U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

SMUG1 single-strand-selective monofunctional uracil-DNA glycosylase 1 [ Homo sapiens (human) ]

Gene ID: 23583, updated on 2-Nov-2024

Summary

Official Symbol
SMUG1provided by HGNC
Official Full Name
single-strand-selective monofunctional uracil-DNA glycosylase 1provided by HGNC
Primary source
HGNC:HGNC:17148
See related
Ensembl:ENSG00000123415 MIM:607753; AllianceGenome:HGNC:17148
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
FDG; UNG3; HMUDG
Summary
This gene encodes a protein that participates in base excision repair by removing uracil from single- and double-stranded DNA. Many alternatively spliced transcript variants exist for this gene; the full-length nature is known for some but not all of the variants. [provided by RefSeq, Aug 2011]
Expression
Ubiquitous expression in skin (RPKM 3.7), placenta (RPKM 3.4) and 25 other tissues See more
Orthologs
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

See SMUG1 in Genome Data Viewer
Location:
12q13.13
Exon count:
10
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 12 NC_000012.12 (54158235..54188985, complement)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 12 NC_060936.1 (54119277..54154492, complement)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 12 NC_000012.11 (54574150..54582769, complement)

Chromosome 12 - NC_000012.12Genomic Context describing neighboring genes Neighboring gene H3K4me1 hESC enhancer GRCh37_chr12:54520229-54520862 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr12:54520863-54521498 Neighboring gene family with sequence similarity 242 member C Neighboring gene long intergenic non-protein coding RNA 2381 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr12:54526452-54527376 Neighboring gene ReSE screen-validated silencer GRCh37_chr12:54528656-54528824 Neighboring gene SMUG1 antisense RNA 1 Neighboring gene Sharpr-MPRA regulatory region 1237 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr12:54556725-54557225 Neighboring gene uncharacterized LOC102724030 Neighboring gene uncharacterized LOC105369777 Neighboring gene Sharpr-MPRA regulatory region 1888 Neighboring gene ReSE screen-validated silencer GRCh37_chr12:54609784-54609969 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 4524 Neighboring gene microRNA 3198-2 Neighboring gene chromobox 5

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Vpr vpr HIV-1 Vpr-induced reduction in single-strand selective monofunctional uracil DNA glycosylase (SMUG1) is mediated through proteasomal degradation PubMed
vpr The interaction of Vpr with DDB1 facilitates the formation of complexes containing Cul4A-Roc1 E3 ubiquitin ligase. The association of Vpr with DDB1-containing E3 ligase mediates the degradation of UNG2 and SMUG1 PubMed
vpr HIV-1 Vpr induces the ubiquitination of SMUG1 and forms a complex with SMUG1 PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Clone Names

  • MGC104370

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables DNA N-glycosylase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables DNA binding IEA
Inferred from Electronic Annotation
more info
 
enables identical protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables oxidized pyrimidine nucleobase lesion DNA N-glycosylase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables single-strand selective uracil DNA N-glycosylase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables single-strand selective uracil DNA N-glycosylase activity TAS
Traceable Author Statement
more info
 
enables uracil DNA N-glycosylase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables uracil DNA N-glycosylase activity IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
involved_in base-excision repair IDA
Inferred from Direct Assay
more info
PubMed 
involved_in depyrimidination TAS
Traceable Author Statement
more info
 
Component Evidence Code Pubs
located_in cytosol IDA
Inferred from Direct Assay
more info
 
located_in fibrillar center IDA
Inferred from Direct Assay
more info
 
located_in nucleolus IDA
Inferred from Direct Assay
more info
PubMed 
located_in nucleoplasm IDA
Inferred from Direct Assay
more info
 
located_in nucleoplasm TAS
Traceable Author Statement
more info
 

General protein information

Preferred Names
single-strand selective monofunctional uracil DNA glycosylase
NP_001230716.1
NP_001230717.1
NP_001230718.1
NP_001230719.1
NP_001230720.1
NP_001338166.1
NP_001338167.1
NP_001338168.1
NP_001338169.1
NP_001338170.1
NP_001338171.1
NP_001338172.1
NP_001338173.1
NP_001338174.1
NP_001338175.1
NP_001338176.1
NP_001338177.1
NP_001338178.1
NP_001338179.1
NP_001338180.1
NP_001338181.1
NP_001338182.1
NP_001338183.1
NP_001338184.1
NP_001338185.1
NP_001338186.1
NP_001338187.1
NP_001338188.1
NP_001338189.1
NP_001338190.1
NP_001338191.1
NP_055126.1
XP_006719382.1
XP_011536414.1
XP_011536418.1
XP_011536420.1
XP_011536421.1
XP_011536423.1
XP_047284588.1
XP_047284589.1
XP_047284590.1
XP_047284591.1
XP_047284592.1
XP_047284593.1
XP_047284594.1
XP_047284595.1
XP_047284596.1
XP_047284597.1
XP_047284598.1
XP_047284599.1
XP_047284600.1
XP_047284601.1
XP_047284602.1
XP_047284604.1
XP_047284605.1
XP_047284606.1
XP_047284607.1
XP_047284608.1
XP_047284609.1
XP_047284610.1
XP_047284611.1
XP_054227595.1
XP_054227596.1
XP_054227597.1
XP_054227598.1
XP_054227599.1
XP_054227600.1
XP_054227601.1
XP_054227602.1
XP_054227603.1
XP_054227604.1
XP_054227605.1
XP_054227606.1
XP_054227607.1
XP_054227608.1
XP_054227609.1
XP_054227610.1
XP_054227611.1
XP_054227612.1
XP_054227613.1
XP_054227614.1
XP_054227615.1
XP_054227616.1
XP_054227617.1
XP_054227618.1
XP_054227619.1
XP_054227620.1
XP_054227621.1
XP_054227622.1
XP_054227623.1

