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Snx33 sorting nexin 33 [ Mus musculus (house mouse) ]

Gene ID: 235406, updated on 2-Nov-2024

Summary

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Official Symbol
Snx33provided by MGI
Official Full Name
sorting nexin 33provided by MGI
Primary source
MGI:MGI:2443239
See related
Ensembl:ENSMUSG00000032733 AllianceGenome:MGI:2443239
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Sh3px3; E130307J07Rik
Summary
Predicted to enable identical protein binding activity and phosphatidylinositol binding activity. Predicted to be involved in several processes, including cytoskeleton-dependent cytokinesis; plasma membrane tubulation; and regulation of protein localization to cell surface. Predicted to be located in cytosol and membrane. Predicted to be active in cytoplasmic vesicle and plasma membrane. Orthologous to human SNX33 (sorting nexin 33). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Ubiquitous expression in lung adult (RPKM 10.6), ovary adult (RPKM 9.3) and 27 other tissues See more
Orthologs
human all
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Genomic context

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See Snx33 in Genome Data Viewer
Location:
9 B; 9 30.48 cM
Exon count:
3
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 9 NC_000075.7 (56824472..56835726, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 9 NC_000075.6 (56917188..56928442, complement)

Chromosome 9 - NC_000075.7Genomic Context describing neighboring genes Neighboring gene leucine rich repeat and Ig domain containing 1 Neighboring gene predicted gene, 31586 Neighboring gene ciliary microtubule associated protein 1C Neighboring gene chondroitin sulfate proteoglycan 4 Neighboring gene STARR-positive B cell enhancer ABC_E10548 Neighboring gene CapStarr-seq enhancer MGSCv37_chr9:56776219-56776328 Neighboring gene STARR-positive B cell enhancer ABC_E1386 Neighboring gene predicted gene, 19936 Neighboring gene IMP3, U3 small nucleolar ribonucleoprotein

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. The novel sorting nexin SNX33 interferes with cellular PrP formation by modulation of PrP shedding. Heiseke A, et al. Traffic, 2008 Jul. PMID 18419754
  2. Hdac4 Interactions in Huntington's Disease Viewed Through the Prism of Multiomics. Federspiel JD, et al. Mol Cell Proteomics, 2019 Aug 9. PMID 31040226, Free PMC Article
  3. Irisin Mediates Effects on Bone and Fat via αV Integrin Receptors. Kim H, et al. Cell, 2018 Dec 13. PMID 30550785, Free PMC Article
  4. Database resources of the National Center for Biotechnology Information. Wheeler DL, et al. Nucleic Acids Res, 2001 Jan 1. PMID 11125038, Free PMC Article
  5. Libraries enriched for alternatively spliced exons reveal splicing patterns in melanocytes and melanomas. Watahiki A, et al. Nat Methods, 2004 Dec. PMID 15782199

See all (17) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. SNX33 interferes with cellular PrP formation by modulation of PrP shedding
    Title: The novel sorting nexin SNX33 interferes with cellular PrP formation by modulation of PrP shedding.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables identical protein binding IEA
Inferred from Electronic Annotation
more info
  
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
  
enables phosphatidylinositol binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables phosphatidylinositol binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in cleavage furrow formation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in cleavage furrow formation ISO
Inferred from Sequence Orthology
more info
  
involved_in cleavage furrow formation ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in endocytosis IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in endocytosis ISO
Inferred from Sequence Orthology
more info
  
involved_in endocytosis ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in endosomal transport IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in endosomal transport ISO
Inferred from Sequence Orthology
more info
  
involved_in endosomal transport ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in endosome organization ISO
Inferred from Sequence Orthology
more info
  
involved_in endosome organization ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in intracellular protein transport IEA
Inferred from Electronic Annotation
more info
  
involved_in macropinocytosis ISO
Inferred from Sequence Orthology
more info
  
involved_in macropinocytosis ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in mitotic cytokinesis ISO
Inferred from Sequence Orthology
more info
  
involved_in mitotic cytokinesis ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in negative regulation of endocytosis IEA
Inferred from Electronic Annotation
more info
  
involved_in negative regulation of endocytosis ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of protein localization to cell surface IEA
Inferred from Electronic Annotation
more info
  
involved_in negative regulation of protein localization to cell surface ISO
Inferred from Sequence Orthology
more info
  
involved_in plasma membrane tubulation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in plasma membrane tubulation ISO
Inferred from Sequence Orthology
more info
  
involved_in plasma membrane tubulation ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in positive regulation of membrane protein ectodomain proteolysis IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of membrane protein ectodomain proteolysis ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of protein localization to cell surface IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of protein localization to cell surface ISO
Inferred from Sequence Orthology
more info
  
involved_in protein import IEA
Inferred from Electronic Annotation
more info
  
involved_in protein import ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
is_active_in cytoplasmic vesicle IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasmic vesicle ISO
Inferred from Sequence Orthology
more info
  
located_in cytoplasmic vesicle ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in cytoplasmic vesicle membrane IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in membrane ISO
Inferred from Sequence Orthology
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
sorting nexin-33
Names
SH3 and PX domain containing 3
SH3 and PX domain-containing protein 3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_175483.5 → NP_780692.2  sorting nexin-33

    See identical proteins and their annotated locations for NP_780692.2

    Status: PROVISIONAL

    Source sequence(s)
    AK142274
    Consensus CDS
    CCDS23212.1
    UniProtKB/Swiss-Prot
    Q4VAA7, Q8BPM5, Q8C832
    Related
    ENSMUSP00000060225.6, ENSMUST00000050916.7
    Conserved Domains (3) summary
    cd07669
    Location:365 → 571
    BAR_SNX33; The Bin/Amphiphysin/Rvs (BAR) domain of Sorting Nexin 33
    cd11896
    Location:4 → 58
    SH3_SNX33; Src Homology 3 domain of Sorting Nexin 33
    cl02563
    Location:230 → 354
    PX_domain; The Phox Homology domain, a phosphoinositide binding module

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000075.7 Reference GRCm39 C57BL/6J

    Range
    56824472..56835726 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006511091.3 → XP_006511154.1  sorting nexin-33 isoform X1

    See identical proteins and their annotated locations for XP_006511154.1

    UniProtKB/Swiss-Prot
    Q4VAA7, Q8BPM5, Q8C832
    Conserved Domains (3) summary
    cd07669
    Location:365 → 571
    BAR_SNX33; The Bin/Amphiphysin/Rvs (BAR) domain of Sorting Nexin 33
    cd11896
    Location:4 → 58
    SH3_SNX33; Src Homology 3 domain of Sorting Nexin 33
    cl02563
    Location:230 → 354
    PX_domain; The Phox Homology domain, a phosphoinositide binding module
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q4VAA7.1 GenPept UniProtKB/Swiss-Prot:Q4VAA7

Gene LinkOut

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