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ZNF346 zinc finger protein 346 [ Homo sapiens (human) ]

Gene ID: 23567, updated on 7-Jun-2020

Summary

Official Symbol
ZNF346provided by HGNC
Official Full Name
zinc finger protein 346provided by HGNC
Primary source
HGNC:HGNC:16403
See related
Ensembl:ENSG00000113761 MIM:605308
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
JAZ; Zfp346
Summary
The protein encoded by this gene is a nucleolar, zinc finger protein that preferentially binds to double-stranded (ds) RNA or RNA/DNA hybrids, rather than DNA alone. Mutational studies indicate that the zinc finger domains are not only essential for dsRNA binding, but are also required for its nucleolar localization. The encoded protein may be involved in cell growth and survival. It plays a role in protecting neurons by inhibiting cell cycle re-entry via stimulation of p21 gene expression. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Apr 2015]
Expression
Ubiquitous expression in ovary (RPKM 2.4), thyroid (RPKM 2.2) and 25 other tissues See more
Orthologs

Genomic context

See ZNF346 in Genome Data Viewer
Location:
5q35.2
Exon count:
13
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 5 NC_000005.10 (177022680..177081189)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 5 NC_000005.9 (176449681..176508189)

Chromosome 5 - NC_000005.10Genomic Context describing neighboring genes Neighboring gene unc-5 netrin receptor A Neighboring gene hexokinase 3 Neighboring gene ubiquitin interaction motif containing 1 Neighboring gene FGFR4 5' regulatory region Neighboring gene fibroblast growth factor receptor 4 Neighboring gene nuclear receptor binding SET domain protein 1 Neighboring gene ribosomal protein L21 pseudogene 60

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • DKFZp547M223

Gene Ontology Provided by GOA

Function Evidence Code Pubs
RNA binding HDA PubMed 
double-stranded RNA binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
double-stranded RNA binding IDA
Inferred from Direct Assay
more info
PubMed 
enzyme binding IPI
Inferred from Physical Interaction
more info
PubMed 
miRNA binding IDA
Inferred from Direct Assay
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
zinc ion binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
positive regulation of apoptotic process IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
cytoplasm IEA
Inferred from Electronic Annotation
more info
 
nucleolus IDA
Inferred from Direct Assay
more info
PubMed 
nucleus IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
zinc finger protein 346
Names
double-stranded RNA-binding zinc finger protein JAZ
just another zinc finger protein

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001308213.1NP_001295142.1  zinc finger protein 346 isoform b

    See identical proteins and their annotated locations for NP_001295142.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) contains an additional in-frame exon in the 5' coding region, and contains an alternate 3' terminal exon and thus differs in the 3' UTR, compared to variant 1. The encoded isoform (b) is longer than isoform a.
    Source sequence(s)
    AK131469, AK297584, CR627467, DA789054, DB340780
    Consensus CDS
    CCDS78094.1
    UniProtKB/Swiss-Prot
    Q9UL40
    UniProtKB/TrEMBL
    B7Z4N4
    Related
    ENSP00000424495.1, ENST00000503039.1
    Conserved Domains (2) summary
    smart00451
    Location:207241
    ZnF_U1; U1-like zinc finger
    sd00020
    Location:161183
    ZF_C2H2; C2H2 Zn finger [structural motif]
  2. NM_001308214.2NP_001295143.1  zinc finger protein 346 isoform c

    See identical proteins and their annotated locations for NP_001295143.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) lacks an alternate in-frame exon and uses an alternate in-frame splice site in the central coding region, compared to variant 1, resulting in an isoform (c) that is shorter than isoform a.
    Source sequence(s)
    AC027317, AK295549, DA789054, DB548047
    Consensus CDS
    CCDS83052.1
    UniProtKB/Swiss-Prot
    Q9UL40
    Related
    ENSP00000421212.1, ENST00000503425.5
    Conserved Domains (2) summary
    smart00451
    Location:150184
    ZnF_U1; U1-like zinc finger
    sd00020
    Location:104126
    ZF_C2H2; C2H2 Zn finger [structural motif]
  3. NM_001308215.2NP_001295144.1  zinc finger protein 346 isoform d

    See identical proteins and their annotated locations for NP_001295144.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) lacks an alternate in-frame exon in the central coding region, compared to variant 1, resulting in an isoform (d) that is shorter than isoform a.
    Source sequence(s)
    AC027317, BU860103, DA789054, DB548047
    Conserved Domains (2) summary
    smart00451
    Location:135164
    ZnF_U1; U1-like zinc finger
    sd00020
    Location:136158
    ZF_C2H2; C2H2 Zn finger [structural motif]
  4. NM_001308216.2NP_001295145.1  zinc finger protein 346 isoform e