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_047137.2 RefSeqGene

    Range
    5000..13619
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001243787.2NP_001230716.1  single-strand selective monofunctional uracil DNA glycosylase isoform 1

    See identical proteins and their annotated locations for NP_001230716.1

    Status: REVIEWED

    Source sequence(s)
    AC023794, AI002776, AK222473, BG706635, CD245413
    Consensus CDS
    CCDS8874.1
    UniProtKB/Swiss-Prot
    A8K2K9, O95862, Q0D2M0, Q53HV7, Q8NB71, Q9BWC8
    UniProtKB/TrEMBL
    A0A024RAZ8
    Related
    ENSP00000507590.1, ENST00000682136.1
    Conserved Domains (1) summary
    cd19374
    Location:29258
    UDG-F3_SMUG1-like; Uracil DNA glycosylase family 3 subfamily, includes single-strand-selective monofunctional uracil-DNA glycosylase 1 and similar proteins
  2. NM_001243788.2NP_001230717.1  single-strand selective monofunctional uracil DNA glycosylase isoform 1

    See identical proteins and their annotated locations for NP_001230717.1

    Status: REVIEWED

    Source sequence(s)
    AC023794, AI002776, DA430734
    Consensus CDS
    CCDS8874.1
    UniProtKB/Swiss-Prot
    A8K2K9, O95862, Q0D2M0, Q53HV7, Q8NB71, Q9BWC8
    UniProtKB/TrEMBL
    A0A024RAZ8
    Related
    ENSP00000424191.1, ENST00000508394.6
    Conserved Domains (1) summary
    cd19374
    Location:29258
    UDG-F3_SMUG1-like; Uracil DNA glycosylase family 3 subfamily, includes single-strand-selective monofunctional uracil-DNA glycosylase 1 and similar proteins
  3. NM_001243789.2NP_001230718.1  single-strand selective monofunctional uracil DNA glycosylase isoform 2

    See identical proteins and their annotated locations for NP_001230718.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) differs in the 5' UTR, 3' UTR, and coding region compared to variant 1. The resulting isoform (2) has a shorter and distinct C-terminus compared to isoform 1. Variants 4-11 all encode the same isoform (2).
    Source sequence(s)
    AC023794, BC000417, BC088352, BG764502, DA703553
    Consensus CDS
    CCDS58239.1
    UniProtKB/TrEMBL
    A0A0S2Z526
    Related
    ENSP00000423629.1, ENST00000513838.5
    Conserved Domains (1) summary
    cl00483
    Location:29135
    UDG_like; Uracil-DNA glycosylases (UDG) and related enzymes
  4. NM_001243790.2NP_001230719.1  single-strand selective monofunctional uracil DNA glycosylase isoform 2

    See identical proteins and their annotated locations for NP_001230719.1

    Status: REVIEWED

    Source sequence(s)
    AC023794, BC088352, BG764502, DA703553
    Consensus CDS
    CCDS58239.1
    UniProtKB/TrEMBL
    A0A0S2Z526
    Related
    ENSP00000421139.1, ENST00000514685.5
    Conserved Domains (1) summary
    cl00483
    Location:29135
    UDG_like; Uracil-DNA glycosylases (UDG) and related enzymes
  5. NM_001243791.2NP_001230720.1  single-strand selective monofunctional uracil DNA glycosylase isoform 2

    See identical proteins and their annotated locations for NP_001230720.1

    Status: REVIEWED

    Source sequence(s)
    AC023794, BC088352, BC105607, BG706635
    Consensus CDS
    CCDS58239.1
    UniProtKB/TrEMBL
    A0A0S2Z526
    Related
    ENSP00000243112.5, ENST00000243112.9
    Conserved Domains (1) summary
    cl00483
    Location:29135
    UDG_like; Uracil-DNA glycosylases (UDG) and related enzymes
  6. NM_001351237.2NP_001338166.1  single-strand selective monofunctional uracil DNA glycosylase isoform 2

    Status: REVIEWED

    Source sequence(s)
    AC023794
    Consensus CDS
    CCDS58239.1
    UniProtKB/TrEMBL
    A0A0S2Z526
    Related
    ENSP00000421206.1, ENST00000506595.5
    Conserved Domains (1) summary
    cl00483
    Location:29135
    UDG_like; Uracil-DNA glycosylases (UDG) and related enzymes
  7. NM_001351238.2NP_001338167.1  single-strand selective monofunctional uracil DNA glycosylase isoform 2

    Status: REVIEWED

    Source sequence(s)
    AC023794
    Consensus CDS
    CCDS58239.1
    UniProtKB/TrEMBL
    A0A0S2Z526
    Conserved Domains (1) summary
    cl00483
    Location:29135
    UDG_like; Uracil-DNA glycosylases (UDG) and related enzymes
  8. NM_001351239.2NP_001338168.1  single-strand selective monofunctional uracil DNA glycosylase isoform 2

    Status: REVIEWED

    Source sequence(s)
    AC023794
    Consensus CDS
    CCDS58239.1
    UniProtKB/TrEMBL
    A0A0S2Z526
    Conserved Domains (1) summary
    cl00483
    Location:29135
    UDG_like; Uracil-DNA glycosylases (UDG) and related enzymes
  9. NM_001351240.2NP_001338169.1  single-strand selective monofunctional uracil DNA glycosylase isoform 2

    Status: REVIEWED

    Source sequence(s)
    AC023794
    Consensus CDS
    CCDS58239.1
    UniProtKB/TrEMBL
    A0A0S2Z526
    Conserved Domains (1) summary
    cl00483
    Location:29135
    UDG_like; Uracil-DNA glycosylases (UDG) and related enzymes
  10. NM_001351241.2NP_001338170.1  single-strand selective monofunctional uracil DNA glycosylase isoform 2

    Status: REVIEWED

    Source sequence(s)
    AC023794
    Consensus CDS
    CCDS58239.1
    UniProtKB/TrEMBL
    A0A0S2Z526
    Conserved Domains (1) summary
    cl00483
    Location:29135
    UDG_like; Uracil-DNA glycosylases (UDG) and related enzymes
  11. NM_001351242.2NP_001338171.1  single-strand selective monofunctional uracil DNA glycosylase isoform 1

    Status: REVIEWED

    Source sequence(s)
    AC023794
    Consensus CDS
    CCDS8874.1
    UniProtKB/Swiss-Prot
    A8K2K9, O95862, Q0D2M0, Q53HV7, Q8NB71, Q9BWC8
    UniProtKB/TrEMBL
    A0A024RAZ8
    Conserved Domains (1) summary
    cd19374
    Location:29258
    UDG-F3_SMUG1-like; Uracil DNA glycosylase family 3 subfamily, includes single-strand-selective monofunctional uracil-DNA glycosylase 1 and similar proteins
  12. NM_001351243.2NP_001338172.1  single-strand selective monofunctional uracil DNA glycosylase isoform 1

    Status: REVIEWED

    Source sequence(s)
    AC023794
    Consensus CDS
    CCDS8874.1
    UniProtKB/Swiss-Prot
    A8K2K9, O95862, Q0D2M0, Q53HV7, Q8NB71, Q9BWC8
    UniProtKB/TrEMBL
    A0A024RAZ8
    Conserved Domains (1) summary
    cd19374
    Location:29258
    UDG-F3_SMUG1-like; Uracil DNA glycosylase family 3 subfamily, includes single-strand-selective monofunctional uracil-DNA glycosylase 1 and similar proteins
  13. NM_001351244.2NP_001338173.1  single-strand selective monofunctional uracil DNA glycosylase isoform 1

    Status: REVIEWED

    Source sequence(s)
    AC023794
    Consensus CDS
    CCDS8874.1
    UniProtKB/Swiss-Prot
    A8K2K9, O95862, Q0D2M0, Q53HV7, Q8NB71, Q9BWC8
    UniProtKB/TrEMBL
    A0A024RAZ8
    Conserved Domains (1) summary
    cd19374
    Location:29258
    UDG-F3_SMUG1-like; Uracil DNA glycosylase family 3 subfamily, includes single-strand-selective monofunctional uracil-DNA glycosylase 1 and similar proteins
  14. NM_001351245.2NP_001338174.1  single-strand selective monofunctional uracil DNA glycosylase isoform 1

    Status: REVIEWED

    Source sequence(s)
    AC023794
    Consensus CDS
    CCDS8874.1
    UniProtKB/Swiss-Prot
    A8K2K9, O95862, Q0D2M0, Q53HV7, Q8NB71, Q9BWC8
    UniProtKB/TrEMBL
    A0A024RAZ8
    Conserved Domains (1) summary
    cd19374
    Location:29258
    UDG-F3_SMUG1-like; Uracil DNA glycosylase family 3 subfamily, includes single-strand-selective monofunctional uracil-DNA glycosylase 1 and similar proteins
  15. NM_001351246.2NP_001338175.1  single-strand selective monofunctional uracil DNA glycosylase isoform 1

    Status: REVIEWED

    Source sequence(s)
    AC023794
    Consensus CDS
    CCDS8874.1
    UniProtKB/Swiss-Prot
    A8K2K9, O95862, Q0D2M0, Q53HV7, Q8NB71, Q9BWC8
    UniProtKB/TrEMBL
    A0A024RAZ8
    Conserved Domains (1) summary
    cd19374
    Location:29258
    UDG-F3_SMUG1-like; Uracil DNA glycosylase family 3 subfamily, includes single-strand-selective monofunctional uracil-DNA glycosylase 1 and similar proteins
  16. NM_001351247.2NP_001338176.1  single-strand selective monofunctional uracil DNA glycosylase isoform 1

    Status: REVIEWED

    Source sequence(s)
    AC023794
    Consensus CDS
    CCDS8874.1
    UniProtKB/Swiss-Prot
    A8K2K9, O95862, Q0D2M0, Q53HV7, Q8NB71, Q9BWC8
    UniProtKB/TrEMBL
    A0A024RAZ8
    Conserved Domains (1) summary
    cd19374
    Location:29258
    UDG-F3_SMUG1-like; Uracil DNA glycosylase family 3 subfamily, includes single-strand-selective monofunctional uracil-DNA glycosylase 1 and similar proteins
  17. NM_001351248.2NP_001338177.1  single-strand selective monofunctional uracil DNA glycosylase isoform 1

    Status: REVIEWED

    Source sequence(s)
    AC023794
    Consensus CDS
    CCDS8874.1
    UniProtKB/Swiss-Prot
    A8K2K9, O95862, Q0D2M0, Q53HV7, Q8NB71, Q9BWC8
    UniProtKB/TrEMBL
    A0A024RAZ8
    Conserved Domains (1) summary
    cd19374
    Location:29258
    UDG-F3_SMUG1-like; Uracil DNA glycosylase family 3 subfamily, includes single-strand-selective monofunctional uracil-DNA glycosylase 1 and similar proteins
  18. NM_001351249.2NP_001338178.1  single-strand selective monofunctional uracil DNA glycosylase isoform 1

    Status: REVIEWED

    Source sequence(s)
    AC023794
    Consensus CDS
    CCDS8874.1
    UniProtKB/Swiss-Prot
    A8K2K9, O95862, Q0D2M0, Q53HV7, Q8NB71, Q9BWC8
    UniProtKB/TrEMBL
    A0A024RAZ8
    Conserved Domains (1) summary
    cd19374
    Location:29258
    UDG-F3_SMUG1-like; Uracil DNA glycosylase family 3 subfamily, includes single-strand-selective monofunctional uracil-DNA glycosylase 1 and similar proteins
  19. NM_001351250.2NP_001338179.1  single-strand selective monofunctional uracil DNA glycosylase isoform 1

    Status: REVIEWED

    Source sequence(s)
    AC023794
    Consensus CDS
    CCDS8874.1
    UniProtKB/Swiss-Prot
    A8K2K9, O95862, Q0D2M0, Q53HV7, Q8NB71, Q9BWC8
    UniProtKB/TrEMBL
    A0A024RAZ8
    Conserved Domains (1) summary
    cd19374
    Location:29258
    UDG-F3_SMUG1-like; Uracil DNA glycosylase family 3 subfamily, includes single-strand-selective monofunctional uracil-DNA glycosylase 1 and similar proteins
  20. NM_001351251.2NP_001338180.1  single-strand selective monofunctional uracil DNA glycosylase isoform 1

    Status: REVIEWED

    Source sequence(s)
    AC023794
    Consensus CDS
    CCDS8874.1
    UniProtKB/Swiss-Prot
    A8K2K9, O95862, Q0D2M0, Q53HV7, Q8NB71, Q9BWC8
    UniProtKB/TrEMBL
    A0A024RAZ8
    Conserved Domains (1) summary
    cd19374
    Location:29258
    UDG-F3_SMUG1-like; Uracil DNA glycosylase family 3 subfamily, includes single-strand-selective monofunctional uracil-DNA glycosylase 1 and similar proteins
  21. NM_001351252.2NP_001338181.1  single-strand selective monofunctional uracil DNA glycosylase isoform 1

    Status: REVIEWED

    Source sequence(s)
    AC023794
    Consensus CDS
    CCDS8874.1
    UniProtKB/Swiss-Prot
    A8K2K9, O95862, Q0D2M0, Q53HV7, Q8NB71, Q9BWC8
    UniProtKB/TrEMBL
    A0A024RAZ8
    Conserved Domains (1) summary
    cd19374
    Location:29258
    UDG-F3_SMUG1-like; Uracil DNA glycosylase family 3 subfamily, includes single-strand-selective monofunctional uracil-DNA glycosylase 1 and similar proteins
  22. NM_001351253.2NP_001338182.1  single-strand selective monofunctional uracil DNA glycosylase isoform 1

    Status: REVIEWED

    Source sequence(s)
    AC023794
    Consensus CDS
    CCDS8874.1
    UniProtKB/Swiss-Prot
    A8K2K9, O95862, Q0D2M0, Q53HV7, Q8NB71, Q9BWC8
    UniProtKB/TrEMBL
    A0A024RAZ8
    Conserved Domains (1) summary
    cd19374
    Location:29258
    UDG-F3_SMUG1-like; Uracil DNA glycosylase family 3 subfamily, includes single-strand-selective monofunctional uracil-DNA glycosylase 1 and similar proteins
  23. NM_001351254.2NP_001338183.1  single-strand selective monofunctional uracil DNA glycosylase isoform 1

    Status: REVIEWED

    Source sequence(s)
    AC023794
    Consensus CDS
    CCDS8874.1
    UniProtKB/Swiss-Prot
    A8K2K9, O95862, Q0D2M0, Q53HV7, Q8NB71, Q9BWC8
    UniProtKB/TrEMBL
    A0A024RAZ8
    Conserved Domains (1) summary
    cd19374
    Location:29258
    UDG-F3_SMUG1-like; Uracil DNA glycosylase family 3 subfamily, includes single-strand-selective monofunctional uracil-DNA glycosylase 1 and similar proteins
  24. NM_001351255.2NP_001338184.1  single-strand selective monofunctional uracil DNA glycosylase isoform 1

    Status: REVIEWED

    Source sequence(s)
    AC023794
    Consensus CDS
    CCDS8874.1
    UniProtKB/Swiss-Prot
    A8K2K9, O95862, Q0D2M0, Q53HV7, Q8NB71, Q9BWC8
    UniProtKB/TrEMBL
    A0A024RAZ8
    Conserved Domains (1) summary
    cd19374
    Location:29258
    UDG-F3_SMUG1-like; Uracil DNA glycosylase family 3 subfamily, includes single-strand-selective monofunctional uracil-DNA glycosylase 1 and similar proteins
  25. NM_001351256.2NP_001338185.1  single-strand selective monofunctional uracil DNA glycosylase isoform 1

    Status: REVIEWED

    Source sequence(s)
    AC023794
    Consensus CDS
    CCDS8874.1
    UniProtKB/Swiss-Prot
    A8K2K9, O95862, Q0D2M0, Q53HV7, Q8NB71, Q9BWC8
    UniProtKB/TrEMBL
    A0A024RAZ8
    Conserved Domains (1) summary
    cd19374
    Location:29258
    UDG-F3_SMUG1-like; Uracil DNA glycosylase family 3 subfamily, includes single-strand-selective monofunctional uracil-DNA glycosylase 1 and similar proteins
  26. NM_001351257.2NP_001338186.1  single-strand selective monofunctional uracil DNA glycosylase isoform 1

    Status: REVIEWED

    Source sequence(s)
    AC023794
    Consensus CDS
    CCDS8874.1
    UniProtKB/Swiss-Prot
    A8K2K9, O95862, Q0D2M0, Q53HV7, Q8NB71, Q9BWC8
    UniProtKB/TrEMBL
    A0A024RAZ8
    Conserved Domains (1) summary
    cd19374
    Location:29258
    UDG-F3_SMUG1-like; Uracil DNA glycosylase family 3 subfamily, includes single-strand-selective monofunctional uracil-DNA glycosylase 1 and similar proteins
  27. NM_001351258.2NP_001338187.1  single-strand selective monofunctional uracil DNA glycosylase isoform 3

    Status: REVIEWED

    Source sequence(s)
    AC023794
    Conserved Domains (1) summary
    cl00483
    Location:29201
    UDG_like; Uracil-DNA glycosylases (UDG) and related enzymes
  28. NM_001351259.2NP_001338188.1  single-strand selective monofunctional uracil DNA glycosylase isoform 4

    Status: REVIEWED

    Description
    Transcript Variant: This variant (29) encodes isoform (4). Variants 29 and 30 both encode the same isoform (4).
    Source sequence(s)
    AC023794
    Conserved Domains (1) summary
    cl00483
    Location:1156
    UDG-like; uracil-DNA glycosylases (UDG) and related enzymes
  29. NM_001351260.2NP_001338189.1  single-strand selective monofunctional uracil DNA glycosylase isoform 4

    Status: REVIEWED

    Source sequence(s)
    AC023794
    Conserved Domains (1) summary
    cl00483
    Location:1156
    UDG-like; uracil-DNA glycosylases (UDG) and related enzymes
  30. NM_001351261.2NP_001338190.1  single-strand selective monofunctional uracil DNA glycosylase isoform 5

    Status: REVIEWED

    Source sequence(s)
    AC023794
    Consensus CDS
    CCDS86305.1
    UniProtKB/TrEMBL
    D6RI04, H0YA95
    Related
    ENSP00000425974.1, ENST00000514196.5
    Conserved Domains (2) summary
    cd09593
    Location:8387
    UDG-like; motif A [structural motif]
    cl00483
    Location:29135
    UDG-like; uracil-DNA glycosylases (UDG) and related enzymes
  31. NM_001351262.2NP_001338191.1  single-strand selective monofunctional uracil DNA glycosylase isoform 1

    Status: REVIEWED

    Source sequence(s)
    AC023794
    Consensus CDS
    CCDS8874.1
    UniProtKB/Swiss-Prot
    A8K2K9, O95862, Q0D2M0, Q53HV7, Q8NB71, Q9BWC8
    UniProtKB/TrEMBL
    A0A024RAZ8
    Related
    ENSP00000384828.2, ENST00000401977.6
    Conserved Domains (1) summary
    cd19374
    Location:29258
    UDG-F3_SMUG1-like; Uracil DNA glycosylase family 3 subfamily, includes single-strand-selective monofunctional uracil-DNA glycosylase 1 and similar proteins
  32. NM_014311.3NP_055126.1  single-strand selective monofunctional uracil DNA glycosylase isoform 1

    See identical proteins and their annotated locations for NP_055126.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (1). Variants 1-3, 12-27, and 32 all encode the same isoform (1).
    Source sequence(s)
    AC023794, AI002776, AK001235, BG706635
    Consensus CDS
    CCDS8874.1
    UniProtKB/Swiss-Prot
    A8K2K9, O95862, Q0D2M0, Q53HV7, Q8NB71, Q9BWC8
    UniProtKB/TrEMBL
    A0A024RAZ8
    Related
    ENSP00000338606.3, ENST00000337581.7
    Conserved Domains (1) summary
    cd19374
    Location:29258
    UDG-F3_SMUG1-like; Uracil DNA glycosylase family 3 subfamily, includes single-strand-selective monofunctional uracil-DNA glycosylase 1 and similar proteins

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000012.12 Reference GRCh38.p14 Primary Assembly

    Range
    54158235..54188985 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047428642.1XP_047284598.1  single-strand selective monofunctional uracil DNA glycosylase isoform X1

    UniProtKB/Swiss-Prot
    A8K2K9, O95862, Q0D2M0, Q53HV7, Q8NB71, Q9BWC8
    UniProtKB/TrEMBL
    A0A024RAZ8
  2. XM_047428640.1XP_047284596.1  single-strand selective monofunctional uracil DNA glycosylase isoform X1

    UniProtKB/Swiss-Prot
    A8K2K9, O95862, Q0D2M0, Q53HV7, Q8NB71, Q9BWC8
    UniProtKB/TrEMBL
    A0A024RAZ8
  3. XM_047428654.1XP_047284610.1  single-strand selective monofunctional uracil DNA glycosylase isoform X2

    UniProtKB/TrEMBL
    A0A0S2Z526
  4. XM_006719319.4XP_006719382.1  single-strand selective monofunctional uracil DNA glycosylase isoform X1

