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OR52A1 olfactory receptor family 52 subfamily A member 1 [ Homo sapiens (human) ]

Gene ID: 23538, updated on 10-Dec-2024

Summary

Official Symbol
OR52A1provided by HGNC
Official Full Name
olfactory receptor family 52 subfamily A member 1provided by HGNC
Primary source
HGNC:HGNC:8318
See related
Ensembl:ENSG00000182070 AllianceGenome:HGNC:8318
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
HPFH1OR
Summary
Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. [provided by RefSeq, Jul 2008]
Orthologs
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Genomic context

See OR52A1 in Genome Data Viewer
Location:
11p15.4
Exon count:
2
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 11 NC_000011.10 (5146824..5154757, complement)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 11 NC_060935.1 (5206166..5214099, complement)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (5168054..5175987, complement)

Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene olfactory receptor family 52 subfamily A member 4 pseudogene Neighboring gene olfactory receptor family 52 subfamily A member 5 Neighboring gene hereditary persistence of fetal hemoglobin-1 and -2 3' breakpoint enhancers Neighboring gene hereditary persistence of fetal hemoglobin-6 3' breakpoint enhancer Neighboring gene olfactory receptor family 51 subfamily A member 1 pseudogene Neighboring gene olfactory receptor family 52 subfamily Z member 1 pseudogene

Genomic regions, transcripts, and products

HIV-1 interactions

Replication interactions

Interaction Pubs
Knockdown of olfactory receptor, family 52, subfamily A, member 1 (OR52A1) by siRNA inhibits HIV-1 replication in HeLa P4/R5 cells PubMed

Go to the HIV-1, Human Interaction Database

General gene information

Markers

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables G protein-coupled receptor activity IEA
Inferred from Electronic Annotation
more info
 
enables olfactory receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables transmembrane signaling receptor activity TAS
Traceable Author Statement
more info
PubMed 
Component Evidence Code Pubs
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
 

General protein information

Preferred Names
olfactory receptor 52A1
Names
odorant receptor HOR3'beta4
olfactory receptor OR11-319

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_027733.1 RefSeqGene

    Range
    5001..5939
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_012375.3NP_036507.2  olfactory receptor 52A1

    See identical proteins and their annotated locations for NP_036507.2

    Status: VALIDATED

    Source sequence(s)
    AC129505
    Consensus CDS
    CCDS31374.1
    UniProtKB/Swiss-Prot
    Q6IF31, Q9UKL2
    UniProtKB/TrEMBL
    A0A126GVH8
    Related
    ENSP00000369725.1, ENST00000380367.3
    Conserved Domains (2) summary
    pfam00001
    Location:43295
    7tm_1; 7 transmembrane receptor (rhodopsin family)
    cl21561
    Location:33311
    7tm_4; Olfactory receptor

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000011.10 Reference GRCh38.p14 Primary Assembly

    Range
    5146824..5154757 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060935.1 Alternate T2T-CHM13v2.0

    Range
    5206166..5214099 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)