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Elp5 elongator acetyltransferase complex subunit 5 [ Mus musculus (house mouse) ]

Gene ID: 54351, updated on 26-Sep-2022

Summary

Official Symbol
Elp5provided by MGI
Official Full Name
elongator acetyltransferase complex subunit 5provided by MGI
Primary source
MGI:MGI:1859017
See related
Ensembl:ENSMUSG00000018565 AllianceGenome:MGI:1859017
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Derp6; Rai12
Summary
Predicted to contribute to tRNA binding activity. Involved in positive regulation of cell migration. Predicted to be located in cytoplasm and nucleoplasm. Predicted to be part of elongator holoenzyme complex. Predicted to be active in cytosol and nucleus. Is expressed in genitourinary system and telencephalon. Orthologous to human ELP5 (elongator acetyltransferase complex subunit 5). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in testis adult (RPKM 72.9), CNS E18 (RPKM 36.1) and 28 other tissues See more
Orthologs
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Genomic context

See Elp5 in Genome Data Viewer
Location:
11; 11 B3
Exon count:
9
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (69859050..69872352, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (69968224..69981447, complement)

Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene cofilin 1, non-muscle pseudogene Neighboring gene claudin 7 Neighboring gene CTD nuclear envelope phosphatase 1 Neighboring gene gamma-aminobutyric acid receptor associated protein Neighboring gene PHD finger protein 23

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
contributes_to tRNA binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Process Evidence Code Pubs
involved_in positive regulation of cell migration IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in tRNA modification IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
acts_upstream_of_or_within tRNA processing IEA
Inferred from Electronic Annotation
more info
 
involved_in tRNA wobble uridine modification IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
 
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in cytosol ISO
Inferred from Sequence Orthology
more info
 
part_of elongator holoenzyme complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
part_of elongator holoenzyme complex ISO
Inferred from Sequence Orthology
more info
 
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
elongator complex protein 5
Names
dermal papilla-derived protein 6 homolog
retinoic acid induced 12
retinoic acid-induced protein 12

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001253700.1NP_001240629.1  elongator complex protein 5 isoform 2

    See identical proteins and their annotated locations for NP_001240629.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR, lacks a portion of the 5' coding region, and uses an alternate start codon, compared to variant 1. The encoded isoform (2) has a distinct and shorter N-terminus, compared to isoform 1.
    Source sequence(s)
    AA646690, AL596185, BE862527, CD741073
    Conserved Domains (1) summary
    pfam10483
    Location:105150
    Elong_Iki1; Elongator subunit Iki1
  2. NM_018740.2NP_061210.2  elongator complex protein 5 isoform 1

    See identical proteins and their annotated locations for NP_061210.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AK152582, CD776986
    Consensus CDS
    CCDS24926.1
    UniProtKB/Swiss-Prot
    Q99L85, Q9CUX2
    Related
    ENSMUSP00000104235.2, ENSMUST00000108594.8
    Conserved Domains (1) summary
    pfam10483
    Location:11282
    Elong_Iki1; Elongator subunit Iki1

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000077.7 Reference GRCm39 C57BL/6J

    Range
    69859050..69872352 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006533752.5XP_006533815.1  elongator complex protein 5 isoform X1

    See identical proteins and their annotated locations for XP_006533815.1

    UniProtKB/Swiss-Prot
    Q99L85, Q9CUX2
    Conserved Domains (1) summary
    pfam10483
    Location:11282
    Elong_Iki1; Elongator subunit Iki1
  2. XM_030246159.1XP_030102019.1  elongator complex protein 5 isoform X2

    Conserved Domains (1) summary
    pfam10483
    Location:105150
    Elong_Iki1; Elongator subunit Iki1
  3. XM_036156855.1XP_036012748.1  elongator complex protein 5 isoform X2

    Conserved Domains (1) summary
    pfam10483
    Location:105150
    Elong_Iki1; Elongator subunit Iki1

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NR_027884.1: Suppressed sequence

    Description
    NR_027884.1: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript, which retains intronic sequence.