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DAPK2 death associated protein kinase 2 [ Homo sapiens (human) ]

Gene ID: 23604, updated on 3-Jul-2020

Summary

Official Symbol
DAPK2provided by HGNC
Official Full Name
death associated protein kinase 2provided by HGNC
Primary source
HGNC:HGNC:2675
See related
Ensembl:ENSG00000035664 MIM:616567
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
DRP1; DRP-1
Summary
This gene encodes a protein that belongs to the serine/threonine protein kinase family. This protein contains a N-terminal protein kinase domain followed by a conserved calmodulin-binding domain with significant similarity to that of death-associated protein kinase 1 (DAPK1), a positive regulator of programmed cell death. Overexpression of this gene was shown to induce cell apoptosis. It uses multiple polyadenylation sites. [provided by RefSeq, Jul 2008]
Expression
Broad expression in thyroid (RPKM 7.0), lung (RPKM 4.4) and 18 other tissues See more
Orthologs

Genomic context

See DAPK2 in Genome Data Viewer
Location:
15q22.31
Exon count:
17
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 15 NC_000015.10 (63907036..64046485, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 15 NC_000015.9 (64199235..64363614, complement)

Chromosome 15 - NC_000015.10Genomic Context describing neighboring genes Neighboring gene HECT and RLD domain containing E3 ubiquitin protein ligase family member 1 Neighboring gene microRNA 422a Neighboring gene uncharacterized LOC101928988 Neighboring gene cytosolic iron-sulfur assembly component 2A Neighboring gene sorting nexin 1

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

HIV-1 interactions

Replication interactions

Interaction Pubs
Knockdown of death-associated protein kinase 2 (DAPK2) by siRNA inhibits HIV-1 replication in HeLa P4/R5 cells PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC119312

Gene Ontology Provided by GOA

Function Evidence Code Pubs
ATP binding IDA
Inferred from Direct Assay
more info
PubMed 
calmodulin binding IDA
Inferred from Direct Assay
more info
PubMed 
identical protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein serine/threonine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein serine/threonine kinase activity TAS
Traceable Author Statement
more info
PubMed 
Process Evidence Code Pubs
anoikis IMP
Inferred from Mutant Phenotype
more info
PubMed 
apoptotic process TAS
Traceable Author Statement
more info
PubMed 
intracellular signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
intracellular signal transduction IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of apoptotic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
positive regulation of eosinophil chemotaxis IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of neutrophil chemotaxis IMP
Inferred from Mutant Phenotype
more info
PubMed 
protein autophosphorylation TAS
Traceable Author Statement
more info
PubMed 
protein phosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
regulation of apoptotic process TAS
Traceable Author Statement
more info
PubMed 
regulation of autophagy TAS
Traceable Author Statement
more info
PubMed 
regulation of intrinsic apoptotic signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
Golgi apparatus IDA
Inferred from Direct Assay
more info
 
autophagosome lumen IEA
Inferred from Electronic Annotation
more info
 
cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
cytoplasmic vesicle IEA
Inferred from Electronic Annotation
more info
 
intracellular membrane-bounded organelle IDA
Inferred from Direct Assay
more info
 
nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
death-associated protein kinase 2
Names
DAP kinase 2
DAP-kinase-related protein 1 beta isoform
NP_001350659.1
NP_055141.2
XP_011519715.1
XP_011519716.1
XP_011519717.1
XP_011519719.1
XP_011519723.1
XP_016877532.1
XP_016877533.1
XP_016877534.1
XP_016877535.1
XP_016877536.1
XP_016877537.1
XP_016877538.1
XP_016877539.1
XP_016877540.1
XP_016877541.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001363730.2NP_001350659.1  death-associated protein kinase 2 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC015914, AC021541, GU056176
    Consensus CDS
    CCDS86463.1
    Related
    ENSP00000484390.1, ENST00000612884.4
    Conserved Domains (1) summary
    cd14196
    Location:17285
    STKc_DAPK2; Catalytic domain of the Serine/Threonine Kinase, Death-Associated Protein Kinase 2
  2. NM_001384997.1NP_001371926.1  death-associated protein kinase 2 isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC015914, AC021541
  3. NM_001384998.1NP_001371927.1  death-associated protein kinase 2 isoform 4

