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DAPK2 death associated protein kinase 2 [ Homo sapiens (human) ]

Gene ID: 23604, updated on 1-Mar-2024

Summary

Official Symbol
DAPK2provided by HGNC
Official Full Name
death associated protein kinase 2provided by HGNC
Primary source
HGNC:HGNC:2675
See related
Ensembl:ENSG00000035664 MIM:616567; AllianceGenome:HGNC:2675
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
DRP1; DRP-1
Summary
This gene encodes a protein that belongs to the serine/threonine protein kinase family. This protein contains a N-terminal protein kinase domain followed by a conserved calmodulin-binding domain with significant similarity to that of death-associated protein kinase 1 (DAPK1), a positive regulator of programmed cell death. Overexpression of this gene was shown to induce cell apoptosis. It uses multiple polyadenylation sites. [provided by RefSeq, Jul 2008]
Expression
Broad expression in thyroid (RPKM 7.0), lung (RPKM 4.4) and 18 other tissues See more
Orthologs
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Genomic context

See DAPK2 in Genome Data Viewer
Location:
15q22.31
Exon count:
16
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 15 NC_000015.10 (63907036..64046485, complement)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 15 NC_060939.1 (61714186..61853651, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 15 NC_000015.9 (64199235..64338684, complement)

Chromosome 15 - NC_000015.10Genomic Context describing neighboring genes Neighboring gene HECT and RLD domain containing E3 ubiquitin protein ligase family member 1 Neighboring gene ReSE screen-validated silencer GRCh37_chr15:63958187-63958357 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr15:64006953-64007452 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr15:64006451-64006952 Neighboring gene ReSE screen-validated silencer GRCh37_chr15:64014173-64014349 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr15:64057331-64058088 Neighboring gene H3K27ac hESC enhancer GRCh37_chr15:64058904-64059404 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6522 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr15:64107893-64108654 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr15:64114122-64114622 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr15:64125303-64126168 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr15:64126169-64127032 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9542 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr15:64171093-64171988 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9543 Neighboring gene Sharpr-MPRA regulatory region 4498 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr15:64186155-64186656 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9545 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9546 Neighboring gene microRNA 422a Neighboring gene uncharacterized LOC101928988 Neighboring gene Sharpr-MPRA regulatory region 12240 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr15:64264631-64265378 Neighboring gene H3K27ac hESC enhancer GRCh37_chr15:64277639-64278140 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr15:64290279-64290780 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6524 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9547 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9548 Neighboring gene ReSE screen-validated silencer GRCh37_chr15:64318331-64318496 Neighboring gene NANOG hESC enhancer GRCh37_chr15:64330918-64331419 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9549 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9550 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6527 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6526 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6525 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr15:64342658-64343204 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9551 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9552 Neighboring gene H3K27ac hESC enhancer GRCh37_chr15:64385112-64385674 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9554 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9555 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9556 Neighboring gene Sharpr-MPRA regulatory region 7733 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9557 Neighboring gene cytosolic iron-sulfur assembly component 2A Neighboring gene sorting nexin 1

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

HIV-1 interactions

Replication interactions

Interaction Pubs
Knockdown of death-associated protein kinase 2 (DAPK2) by siRNA inhibits HIV-1 replication in HeLa P4/R5 cells PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Clone Names

  • MGC119312

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables ATP binding IDA
Inferred from Direct Assay
more info
PubMed 
enables calmodulin binding IDA
Inferred from Direct Assay
more info
PubMed 
enables identical protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein serine kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables protein serine/threonine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables protein serine/threonine kinase activity TAS
Traceable Author Statement
more info
PubMed 
Component Evidence Code Pubs
located_in Golgi apparatus IDA
Inferred from Direct Assay
more info
 
located_in autophagosome lumen IEA
Inferred from Electronic Annotation
more info
 
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytoplasmic vesicle IEA
Inferred from Electronic Annotation
more info
 
located_in intracellular membrane-bounded organelle IDA
Inferred from Direct Assay
more info
 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
 

