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KLHDC2 kelch domain containing 2 [ Homo sapiens (human) ]

Gene ID: 23588, updated on 13-Mar-2020

Summary

Official Symbol
KLHDC2provided by HGNC
Official Full Name
kelch domain containing 2provided by HGNC
Primary source
HGNC:HGNC:20231
See related
Ensembl:ENSG00000165516 MIM:611280
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
LCP; HCLP1; HCLP-1
Expression
Ubiquitous expression in thyroid (RPKM 22.9), kidney (RPKM 22.5) and 25 other tissues See more
Orthologs

Genomic context

See KLHDC2 in Genome Data Viewer
Location:
14q21.3
Exon count:
14
Annotation release Status Assembly Chr Location
109.20200228 current GRCh38.p13 (GCF_000001405.39) 14 NC_000014.9 (49767608..49786385)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 14 NC_000014.8 (50234787..50249856)

Chromosome 14 - NC_000014.9Genomic Context describing neighboring genes Neighboring gene DNA polymerase epsilon 2, accessory subunit Neighboring gene RNA, U6atac small nuclear 30, pseudogene Neighboring gene kelch domain containing 1 Neighboring gene nuclear export mediator factor Neighboring gene RNA, U6 small nuclear 539, pseudogene Neighboring gene RNA component of signal recognition particle 7SL3

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

HIV-1 interactions

Replication interactions

Interaction Pubs
Knockdown of kelch domain containing 2 (KLHDC2) by siRNA inhibits HIV-1 replication in HeLa-derived TZM-bl cells PubMed

Go to the HIV-1, Human Interaction Database

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Component Evidence Code Pubs
nuclear body IDA
Inferred from Direct Assay
more info
 
nuclear membrane IDA
Inferred from Direct Assay
more info
 
nucleoplasm IDA
Inferred from Direct Assay
more info
 

General protein information

Preferred Names
kelch domain-containing protein 2
Names
hepatocellular carcinoma-associated antigen 33
host cell factor homolog LCP
host cell factor-like protein 1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_014315.3NP_055130.1  kelch domain-containing protein 2

    See identical proteins and their annotated locations for NP_055130.1

    Status: VALIDATED

    Source sequence(s)
    AL591767, KF459555
    Consensus CDS
    CCDS9693.1
    UniProtKB/Swiss-Prot
    Q9Y2U9
    Related
    ENSP00000298307.5, ENST00000298307.10
    Conserved Domains (3) summary
    sd00038
    Location:218265
    Kelch; KELCH repeat [structural motif]
    pfam13415
    Location:279326
    Kelch_3; Galactose oxidase, central domain
    cl26061
    Location:29296
    PLN02193; nitrile-specifier protein

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000014.9 Reference GRCh38.p13 Primary Assembly

    Range
    49767608..49786385
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006720094.4XP_006720157.1  kelch domain-containing protein 2 isoform X1

    See identical proteins and their annotated locations for XP_006720157.1

    Related
    ENSP00000450658.1, ENST00000557247.1
    Conserved Domains (5) summary
    PLN02153
    Location:29303
    PLN02153; epithiospecifier protein
    sd00038
    Location:218265
    Kelch; KELCH repeat [structural motif]
    pfam13415
    Location:227274
    Kelch_3; Galactose oxidase, central domain
    pfam13418
    Location:267307
    Kelch_4; Galactose oxidase, central domain
    pfam13854
    Location:2976
    Kelch_5; Kelch motif
  2. XM_011536610.1XP_011534912.1  kelch domain-containing protein 2 isoform X2

    Conserved Domains (4) summary
    sd00038
    Location:146193
    Kelch; KELCH repeat [structural motif]
    pfam01344
    Location:145186
    Kelch_1; Kelch motif
    pfam13418
    Location:195235
    Kelch_4; Galactose oxidase, central domain
    pfam13854
    Location:1653
    Kelch_5; Kelch motif
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