    Status: REVIEWED

    Description
    Transcript Variant: This variant (5) lacks three alternate exons that result in a frameshift in the 3' coding region, compared to variant 1. The encoded isoform (e) has a distinct C-terminus and is shorter than isoform a.
    Source sequence(s)
    AC027317, DA169130, DA789054, DB548047
    Conserved Domains (1) summary
    smart00451
    Location:71104
    ZnF_U1; U1-like zinc finger
  5. NM_001308218.2NP_001295147.1  zinc finger protein 346 isoform f

    See identical proteins and their annotated locations for NP_001295147.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (6) lacks three alternate exons and uses an alternate splice site, resulting in the loss of an in-frame segment in the 5' and central coding regions, compared to variant 1. The encoded isoform (f) is shorter than isoform a.
    Source sequence(s)
    AC027317, AK297448, DB548047
    Consensus CDS
    CCDS83053.1
    UniProtKB/TrEMBL
    B7Z4J8
    Related
    ENSP00000423515.1, ENST00000506693.5
    Conserved Domains (3) summary
    smart00451
    Location:84118
    ZnF_U1; U1-like zinc finger
    sd00020
    Location:89111
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam12874
    Location:143165
    zf-met; Zinc-finger of C2H2 type
  6. NM_001308219.1NP_001295148.1  zinc finger protein 346 isoform g

    Status: REVIEWED

    Description
    Transcript Variant: This variant (7) lacks three alternate exons and contains an alternate 3' terminal exon, resulting in a frameshift in the 3' coding region and an alternate 3' UTR, compared to variant 1. The encoded isoform (g) has a distinct C-terminus and is shorter than isoform a.
    Source sequence(s)
    AK131469, AK297584, BX331331, CR627467, DA789054, DB340780
    UniProtKB/Swiss-Prot
    Q9UL40
    UniProtKB/TrEMBL
    B7Z4N4
    Conserved Domains (1) summary
    smart00451
    Location:71104
    ZnF_U1; U1-like zinc finger
  7. NM_001308221.2NP_001295150.1  zinc finger protein 346 isoform h

    See identical proteins and their annotated locations for NP_001295150.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (8) lacks four alternate exons that result in the loss of an in-frame segment in the 5' and central coding regions, compared to variant 1. The encoded isoform (h) is shorter than isoform a. Both variants 8 and 9 encode isoform h.
    Source sequence(s)
    AC027317, DA789054, DB548047, DR003225
    Consensus CDS
    CCDS83054.1
    UniProtKB/TrEMBL
    B7Z4N4
    Conserved Domains (2) summary
    sd00020
    Location:6587
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam12874
    Location:6587
    zf-met; Zinc-finger of C2H2 type
  8. NM_001308223.1NP_001295152.1  zinc finger protein 346 isoform h

    See identical proteins and their annotated locations for NP_001295152.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (9) lacks four alternate exons that result in the loss of an in-frame segment in the 5' and central coding regions, and it also contains an alternate 3' terminal exon and thus differs in the 3' UTR, compared to variant 1. The encoded isoform (h) is shorter than isoform a. Both variants 8 and 9 encode isoform h.
    Source sequence(s)
    AK131469, AK297584, CR627467, DA789054, DB340780
    Consensus CDS
    CCDS83054.1
    UniProtKB/Swiss-Prot
    Q9UL40
    UniProtKB/TrEMBL
    B7Z4N4
    Related
    ENSP00000421089.1, ENST00000512315.5
    Conserved Domains (2) summary
    sd00020
    Location:6587
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam12874
    Location:6587
    zf-met; Zinc-finger of C2H2 type
  9. NM_001363713.1NP_001350642.1  zinc finger protein 346 isoform i

    Status: REVIEWED

    Description
    Transcript Variant: This variant (12) uses an alternate in-frame splice junction compared to variant 1. The resulting isoform (i) has the same N- and C-termini and is longer compared to isoform a.
    Source sequence(s)
    AC027314, AC027317
    Consensus CDS
    CCDS87353.1
    Related
    ENSP00000425725.1, ENST00000511834.5
    Conserved Domains (2) summary
    smart00451
    Location:198232
    ZnF_U1; U1-like zinc finger
    sd00020
    Location:203225
    ZF_C2H2; C2H2 Zn finger [structural motif]
  10. NM_012279.4NP_036411.1  zinc finger protein 346 isoform a