General protein information

Preferred Names
death-associated protein kinase 2
Names
DAP kinase 2
NP_001350659.1
NP_001371926.1
NP_001371927.1
NP_001371928.1
NP_001371929.1
NP_001382208.1
NP_001382210.1
NP_001382211.1
NP_001382212.1
NP_001382213.1
NP_001382214.1
NP_001382215.1
NP_001382216.1
NP_001382217.1
NP_001382218.1
NP_001382219.1
NP_001382220.1
NP_001382221.1
NP_001382222.1
NP_055141.2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001363730.2NP_001350659.1  death-associated protein kinase 2 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC015914, AC021541, GU056176
    Consensus CDS
    CCDS86463.1
    Related
    ENSP00000484390.1, ENST00000612884.4
    Conserved Domains (1) summary
    cd14196
    Location:17285
    STKc_DAPK2; Catalytic domain of the Serine/Threonine Kinase, Death-Associated Protein Kinase 2
  2. NM_001384997.1NP_001371926.1  death-associated protein kinase 2 isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC015914, AC021541
    Conserved Domains (1) summary
    cd14196
    Location:17285
    STKc_DAPK2; Catalytic domain of the Serine/Threonine Kinase, Death-Associated Protein Kinase 2
  3. NM_001384998.1NP_001371927.1  death-associated protein kinase 2 isoform 4

    Status: VALIDATED

    Source sequence(s)
    AC015914, AC021541
    Conserved Domains (1) summary
    cl21453
    Location:17279
    PKc_like; Protein Kinases, catalytic domain
  4. NM_001384999.1NP_001371928.1  death-associated protein kinase 2 isoform 5

    Status: VALIDATED

    Source sequence(s)
    AC015914, AC021541
    Conserved Domains (1) summary
    cl21453
    Location:17220
    PKc_like; Protein Kinases, catalytic domain
  5. NM_001385000.1NP_001371929.1  death-associated protein kinase 2 isoform 6

    Status: VALIDATED

    Source sequence(s)
    AC015914, AC021541
    Conserved Domains (1) summary
    cl21453
    Location:1130
    PKc_like; Protein Kinases, catalytic domain
  6. NM_001395279.1NP_001382208.1  death-associated protein kinase 2 isoform 7

    Status: VALIDATED

    Source sequence(s)
    AC015914, AC021541
    Conserved Domains (1) summary
    cd14196
    Location:17285
    STKc_DAPK2; Catalytic domain of the Serine/Threonine Kinase, Death-Associated Protein Kinase 2
  7. NM_001395281.1NP_001382210.1  death-associated protein kinase 2 isoform 8

    Status: VALIDATED

    Source sequence(s)
    AC015914, AC021541
    Conserved Domains (1) summary
    cl21453
    Location:1130
    PKc_like; Protein Kinases, catalytic domain
  8. NM_001395282.1NP_001382211.1  death-associated protein kinase 2 isoform 4

    Status: VALIDATED

    Source sequence(s)
    AC015914, AC021541
    Conserved Domains (1) summary
    cl21453
    Location:17279
    PKc_like; Protein Kinases, catalytic domain
  9. NM_001395283.1NP_001382212.1  death-associated protein kinase 2 isoform 9

    Status: VALIDATED

    Source sequence(s)
    AC015914, AC021541
    Conserved Domains (1) summary
    cl21453
    Location:1124
    PKc_like; Protein Kinases, catalytic domain
  10. NM_001395284.1NP_001382213.1  death-associated protein kinase 2 isoform 9

    Status: VALIDATED

    Source sequence(s)
    AC015914, AC021541
    Conserved Domains (1) summary
    cl21453
    Location:1124
    PKc_like; Protein Kinases, catalytic domain
  11. NM_001395285.1NP_001382214.1  death-associated protein kinase 2 isoform 10

