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SNX33 sorting nexin 33 [ Homo sapiens (human) ]

Gene ID: 257364, updated on 17-Jun-2019

Summary

Official Symbol
SNX33provided by HGNC
Official Full Name
sorting nexin 33provided by HGNC
Primary source
HGNC:HGNC:28468
See related
Ensembl:ENSG00000173548
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
SNX30; SH3PX3; SH3PXD3C
Summary
The protein encoded by this gene is involved in cytoskeletal reorganization, vesicle trafficking, endocytosis, and mitosis. The encoded protein is essential for the creation of the cleavage furrow during mitosis and for completion of mitosis. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2015]
Expression
Ubiquitous expression in esophagus (RPKM 14.6), ovary (RPKM 14.1) and 24 other tissues See more
Orthologs

Genomic context

See SNX33 in Genome Data Viewer
Location:
15q24.2
Exon count:
2
Annotation release Status Assembly Chr Location
109.20190607 current GRCh38.p13 (GCF_000001405.39) 15 NC_000015.10 (75649007..75658627)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 15 NC_000015.9 (75941348..75950968)

Chromosome 15 - NC_000015.10Genomic Context describing neighboring genes Neighboring gene snurportin 1 Neighboring gene IMP U3 small nucleolar ribonucleoprotein 3 Neighboring gene chondroitin sulfate proteoglycan 4 Neighboring gene outer dense fiber of sperm tails 3 like 1 Neighboring gene dynamin 1 pseudogene 35

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC32065

Gene Ontology Provided by GOA

Function Evidence Code Pubs
identical protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
phosphatidylinositol binding IEA
Inferred from Electronic Annotation
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
cleavage furrow formation IMP
Inferred from Mutant Phenotype
more info
PubMed 
endocytosis IMP
Inferred from Mutant Phenotype
more info
PubMed 
endosomal transport IMP
Inferred from Mutant Phenotype
more info
PubMed 
endosome organization IMP
Inferred from Mutant Phenotype
more info
PubMed 
intracellular protein transport IEA
Inferred from Electronic Annotation
more info
 
macropinocytosis IMP
Inferred from Mutant Phenotype
more info
PubMed 
mitotic cytokinesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of endocytosis IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of protein localization to cell surface IDA
Inferred from Direct Assay
more info
PubMed 
plasma membrane tubulation IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of membrane protein ectodomain proteolysis IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of protein localization to cell surface IDA
Inferred from Direct Assay
more info
PubMed 
protein import IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
cytoplasmic vesicle IDA
Inferred from Direct Assay
more info
PubMed 
cytoplasmic vesicle membrane IEA
Inferred from Electronic Annotation
more info
 
cytosol IDA
Inferred from Direct Assay
more info
PubMed 
extrinsic component of membrane IDA
Inferred from Direct Assay
more info
PubMed 
membrane IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
sorting nexin-33
Names
SH3 and PX domain containing 3
SH3 and PX domain-containing protein 3

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001318146.1NP_001305075.1  sorting nexin-33 isoform 2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) lacks an alternate in-frame segment compared to variant 1. The resulting isoform (2) has the same N- and C-termini but is shorter compared to isoform 1.
    Source sequence(s)
    AK091291, BC018775
    UniProtKB/Swiss-Prot
    Q8WV41
    Conserved Domains (3) summary
    cd11896
    Location:458
    SH3_SNX33; Src Homology 3 domain of Sorting Nexin 33
    cl02563
    Location:230354
    PX_domain; The Phox Homology domain, a phosphoinositide binding module
    cl12013
    Location:365497
    BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature
  2. NM_153271.1NP_695003.1  sorting nexin-33 isoform 1

    See identical proteins and their annotated locations for NP_695003.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    BC018775
    Consensus CDS
    CCDS10283.1
    UniProtKB/Swiss-Prot
    Q8WV41
    Related
    ENSP00000311427.5, ENST00000308527.5
    Conserved Domains (3) summary
    cd07669
    Location:365571
    BAR_SNX33; The Bin/Amphiphysin/Rvs (BAR) domain of Sorting Nexin 33
    cd11896
    Location:458
    SH3_SNX33; Src Homology 3 domain of Sorting Nexin 33
    cl02563
    Location:230354
    PX_domain; The Phox Homology domain, a phosphoinositide binding module

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000015.10 Reference GRCh38.p13 Primary Assembly

    Range
    75649007..75658627
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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