    See identical proteins and their annotated locations for NP_036411.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes isoform a.
    Source sequence(s)
    AC027317, AF083340, AL359576, DA789054, DB548047
    Consensus CDS
    CCDS4409.1
    UniProtKB/Swiss-Prot
    Q9UL40
    Related
    ENSP00000350869.3, ENST00000358149.8
    Conserved Domains (2) summary
    smart00451
    Location:182216
    ZnF_U1; U1-like zinc finger
    sd00020
    Location:136158
    ZF_C2H2; C2H2 Zn finger [structural motif]

RNA

  1. NR_131773.2 RNA Sequence

    Status: REVIEWED

    Description
    Transcript Variant: This variant (10) lacks an alternate exon in the central region, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AC027317, AK300065, DA789054, DB548047
  2. NR_131774.2 RNA Sequence

    Status: REVIEWED

    Description
    Transcript Variant: This variant (11) lacks two alternate exons in the central region, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AC027317, AK300738, DA789054, DB548047

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000005.10 Reference GRCh38.p13 Primary Assembly

    Range
    177022680..177081189
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017009295.2XP_016864784.1  zinc finger protein 346 isoform X6

    UniProtKB/Swiss-Prot
    Q9UL40
    Conserved Domains (2) summary
    smart00451
    Location:182216
    ZnF_U1; U1-like zinc finger
    sd00020
    Location:136158
    ZF_C2H2; C2H2 Zn finger [structural motif]
  2. XM_017009297.2XP_016864786.1  zinc finger protein 346 isoform X7

  3. XM_017009296.2XP_016864785.1  zinc finger protein 346 isoform X6

    UniProtKB/Swiss-Prot
    Q9UL40
    Conserved Domains (2) summary
    smart00451
    Location:182216
    ZnF_U1; U1-like zinc finger
    sd00020
    Location:136158
    ZF_C2H2; C2H2 Zn finger [structural motif]
  4. XM_017009299.2XP_016864788.1  zinc finger protein 346 isoform X9

  5. XM_017009301.2XP_016864790.1  zinc finger protein 346 isoform X12

    Conserved Domains (2) summary
    smart00451
    Location:135164
    ZnF_U1; U1-like zinc finger
    sd00020
    Location:136158
    ZF_C2H2; C2H2 Zn finger [structural motif]
  6. XM_011534497.2XP_011532799.1  zinc finger protein 346 isoform X15

    Conserved Domains (1) summary
    smart00451
    Location:96129
    ZnF_U1; U1-like zinc finger
  7. XM_017009302.1XP_016864791.1  zinc finger protein 346 isoform X13

  8. XM_005265860.2XP_005265917.1  zinc finger protein 346 isoform X1

    See identical proteins and their annotated locations for XP_005265917.1

    Conserved Domains (2) summary
    smart00451
    Location:223257
    ZnF_U1; U1-like zinc finger
    sd00020
    Location:228250
    ZF_C2H2; C2H2 Zn finger [structural motif]
  9. XM_011534494.1XP_011532796.1  zinc finger protein 346 isoform X2

    Conserved Domains (2) summary
    smart00451
    Location:223257
    ZnF_U1; U1-like zinc finger
    sd00020
    Location:161183
    ZF_C2H2; C2H2 Zn finger [structural motif]
  10. XM_011534495.3XP_011532797.1  zinc finger protein 346 isoform X3

    Conserved Domains (2) summary
    smart00451
    Location:223257
    ZnF_U1; U1-like zinc finger
    sd00020
    Location:161183
    ZF_C2H2; C2H2 Zn finger [structural motif]
  11. XM_011534496.2XP_011532798.1  zinc finger protein 346 isoform X5

    Conserved Domains (2) summary
    smart00451
    Location:207241
    ZnF_U1; U1-like zinc finger
    sd00020
    Location:161183
    ZF_C2H2; C2H2 Zn finger [structural motif]
  12. XM_005265864.3XP_005265921.1  zinc finger protein 346 isoform X11

    Conserved Domains (2) summary
    smart00451
    Location:160189
    ZnF_U1; U1-like zinc finger
    sd00020
    Location:161183
    ZF_C2H2; C2H2 Zn finger [structural motif]
  13. XM_011534493.1XP_011532795.1  zinc finger protein 346 isoform X1

    See identical proteins and their annotated locations for XP_011532795.1

    Conserved Domains (2) summary
    smart00451
    Location:223257
    ZnF_U1; U1-like zinc finger
    sd00020
    Location:228250
    ZF_C2H2; C2H2 Zn finger [structural motif]
  14. XM_017009298.1XP_016864787.1  zinc finger protein 346 isoform X8

  15. XM_017009300.1XP_016864789.1  zinc finger protein 346 isoform X10

  16. XM_017009303.1XP_016864792.1  zinc finger protein 346 isoform X14

RNA

  1. XR_941096.1 RNA Sequence

  2. XR_427802.3 RNA Sequence

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