    Status: VALIDATED

    Source sequence(s)
    AC015914, AC021541
    Conserved Domains (1) summary
    cd14196
    Location:17285
    STKc_DAPK2; Catalytic domain of the Serine/Threonine Kinase, Death-Associated Protein Kinase 2
  12. NM_001395286.1NP_001382215.1  death-associated protein kinase 2 isoform 11

    Status: VALIDATED

    Source sequence(s)
    AC015914, AC021541
    UniProtKB/TrEMBL
    Q1RMF4
    Conserved Domains (1) summary
    cl21453
    Location:1130
    PKc_like; Protein Kinases, catalytic domain
  13. NM_001395287.1NP_001382216.1  death-associated protein kinase 2 isoform 11

    Status: VALIDATED

    Source sequence(s)
    AC015914, AC021541
    UniProtKB/TrEMBL
    Q1RMF4
    Conserved Domains (1) summary
    cl21453
    Location:1130
    PKc_like; Protein Kinases, catalytic domain
  14. NM_001395288.1NP_001382217.1  death-associated protein kinase 2 isoform 12

    Status: VALIDATED

    Source sequence(s)
    AC015914, AC021541
    Conserved Domains (1) summary
    cd14196
    Location:17285
    STKc_DAPK2; Catalytic domain of the Serine/Threonine Kinase, Death-Associated Protein Kinase 2
  15. NM_001395289.1NP_001382218.1  death-associated protein kinase 2 isoform 9

    Status: VALIDATED

    Source sequence(s)
    AC015914, AC021541
    Conserved Domains (1) summary
    cl21453
    Location:1124
    PKc_like; Protein Kinases, catalytic domain
  16. NM_001395290.1NP_001382219.1  death-associated protein kinase 2 isoform 13 precursor

    Status: VALIDATED

    Source sequence(s)
    AC015914, AC021541
    Conserved Domains (1) summary
    cl21453
    Location:176
    PKc_like; Protein Kinases, catalytic domain
  17. NM_001395291.1NP_001382220.1  death-associated protein kinase 2 isoform 14

    Status: VALIDATED

    Source sequence(s)
    AC015914, AC021541
    Conserved Domains (1) summary
    cd14196
    Location:17285
    STKc_DAPK2; Catalytic domain of the Serine/Threonine Kinase, Death-Associated Protein Kinase 2
  18. NM_001395292.1NP_001382221.1  death-associated protein kinase 2 isoform 8

    Status: VALIDATED

    Source sequence(s)
    AC015914, AC021541
    Conserved Domains (1) summary
    cl21453
    Location:1130
    PKc_like; Protein Kinases, catalytic domain
  19. NM_001395293.1NP_001382222.1  death-associated protein kinase 2 isoform 15

    Status: VALIDATED

    Source sequence(s)
    AC015914, AC021541
    Conserved Domains (1) summary
    cd14196
    Location:17285
    STKc_DAPK2; Catalytic domain of the Serine/Threonine Kinase, Death-Associated Protein Kinase 2
  20. NM_014326.5NP_055141.2  death-associated protein kinase 2 isoform 1

    See identical proteins and their annotated locations for NP_055141.2

    Status: VALIDATED

    Source sequence(s)
    AB018001, AC015914, AC021541, AF052941
    Consensus CDS
    CCDS10188.1
    UniProtKB/Swiss-Prot
    E9JGM7, O75892, Q24JS1, Q9UIK4
    Related
    ENSP00000408277.1, ENST00000457488.6
    Conserved Domains (1) summary
    cd14196
    Location:17285
    STKc_DAPK2; Catalytic domain of the Serine/Threonine Kinase, Death-Associated Protein Kinase 2

RNA

  1. NR_169522.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC015914, AC021541
  2. NR_169523.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC015914, AC021541
  3. NR_169524.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC015914, AC021541
  4. NR_172521.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC015914, AC021541

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000015.10 Reference GRCh38.p14 Primary Assembly

    Range
    63907036..64046485 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060939.1 Alternate T2T-CHM13v2.0

    Range
    61714186..61853651 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)