    Status: VALIDATED

    Source sequence(s)
    AC015914, AC021541
  4. NM_001384999.1NP_001371928.1  death-associated protein kinase 2 isoform 5

    Status: VALIDATED

    Source sequence(s)
    AC015914, AC021541
  5. NM_001385000.1NP_001371929.1  death-associated protein kinase 2 isoform 6

    Status: VALIDATED

    Source sequence(s)
    AC015914, AC021541
  6. NM_014326.5NP_055141.2  death-associated protein kinase 2 isoform 1

    See identical proteins and their annotated locations for NP_055141.2

    Status: VALIDATED

    Source sequence(s)
    AB018001, AC015914, AC021541, AF052941
    Consensus CDS
    CCDS10188.1
    UniProtKB/Swiss-Prot
    Q9UIK4
    UniProtKB/TrEMBL
    A0A024R603
    Related
    ENSP00000408277.1, ENST00000457488.5
    Conserved Domains (1) summary
    cd14196
    Location:17285
    STKc_DAPK2; Catalytic domain of the Serine/Threonine Kinase, Death-Associated Protein Kinase 2

RNA

  1. NR_169522.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC015914, AC021541
  2. NR_169523.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC015914, AC021541
  3. NR_169524.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC015914, AC021541

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000015.10 Reference GRCh38.p13 Primary Assembly

    Range
    63907036..64046485 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011521421.3XP_011519723.1  death-associated protein kinase 2 isoform X10

    Conserved Domains (2) summary
    smart00220
    Location:2130
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cl21453
    Location:1130
    PKc_like; Protein Kinases, catalytic domain
  2. XM_011521417.1XP_011519719.1  death-associated protein kinase 2 isoform X7

    Conserved Domains (2) summary
    smart00220
    Location:23279
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cl21453
    Location:17279
    PKc_like; Protein Kinases, catalytic domain
  3. XM_017022045.1XP_016877534.1  death-associated protein kinase 2 isoform X7

    Conserved Domains (2) summary
    smart00220
    Location:23279
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cl21453
    Location:17279
    PKc_like; Protein Kinases, catalytic domain
  4. XM_011521413.2XP_011519715.1  death-associated protein kinase 2 isoform X2

    Conserved Domains (2) summary
    smart00220
    Location:23285
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd14196
    Location:17285
    STKc_DAPK2; Catalytic domain of the Serine/Threonine Kinase, Death-Associated Protein Kinase 2
  5. XM_017022044.1XP_016877533.1  death-associated protein kinase 2 isoform X6

  6. XM_011521414.1XP_011519716.1  death-associated protein kinase 2 isoform X4

    Conserved Domains (2) summary
    smart00220
    Location:23285
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd14196
    Location:17285
    STKc_DAPK2; Catalytic domain of the Serine/Threonine Kinase, Death-Associated Protein Kinase 2
  7. XM_017022046.1XP_016877535.1  death-associated protein kinase 2 isoform X7

    Conserved Domains (2) summary
    smart00220
    Location:23279
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cl21453
    Location:17279
    PKc_like; Protein Kinases, catalytic domain
  8. XM_011521415.3XP_011519717.1  death-associated protein kinase 2 isoform X5

    Conserved Domains (2) summary
    smart00220
    Location:23285
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd14196
    Location:17285
    STKc_DAPK2; Catalytic domain of the Serine/Threonine Kinase, Death-Associated Protein Kinase 2
  9. XM_017022043.1XP_016877532.1  death-associated protein kinase 2 isoform X1

  10. XM_017022049.1XP_016877538.1  death-associated protein kinase 2 isoform X8

  11. XM_017022047.1XP_016877536.1  death-associated protein kinase 2 isoform X8

  12. XM_017022050.1XP_016877539.1  death-associated protein kinase 2 isoform X8

  13. XM_017022051.1XP_016877540.1  death-associated protein kinase 2 isoform X8

  14. XM_017022048.2XP_016877537.1  death-associated protein kinase 2 isoform X8

  15. XM_017022052.1XP_016877541.1  death-associated protein kinase 2 isoform X9

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