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PRAME PRAME nuclear receptor transcriptional regulator [ Homo sapiens (human) ]

Gene ID: 23532, updated on 10-Dec-2024

Summary

Official Symbol
PRAMEprovided by HGNC
Official Full Name
PRAME nuclear receptor transcriptional regulatorprovided by HGNC
Primary source
HGNC:HGNC:9336
See related
Ensembl:ENSG00000185686 MIM:606021; AllianceGenome:HGNC:9336
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
MAPE; OIP4; CT130; OIP-4
Summary
This gene encodes an antigen that is preferentially expressed in human melanomas and that is recognized by cytolytic T lymphocytes. It is not expressed in normal tissues, except testis. The encoded protein acts as a repressor of retinoic acid receptor, and likely confers a growth advantage to cancer cells via this function. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2014]
Expression
Restricted expression toward testis (RPKM 47.0) See more
Orthologs
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Genomic context

See PRAME in Genome Data Viewer
Location:
22q11.22
Exon count:
8
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 22 NC_000022.11 (22547701..22559265, complement)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 22 NC_060946.1 (22970590..22982125, complement)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 22 NC_000022.10 (22890123..22901672, complement)

Chromosome 22 - NC_000022.11Genomic Context describing neighboring genes Neighboring gene immunoglobulin lambda locus Neighboring gene uncharacterized LOC124905161 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr22:22874253-22875452 Neighboring gene uncharacterized LOC648691 Neighboring gene zinc finger protein 280B Neighboring gene ReSE screen-validated silencer GRCh37_chr22:22896585-22896782 Neighboring gene IGL region enhancer-blocking element 22-2 Neighboring gene NANOG hESC enhancer GRCh37_chr22:22915922-22916455 Neighboring gene zinc finger protein 280A Neighboring gene immunoglobulin lambda variable 2-34 (pseudogene)

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables nuclear retinoic acid receptor binding IDA
Inferred from Direct Assay
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables ubiquitin-like ligase-substrate adaptor activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables ubiquitin-like ligase-substrate adaptor activity IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
part_of Cul2-RING ubiquitin ligase complex IBA
Inferred from Biological aspect of Ancestor
more info
 
part_of Cul2-RING ubiquitin ligase complex IDA
Inferred from Direct Assay
more info
PubMed 
located_in Golgi apparatus IEA
Inferred from Electronic Annotation
more info
 
located_in chromatin IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in nucleoplasm IDA
Inferred from Direct Assay
more info
 
is_active_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 
located_in plasma membrane IDA
Inferred from Direct Assay
more info
 

General protein information

Preferred Names
melanoma antigen preferentially expressed in tumors
Names
Opa-interacting protein OIP4
cancer/testis antigen 130
opa-interacting protein 4
preferentially expressed antigen in melanoma
preferentially expressed antigen of melanoma

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_000002.1 

    Range
    514106..525756 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001291715.2NP_001278644.1  melanoma antigen preferentially expressed in tumors isoform a

    See identical proteins and their annotated locations for NP_001278644.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (6) differs in the 5' UTR, compared to variant 2. Variants 1-7 encode the same isoform (a).
    Source sequence(s)
    AK129783, BC022008, DC395455
    Consensus CDS
    CCDS13801.1
    UniProtKB/Swiss-Prot
    B2R6Y7, O43481, P78395, Q8IXN8
    UniProtKB/TrEMBL
    K9MRS9, K9MSY5
    Conserved Domains (2) summary
    sd00034
    Location:324350
    LRR_AMN1; leucine-rich repeat [structural motif]
    cl39015
    Location:323436
    LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
  2. NM_001291716.2NP_001278645.1  melanoma antigen preferentially expressed in tumors isoform a

