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ELP5 elongator acetyltransferase complex subunit 5 [ Homo sapiens (human) ]

Gene ID: 23587, updated on 1-Jun-2020

Summary

Official Symbol
ELP5provided by HGNC
Official Full Name
elongator acetyltransferase complex subunit 5provided by HGNC
Primary source
HGNC:HGNC:30617
See related
Ensembl:ENSG00000170291 MIM:615019
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
DERP6; MST071; HSPC002; MSTP071; C17orf81
Expression
Broad expression in testis (RPKM 39.1), brain (RPKM 8.9) and 24 other tissues See more
Orthologs

Genomic context

See ELP5 in Genome Data Viewer
Location:
17p13.1
Exon count:
10
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 17 NC_000017.11 (7251737..7259940)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (7155372..7163259)

Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene PHD finger protein 23 Neighboring gene GABA type A receptor-associated protein Neighboring gene CTD nuclear envelope phosphatase 1 Neighboring gene claudin 7 Neighboring gene solute carrier family 2 member 4 Neighboring gene Y-box binding protein 2 Neighboring gene eukaryotic translation initiation factor 5A

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
positive regulation of cell migration ISS
Inferred from Sequence or Structural Similarity
more info
 
tRNA wobble uridine modification IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
Elongator holoenzyme complex IDA
Inferred from Direct Assay
more info
PubMed 
cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
cytosol IDA
Inferred from Direct Assay
more info
 
nucleoplasm IDA
Inferred from Direct Assay
more info
 
nucleus IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
elongator complex protein 5
Names
S-phase 2 protein
dermal papilla derived protein 6

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_015362.4NP_056177.3  elongator complex protein 5 isoform 1

    See identical proteins and their annotated locations for NP_056177.3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longer isoform (1). Variants 1, 3 and 4 encode the same isoform.
    Source sequence(s)
    AL713741, BC002762, BI916017, BP230198
    Consensus CDS
    CCDS11094.1
    UniProtKB/Swiss-Prot
    Q8TE02
    Related
    ENSP00000379868.2, ENST00000396627.6
    Conserved Domains (1) summary
    pfam10483
    Location:204283
    Elong_Iki1; Elongator subunit Iki1
  2. NM_203413.2NP_981958.1  elongator complex protein 5 isoform 2

    See identical proteins and their annotated locations for NP_981958.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) contains a 3' terminal exon that extends past three splice sites used in variant 1. This results in a novel 3' coding region and 3' UTR, compared to variant 1. It encodes isoform 2, which is shorter and has a distinct C-terminus, compared to isoform 1.
    Source sequence(s)
    AF163262, AK289940, AL713741, BF921423, BI916017, BP230198, BQ648358
    Consensus CDS
    CCDS11095.1
    UniProtKB/Swiss-Prot
    Q8TE02
    Related
    ENSP00000349111.2, ENST00000356683.6
  3. NM_203414.2NP_981959.1  elongator complex protein 5 isoform 1

    See identical proteins and their annotated locations for NP_981959.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1. Variants 1, 3 and 4 encode the same isoform (1).
    Source sequence(s)
    AK225983, AK289940, AL713741, BI916017, BP230198
    Consensus CDS
    CCDS11094.1
    UniProtKB/Swiss-Prot
    Q8TE02
    Related
    ENSP00000379869.2, ENST00000396628.6
    Conserved Domains (1) summary
    pfam10483
    Location:204283
    Elong_Iki1; Elongator subunit Iki1
  4. NM_203415.2NP_981960.1  elongator complex protein 5 isoform 1

    See identical proteins and their annotated locations for NP_981960.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) differs in the 5' UTR compared to variant 1. Variants 1, 3 and 4 encode the same isoform (1).
    Source sequence(s)
    AL713741, BE743557, BQ648358, CA431021, HY021862
    Consensus CDS
    CCDS11094.1
    UniProtKB/Swiss-Prot
    Q8TE02
    Related
    ENSP00000346412.2, ENST00000354429.6
    Conserved Domains (1) summary
    pfam10483
    Location:204283
    Elong_Iki1; Elongator subunit Iki1

RNA

  1. NR_145515.1 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (5) lacks an alternate internal exon compared to variant 1. This variant is represented as non-coding because the use of the 5'-most supported translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AC003688, AL713741

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000017.11 Reference GRCh38.p13 Primary Assembly

    Range
    7251737..7259940
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011523779.2XP_011522081.1  elongator complex protein 5 isoform X1

    See identical proteins and their annotated locations for XP_011522081.1

    UniProtKB/Swiss-Prot
    Q8TE02
    Conserved Domains (1) summary
    pfam10483
    Location:204283
    Elong_Iki1; Elongator subunit Iki1

Reference GRCh38.p13 PATCHES

Genomic

  1. NW_021160020.1 Reference GRCh38.p13 PATCHES

    Range
    7065..15268
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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