Opn3 opsin 3 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Opn3provided by MGI
Official Full Name: opsin 3provided by MGI
Primary source: MGI:MGI:1338022
See related: Ensembl:ENSMUSG00000026525 AllianceGenome:MGI:1338022
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: ERO; Ecpn
Summary: Predicted to enable 11-cis retinal binding activity; G protein-coupled photoreceptor activity; and all-trans retinal binding activity. Involved in positive regulation of cellular respiration; positive regulation of glucose import; and response to blue light. Predicted to be located in cytoplasm and plasma membrane. Predicted to be active in photoreceptor outer segment. Predicted to be integral component of plasma membrane. Is expressed in eye and orbito-sphenoid. Orthologous to human OPN3 (opsin 3). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Broad expression in subcutaneous fat pad adult (RPKM 13.2), adrenal adult (RPKM 13.0) and 24 other tissues See more
Orthologs: human all
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Genomic context

Location:: 1; 1 H3

Exon count:: 5

Annotation release	Status	Assembly	Chr	Location
109	current	GRCm39 (GCF_000001635.27)	1	NC_000067.7 (175489987..175520465, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	1	NC_000067.6 (175662421..175692901, complement)

Chromosome 1 - NC_000067.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Comprehensive Behavioral Analysis of Opsin 3 (Encephalopsin)-Deficient Mice Identifies Role in Modulation of Acoustic Startle Reflex.
Title: Comprehensive Behavioral Analysis of Opsin 3 (Encephalopsin)-Deficient Mice Identifies Role in Modulation of Acoustic Startle Reflex.
Endogenous Opsin 3 (OPN3) Protein Expression in the Adult Brain Using a Novel OPN3-mCherry Knock-In Mouse Model.
Title: Endogenous Opsin 3 (OPN3) Protein Expression in the Adult Brain Using a Novel OPN3-mCherry Knock-In Mouse Model.
Adaptive Thermogenesis in Mice Is Enhanced by Opsin 3-Dependent Adipocyte Light Sensing.
Title: Adaptive Thermogenesis in Mice Is Enhanced by Opsin 3-Dependent Adipocyte Light Sensing.
Opsin 3-Galphas Promotes Airway Smooth Muscle Relaxation Modulated by G Protein Receptor Kinase 2.
Title: Opsin 3-G(αs) Promotes Airway Smooth Muscle Relaxation Modulated by G Protein Receptor Kinase 2.
Illuminating insights into opsin 3 function in the skin.
Title: Illuminating insights into opsin 3 function in the skin.
Opsin3-knockout (Opn3-KO) mice are prone to diet-induced obesity and insulin resistance. Opn3-KO brown adipocytes cultured in darkness have decreased glucose uptake and lower nutrient-induced mitochondrial respiration than wild-type (WT) cells. Direct exposure of brown adipose tissue (BAT) to light in living mice significantly enhances thermogenic capacity of BAT, and this effect is diminished in Opn3-KO animals.
Title: Cell-autonomous light sensitivity via Opsin3 regulates fuel utilization in brown adipocytes.
This is the first demonstration of photorelaxation in airway smooth muscle via an OPN receptor-mediated pathway.
Title: Airway smooth muscle photorelaxation via opsin receptor activation.
studies clearly show that activation of sensory transduction by unliganded opsin, and not the accumulation of retinyl esters, causes light-independent retinal degeneration in Leber congenital amaurosis
Title: Spontaneous activity of opsin apoprotein is a cause of Leber congenital amaurosis.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (4) 1 citation
Endonuclease-mediated (5) 1 citation

General gene information

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Markers

Opn3 (e-PCR), detects polymorphism
- UniSTS:265733

NoName (e-PCR)
- UniSTS:489126

AI450814 (e-PCR)
- UniSTS:158896

Homology

Homologs of the Opn3 gene: The Opn3 gene is conserved in human, chimpanzee, Rhesus monkey, dog, cow, rat, chicken, zebrafish, and frog.
Orthologs from Annotation Pipeline: 465 organisms have orthologs with human gene Opn3
Orthologs

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables 11-cis retinal binding	ISO Inferred from Sequence Orthology more info
enables G protein-coupled photoreceptor activity	IBA Inferred from Biological aspect of Ancestor more info	PubMed
enables G protein-coupled receptor activity	IEA Inferred from Electronic Annotation more info
enables all-trans retinal binding	ISO Inferred from Sequence Orthology more info
enables photoreceptor activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in G protein-coupled receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info	PubMed
involved_in cellular response to UV-A	ISO Inferred from Sequence Orthology more info
involved_in cellular response to light stimulus	IBA Inferred from Biological aspect of Ancestor more info	PubMed
involved_in keratinocyte differentiation	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of apoptotic process	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of melanin biosynthetic process	ISO Inferred from Sequence Orthology more info
involved_in phototransduction	IBA Inferred from Biological aspect of Ancestor more info	PubMed
involved_in positive regulation of cellular respiration	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of glucose import	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of melanin biosynthetic process	ISO Inferred from Sequence Orthology more info
involved_in response to blue light	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in response to blue light	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within response to stimulus	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within signal transduction	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in membrane	IEA Inferred from Electronic Annotation more info
is_active_in photoreceptor outer segment	IBA Inferred from Biological aspect of Ancestor more info	PubMed
located_in plasma membrane	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: opsin-3

Names: encephalopsin; opsin (encephalopsin); panopsin

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_010098.3 → NP_034228.1 opsin-3

See identical proteins and their annotated locations for NP_034228.1

Status: VALIDATED

Source sequence(s)

AC124366, AK043135, AW492784

Consensus CDS

CCDS15549.1

UniProtKB/Swiss-Prot

Q3V0X3, Q9WUK7

Related

ENSMUSP00000027809.8, ENSMUST00000027809.8

Conserved Domains (1) summary

pfam00001
Location:65 → 307

7tm_1; 7 transmembrane receptor (rhodopsin family)

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000067.7 Reference GRCm39 C57BL/6J

Range

175489987..175520465 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006496642.4 → XP_006496705.1 opsin-3 isoform X1

Conserved Domains (2) summary

cd14964
Location:32 → 54

7tm_GPCRs; TM helix 4 [structural motif]

cl28897
Location:5 → 199

7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily