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FPR1 formyl peptide receptor 1 [ Homo sapiens (human) ]

Gene ID: 2357, updated on 29-Mar-2020

Summary

Official Symbol
FPR1provided by HGNC
Official Full Name
formyl peptide receptor 1provided by HGNC
Primary source
HGNC:HGNC:3826
See related
Ensembl:ENSG00000171051 MIM:136537
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
FPR; FMLP
Summary
This gene encodes a G protein-coupled receptor of mammalian phagocytic cells that is a member of the G-protein coupled receptor 1 family. The protein mediates the response of phagocytic cells to invasion of the host by microorganisms and is important in host defense and inflammation.[provided by RefSeq, Jul 2010]
Expression
Biased expression in appendix (RPKM 94.6), bone marrow (RPKM 64.2) and 9 other tissues See more
Orthologs

Genomic context

See FPR1 in Genome Data Viewer
Location:
19q13.41
Exon count:
3
Annotation release Status Assembly Chr Location
109.20200228 current GRCh38.p13 (GCF_000001405.39) 19 NC_000019.10 (51745172..51751878, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (52249023..52255150, complement)

Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene SPACA6P antisense RNA Neighboring gene sperm acrosome associated 6 Neighboring gene microRNA 125a Neighboring gene hyaluronan synthase 1 Neighboring gene formyl peptide receptor 2 Neighboring gene uncharacterized LOC105372448

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Envelope surface glycoprotein gp120 env Interaction of HIV-1 gp120 with CD4 is sufficient to trigger a marked reduction in C5a Receptor and a modest reduction in FMLP Receptor on monocytes PubMed
env N-formyl-methionyl-leucylphenyl-alanine binding to formyl peptide receptor (FPR) results in significant attenuation of cell responses to CCR5 ligands and in inhibition of HIV-1 gp120-mediated fusion and infection of cells expressing CD4, CCR5, and FPR PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
G protein-coupled receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
G protein-coupled receptor binding IDA
Inferred from Direct Assay
more info
PubMed 
N-formyl peptide receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
N-formyl peptide receptor activity IDA
Inferred from Direct Assay
more info
PubMed 
RAGE receptor binding IEA
Inferred from Electronic Annotation
more info
 
complement receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
scavenger receptor binding IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
azurophil granule membrane TAS
Traceable Author Statement
more info
 
cell IEA
Inferred from Electronic Annotation
more info
 
cytoplasm ISS
Inferred from Sequence or Structural Similarity
more info
 
ficolin-1-rich granule membrane TAS
Traceable Author Statement
more info
 
integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
plasma membrane ISS
Inferred from Sequence or Structural Similarity
more info
 
plasma membrane TAS
Traceable Author Statement
more info
 
secretory granule membrane TAS
Traceable Author Statement
more info
 

General protein information

Preferred Names
fMet-Leu-Phe receptor
Names
N-formylpeptide chemoattractant receptor
fMLP receptor

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_023426.1 RefSeqGene

    Range
    5001..11128
    Download
    GenBank, FASTA, Sequence Viewer (Graphics), LRG_146

mRNA and Protein(s)

  1. NM_001193306.2NP_001180235.1  fMet-Leu-Phe receptor

    See identical proteins and their annotated locations for NP_001180235.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longer transcript. Both variants 1 and 2 encode the same protein.
    Source sequence(s)
    AC018755
    Consensus CDS
    CCDS12839.1
    UniProtKB/Swiss-Prot
    P21462
    Related
    ENSP00000471493.1, ENST00000595042.5
    Conserved Domains (2) summary
    cd14964
    Location:2953
    7tm_GPCRs; TM helix 1 [structural motif]
    cl28897
    Location:27312
    7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily
  2. NM_002029.4NP_002020.1  fMet-Leu-Phe receptor

    See identical proteins and their annotated locations for NP_002020.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Both variants 1 and 2 encode the same protein.
    Source sequence(s)
    BC005315, BQ016000, M60627
    Consensus CDS
    CCDS12839.1
    UniProtKB/Swiss-Prot
    P21462
    Related
    ENSP00000302707.3, ENST00000304748.4
    Conserved Domains (2) summary
    cd14964
    Location:2953
    7tm_GPCRs; TM helix 1 [structural motif]
    cl28897
    Location:27312
    7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000019.10 Reference GRCh38.p13 Primary Assembly

    Range
    51745172..51751878 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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