon in the 3' coding region, compared to variant 1. The encoded isoform (b) is shorter, compared to isoform a.
    Source sequence(s)
    AI275390, AL022342, BC146802, DC362133, DQ368670, DR422399
    Consensus CDS
    CCDS13404.1
    UniProtKB/Swiss-Prot
    Q9ULU4
    UniProtKB/TrEMBL
    A6H8Y8
    Related
    ENSP00000335537.3, ENST00000352431.6
    Conserved Domains (6) summary
    cd05841
    Location:289369
    BS69_related; The PWWP domain is part of BS69 protein, a nuclear protein that specifically binds adenoviral E1A and Epstein-Barr viral EBNA2 proteins, suppressing their transactivation functions. BS69 is a multi-domain protein, containing bromo, PHD, PWWP, and MYND ...
    cd05508
    Location:171269
    Bromo_RACK7; Bromodomain, RACK7_like subfamily. RACK7 (also called human protein kinase C-binding protein) was identified as a potential tumor suppressor genes, it shares domain architecture with BS69/ZMYND11; both have been implicated in the regulation of cellular ...
    cd15538
    Location:110150
    PHD_PRKCBP1; PHD finger found in protein kinase C-binding protein 1 (PRKCBP1)
    pfam01753
    Location:10021036
    zf-MYND; MYND finger
    pfam07798
    Location:907998
    DUF1640; Protein of unknown function (DUF1640)
    pfam12064
    Location:446640
    DUF3544; Domain of unknown function (DUF3544)
  19. NM_183047.4NP_898868.1  protein kinase C-binding protein 1 isoform a

    See identical proteins and their annotated locations for NP_898868.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes isoform a.
    Source sequence(s)
    AI275390, AL022342, BC146802, DC362133, DQ368669, DR422399
    Consensus CDS
    CCDS13405.1
    UniProtKB/Swiss-Prot
    Q9ULU4
    UniProtKB/TrEMBL
    A6H8Y8
    Related
    ENSP00000418210.1, ENST00000461685.5
    Conserved Domains (6) summary
    cd05841
    Location:289369
    BS69_related; The PWWP domain is part of BS69 protein, a nuclear protein that specifically binds adenoviral E1A and Epstein-Barr viral EBNA2 proteins, suppressing their transactivation functions. BS69 is a multi-domain protein, containing bromo, PHD, PWWP, and MYND ...
    cd05508
    Location:171269
    Bromo_RACK7; Bromodomain, RACK7_like subfamily. RACK7 (also called human protein kinase C-binding protein) was identified as a potential tumor suppressor genes, it shares domain architecture with BS69/ZMYND11; both have been implicated in the regulation of cellular ...
    cd15538
    Location:110150
    PHD_PRKCBP1; PHD finger found in protein kinase C-binding protein 1 (PRKCBP1)
    pfam01753
    Location:10021036
    zf-MYND; MYND finger
    pfam07798
    Location:907998
    DUF1640; Protein of unknown function (DUF1640)
    pfam12064
    Location:446640
    DUF3544; Domain of unknown function (DUF3544)
  20. NM_183048.4NP_898869.1  protein kinase C-binding protein 1 isoform c

    See identical proteins and their annotated locations for NP_898869.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) lacks an in-frame exon in the 3' coding region and uses an alternate in-frame splice site in the 5' coding region, compared to variant 1. The encoded isoform (c) is shorter, compared to isoform a.
    Source sequence(s)
    AI275390, AL022342, BC146802, DC362133, DQ368671, DR422399
    Consensus CDS
    CCDS46613.1
    UniProtKB/Swiss-Prot
    Q9ULU4
    UniProtKB/TrEMBL
    A6H8Y8
    Related
    ENSP00000354166.3, ENST00000360911.7
    Conserved Domains (6) summary
    cd05841
    Location:264344
    BS69_related; The PWWP domain is part of BS69 protein, a nuclear protein that specifically binds adenoviral E1A and Epstein-Barr viral EBNA2 proteins, suppressing their transactivation functions. BS69 is a multi-domain protein, containing bromo, PHD, PWWP, and MYND ...
    cd05508
    Location:146244
    Bromo_RACK7; Bromodomain, RACK7_like subfamily. RACK7 (also called human protein kinase C-binding protein) was identified as a potential tumor suppressor genes, it shares domain architecture with BS69/ZMYND11; both have been implicated in the regulation of cellular ...
    cd15538
    Location:85125
    PHD_PRKCBP1; PHD finger found in protein kinase C-binding protein 1 (PRKCBP1)
    pfam01753
    Location:9771011
    zf-MYND; MYND finger
    pfam07798
    Location:882973
    DUF1640; Protein of unknown function (DUF1640)
    pfam12064
    Location:421615
    DUF3544; Domain of unknown function (DUF3544)

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000020.11 Reference GRCh38.p13 Primary Assembly

    Range
    47209214..47356889 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Support Center