    See identical proteins and their annotated locations for XP_006719382.1

    UniProtKB/Swiss-Prot
    A8K2K9, O95862, Q0D2M0, Q53HV7, Q8NB71, Q9BWC8
    UniProtKB/TrEMBL
    A0A024RAZ8
    Conserved Domains (1) summary
    cd19374
    Location:29258
    UDG-F3_SMUG1-like; Uracil DNA glycosylase family 3 subfamily, includes single-strand-selective monofunctional uracil-DNA glycosylase 1 and similar proteins
  5. XM_047428653.1XP_047284609.1  single-strand selective monofunctional uracil DNA glycosylase isoform X2

    UniProtKB/TrEMBL
    A0A0S2Z526
  6. XM_047428650.1XP_047284606.1  single-strand selective monofunctional uracil DNA glycosylase isoform X2

    UniProtKB/TrEMBL
    A0A0S2Z526
  7. XM_011538119.3XP_011536421.1  single-strand selective monofunctional uracil DNA glycosylase isoform X1

    See identical proteins and their annotated locations for XP_011536421.1

    UniProtKB/Swiss-Prot
    A8K2K9, O95862, Q0D2M0, Q53HV7, Q8NB71, Q9BWC8
    UniProtKB/TrEMBL
    A0A024RAZ8
    Conserved Domains (1) summary
    cd19374
    Location:29258
    UDG-F3_SMUG1-like; Uracil DNA glycosylase family 3 subfamily, includes single-strand-selective monofunctional uracil-DNA glycosylase 1 and similar proteins
  8. XM_011538121.3XP_011536423.1  single-strand selective monofunctional uracil DNA glycosylase isoform X1

    See identical proteins and their annotated locations for XP_011536423.1

    UniProtKB/Swiss-Prot
    A8K2K9, O95862, Q0D2M0, Q53HV7, Q8NB71, Q9BWC8
    UniProtKB/TrEMBL
    A0A024RAZ8
    Conserved Domains (1) summary
    cd19374
    Location:29258
    UDG-F3_SMUG1-like; Uracil DNA glycosylase family 3 subfamily, includes single-strand-selective monofunctional uracil-DNA glycosylase 1 and similar proteins
  9. XM_047428649.1XP_047284605.1  single-strand selective monofunctional uracil DNA glycosylase isoform X2

    UniProtKB/TrEMBL
    A0A0S2Z526
  10. XM_047428655.1XP_047284611.1  single-strand selective monofunctional uracil DNA glycosylase isoform X2

    UniProtKB/TrEMBL
    A0A0S2Z526
  11. XM_047428641.1XP_047284597.1  single-strand selective monofunctional uracil DNA glycosylase isoform X1

    UniProtKB/Swiss-Prot
    A8K2K9, O95862, Q0D2M0, Q53HV7, Q8NB71, Q9BWC8
    UniProtKB/TrEMBL
    A0A024RAZ8
  12. XM_011538116.3XP_011536418.1  single-strand selective monofunctional uracil DNA glycosylase isoform X1

    See identical proteins and their annotated locations for XP_011536418.1

    UniProtKB/Swiss-Prot
    A8K2K9, O95862, Q0D2M0, Q53HV7, Q8NB71, Q9BWC8
    UniProtKB/TrEMBL
    A0A024RAZ8
    Conserved Domains (1) summary
    cd19374
    Location:29258
    UDG-F3_SMUG1-like; Uracil DNA glycosylase family 3 subfamily, includes single-strand-selective monofunctional uracil-DNA glycosylase 1 and similar proteins
  13. XM_047428648.1XP_047284604.1  single-strand selective monofunctional uracil DNA glycosylase isoform X2

    UniProtKB/TrEMBL
    A0A0S2Z526
  14. XM_047428646.1XP_047284602.1  single-strand selective monofunctional uracil DNA glycosylase isoform X2

    UniProtKB/TrEMBL
    A0A0S2Z526
  15. XM_047428644.1XP_047284600.1  single-strand selective monofunctional uracil DNA glycosylase isoform X2

    UniProtKB/TrEMBL
    A0A0S2Z526
  16. XM_047428645.1XP_047284601.1  single-strand selective monofunctional uracil DNA glycosylase isoform X2

    UniProtKB/TrEMBL
    A0A0S2Z526
  17. XM_047428633.1XP_047284589.1  single-strand selective monofunctional uracil DNA glycosylase isoform X1

    UniProtKB/Swiss-Prot
    A8K2K9, O95862, Q0D2M0, Q53HV7, Q8NB71, Q9BWC8
    UniProtKB/TrEMBL
    A0A024RAZ8
  18. XM_047428636.1XP_047284592.1  single-strand selective monofunctional uracil DNA glycosylase isoform X1

    UniProtKB/Swiss-Prot
    A8K2K9, O95862, Q0D2M0, Q53HV7, Q8NB71, Q9BWC8
    UniProtKB/TrEMBL
    A0A024RAZ8
  19. XM_011538112.3XP_011536414.1  single-strand selective monofunctional uracil DNA glycosylase isoform X1

    See identical proteins and their annotated locations for XP_011536414.1

    UniProtKB/Swiss-Prot
    A8K2K9, O95862, Q0D2M0, Q53HV7, Q8NB71, Q9BWC8
    UniProtKB/TrEMBL
    A0A024RAZ8
    Conserved Domains (1) summary
    cd19374
    Location:29258
    UDG-F3_SMUG1-like; Uracil DNA glycosylase family 3 subfamily, includes single-strand-selective monofunctional uracil-DNA glycosylase 1 and similar proteins
  20. XM_047428635.1XP_047284591.1  single-strand selective monofunctional uracil DNA glycosylase isoform X1

