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PDSS1 decaprenyl diphosphate synthase subunit 1 [ Homo sapiens (human) ]

Gene ID: 23590, updated on 1-Jun-2020

Summary

Official Symbol
PDSS1provided by HGNC
Official Full Name
decaprenyl diphosphate synthase subunit 1provided by HGNC
Primary source
HGNC:HGNC:17759
See related
Ensembl:ENSG00000148459 MIM:607429
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
DPS; SPS; TPT; COQ1; TPRT; COQ1A; TPT 1; hDPS1; COQ10D2
Summary
The protein encoded by this gene is an enzyme that elongates the prenyl side-chain of coenzyme Q, or ubiquinone, one of the key elements in the respiratory chain. The gene product catalyzes the formation of all trans-polyprenyl pyrophosphates from isopentyl diphosphate in the assembly of polyisoprenoid side chains, the first step in coenzyme Q biosynthesis. The protein may be peripherally associated with the inner mitochondrial membrane, though no transit peptide has been definitively identified to date. Defects in this gene are a cause of coenzyme Q10 deficiency. [provided by RefSeq, Jul 2008]
Expression
Broad expression in duodenum (RPKM 4.4), small intestine (RPKM 3.8) and 24 other tissues See more
Orthologs

Genomic context

See PDSS1 in Genome Data Viewer
Location:
10p12.1
Exon count:
14
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 10 NC_000010.11 (26697424..26747246)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 10 NC_000010.10 (26986353..27035727)

Chromosome 10 - NC_000010.11Genomic Context describing neighboring genes Neighboring gene family with sequence similarity 238 member B Neighboring gene selenoprotein O like, pseudogene Neighboring gene heat shock protein family A (Hsp70) member 8 pseudogene 3 Neighboring gene abl interactor 1 Neighboring gene RNA, U6 small nuclear 946, pseudogene Neighboring gene family with sequence similarity 238 member C Neighboring gene ankyrin repeat domain 26

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

HIV-1 interactions

Replication interactions

Interaction Pubs
Knockdown of prenyl (decaprenyl) diphosphate synthase, subunit 1 (PDSS1) by siRNA inhibits HIV-1 replication in HeLa P4/R5 cells PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC70953

Gene Ontology Provided by GOA

Function Evidence Code Pubs
metal ion binding IEA
Inferred from Electronic Annotation
more info
 
prenyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein heterodimerization activity IEA
Inferred from Electronic Annotation
more info
 
contributes_to trans-hexaprenyltranstransferase activity IDA
Inferred from Direct Assay
more info
PubMed 
trans-octaprenyltranstransferase activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
isoprenoid biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
isoprenoid biosynthetic process IDA
Inferred from Direct Assay
more info
PubMed 
ubiquinone biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
ubiquinone biosynthetic process IDA
Inferred from Direct Assay
more info
PubMed 
ubiquinone biosynthetic process IEA
Inferred from Electronic Annotation
more info
 
ubiquinone biosynthetic process TAS
Traceable Author Statement
more info
 
Component Evidence Code Pubs
mitochondrial matrix TAS
Traceable Author Statement
more info
 
mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
transferase complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
transferase complex IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
decaprenyl-diphosphate synthase subunit 1
Names
all-trans-decaprenyl-diphosphate synthase subunit 1
coenzyme Q1 homolog
decaprenyl pyrophosphate synthase subunit 1
polyprenyl pyrophosphate synthetase
prenyl (decaprenyl) diphosphate synthase, subunit 1
subunit 1 of decaprenyl diphosphate synthase
trans-prenyltransferase (TPT)
trans-prenyltransferase 1
NP_001308907.1
NP_001308908.1
NP_055132.2
XP_011517739.1
XP_016871500.1
XP_024303690.1
XP_024303691.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_008972.2 RefSeqGene

    Range
    5036..54133
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001321978.1NP_001308907.1  decaprenyl-diphosphate synthase subunit 1 isoform 2

    Status: REVIEWED

    Source sequence(s)
    AK024802, AL390961, BC063635
    UniProtKB/Swiss-Prot
    Q5T2R2
    Conserved Domains (1) summary
    cd00685
    Location:121277
    Trans_IPPS_HT; Trans-Isoprenyl Diphosphate Synthases, head-to-tail
  2. NM_001321979.1NP_001308908.1  decaprenyl-diphosphate synthase subunit 1 isoform 3

    Status: REVIEWED

    Source sequence(s)
    AL390961
    Conserved Domains (1) summary
    cl00210
    Location:1243
    Isoprenoid_Biosyn_C1; Isoprenoid Biosynthesis enzymes, Class 1
  3. NM_014317.5NP_055132.2  decaprenyl-diphosphate synthase subunit 1 isoform 1

    See identical proteins and their annotated locations for NP_055132.2

    Status: REVIEWED

    Source sequence(s)
    AK024802, BC049211
    Consensus CDS
    CCDS31168.1
    UniProtKB/Swiss-Prot
    Q5T2R2
    Related
    ENSP00000365388.5, ENST00000376215.10
    Conserved Domains (2) summary
    PLN02890
    Location:6415
    PLN02890; geranyl diphosphate synthase
    cl00210
    Location:102413
    Isoprenoid_Biosyn_C1; Isoprenoid Biosynthesis enzymes, Class 1

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000010.11 Reference GRCh38.p13 Primary Assembly

    Range
    26697424..26747246
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_024447922.1XP_024303690.1  decaprenyl-diphosphate synthase subunit 1 isoform X1

    Conserved Domains (1) summary
    cd00685
    Location:121343
    Trans_IPPS_HT; Trans-Isoprenyl Diphosphate Synthases, head-to-tail
  2. XM_017016011.2XP_016871500.1  decaprenyl-diphosphate synthase subunit 1 isoform X2

  3. XM_024447923.1XP_024303691.1  decaprenyl-diphosphate synthase subunit 1 isoform X4

    Conserved Domains (1) summary
    cl00210
    Location:1243
    Isoprenoid_Biosyn_C1; Isoprenoid Biosynthesis enzymes, Class 1
  4. XM_011519437.3XP_011517739.1  decaprenyl-diphosphate synthase subunit 1 isoform X3

    Conserved Domains (1) summary
    cl00210
    Location:2290
    Isoprenoid_Biosyn_C1; Isoprenoid Biosynthesis enzymes, Class 1

RNA

  1. XR_428636.4 RNA Sequence

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