    See identical proteins and their annotated locations for NP_001278645.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (7) differs in the 5' UTR, compared to variant 2. Variants 1-7 encode the same isoform (a).
    Source sequence(s)
    AK129783, BC022008, DC395455
    Consensus CDS
    CCDS13801.1
    UniProtKB/Swiss-Prot
    B2R6Y7, O43481, P78395, Q8IXN8
    UniProtKB/TrEMBL
    K9MRS9, K9MSY5
    Conserved Domains (2) summary
    sd00034
    Location:324350
    LRR_AMN1; leucine-rich repeat [structural motif]
    cl39015
    Location:323436
    LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
  3. NM_001291717.2NP_001278646.1  melanoma antigen preferentially expressed in tumors isoform b

    See identical proteins and their annotated locations for NP_001278646.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (8) differs in the 5' UTR, lacks part of the 5' coding region, and uses a downstream start codon, compared to variant 2. The encoded isoform (b) has a shorter N-terminus, compared to isoform a.
    Source sequence(s)
    AK304593, BC022008, DB024053
    UniProtKB/TrEMBL
    B7ZAT0
    Conserved Domains (2) summary
    cd00116
    Location:307420
    LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
    sd00034
    Location:308334
    LRR_AMN1; leucine-rich repeat [structural motif]
  4. NM_001291719.2NP_001278648.1  melanoma antigen preferentially expressed in tumors isoform b

    See identical proteins and their annotated locations for NP_001278648.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (9) differs in the 5' UTR, lacks part of the 5' coding region, and uses a downstream start codon, compared to variant 2. The encoded isoform (b) has a shorter N-terminus, compared to isoform a. Variants 9-11 encode the same isoform (b).
    Source sequence(s)
    AK129783, BC022008, DC395455
    UniProtKB/TrEMBL
    B7ZAT0
    Conserved Domains (2) summary
    cd00116
    Location:307420
    LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
    sd00034
    Location:308334
    LRR_AMN1; leucine-rich repeat [structural motif]
  5. NM_001318126.2NP_001305055.1  melanoma antigen preferentially expressed in tumors isoform b

    Status: REVIEWED

    Description
    Transcript Variant: This variant (10) differs in the 5' UTR, lacks part of the 5' coding region, and uses a downstream start codon compared to variant 2. The encoded isoform (b) has a shorter N-terminus compared to isoform a. Variants 9-11 encode the same isoform (b).
    Source sequence(s)
    AK316395, BC022008
    UniProtKB/TrEMBL
    B7ZAT0
    Conserved Domains (2) summary
    cd00116
    Location:307420
    LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
    sd00034
    Location:308334
    LRR_AMN1; leucine-rich repeat [structural motif]
  6. NM_001318127.2NP_001305056.1  melanoma antigen preferentially expressed in tumors isoform b

    Status: REVIEWED

    Description
    Transcript Variant: This variant (11) differs in the 5' UTR, lacks part of the 5' coding region, and uses a downstream start codon compared to variant 2. The encoded isoform (b) has a shorter N-terminus compared to isoform a. Variants 9-11 encode the same isoform (b).
    Source sequence(s)
    AC246793, AK302188, BC022008
    UniProtKB/TrEMBL
    B7ZAT0
    Conserved Domains (2) summary
    cd00116
    Location:307420
    LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
    sd00034
    Location:308334
    LRR_AMN1; leucine-rich repeat [structural motif]
  7. NM_006115.5NP_006106.1  melanoma antigen preferentially expressed in tumors isoform a

    See identical proteins and their annotated locations for NP_006106.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) differs in the 5' UTR, compared to variant 2. Variants 1-7 encode the same isoform (a).
    Source sequence(s)
    BC022008
    Consensus CDS
    CCDS13801.1
    UniProtKB/Swiss-Prot
    B2R6Y7, O43481, P78395, Q8IXN8
    UniProtKB/TrEMBL
    K9MRS9, K9MSY5
    Related
    ENSP00000381728.2, ENST00000398743.6
    Conserved Domains (2) summary
    sd00034
    Location:324350
    LRR_AMN1; leucine-rich repeat [structural motif]
    cl39015
    Location:323436
    LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
  8. NM_206953.3NP_996836.1  melanoma antigen preferentially expressed in tumors isoform a