    UniProtKB/Swiss-Prot
    A8K2K9, O95862, Q0D2M0, Q53HV7, Q8NB71, Q9BWC8
    UniProtKB/TrEMBL
    A0A024RAZ8
  21. XM_011538118.3XP_011536420.1  single-strand selective monofunctional uracil DNA glycosylase isoform X1

    See identical proteins and their annotated locations for XP_011536420.1

    UniProtKB/Swiss-Prot
    A8K2K9, O95862, Q0D2M0, Q53HV7, Q8NB71, Q9BWC8
    UniProtKB/TrEMBL
    A0A024RAZ8
    Conserved Domains (1) summary
    cd19374
    Location:29258
    UDG-F3_SMUG1-like; Uracil DNA glycosylase family 3 subfamily, includes single-strand-selective monofunctional uracil-DNA glycosylase 1 and similar proteins
  22. XM_047428643.1XP_047284599.1  single-strand selective monofunctional uracil DNA glycosylase isoform X2

    UniProtKB/TrEMBL
    A0A0S2Z526
  23. XM_047428634.1XP_047284590.1  single-strand selective monofunctional uracil DNA glycosylase isoform X1

    UniProtKB/Swiss-Prot
    A8K2K9, O95862, Q0D2M0, Q53HV7, Q8NB71, Q9BWC8
    UniProtKB/TrEMBL
    A0A024RAZ8
  24. XM_047428652.1XP_047284608.1  single-strand selective monofunctional uracil DNA glycosylase isoform X2

    UniProtKB/TrEMBL
    A0A0S2Z526
  25. XM_047428638.1XP_047284594.1  single-strand selective monofunctional uracil DNA glycosylase isoform X1

    UniProtKB/Swiss-Prot
    A8K2K9, O95862, Q0D2M0, Q53HV7, Q8NB71, Q9BWC8
    UniProtKB/TrEMBL
    A0A024RAZ8
  26. XM_047428651.1XP_047284607.1  single-strand selective monofunctional uracil DNA glycosylase isoform X2

    UniProtKB/TrEMBL
    A0A0S2Z526
  27. XM_047428632.1XP_047284588.1  single-strand selective monofunctional uracil DNA glycosylase isoform X1

    UniProtKB/Swiss-Prot
    A8K2K9, O95862, Q0D2M0, Q53HV7, Q8NB71, Q9BWC8
    UniProtKB/TrEMBL
    A0A024RAZ8
  28. XM_047428639.1XP_047284595.1  single-strand selective monofunctional uracil DNA glycosylase isoform X1

    UniProtKB/Swiss-Prot
    A8K2K9, O95862, Q0D2M0, Q53HV7, Q8NB71, Q9BWC8
    UniProtKB/TrEMBL
    A0A024RAZ8
  29. XM_047428637.1XP_047284593.1  single-strand selective monofunctional uracil DNA glycosylase isoform X1

    UniProtKB/Swiss-Prot
    A8K2K9, O95862, Q0D2M0, Q53HV7, Q8NB71, Q9BWC8
    UniProtKB/TrEMBL
    A0A024RAZ8

RNA

  1. XR_007063064.1 RNA Sequence

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060936.1 Alternate T2T-CHM13v2.0

    Range
    54119277..54154492 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054371632.1XP_054227607.1  single-strand selective monofunctional uracil DNA glycosylase isoform X1

    UniProtKB/Swiss-Prot
    A8K2K9, O95862, Q0D2M0, Q53HV7, Q8NB71, Q9BWC8
    UniProtKB/TrEMBL
    A0A024RAZ8
  2. XM_054371631.1XP_054227606.1  single-strand selective monofunctional uracil DNA glycosylase isoform X1

    UniProtKB/Swiss-Prot
    A8K2K9, O95862, Q0D2M0, Q53HV7, Q8NB71, Q9BWC8
    UniProtKB/TrEMBL
    A0A024RAZ8
  3. XM_054371641.1XP_054227616.1  single-strand selective monofunctional uracil DNA glycosylase isoform X2

    UniProtKB/TrEMBL
    A0A0S2Z526
  4. XM_054371630.1XP_054227605.1  single-strand selective monofunctional uracil DNA glycosylase isoform X1

    UniProtKB/Swiss-Prot
    A8K2K9, O95862, Q0D2M0, Q53HV7, Q8NB71, Q9BWC8
    UniProtKB/TrEMBL
    A0A024RAZ8
  5. XM_054371640.1XP_054227615.1  single-strand selective monofunctional uracil DNA glycosylase isoform X2

    UniProtKB/TrEMBL
    A0A0S2Z526
  6. XM_054371645.1XP_054227620.1  single-strand selective monofunctional uracil DNA glycosylase isoform X2

    UniProtKB/TrEMBL
    A0A0S2Z526
  7. XM_054371624.1XP_054227599.1  single-strand selective monofunctional uracil DNA glycosylase isoform X1

    UniProtKB/Swiss-Prot
    A8K2K9, O95862, Q0D2M0, Q53HV7, Q8NB71, Q9BWC8
    UniProtKB/TrEMBL
    A0A024RAZ8
  8. XM_054371636.1XP_054227611.1  single-strand selective monofunctional uracil DNA glycosylase isoform X1

    UniProtKB/Swiss-Prot
    A8K2K9, O95862, Q0D2M0, Q53HV7, Q8NB71, Q9BWC8
    UniProtKB/TrEMBL
    A0A024RAZ8
  9. XM_054371646.1XP_054227621.1  single-strand selective monofunctional uracil DNA glycosylase isoform X2

