Format

Send to:

Choose Destination

OPN3 opsin 3 [ Homo sapiens (human) ]

Gene ID: 23596, updated on 24-Nov-2020

Summary

Official Symbol
OPN3provided by HGNC
Official Full Name
opsin 3provided by HGNC
Primary source
HGNC:HGNC:14007
See related
Ensembl:ENSG00000054277 Ensembl:ENSG00000203668 MIM:606695
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
ECPN; PPP1R116
Summary
Opsins are members of the guanine nucleotide-binding protein (G protein)-coupled receptor superfamily. In addition to the visual opsins, mammals possess several photoreceptive non-visual opsins that are expressed in extraocular tissues. This gene, opsin 3, is strongly expressed in brain and testis and weakly expressed in liver, placenta, heart, lung, skeletal muscle, kidney, and pancreas. The gene may also be expressed in the retina. The protein has the canonical features of a photoreceptive opsin protein. [provided by RefSeq, Jul 2008]
Expression
Broad expression in placenta (RPKM 19.5), lung (RPKM 11.0) and 24 other tissues See more
Orthologs

Genomic context

See OPN3 in Genome Data Viewer
Location:
1q43
Exon count:
5
Annotation release Status Assembly Chr Location
109.20201120 current GRCh38.p13 (GCF_000001405.39) 1 NC_000001.11 (241593124..241640369, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (241756452..241803701, complement)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene fumarate hydratase Neighboring gene kynurenine 3-monooxygenase Neighboring gene uncharacterized LOC105373233 Neighboring gene CHM like Rab escort protein Neighboring gene WD repeat domain 64 Neighboring gene CRISPRi-validated cis-regulatory element chr1.12743

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
11-cis retinal binding IDA
Inferred from Direct Assay
more info
PubMed 
G protein-coupled photoreceptor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
G protein-coupled photoreceptor activity NAS
Non-traceable Author Statement
more info
PubMed 
G protein-coupled receptor activity TAS
Traceable Author Statement
more info
PubMed 
all-trans retinal binding IDA
Inferred from Direct Assay
more info
PubMed 
photoreceptor activity NAS
Non-traceable Author Statement
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
G protein-coupled receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cellular response to UV-A IDA
Inferred from Direct Assay
more info
PubMed 
cellular response to light stimulus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
detection of light stimulus NAS
Non-traceable Author Statement
more info
PubMed 
detection of visible light IEA
Inferred from Electronic Annotation
more info
 
keratinocyte differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of apoptotic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of melanin biosynthetic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
phototransduction IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
phototransduction NAS
Non-traceable Author Statement
more info
PubMed 
positive regulation of cellular respiration IEA
Inferred from Electronic Annotation
more info
 
positive regulation of glucose import IEA
Inferred from Electronic Annotation
more info
 
positive regulation of melanin biosynthetic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
protein-chromophore linkage IEA
Inferred from Electronic Annotation
more info
 
regulation of circadian rhythm NAS
Non-traceable Author Statement
more info
PubMed 
response to blue light IDA
Inferred from Direct Assay
more info
PubMed 
response to blue light IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
integral component of membrane NAS
Non-traceable Author Statement
more info
PubMed 
integral component of plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
photoreceptor outer segment IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
opsin-3
Names
encephalopsin
opsin 3 (encephalopsin, panopsin)
protein phosphatase 1, regulatory subunit 116

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001381855.1NP_001368784.1  opsin-3 isoform 2

    Status: REVIEWED

    Source sequence(s)
    AL133390
    Related
    ENSP00000490433.1, ENST00000638160.1
  2. NM_001381856.1NP_001368785.1  opsin-3 isoform 3

    Status: REVIEWED

    Source sequence(s)
    AL133390
    Related
    ENSP00000490694.1, ENST00000638121.1
  3. NM_014322.3NP_055137.2  opsin-3 isoform 1

    See identical proteins and their annotated locations for NP_055137.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (1).
    Source sequence(s)
    AF140242, AF303588, AL133390, BM679966, CB989739
    Consensus CDS
    CCDS31072.1
    UniProtKB/Swiss-Prot
    Q9H1Y3
    Related
    ENSP00000355512.2, ENST00000366554.3
    Conserved Domains (1) summary
    cd15078
    Location:58316
    7tmA_Encephalopsin; encephalopsins (opsin-3), member of the class A family of seven-transmembrane G protein-coupled receptors

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20201120

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p13 Primary Assembly

    Range
    241593124..241640369 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_001030011.1: Suppressed sequence

    Description
    NM_001030011.1: This RefSeq was permanently suppressed because it is a nonsense-mediated mRNA decay (NMD) candidate.
  2. NM_001030012.1: Suppressed sequence

    Description
    NM_001030012.1: This RefSeq was permanently suppressed because it is a nonsense-mediated mRNA decay (NMD) candidate.
Support Center