    See identical proteins and their annotated locations for NP_996836.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) represents the longest transcript and encodes the longer isoform (a). Variants 1-7 encode the same isoform.
    Source sequence(s)
    BC022008
    Consensus CDS
    CCDS13801.1
    UniProtKB/Swiss-Prot
    B2R6Y7, O43481, P78395, Q8IXN8
    UniProtKB/TrEMBL
    K9MRS9, K9MSY5
    Related
    ENSP00000445675.1, ENST00000543184.5
    Conserved Domains (2) summary
    sd00034
    Location:324350
    LRR_AMN1; leucine-rich repeat [structural motif]
    cl39015
    Location:323436
    LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
  9. NM_206954.3NP_996837.1  melanoma antigen preferentially expressed in tumors isoform a

    See identical proteins and their annotated locations for NP_996837.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR, compared to variant 2. Variants 1-7 encode the same isoform (a).
    Source sequence(s)
    BC022008
    Consensus CDS
    CCDS13801.1
    UniProtKB/Swiss-Prot
    B2R6Y7, O43481, P78395, Q8IXN8
    UniProtKB/TrEMBL
    K9MRS9, K9MSY5
    Related
    ENSP00000385198.1, ENST00000402697.5
    Conserved Domains (2) summary
    sd00034
    Location:324350
    LRR_AMN1; leucine-rich repeat [structural motif]
    cl39015
    Location:323436
    LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
  10. NM_206955.3NP_996838.1  melanoma antigen preferentially expressed in tumors isoform a

    See identical proteins and their annotated locations for NP_996838.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) differs in the 5' UTR, compared to variant 2. Variants 1-7 encode the same isoform (a).
    Source sequence(s)
    AK304593, BC022008, DB024053
    Consensus CDS
    CCDS13801.1
    UniProtKB/Swiss-Prot
    B2R6Y7, O43481, P78395, Q8IXN8
    UniProtKB/TrEMBL
    K9MRS9, K9MSY5
    Related
    ENSP00000381726.1, ENST00000398741.5
    Conserved Domains (2) summary
    sd00034
    Location:324350
    LRR_AMN1; leucine-rich repeat [structural motif]
    cl39015
    Location:323436
    LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
  11. NM_206956.3NP_996839.1  melanoma antigen preferentially expressed in tumors isoform a

    See identical proteins and their annotated locations for NP_996839.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (5) differs in the 5' UTR, compared to variant 2. Variants 1-7 encode the same isoform (a).
    Source sequence(s)
    AK304593, BC022008, DB024053
    Consensus CDS
    CCDS13801.1
    UniProtKB/Swiss-Prot
    B2R6Y7, O43481, P78395, Q8IXN8
    UniProtKB/TrEMBL
    K9MRS9, K9MSY5
    Related
    ENSP00000384343.3, ENST00000405655.8
    Conserved Domains (2) summary
    sd00034
    Location:324350
    LRR_AMN1; leucine-rich repeat [structural motif]
    cl39015
    Location:323436
    LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000022.11 Reference GRCh38.p14 Primary Assembly

    Range
    22547701..22559265 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011530034.4XP_011528336.1  melanoma antigen preferentially expressed in tumors isoform X1

    See identical proteins and their annotated locations for XP_011528336.1

    UniProtKB/TrEMBL
    B7ZAT0
    Conserved Domains (2) summary
    cd00116
    Location:307420
    LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
    sd00034
    Location:308334
    LRR_AMN1; leucine-rich repeat [structural motif]

Reference GRCh38.p14 ALT_REF_LOCI_1

Genomic

  1. NT_187629.1 Reference GRCh38.p14 ALT_REF_LOCI_1

    Range
    183358..194922 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054329448.1XP_054185423.1  melanoma antigen preferentially expressed in tumors isoform X1

    UniProtKB/TrEMBL
    B7ZAT0

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060946.1 Alternate T2T-CHM13v2.0

    Range
    22970590..22982125 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054325361.1XP_054181336.1  melanoma antigen preferentially expressed in tumors isoform X1

    UniProtKB/TrEMBL
    B7ZAT0