    UniProtKB/TrEMBL
    A0A0S2Z526
  10. XM_054371648.1XP_054227623.1  single-strand selective monofunctional uracil DNA glycosylase isoform X2

    UniProtKB/TrEMBL
    A0A0S2Z526
  11. XM_054371635.1XP_054227610.1  single-strand selective monofunctional uracil DNA glycosylase isoform X1

    UniProtKB/Swiss-Prot
    A8K2K9, O95862, Q0D2M0, Q53HV7, Q8NB71, Q9BWC8
    UniProtKB/TrEMBL
    A0A024RAZ8
  12. XM_054371633.1XP_054227608.1  single-strand selective monofunctional uracil DNA glycosylase isoform X1

    UniProtKB/Swiss-Prot
    A8K2K9, O95862, Q0D2M0, Q53HV7, Q8NB71, Q9BWC8
    UniProtKB/TrEMBL
    A0A024RAZ8
  13. XM_054371638.1XP_054227613.1  single-strand selective monofunctional uracil DNA glycosylase isoform X2

    UniProtKB/TrEMBL
    A0A0S2Z526
  14. XM_054371644.1XP_054227619.1  single-strand selective monofunctional uracil DNA glycosylase isoform X2

    UniProtKB/TrEMBL
    A0A0S2Z526
  15. XM_054371643.1XP_054227618.1  single-strand selective monofunctional uracil DNA glycosylase isoform X2

    UniProtKB/TrEMBL
    A0A0S2Z526
  16. XM_054371642.1XP_054227617.1  single-strand selective monofunctional uracil DNA glycosylase isoform X2

    UniProtKB/TrEMBL
    A0A0S2Z526
  17. XM_054371625.1XP_054227600.1  single-strand selective monofunctional uracil DNA glycosylase isoform X1

    UniProtKB/Swiss-Prot
    A8K2K9, O95862, Q0D2M0, Q53HV7, Q8NB71, Q9BWC8
    UniProtKB/TrEMBL
    A0A024RAZ8
  18. XM_054371626.1XP_054227601.1  single-strand selective monofunctional uracil DNA glycosylase isoform X1

    UniProtKB/Swiss-Prot
    A8K2K9, O95862, Q0D2M0, Q53HV7, Q8NB71, Q9BWC8
    UniProtKB/TrEMBL
    A0A024RAZ8
  19. XM_054371620.1XP_054227595.1  single-strand selective monofunctional uracil DNA glycosylase isoform X1

    UniProtKB/Swiss-Prot
    A8K2K9, O95862, Q0D2M0, Q53HV7, Q8NB71, Q9BWC8
    UniProtKB/TrEMBL
    A0A024RAZ8
  20. XM_054371634.1XP_054227609.1  single-strand selective monofunctional uracil DNA glycosylase isoform X1

    UniProtKB/Swiss-Prot
    A8K2K9, O95862, Q0D2M0, Q53HV7, Q8NB71, Q9BWC8
    UniProtKB/TrEMBL
    A0A024RAZ8
  21. XM_054371623.1XP_054227598.1  single-strand selective monofunctional uracil DNA glycosylase isoform X1

    UniProtKB/Swiss-Prot
    A8K2K9, O95862, Q0D2M0, Q53HV7, Q8NB71, Q9BWC8
    UniProtKB/TrEMBL
    A0A024RAZ8
  22. XM_054371637.1XP_054227612.1  single-strand selective monofunctional uracil DNA glycosylase isoform X2

    UniProtKB/TrEMBL
    A0A0S2Z526
  23. XM_054371621.1XP_054227596.1  single-strand selective monofunctional uracil DNA glycosylase isoform X1

    UniProtKB/Swiss-Prot
    A8K2K9, O95862, Q0D2M0, Q53HV7, Q8NB71, Q9BWC8
    UniProtKB/TrEMBL
    A0A024RAZ8
  24. XM_054371639.1XP_054227614.1  single-strand selective monofunctional uracil DNA glycosylase isoform X2

    UniProtKB/TrEMBL
    A0A0S2Z526
  25. XM_054371628.1XP_054227603.1  single-strand selective monofunctional uracil DNA glycosylase isoform X1

    UniProtKB/Swiss-Prot
    A8K2K9, O95862, Q0D2M0, Q53HV7, Q8NB71, Q9BWC8
    UniProtKB/TrEMBL
    A0A024RAZ8
  26. XM_054371647.1XP_054227622.1  single-strand selective monofunctional uracil DNA glycosylase isoform X2

    UniProtKB/TrEMBL
    A0A0S2Z526
  27. XM_054371622.1XP_054227597.1  single-strand selective monofunctional uracil DNA glycosylase isoform X1

    UniProtKB/Swiss-Prot
    A8K2K9, O95862, Q0D2M0, Q53HV7, Q8NB71, Q9BWC8
    UniProtKB/TrEMBL
    A0A024RAZ8
  28. XM_054371629.1XP_054227604.1  single-strand selective monofunctional uracil DNA glycosylase isoform X1

    UniProtKB/Swiss-Prot
    A8K2K9, O95862, Q0D2M0, Q53HV7, Q8NB71, Q9BWC8
    UniProtKB/TrEMBL
    A0A024RAZ8
  29. XM_054371627.1XP_054227602.1  single-strand selective monofunctional uracil DNA glycosylase isoform X1

    UniProtKB/Swiss-Prot
    A8K2K9, O95862, Q0D2M0, Q53HV7, Q8NB71, Q9BWC8
    UniProtKB/TrEMBL
    A0A024RAZ8

RNA

  1. XR_008488560.1 RNA Sequence